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p53 in senescence - it's a marathon, not a sprint.
The tumour suppressor p53, a stress-responsive transcription factor, plays a central role in cellular senescence. The role of p53 in senescence-associated stable proliferative arrest has been extensively studied. However...
Dynamic modulation of autophagy
Reduced autophagy has been implicated in aging, yet whether its loss can promote aging phenotypes and pathologies in mammals, and how reversible this process is, has never been fully explored. Using inducible short hairpin RNA...
F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis.
Capture of each and every chromosome by spindle microtubules is essential to prevent chromosome loss and aneuploidy. In somatic cells, astral microtubules search and capture chromosomes forming lateral attachments to...
The expanding territories of condensin II.
This is the author accepted manuscript. The final version is available from Taylor & Francis via http://dx.doi.org/10.1080/15384101.2015.1063356
Discrete Weierstrass-Type Representations
Discrete Weierstrass-type representations yield a construction method in discrete differential geometry for certain classes of discrete surfaces. We show that the known discrete Weierstrass-type representations of certain...
Discrete curvature theory Discrete isothermic sphere congruence Discrete Omega surface Laguerre geometry Weierstrass representation /dk/atira/pure/subjectarea/asjc/2600/2614 name=Theoretical Computer Science /dk/atira/pure/subjectarea/asjc/2600/2608 name=Geometry and Topology /dk/atira/pure/subjectarea/asjc/2600/2607 name=Discrete Mathematics and Combinatorics /dk/atira/pure/subjectarea/asjc/1700/1703 name=Computational Theory and Mathematics
Discrete Weierstrass-Type Representations
Discrete Weierstrass-type representations yield a construction method in discrete differential geometry for certain classes of discrete surfaces. We show that the known discrete Weierstrass-type representations of certain...
Discrete curvature theory Discrete isothermic sphere congruence Discrete Omega surface Laguerre geometry Weierstrass representation /dk/atira/pure/subjectarea/asjc/2600/2614 name=Theoretical Computer Science /dk/atira/pure/subjectarea/asjc/2600/2608 name=Geometry and Topology /dk/atira/pure/subjectarea/asjc/2600/2607 name=Discrete Mathematics and Combinatorics /dk/atira/pure/subjectarea/asjc/1700/1703 name=Computational Theory and Mathematics
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow
The developmental origin of dendritic cells, a specialized system of major histocompatibility complex (MHC) class II-rich antigen-presenting cells for T-cell immunity and tolerance, is not well characterized....
bone marrow cell cell granule cellular immunity dendritic cell granulocyte macrophage mixed lymphocyte reaction stem cell
Published by: Rockefeller University
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow
Inaba, K., Inaba, M., Deguchi, M., Hagi, K., Yasumizu, R., Ikehara, S., Muramatsu, S., and Steinman, R.M. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative...
bone marrow cell cell granule cellular immunity dendritic cell granulocyte macrophage mixed lymphocyte reaction stem cell
Published by: The National Academy of Sciences
Autophagy at the intersection of aging, senescence, and cancer.
Autophagy is an evolutionarily conserved cellular process in which macromolecules undergo lysosomal degradation. It fulfills essential roles in quality controlling cellular constituents and in energy homeostasis. Basal autophagy...
Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension.
Masashi Tachikawa, Nobuhiro Morone, Yosuke Senju, Tadao Sugiura, Kyoko Hanawa-Suetsugu, Atsushi Mochizuki, Shiro Suetsugu
May 24, 2019
Caveolae are abundant flask-shaped invaginations of plasma membranes that buffer membrane tension through their deformation. Few quantitative studies on the deformation of caveolae have been reported. Each caveola contains...
IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.
Kimberley A Wiggins, Aled J Parry, Liam D Cassidy, Melanie Humphry, Steve J Webster, Jane C Goodall, Masashi Narita, Murray CH Clarke
Mar 04, 2019
Core-Shell Spheroid-Laden Microgels Crosslinked under Biocompatible Conditions for Probing Cancer-Stromal Communication
Hongjia Zhu, Lianne WY Roode, Aled J Parry, Nadia A Erkamp, Marc Rodriguez-Garcia, Masako Narita, Yi Shen, Yangteng Ou, Zenon Toprakcioglu, Masashi Narita, Tuomas PJ Knowles
Nov 20, 2022
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme.
Luis F Duarte, Andrew RJ Young, Zichen Wang, Hsan-Au Wu, Taniya Panda, Yan Kou, Avnish Kapoor, Dan Hasson, Nicholas R Mills, Avi Ma'ayan, Masashi Narita, Emily Bernstein
Sep 11, 2014
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Yiqun Zhang, Fengju Chen, Nuno A Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Chad J Creighton, PCAWG Consortium
Feb 04, 2021
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing...
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser, Masashi Narita
Nov 27, 2020
Abstract: Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin...
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance.
Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan, Liam Cassidy, Marta Poblocka, Haoran Zhu, Aaron Lun, Martijn Schuijs, Andrew Young, Celia Martinez-Jimenez, Timotheus YF Halim, Shishir Shetty, Masashi Narita, Matthew Hoare
Jun 29, 2022
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