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Gut microbiome composition is similar between pregnant women with excess body fat with healthy and less healthy dietary intake patterns.
Hannah O'Connor, Sherly Li, Allison Hodge, Leonie Callaway, Harold David Mclntyre, Helen Barrett, Shelley A Wilkinson, Marloes Dekker Nitert
Jan 04, 2023
BACKGROUND: Dietary composition influences the composition of the gut microbiota in healthy adults. Little is known about the effect of dietary patterns on gut microbiota composition in pregnancy. This cross-sectional study...
Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank.
Aurora Perez-Cornago, Zoe Pollard, Heather Young, Marloes van Uden, Colm Andrews, Carmen Piernas, Timothy J Key, Angela Mulligan, Marleen Lentjes
Nov 25, 2021
PURPOSE: The Oxford WebQ is a web-based 24-h dietary assessment method which has been used in UK Biobank and other large prospective studies. The food composition table used to calculate nutrient intakes has recently been...
Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank
Aurora Perez-Cornago, Zoe Pollard, Heather Young, Marloes van Uden, Colm Andrews, Carmen Piernas, Timothy J. Key, Angela Mulligan, Marleen Lentjes
Sep 14, 2021
Polydrug Use Typologies of Regular Ecstasy Users Visiting Electronic Dance Music Events
Ruben Johannes Jacob van Beek, Matthijs Blankers, Marloes Kleinjan, Jon Waldron, Meryem Grabski, Tom Freeman, Valerie Curran, Peggy van der Pol, Margriet van Laar
Feb 29, 2024
Introduction: Polydrug use patterns among young adults using ecstasy vary, as well as their willingness to change them. Polydrug use patterns are likely associated with different adverse health outcomes. It is unknown whether...
Ecstasy Electronic dance music latent class analysis Nightlife Polydrug use /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils.
Tomasz K Prajsnar, Justyna J Serba, Bernice M Dekker, Josie F Gibson, Samrah Masud, Angeleen Fleming, Simon A Johnston, Stephen A Renshaw, Annemarie H Meijer
Mar 30, 2020
Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis. Although neutrophils contribute to immunity against S. aureus, multiple lines of evidence suggest...
Autophagy NADPH oxidase ROS Staphylococcus aureus lc3-associated phagocytosis (LAP) neutrophil Zebrafish Animals Animals Genetically Modified Autophagy Intracellular Space Kinetics MACROPHAGES Microtubule-Associated Proteins NADPH Oxidases Neutrophils Phagocytosis Phagosomes Protein Aggregates Sequestosome-1 Protein Staphylococcus aureus Zebrafish Zebrafish Proteins
Polydrug Use Typologies of Regular Ecstasy Users Visiting Electronic Dance Music Events
Ruben Johannes Jacob van Beek, Matthijs Blankers, Marloes Kleinjan, Jon Waldron, Meryem Grabski, Tom Freeman, Valerie Curran, Peggy van der Pol, Margriet van Laar
Feb 29, 2024
Introduction: Polydrug use patterns among young adults using ecstasy vary, as well as their willingness to change them. Polydrug use patterns are likely associated with different adverse health outcomes. It is unknown whether...
Ecstasy Electronic dance music latent class analysis Nightlife Polydrug use /dk/atira/pure/subjectarea/asjc/2700/2701 name=Medicine (miscellaneous) /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Transcription Factor Levels after Forward Programming of Human Pluripotent Stem Cells with GATA1, FLI1, and TAL1 Determine Megakaryocyte versus Erythroid Cell Fate Decision.
Amanda Dalby, Jose Ballester-Beltrán, Chiara Lincetto, Annett Mueller, Nicola Foad, Amanda Evans, James Baye, Ernest Turro, Thomas Moreau, Marloes R Tijssen, Cedric Ghevaert
Dec 21, 2018
erythroblast Forward programming lineage fate decision megakaryocyte Pluripotent Stem Cells Cell Differentiation Cell Lineage Cells Cultured Cytokines Erythroid Cells Erythropoietin GATA1 Transcription Factor Gene Silencing Humans Megakaryocytes Pluripotent Stem Cells Proto-Oncogene Protein c-fli-1 T-Cell Acute Lymphocytic Leukemia Protein 1 Thrombopoietin Transgenes
Cost-Effectiveness of Telemonitoring and Self-Monitoring of Blood Pressure for Antihypertensive Titration in Primary Care (TASMINH4).
