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Results: 91
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition
Qin Wang, Clare Oliver-Williams, Olli T Raitakari, Jorma Viikari, Terho Lehtimäki, Mika Kähönen, Marjo-Riitta Järvelin, Veikko Salomaa, Markus Perola, John Danesh, Johannes Kettunen, Adam S Butterworth, Michael V Holmes, Mika Ala-Korpela
Nov 05, 2020
ANGPTL3 ANGPTL4 Amino Acids Drug targets Glycoprotein acetyls LPL lipoprotein lipids Lipoprotein subclasses Mendelian randomization Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiopoietin-like Proteins Angiopoietins Diabetes mellitus Type 2 Humans Mendelian Randomization Analysis Pharmaceutical Preparations
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 27, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Johannes Kettunen, Michael V. Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D. Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T. Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Mika Ala-Korpela
Jan 06, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 10, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Adolescent Adult Alleles Apolipoproteins B Cholesterol Ester Transfer Proteins Cholesterol LDL Cohort Studies Coronary Disease Female Follow-Up Studies genetic variation Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipoproteins Male Middle Aged Triglycerides Young Adult
Development of Timd2 as a reporter gene for MRI.
P Stephen Patrick, Tiago B Rodrigues, Mikko I Kettunen, Scott K Lyons, André A Neves, Kevin M Brindle
Jun 22, 2015
Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid
Sarah E Bohndiek, Mikko I Kettunen, De-En Hu, Brett WC Kennedy, Joan Boren, Ferdia A Gallagher, Kevin M Brindle
Aug 09, 2017
Dynamic nuclear polarization (DNP) of (13)C-labeled metabolic substrates in vitro and their subsequent intravenous administration allow both the location of the hyperpolarized substrate and the dynamics of its subsequent...
A computationally efficient Bayesian seemingly unrelated regressions model for high‐dimensional quantitative trait loci discovery
Leonardo Bottolo, Marco Banterle, Sylvia Richardson, Mika Ala‐Korpela, Marjo‐Riitta Järvelin, Alex Lewin
May 09, 2021
Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.
Eeva Sliz, Johannes Kettunen, Michael V Holmes, Clare Oliver Williams, Charles Boachie, Qin Wang, Minna Männikkö, Sylvain Sebert, Robin Walters, Kuang Lin, Iona Y Millwood, Robert Clarke, Liming Li, Naomi Rankin, Paul Welsh, Christian Delles, J Wouter Jukema, Stella Trompet, Ian Ford, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Zhengming Chen, Debbie A Lawlor, Mika Ala-Korpela, John Danesh, George Davey Smith, Naveed Sattar, Adam Butterworth, Peter Würtz
Feb 08, 2019
BACKGROUND: Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL-C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two...
Mendelian randomization PCSK9 lipids and lipoprotein metabolism Metabolomics statin therapy Aged Aged 80 and over Amino Acids Cardiovascular Diseases Cholesterol LDL Cholesterol VLDL Double-Blind Method Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Mendelian Randomization Analysis Metabolomics PCSK9 Inhibitors Placebo Effect Pravastatin Proprotein Convertase 9
Published by: Circulation
Condition dependence in biosynthesized chemical defenses of an aposematic and mimetic Heliconius butterfly.
Aposematic animals advertise their toxicity or unpalatability with bright warning coloration. However, acquiring and maintaining chemical defenses can be energetically costly, and consequent associations with other important...
Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.
Eva M Serrao, Tiago B Rodrigues, Ferdia A Gallagher, Mikko I Kettunen, Brett WC Kennedy, Sarah L Vowler, Keith A Burling, Kevin M Brindle
Jun 16, 2016
Cancer Fasting hyperpolarization Lymphoma Pyruvate REPEATABILITY Algorithms Animals Biomarkers Tumor Carbon-13 Magnetic Resonance Spectroscopy Fasting Female Mice Mice Inbred C57BL Neoplasms Experimental Pyruvic Acid Reproducibility of Results Sensitivity and Specificity Signal Processing Computer-Assisted
Cavitating Leukoencephalopathy With Posterior Predominance Caused by a Deletion in the APOPT1 Gene in an Indian Boy.
Suvasini Sharma, Preeti Singh, Erika Fernandez-Vizarra, Massimo Zeviani, Marjo S Van der Knaap, Ravindra Kumar Saran
Apr 18, 2018
Specific adolescent prodromal symptoms associated with onset of psychosis in the Northern Finland Birth Cohort 1986.
Johanna Palomäki, Sebastian Therman, Martta Kerkelä, Marjo-Riitta Järvelin, Peter Jones, Graham K Murray, Tanja Nordström, Markus Heinimaa, Jouko Miettunen, Juha Veijola, Tiina Riekki
Oct 11, 2022
BACKGROUND: Several psychological symptoms in adolescence associate with later development of psychosis. However, it is unclear which symptoms specifically predict psychotic disorders rather than psychiatric disorders in...
Evolutionary and ecological processes influencing chemical defense variation in an aposematic and mimetic Heliconius butterfly.
Anniina LK Mattila, Chris D Jiggins, Øystein H Opedal, Gabriela Montejo-Kovacevich, Érika C Pinheiro de Castro, W Owen McMillan, Caroline Bacquet, Marjo Saastamoinen
Jul 26, 2021
Chemical defences against predators underlie the evolution of aposematic coloration and mimicry, which are classic examples of adaptive evolution. Surprisingly little is known about the roles of ecological and evolutionary...
Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-$^{13}$C] Dehydroascorbic Acid Reduction Using $^{13}$C Magnetic Resonance Spectroscopy
KN Timm, D-E Hu, M Williams, AJ Wright, MI Kettunen, BWC Kennedy, TJ Larkin, P Dzien, I Marco-Rius, SE Bohndiek, KM Brindle
Mar 13, 2017
Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.
André A Neves, Yéléna A Wainman, Alan Wright, Mikko I Kettunen, Tiago B Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann, Finian J Leeper, Kevin M Brindle
Aug 11, 2020
Glycosylation is a ubiquitous post-translational modification, present in over 50 % of the proteins in the human genome,1 with important roles in cell-cell communication and migration. Interest in glycome profiling has increased...
Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality.
Scott C Ritchie, Johannes Kettunen, Marta Brozynska, Artika P Nath, Aki S Havulinna, Satu Männistö, Markus Perola, Veikko Salomaa, Mika Ala-Korpela, Gad Abraham, Peter Würtz, Michael Inouye
Feb 07, 2020
BACKGROUND: GlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. It is heterogeneous; arising from five circulating glycoproteins with dynamic concentrations...
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts.
Hugh Ramsay, Jennifer H Barnett, Graham K Murray, Jouko Miettunen, Pirjo Mäki, Marjo-Riitta Järvelin, George Davey Smith, Mika Ala-Korpela, Juha Veijola
Nov 22, 2018
BACKGROUND: Psychoses, especially schizophrenia, are often preceded by cognitive deficits and psychosis risk states. Altered metabolic profiles have been found in schizophrenia. However, the associations between metabolic...
Eva M Serrao, Mikko I Kettunen, Tiago B Rodrigues, Piotr Dzien, Alan J Wright, Aarthi Gopinathan, Ferdia A Gallagher, David Y Lewis, Kristopher K Frese, Jaime Almeida, William J Howat, David A Tuveson, Kevin M Brindle
Aug 07, 2015
(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.
Piotr Dzien, Sui-Seng Tee, Mikko I Kettunen, Scott K Lyons, Timothy J Larkin, Kerstin N Timm, De-En Hu, Alan Wright, Tiago B Rodrigues, Eva M Serrao, Irene Marco-Rius, Elizabeth Mannion, Paula D'Santos, Brett WC Kennedy, Kevin M Brindle
Aug 06, 2015
Zymomonas mobilis pyruvate decarboxylase hyperpolarized [1-13C] pyruvate reporter genes Animals Carbon-13 Magnetic Resonance Spectroscopy Enzyme Activation Female Genes Reporter HEK293 Cells Humans Magnetic Resonance Imaging Mice Mice SCID Molecular Imaging pyruvate decarboxylase Pyruvic Acid Recombinant Proteins Reproducibility of Results Sensitivity and Specificity Tissue Distribution Zymomonas
Stability of the associations between early life risk indicators and adolescent overweight over the evolving obesity epidemic.
Lise Graversen, Thorkild IA Sørensen, Liselotte Petersen, Ulla Sovio, Marika Kaakinen, Annelli Sandbæk, Jaana Laitinen, Anja Taanila, Anneli Pouta, Marjo-Riitta Järvelin, Carsten Obel
Aug 19, 2020
BACKGROUND: Pre- and perinatal factors and preschool body size may help identify children developing overweight, but these factors might have changed during the development of the obesity epidemic. OBJECTIVE: We aimed to assess...
Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.
Johannes Kettunen, Scott C Ritchie, Olga Anufrieva, Leo-Pekka Lyytikäinen, Jussi Hernesniemi, Pekka J Karhunen, Pekka Kuukasjärvi, Jari Laurikka, Mika Kähönen, Terho Lehtimäki, Aki S Havulinna, Veikko Salomaa, Satu Männistö, Mika Ala-Korpela, Markus Perola, Michael Inouye, Peter Würtz
Apr 15, 2019
BACKGROUND: Integration of systems-level biomolecular information with electronic health records has led to recent interest in the glycoprotein acetyls (GlycA) biomarker-a serum- or plasma-derived nuclear magnetic resonance...
Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.
André A Neves, Yéléna A Wainman, Alan Wright, Mikko I Kettunen, Tiago B Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann, Finian J Leeper, Kevin M Brindle
Nov 16, 2015
Analysis of heterogeneity in T$_2$-weighted MR images can differentiate pseudoprogression from progression in glioblastoma
TC Booth, TJ Larkin, Y Yuan, MI Kettunen, SN Dawson, D Scoffings, HC Canuto, SL Vowler, H Kirschenlohr, MP Hobson, F Markowetz, S Jefferies, KM Brindle
Apr 27, 2017
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.
Ferdia A Gallagher, Helen Sladen, Mikko I Kettunen, Eva M Serrao, Tiago B Rodrigues, Alan Wright, Andrew B Gill, Sarah McGuire, Thomas C Booth, Joan Boren, Alan McIntyre, Jodi L Miller, Shen-Han Lee, Davina Honess, Sam E Day, De-En Hu, William J Howat, Adrian L Harris, Kevin M Brindle
Jul 31, 2015
Animals Antigens Neoplasm Bicarbonates Carbon Dioxide Carbon Isotopes Carbonic Anhydrase IX Carbonic Anhydrases Cell Line Tumor Colorectal Neoplasms Heterografts Humans Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy Male Mice Mice Inbred NOD Mice SCID Neoplasm Proteins Recombinant Fusion Proteins Tumor Microenvironment
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