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Results: 45
Correction to: STATAWAARS
Margarida Espada, Sebastian Eves-van den Akker, Tom Maier, Paramasivan Vijayapalani, Thomas Baum, Manuel Mota, John T Jones
Aug 11, 2018
Following publication of the original article [1], the authors reported that one of the authors' names was erroneously changed during proofing and published incorrectly. In this Correction the incorrect and correct author name...
The Ursinus Weekly, October 21, 1977
Ann Weibezahl, Rick Morris, Jack Hauler, John Ingeholm, Nancy Weatherwax, Sharon Tuberty, Jonathan Zap, Donna L. Phillips, Kevin Griffin, Benjamin Shapiro, Denise Davis, Carolyn Graney, Christopher DuVally
Jan 01, 0001
Ursinus news in brief: Espada speaks at conference; Ursinus Homecoming; Buy a slave! Craft elected as officer New dining style proves popular Board to vote on calendar Students experience new dining style Student employment...
Ursinus College Collegeville Pennsylvania newspaper Juan Espadas Homecoming student government slave auction James P. Craft Jr. Wismer dining hall Food Service calendar reform Student employment Washington Winterim fundraising John Mauchly Football field hockey cross country Volleyball cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Fine-scale phylogeographic structure of <i>Borrelia lusitaniae</i> revealed by multilocus sequence typing
Liliana R Vitorino, Gabriele Margos, Edward J Feil, Margarida Collares-Pereira, Libia Zé-Zé, Klaus Kurtenbach
Jan 01, 0001
Borrelia lusitaniae is an Old World species of the Lyme borreliosis (LB) group of tick-borne spirochetes and prevails mainly in countries around the Mediterranean Basin. Lizards of the family Lacertidae have been identified as...
Fine-scale phylogeographic structure of <i>Borrelia lusitaniae</i> revealed by multilocus sequence typing
Liliana R Vitorino, Gabriele Margos, Edward J Feil, Margarida Collares-Pereira, Libia Zé-Zé, Klaus Kurtenbach
Jan 01, 0001
Borrelia lusitaniae is an Old World species of the Lyme borreliosis (LB) group of tick-borne spirochetes and prevails mainly in countries around the Mediterranean Basin. Lizards of the family Lacertidae have been identified as...
Understanding the Local Chemical Environment of Bioelectrocatalysis
Esther Edwardes Moore, Samuel Cobb, Ana Margarida Coito, Ana Rita Oliveira, Ines Pereira, Erwin Reisner
Feb 21, 2022
This work applies electrochemical and computational techniques to explore the local environment of fuel-producing oxidoreductases within porous electrode architectures. This improved understanding of the local environment...
A Semi-artificial Photoelectrochemical Tandem Leaf with a CO2 -to-Formate Efficiency Approaching 1 .
Esther Edwardes Moore, Virgil Andrei, Ana Rita Oliveira, Ana Margarida Coito, Inês AC Pereira, Erwin Reisner
Sep 05, 2021
Semi-artificial photoelectrochemistry can combine state-of-the-art photovoltaic light-absorbers with enzymes evolved for selective fuel-forming reactions such as CO2 reduction, but the overall performance of such hybrid systems...
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
Aug 14, 2021
A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development...
Published by: Chemical science
Optical Structural Analysis of Individual α-Synuclein Oligomers.
Juan A Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M Dobson, David Klenerman, Steven F Lee
Mar 19, 2018
Small aggregates of misfolded proteins play a key role in neurodegenerative disorders. Such species have proved difficult to study due to the lack of suitable methods capable of resolving these heterogeneous aggregates, which...
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Jul 25, 2020
Abstract: Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species...
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
Ji-Eun Lee, Jason C Sang, Margarida Rodrigues, Alexander R Carr, Mathew H Horrocks, Suman De, Marie N Bongiovanni, Patrick Flagmeier, Christopher M Dobson, David J Wales, Steven F Lee, David Klenerman
Dec 10, 2018
Nile red Super-resolution spectroscopy ALPHA-SYNUCLEIN hydrophobicity protein aggregation spectral imaging Fluorescent Dyes Humans Hydrophobic and Hydrophilic Interactions Optical Imaging Parkinson Disease Protein Aggregates protein aggregation Pathological Protein Multimerization Solubility ALPHA-SYNUCLEIN
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C. Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 16, 2020
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of...
