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Spines, skeletons and the strong law of large numbers for superdiffusions
Consider a supercritical superdiffusion (X t ) t≥0 on a domain D⊆R d with branching mechanism
(x,z)↦−β(x)z+α(x)z 2 +∫ (0,∞) (e −zy −1+zy)Π(x,dy).
The skeleton decomposition provides a pathwise description of the...
(x,z)↦−β(x)z+α(x)z 2 +∫ (0,∞) (e −zy −1+zy)Π(x,dy).
The skeleton decomposition provides a pathwise description of the...
Spines, skeletons and the strong law of large numbers for superdiffusions
Consider a supercritical superdiffusion (X t ) t≥0 on a domain D⊆R d with branching mechanism
(x,z)↦−β(x)z+α(x)z 2 +∫ (0,∞) (e −zy −1+zy)Π(x,dy).
The skeleton decomposition provides a pathwise description of the...
(x,z)↦−β(x)z+α(x)z 2 +∫ (0,∞) (e −zy −1+zy)Π(x,dy).
The skeleton decomposition provides a pathwise description of the...
Sleep-wake disturbances in hospitalized patients with traumatic brain injury
Catherine Duclos, Marie Dumont, Jean Paquet, Hélène Blais, Solenne Van der Maren, David K Menon, Francis Bernard, Nadia Gosselin
Nov 26, 2019
STUDY OBJECTIVES: To test whether the sleep-wake cycle disruption in patients hospitalized with traumatic brain injury (TBI) (1) is also found in patients with traumatic injuries other than TBI (non-TBI) and (2) is associated...
Opportunities and Challenges of Using Mobile Applications for Workplace Health Promotion
Workplace health promotion (WHP) needs be adjusted to the new ways of working and improved in terms of participation rates. As mobile applications (apps) have proved to be effective in various health areas, it might also be a...
Published by: IGI Global Scientific Publishing
Co-Production of Assessment Rubrics in an Online Education Context
Marking rubrics is hailed as a transparent and effective way of supporting student success; enhancing their ability to understand and use their learning environment to achieve their goals. Rubrics also enable staff to mark...
classroom management Education Learning Assessment and Measurement Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
VESTIGE: Adjuvant Immunotherapy in Patients With Resected Esophageal, Gastroesophageal Junction and Gastric Cancer Following Preoperative Chemotherapy With High Risk for Recurrence (N+ and/or R1)
Elizabeth Smyth, Maren Knödler, Anne Giraut, Murielle Mauer, Magnus Nilsson, Nicole Van Grieken, Anna Dorothea Wagner, Markus Moehler, Florian Lordick
Mar 25, 2020
Background: Perioperative chemotherapy plus surgery is one recommended standard treatment for patients with resectable gastric and esophageal cancer. Even with a multimodality treatment more than half of patients will relapse...
VESTIGE: Adjuvant Immunotherapy in Patients With Resected Esophageal, Gastroesophageal Junction and Gastric Cancer Following Preoperative Chemotherapy With High Risk for Recurrence (N+ and/or R1)
Elizabeth Smyth, Maren Knödler, Anne Giraut, Murielle Mauer, Magnus Nilsson, Nicole Van Grieken, Anna Dorothea Wagner, Markus Moehler, Florian Lordick
Feb 13, 2020
Background: Perioperative chemotherapy plus surgery is one recommended standard treatment for patients with resectable gastric and esophageal cancer. Even with a multimodality treatment more than half of patients will relapse...
Unlocking the potential of ancient fish DNA in the genomic era.
Tom Oosting, Bastiaan Star, James H Barrett, Maren Wellenreuther, Peter A Ritchie, Nicolas J Rawlence
Sep 04, 2019
Fish are the most diverse group of vertebrates, fulfil important ecological functions and are of significant economic interest for aquaculture and wild fisheries. Advances in DNA extraction methods, sequencing technologies and...
Monitoring a Meat-Free Pledge with Smartphones
Jared Piazza, Rebecca Gregson, Anastasia Kordoni, Tamara Pfeiler, Matthew Ruby, David Ellis, Ensu Sahin, Maren Reith
Jan 01, 2022
Pledges are a popular strategy to encourage meat reduction, though experimental studies of their efficacy are lacking. Three-hundred and twenty-five participants from three different countries (UK, Germany, Australia) were...