Mark Monahan, Sue Jowett, Alecia Nickless, Marloes Franssen, Sabrina Grant, Sheila Greenfield, FD Richard Hobbs, James Hodgkinson, Jonathan Mant, Richard J McManus
Mar 15, 2019
Development and pilot-testing of a colorectal cancer screening decision aid for individuals with varying health literacy levels
Anke Woudstra, Ellen Smets, E Dekker, T Broens, J Penning, Sian K Smith, K McCaffery, Mirjam Fransen
Oct 01, 2019
Objective: Making an informed decision about colorectal cancer screening requires health literacy. Our aim was to develop and pilot-test a computer-based decision aid to support informed decision making about whether or not...
Development and pilot-testing of a colorectal cancer screening decision aid for individuals with varying health literacy levels
Anke Woudstra, Ellen Smets, E Dekker, T Broens, J Penning, Sian K Smith, K McCaffery, Mirjam Fransen
Oct 01, 2019
Objective: Making an informed decision about colorectal cancer screening requires health literacy. Our aim was to develop and pilot-test a computer-based decision aid to support informed decision making about whether or not...
Clinical indicators for bacterial co-infection in Ghanaian children with P. falciparum infection.
Maja Verena Nielsen, Solomon Amemasor, Alex Agyekum, Wibke Loag, Florian Marks, Nimako Sarpong, Denise Dekker, Yaw Adu-Sarkodie, Jürgen May
Feb 19, 2019
Differentiation of infectious causes in severely ill children is essential but challenging in sub- Saharan Africa. The aim of the study was to determine clinical indicators that are able to identify bacterial co-infections in P....
Adolescent Anthropometry Bacteremia Child Child Preschool Coinfection Cough Dehydration Ghana Humans Malaria Falciparum Odds Ratio Predictive Value of Tests prevalence Regression Analysis Rural Population Salmonella Infections Sensitivity and Specificity Socioeconomic Factors Splenomegaly Streptococcal Infections
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.
Michal R Gdula, Tatyana B Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Jun 17, 2019
The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of local topologically associated domains (TADs), A/B compartments and formation of two...
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids.
Susanne C van den Brink, Anna Alemany, Vincent van Batenburg, Naomi Moris, Marloes Blotenburg, Judith Vivié, Peter Baillie-Johnson, Jennifer Nichols, Katharina F Sonnen, Alfonso Martinez Arias, Alexander van Oudenaarden
Oct 28, 2019
Systemic bacteraemia in children presenting with clinical pneumonia and the impact of non-typhoid salmonella (NTS).
Norbert G Schwarz, Nimako Sarpong, Frank Hünger, Florian Marks, Samuel Ek Acquah, Alex Agyekum, Bernard Nkrumah, Wibke Loag, Ralf M Hagen, Jennifer A Evans, Denise Dekker, Julius N Fobil, Christian G Meyer, Jürgen May, Yaw Adu-Sarkodie
Feb 20, 2019
BACKGROUND: The diagnosis and antimicrobial treatment of pneumonia in African children in the absence of diagnostic means such as x-ray facilities or microbiological laboratories relies primarily on clinical symptoms presented...
Late development of cue integration is linked to sensory fusion in cortex.
Tessa M Dekker, Hiroshi Ban, Bauke van der Velde, Martin I Sereno, Andrew E Welchman, Marko Nardini
Oct 22, 2015
Drinking water from dug wells in rural ghana--salmonella contamination, environmental factors, and genotypes.
Denise Myriam Dekker, Ralf Krumkamp, Nimako Sarpong, Hagen Frickmann, Kennedy Gyau Boahen, Michael Frimpong, Renate Asare, Richard Larbi, Ralf Matthias Hagen, Sven Poppert, Wolfgang Rabsch, Florian Marks, Yaw Adu-Sarkodie, Jürgen May
Feb 19, 2019
Salmonellosis is an important but neglected disease in sub-Saharan Africa. Food or fecal-oral associated transmissions are the primary cause of infections, while the role of waterborne transmission is unclear. Samples were...
