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A timer gene network is spatially regulated by the terminal system in the Drosophila embryo.
The Long-Rage Directional Behavior of the Nematode C. Elegans
Margherita Peliti
Jan 01, 0001
Like any mobile organism, C. elegans relies on sensory cues to find food. In the absence of such cues, animals might display defined search patterns or other stereotyped behavior. The motion of C. elegans has previously been...
C. elegans directional behavior off-food trajectories random walk processes daf-19 mutants Life Sciences
Published by: Rockefeller University
Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.
Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and involved in various aspects of cellular life, with a primary role in energy production. The interest in this organelle has grown stronger...
Investigation of infertility using endometrial organoids.
Infertility is a common problem in modern societies with significant socio-psychological implications for women. Therapeutic interventions are often needed which, depending on the cause, can either be medical treatment, surgical...
Development of the human placenta.
development Maternal Placenta trophoblast Animals Bioengineering Cell Culture Techniques Cell Differentiation Cell Lineage Decidua Endometrium Female Fetal Growth Retardation Humans Immune System Leukocytes Mice Organoids Placenta Placentation pre-eclampsia Pregnancy Pregnancy Complications Sequence Analysis RNA Single-Cell Analysis Trophoblasts Uterus
Organoids of the female reproductive tract.
Cancers Female reproductive tract Fertility Infection Organoids Pregnancy Reproductive Health Animals CRISPR-Cas Systems Drug Discovery Estrous Cycle Extracellular Matrix Female Fertility Gene Editing Genital Diseases female Genitalia female Gestational Age Gonadal Steroid Hormones Humans Maternal-Fetal Exchange Mice Organoids Pituitary Hormones Anterior Placenta Precision Medicine Pregnancy Stem Cells Tissue Engineering
Organoid systems to study the human female reproductive tract and pregnancy.
Review
Development of the placenta must always be in advance of that of the embryo. Evidence from domestic species demonstrates that the placenta is capable of stimulating its own development through a signalling dialogue with the...
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Sep 05, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
CRISPR gene editing developmental biology Epithelial-Mesenchymal Transition human MOUSE Placenta Regenerative Medicine stem cell self-renewal Stem Cells trophoblast trophoblast invasion Animals Cell Differentiation Epithelial-Mesenchymal Transition Gene Expression Regulation Humans Mice Repressor Proteins Trophoblasts Tumor Suppressor Proteins Ubiquitin Thiolesterase
What Works to Improve Wellbeing? A Rapid Systematic Review of 223 Interventions Evaluated with the Warwick-Edinburgh Mental Well-Being Scales.
INTRODUCTION: The Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) is a commonly used scale of mental wellbeing focusing entirely on the positive aspect of mental health. It has been widely used in a broad range of clinical and...
Investigation of human trophoblast invasion in vitro.
Menstrual flow as a non-invasive source of endometrial organoids.
Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn JP Jones, Ashley Moffett, Graham J Burton, Margherita Y Turco
May 03, 2021
Post-mortem computed tomography (PMCT) radiological findings and assessment in advanced decomposed bodies.
Gaia Cartocci, Alessandro Santurro, Margherita Neri, Fulvio Zaccagna, Carlo Catalano, Raffaele La Russa, Emanuela Turillazzi, Valeria Panebianco, Paola Frati, Vittorio Fineschi
Oct 17, 2019
PURPOSE: The aim of the study is to report radiological findings and features in advanced decomposed bodies obtained by post-mortem computed tomography (PMCT) with autopsy correlation. MATERIALS AND METHODS: This retrospective...
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration.
Hope I Needs, Margherita Protasoni, Jeremy M Henley, Julien Prudent, Ian Collinson, Gonçalo C Pereira
Jul 26, 2021
The fact that >99% of mitochondrial proteins are encoded by the nuclear genome and synthesised in the cytosol renders the process of mitochondrial protein import fundamental for normal organelle physiology. In addition to this...
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Jul 28, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
human Placenta trophoblast MOUSE trophoblast invasion developmental biology Stem Cells Epithelial-Mesenchymal Transition Regenerative Medicine stem cell self-renewal CRISPR gene editing
Published by: eLife
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration
Hope I. Needs, Margherita Protasoni, Jeremy M. Henley, Julien Prudent, Ian Collinson, Gonçalo C. Pereira
May 20, 2021
The fact that >99% of mitochondrial proteins are encoded by the nuclear genome and synthesised in the cytosol renders the process of mitochondrial protein import fundamental for normal organelle physiology. In addition to this...
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Jun 25, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta.
Cheryl QE Lee, Margherita Y Turco, Lucy Gardner, Benjamin D Simons, Myriam Hemberger, Ashley Moffett
Mar 09, 2018
During pregnancy the trophoblast cells of the placenta are the only fetal cells in direct contact with maternal blood and decidua. Their functions include transport of nutrients and oxygen, secretion of pregnancy hormones...
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin
Tania Velletri, Yin Huang, Yu Wang, Qing Li, Mingyuan Hu, Ningxia Xie, Qian Yang, Xiaodong Chen, Qing Chen, Peishun Shou, Yurun Gan, Eleonora Candi, Annicchiarico-Petruzzelli Margherita, Massimiliano Agostini, Huilin Yang, Gerry Melino, Yufang Shi, Ying Wang
Jul 28, 2021
Abstract: p53 plays a pivotal role in controlling the differentiation of mesenchymal stem cells (MSCs) by regulating genes involved in cell cycle and early steps of differentiation process. In the context of osteogenic...
Menstrual flow as a non-invasive source of endometrial organoids
Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn J. P. Jones, Ashley Moffett, Graham J. Burton, Margherita Y. Turco
Jun 18, 2021
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