Monitoring a Meat-Free Pledge with Smartphones
Jared Piazza, Rebecca Gregson, Anastasia Kordoni, Tamara Pfeiler, Matthew Ruby, David Ellis, Ensu Sahin, Maren Reith
Jan 01, 2022
Pledges are a popular strategy to encourage meat reduction, though experimental studies of their efficacy are lacking. Three-hundred and twenty-five participants from three different countries (UK, Germany, Australia) were...
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero
Aug 31, 2018
AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins
Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.
Laurens H Lindenburg, Teodors Pantelejevs, Fabrice Gielen, Pedro Zuazua-Villar, Maren Butz, Eric Rees, Clemens F Kaminski, Jessica A Downs, Marko Hyvönen, Florian Hollfelder
Aug 18, 2021
A meta-analysis of gene expression signatures of blood pressure and hypertension.
Tianxiao Huan, Tõnu Esko, Marjolein J Peters, Luke C Pilling, Katharina Schramm, Claudia Schurmann, Brian H Chen, Chunyu Liu, Roby Joehanes, Andrew D Johnson, Chen Yao, Sai-Xia Ying, Paul Courchesne, Lili Milani, Nalini Raghavachari, Richard Wang, Poching Liu, Eva Reinmaa, Abbas Dehghan, Albert Hofman, André G Uitterlinden, Dena G Hernandez, Stefania Bandinelli, Andrew Singleton, David Melzer, Andres Metspalu, Maren Carstensen, Harald Grallert, Christian Herder, Thomas Meitinger, Annette Peters, Michael Roden, Melanie Waldenberger, Marcus Dörr, Stephan B Felix, Tanja Zeller, International Consortium for Blood Pressure GWAS (ICBP), Ramachandran Vasan, Christopher J O'Donnell, Peter J Munson, Xia Yang, Holger Prokisch, Uwe Völker, Joyce BJ van Meurs, Luigi Ferrucci, Daniel Levy
Sep 21, 2018
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as...
The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors.
Lucy Thorne, Angela Nalwoga, Alexander J Mentzer, Alexis de Rougemont, Myra Hosmillo, Emily Webb, Margaret Nampiija, Allan Muhwezi, Tommy Carstensen, Deepti Gurdasani, Adrian V Hill, Manj S Sandhu, Alison Elliott, Ian Goodfellow
Jul 25, 2018
BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV...
Antibodies Viral Blood Group Antigens Caliciviridae Infections Child Preschool Cross-Sectional Studies Demography Disease Susceptibility Enzyme-Linked Immunosorbent Assay Female Fucosyltransferases Gastroenteritis genetic variation Genotype Humans Infant Infant Newborn Longitudinal Studies Male Norovirus Polymorphism Single Nucleotide Pregnancy Risk Factors Seroepidemiologic Studies Socioeconomic Factors Uganda
Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA.
Genevieve L Wojcik, Poonum Korpe, Chelsea Marie, Alexander J Mentzer, Tommy Carstensen, Josyf Mychaleckyj, Beth D Kirkpatrick, Stephen S Rich, Patrick Concannon, ASG Faruque, Rashidul Haque, William A Petri, Priya Duggal
Mar 10, 2020
Diarrhea is a major cause of both morbidity and mortality worldwide, especially among young children. Cryptosporidiosis is a leading cause of diarrhea in children, particularly in South Asia and sub-Saharan Africa, where it is...
Cryptosporidium Genetics genome analysis Bangladesh Cryptosporidiosis Cryptosporidium Diarrhea Disease Susceptibility Feces Female Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Meta-Analysis as Topic Polymorphism Single Nucleotide Prospective Studies Protein Kinase C-alpha Risk Factors
Genome-wide association study of type 2 diabetes in Africa
Ji Chen, Meng Sun, Adebowale Adeyemo, Fraser Pirie, Tommy Carstensen, Cristina Pomilla, Ayo P. Doumatey, Guanjie Chen, Elizabeth H. Young, Manjinder Sandhu, Andrew P. Morris, Inês Barroso, Mark I. McCarthy, Anubha Mahajan, Eleanor Wheeler, Charles N. Rotimi, Ayesha A. Motala
Jun 06, 2020
Abstract: Aims/hypothesis: Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes...