Telemonitoring and/or self-monitoring of blood pressure in hypertension (TASMINH4)
Marloes Franssen, Andrew Farmer, Sabrina Grant, Sheila Greenfield, Carl Heneghan, Richard Hobbs, James Hodgkinson, Susan Jowett, Jonathan Mant, Una Martin, Siobhan Milner, Mark Monahan, Emma Ogburn, Rafael Perera-Salazar, Claire Schwartz, Ly-Mee Yu, Richard J McManus
Mar 02, 2018
Hypertension PRIMARY CARE self-monitoring Telemonitoring Antihypertensive Agents blood pressure Blood Pressure Determination Blood Pressure Monitoring Ambulatory Clinical Protocols Humans Hypertension Predictive Value of Tests Primary Health Care Research Design Telemedicine Telemetry Treatment Outcome United Kingdom
MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.
Lital Shaham, Elena Vendramini, Yubin Ge, Yaron Goren, Yehudit Birger, Marloes R Tijssen, Maureen McNulty, Ifat Geron, Omer Schwartzman, Liat Goldberg, Stella T Chou, Holly Pitman, Mitchell J Weiss, Shulamit Michaeli, Benjamin Sredni, Berthold Göttgens, John D Crispino, Jeffrey W Taub, Shai Izraeli
Jan 22, 2016
Molecular Evidence for Flea-Borne Rickettsiosis in Febrile Patients from Madagascar.
Christian Keller, Raphaël Rakotozandrindrainy, Vera von Kalckreuth, Jean Noël Heriniaina, Norbert Georg Schwarz, Gi Deok Pak, Justin Im, Ligia Maria Cruz Espinoza, Ralf Matthias Hagen, Hagen Frickmann, Jean Philibert Rakotondrainiarivelo, Tsiry Razafindrabe, Denise Dekker, Jürgen May, Sven Poppert, Florian Marks
Nov 22, 2021
Rickettsiae may cause febrile infections in humans in tropical and subtropical regions. From Madagascar, no molecular data on the role of rickettsioses in febrile patients are available. Blood samples from patients presenting...
16S rRNA Gene Sequence-Based Identification of Bacteria in Automatically Incubated Blood Culture Materials from Tropical Sub-Saharan Africa.
Hagen Frickmann, Denise Dekker, Norbert Georg Schwarz, Andreas Hahn, Kennedy Boahen, Nimako Sarpong, Yaw Adu-Sarkodie, Eva Halbgewachs, Florian Marks, Vera von Kalckreuth, Sven Poppert, Ulrike Loderstaedt, Jürgen May, Ralf Matthias Hagen
Feb 20, 2019
BACKGROUND: The quality of microbiological diagnostic procedures depends on pre-analytic conditions. We compared the results of 16S rRNA gene PCR and sequencing from automatically incubated blood culture materials from tropical...
Incidence and characteristics of bacteremia among children in rural Ghana.
Maja Verena Nielsen, Nimako Sarpong, Ralf Krumkamp, Denise Dekker, Wibke Loag, Solomon Amemasor, Alex Agyekum, Florian Marks, Frank Huenger, Anne Caroline Krefis, Ralf Matthias Hagen, Yaw Adu-Sarkodie, Jürgen May, Norbert Georg Schwarz
Feb 20, 2019
The objective of the study was to describe systemic bacterial infections occurring in acutely ill and hospitalized children in a rural region in Ghana, regarding frequency, incidence, antimicrobial susceptibility patterns and...
Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4)
Richard J McManus, Jonathan Mant, Marloes Franssen, Alecia Nickless, Claire Schwartz, James Hodgkinson, Peter Bradburn, Andrew Farmer, Sabrina Grant, Sheila M Greenfield, Carl Heneghan, Susan Jowett, Una Martin, Siobhan Milner, Mark Monahan, Sam Mort, Emma Ogburn, Rafael Perera-Salazar, Syed Ahmar Shah, Ly-Mee Yu, Lionel Tarassenko, FD Richard Hobbs, TASMINH4 investigators
May 18, 2018
BACKGROUND: Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to...
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