The final data release of ALLSMOG
C Cicone, M Bothwell, J Wagg, P Møller, CD Breuck, Z Zhang, S Martín, R Maiolino, P Severgnini, M Aravena, F Belfiore, D Espada, A Flütsch, V Impellizzeri, Y Peng, MA Raj, N Ramírez-Olivencia, D Riechers, K Schawinski
Jul 24, 2017
We present the final data release of the APEX low-redshift legacy survey for molecular gas (ALLSMOG), comprising CO(2-1) emission line observations of 88 nearby, low-mass (10^8.5
Synergistic Binding of bHLH Transcription Factors to the Promoter of the Maize NADP-ME Gene Used in C4 Photosynthesis Is Based on an Ancient Code Found in the Ancestral C3 State.
Ana Rita Borba, Tânia S Serra, Alicja Górska, Paulo Gouveia, André M Cordeiro, Ivan Reyna-Llorens, Jana Knerová, Pedro M Barros, Isabel A Abreu, Maria Margarida Oliveira, Julian M Hibberd, Nelson JM Saibo
Apr 30, 2018
C4 photosynthesis has evolved repeatedly from the ancestral C3 state to generate a carbon concentrating mechanism that increases photosynthetic efficiency. This specialized form of photosynthesis is particularly common in the...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 12, 2020
UNLABELLED: Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk...
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.
Suman De, Daniel R Whiten, Francesco S Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I Sideris, Christopher G Taylor, Francesco A Aprile, Serge Muyldermans, Tuomas PJ Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Jul 24, 2019
Alzheimer’s disease cerebrospinal fluid Disease mechanism mild cognitive impairment protein aggregation Structure-function relation Super-resolution imaging Aged Alzheimer Disease Amyloid beta-Peptides Animals Biomarkers Camelids New World Cognitive Dysfunction Disease Progression Female Humans Male Protein Aggregates tau Proteins
Inhibiting the Ca2+ Influx Induced by Human CSF.
Anna Drews, Suman De, Patrick Flagmeier, David C Wirthensohn, Wei-Hsin Chen, Daniel R Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W Paterson, Catherine F Slattery, Nick C Fox, Jonathan M Schott, Henrik Zetterberg, Christopher M Dobson, Sonia Gandhi, David Klenerman
Jun 18, 2018
One potential therapeutic strategy for Alzheimer's disease (AD) is to use antibodies that bind to small soluble protein aggregates to reduce their toxic effects. However, these therapies are rarely tested in human CSF before...
Alzheimer’s disease Antibodies beta amyloid calcium influx cerebrospinal fluid Clusterin fluorescence measurements neurodegenerative conditions OLIGOMERS single molecule imaging Aged Alzheimer Disease Amino Acid Sequence Amyloid beta-Peptides Animals Antibodies Monoclonal Humanized Astrocytes Biological Assay Calcium cerebrospinal fluid Clusterin Culture Media Cytoplasmic Vesicles Female Humans Ion Transport Male Middle Aged Peptide Fragments Primary Cell Culture Protein Aggregates Rats Single-Domain Antibodies
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Marthe HR Ludtmann, Plamena R Angelova, Mathew H Horrocks, Minee L Choi, Margarida Rodrigues, Artyom Y Baev, Alexey V Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T Ranasinghe, Daniel R Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Oct 10, 2018
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that...
Animals Coculture Techniques Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Lipid Peroxidation Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Mitochondrial Proton-Translocating ATPases Neurons Oxidation-Reduction Parkinson Disease Patch-Clamp Techniques Permeability Proteomics Rats Rats Sprague-Dawley Reactive Oxygen Species ALPHA-SYNUCLEIN
Chemical and Carbon Isotopic Characterization of a Karst-Dominated Urbanized Watershed
Urbanization and agriculture are two key factors that place demands on water resources and serve as sources of anthropogenic pollution into inland waterways. The San Antonio River, which is sourced from a karst aquifer, plays an...
Published by: Digital Commons @ Texas A&M University-San Antonio
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.
Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.
Lisa-Maria Needham, Judith Weber, James WB Fyfe, Omaru M Kabia, Dung T Do, Ewa Klimont, Yu Zhang, Margarida Rodrigues, Christopher M Dobson, Sonia Gandhi, Sarah E Bohndiek, Thomas N Snaddon, Steven F Lee
Sep 20, 2018
[This corrects the article DOI: 10.1098/rsos.171399.].
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