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Sep 14, 2021
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand...
DEPTOR Biochemistry Cancer chemical biology cryo-EM human mTOR molecular biophysics partial inhibition Signal Transduction structural biology Binding Sites Cryoelectron Microscopy Escherichia coli Gene Expression Regulation Humans Image Processing Computer-Assisted Intracellular Signaling Peptides and Proteins Mechanistic Target of Rapamycin Complex 1 Models Molecular PDZ Domains Protein Binding Protein Conformation Recombinant Proteins TOR Serine-Threonine Kinases
Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections.
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O Pollard, Alexander T Dilthey, Alexander J Mentzer, Vickie Marshall, Elena M Cornejo Castro, Cristina Pomilla, Elizabeth H Young, Gershim Asiki, Martin L Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Oct 02, 2020
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is...
Adolescent Adult Antibodies Viral Antigens Viral Capsid Proteins Coinfection Disease Resistance Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Gene Expression Genome-Wide Association Study HIV HLA-DQ alpha-Chains Henipavirus Infections Herpesvirus 4 Human Herpesvirus 8 Human Host-Pathogen Interactions Humans Incidence Male Middle Aged Rural Population Sarcoma Kaposi Uganda Urban Population
Distinct genetic architectures and environmental factors associate with host response to the γ 2-herpesvirus infections
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O. Pollard, Alexander T. Dilthey, Alexander J. Mentzer, Vickie Marshall, Elena M. Cornejo Castro, Cristina Pomilla, Elizabeth H. Young, Gershim Asiki, Martin L. Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Jul 31, 2020
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone...
Genome-wide association study of type 2 diabetes in Africa.
Ji Chen, Meng Sun, Adebowale Adeyemo, Fraser Pirie, Tommy Carstensen, Cristina Pomilla, Ayo P Doumatey, Guanjie Chen, Elizabeth H Young, Manjinder Sandhu, Andrew P Morris, Inês Barroso, Mark I McCarthy, Anubha Mahajan, Eleanor Wheeler, Charles N Rotimi, Ayesha A Motala
Jul 25, 2019
AIMS/HYPOTHESIS: Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci...
Distinct genetic architectures and environmental factors associate with host response to the γ 2-herpesvirus infections
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O. Pollard, Alexander T. Dilthey, Alexander J. Mentzer, Vickie Marshall, Elena M. Cornejo Castro, Cristina Pomilla, Elizabeth H. Young, Gershim Asiki, Martin L. Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Aug 02, 2021
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone...
Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Konrad Aden, Ateequr Rehman, Maren Falk-Paulsen, Thomas Secher, Jan Kuiper, Florian Tran, Steffen Pfeuffer, Raheleh Sheibani-Tezerji, Alexandra Breuer, Anne Luzius, Marlene Jentzsch, Robert Häsler, Susanne Billmann-Born, Olga Will, Simone Lipinski, Richa Bharti, Timon Adolph, Juan L Iovanna, Sarah L Kempster, Richard S Blumberg, Stefan Schreiber, Burkhard Becher, Mathias Chamaillard, Arthur Kaser, Philip Rosenstiel
Sep 08, 2016
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
Roland Rad, Juan Cadiñanos, Lena Rad, Ignacio Varela, Alexander Strong, Lydia Kriegl, Fernando Constantino-Casas, Stefan Eser, Maren Hieber, Barbara Seidler, Stacey Price, Mario F Fraga, Vincenzo Calvanese, Gary Hoffman, Hannes Ponstingl, Günter Schneider, Kosuke Yusa, Carolyn Grove, Roland M Schmid, Wei Wang, George Vassiliou, Thomas Kirchner, Ultan McDermott, Pentao Liu, Dieter Saur, Allan Bradley
Oct 14, 2020
We show that BRAF(V600E) initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway underlies significant subsets of CRCs with distinctive...
Animals Cell Transformation Neoplastic Colorectal Neoplasms Cyclin-Dependent Kinase Inhibitor p16 Drug Screening Assays Antitumor MAP Kinase Signaling System Mice Microsatellite Instability Mutation Neoplasm Invasiveness Neoplasm Proteins Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins B-raf Tumor Suppressor Protein p53 Wnt Signaling Pathway
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