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Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.
Alessio Lepore, Pui Man Choy, Nathan CW Lee, Maria Annunziata Carella, Rosy Favicchio, Marco A Briones-Orta, Shannon S Glaser, Gianfranco Alpini, Clive D'Santos, Reuben M Tooze, Mihaela Lorger, Wing-Kin Syn, Athanasios Papakyriakou, Georgios Giamas, Concetta Bubici, Salvatore Papa
Sep 15, 2021
BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c-Jun N-terminal kinase (JNK) pathway is a key feature in ICC...
Animals Antineoplastic Agents Bile Duct Neoplasms Carcinogenesis Cell Line Tumor Cholangiocarcinoma Female Gene Knockdown Techniques Humans MAP Kinase Signaling System Mice Mice Inbred NOD Mice SCID Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 NIMA-Interacting Peptidylprolyl Isomerase Phosphorylation RNA Small Interfering Tretinoin Tumor Burden Xenograft Model Antitumor Assays
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Slow waters
GEOFFREY MAGUIRE
Oct 22, 2019
Recent critical approaches to slow queer film in Latin America have focused almost exclusively on the depiction of non-normative sexualities and desires, neglecting both the representational politics of cinematic slowness and...
Transnational Soldiers and Guerrilla Warfare from the Spanish Civil War to the Second World War
Jorge Marco
Jul 01, 2020
This article analyses how military institutions incorporated innovations in their tactics using the intermediary role of transnational soldiers in the Spanish Civil War. The Soviet experience of guerrilla warfare during the...
Information theory analysis of cascading process in a synthetic model of fluid turbulence
The use of transfer entropy has proven to be helpful in detecting which is the verse of dynamical driving in the interaction of two processes, X and Y . In this paper, we present a different normalization for the transfer...
Information theory analysis of cascading process in a synthetic model of fluid turbulence
The use of transfer entropy has proven to be helpful in detecting which is the verse of dynamical driving in the interaction of two processes, X and Y . In this paper, we present a different normalization for the transfer...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Transnational Soldiers and Guerrilla Warfare from the Spanish Civil War to the Second World War
Jorge Marco
Jul 01, 2020
This article analyses how military institutions incorporated innovations in their tactics using the intermediary role of transnational soldiers in the Spanish Civil War. The Soviet experience of guerrilla warfare during the...
Cybersecurity Standardisation for SMEs
There are various challenges regarding the development and use of cybersecurity standards for SMEs. In particular, SMEs need guidance in interpreting and implementing cybersecurity practices and adopting the standards to their...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
The Antifascist Tower of Babel
Jorge Marco
Dec 01, 2019
The International Brigades were a hybrid bunch: multi-ethnic, multi-national—
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
Rethinking the Postwar Period in Spain
Jorge Marco
Jul 31, 2020
There is a consensus among scholars regarding the slow transformation of ‘hot-blooded terror’ into ‘cold-blooded terror’ during the Civil War and the Post-war period in Spain. This article challenges this framework in two ways....
Rethinking the Postwar Period in Spain
Jorge Marco
Jul 31, 2020
There is a consensus among scholars regarding the slow transformation of ‘hot-blooded terror’ into ‘cold-blooded terror’ during the Civil War and the Post-war period in Spain. This article challenges this framework in two ways....
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
The Antifascist Tower of Babel
Jorge Marco
Dec 01, 2019
The International Brigades were a hybrid bunch: multi-ethnic, multi-national—
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
and multi-lingual: not everybody spoke everybody’s language. This posed serious
organizational challenges for the Republican war effort.
Public opinion as a source of deinstitutionalization
We develop a theoretical model to explain how public opinion can lead to the deinstitutionalization of a practice. Our model draws on the “spiral of silence” theory, which originated in the mass communication literature and...
Carolina Values Summit to Host Ted Cruz, Ben Carson and Rick Santorum
Winthrop University
Jan 01, 0001
The Reconciled Church Movement will hold the "Carolina Values Summit," a presidential forum, at 6 p.m. on Feb. 11 at Byrnes Auditorium. The forum will feature GOP presidential candidates, U.S. Sen. Ted Cruz of Texas and...
Published by: Winthrop University
Public opinion as a source of deinstitutionalization
We develop a theoretical model to explain how public opinion can lead to the deinstitutionalization of a practice. Our model draws on the “spiral of silence” theory, which originated in the mass communication literature and...
A high‐resolution view of the coordination environment in a paramagnetic metalloprotein from its magnetic properties
Enrico Ravera, Lucia Gigli, Elizaveta A. Suturina, Vito Calderone, Marco Fragai, Giacomo Parigi, Claudio Luchinat
Jun 25, 2021
Metalloproteins constitute a significant fraction of the proteome of all organisms and their characterization is critical for both basic sciences and biomedical applications. A large portion of metalloproteins bind paramagnetic...
A high‐resolution view of the coordination environment in a paramagnetic metalloprotein from its magnetic properties
Enrico Ravera, Lucia Gigli, Elizaveta A. Suturina, Vito Calderone, Marco Fragai, Giacomo Parigi, Claudio Luchinat
Jun 25, 2021
Metalloproteins constitute a significant fraction of the proteome of all organisms and their characterization is critical for both basic sciences and biomedical applications. A large portion of metalloproteins bind paramagnetic...
Digital Media Ethics
Digital media and connected technologies have brought some new ethical challenges to the surface. Digital media ethics is the scientific and systematic study of ethical attitudes and problems in relation to the use of digital...
Published by: IGI Global Scientific Publishing
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