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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
Masato Ogishi
Jan 01, 0001
Tuberculosis (TB), a multi-organ infectious disease caused by virulent mycobacteria, most predominantly M. tuberculosis,remains one of the deadliest infectious diseases in human history.Bacillus Calmette-Guérin (BCG)...
Published by: Rockefeller University
The ecology of medical care on an isolated island in Okinawa, Japan
BACKGROUND: We aimed to describe the ecology of medical care on an isolated island with limited access to secondary care, and to evaluate the gatekeeping function of the island's primary care clinic through comparison with a...
Ecology General Practice Medical care Physician visit Primary Health Care Adolescent Adult Ambulatory Care Facilities Emergency Service hospital Female Health Services Accessibility Humans Japan Male Medically Underserved Area Middle Aged Primary Health Care Referral and Consultation Retrospective Studies Young Adult
Selection of antigenically advanced variants of seasonal influenza viruses.
Chengjun Li, Masato Hatta, David F Burke, Jihui Ping, Ying Zhang, Makoto Ozawa, Andrew S Taft, Subash C Das, Anthony P Hanson, Jiasheng Song, Masaki Imai, Peter R Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A Russell, Sarah L James, Eugene Skepner, Eileen A Maher, Gabriele Neumann, Alexander I Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Takato Odagiri, Masato Tashiro, Xiyan Xu, David E Wentworth, Jacqueline M Katz, Nancy J Cox, Derek J Smith, Yoshihiro Kawaoka
Apr 13, 2016
Global circulation patterns of seasonal influenza viruses vary with antigenic drift.
Trevor Bedford, Steven Riley, Ian G Barr, Shobha Broor, Mandeep Chadha, Nancy J Cox, Rodney S Daniels, C Palani Gunasekaran, Aeron C Hurt, Anne Kelso, Alexander Klimov, Nicola S Lewis, Xiyan Li, John W McCauley, Takato Odagiri, Varsha Potdar, Andrew Rambaut, Yuelong Shu, Eugene Skepner, Derek J Smith, Marc A Suchard, Masato Tashiro, Dayan Wang, Xiyan Xu, Philippe Lemey, Colin A Russell
May 27, 2015
The unusual case of plastic deformation and high dislocation densities with the cold sintering of the piezoelectric ceramic K0.5Na0.5NbO3
K0.5Na0.5NbO3 (KNN) can be readily densified using the cold sintering process, but despite observing high relative permittivity, the ferroelectric hysteresis is strongly suppressed along with a major suppression in the...
The unusual case of plastic deformation and high dislocation densities with the cold sintering of the piezoelectric ceramic K0.5Na0.5NbO3
K0.5Na0.5NbO3 (KNN) can be readily densified using the cold sintering process, but despite observing high relative permittivity, the ferroelectric hysteresis is strongly suppressed along with a major suppression in the...
Epoxy-functionalised 4-vinylguaiacol for the synthesis of bio-based, degradable star polymers via a RAFT/ROCOP strategy
An epoxy derivative of a naturally occuring vinylphenolic compound, 4-vinylguaiacol (4VGEP), was used for the synthesis of a well-defined (Mw/Mn = 1.08–1.14), bio-based styrene-type polymer. Block copolymers of 4VGEP with...
Epoxy-functionalised 4-vinylguaiacol for the synthesis of bio-based, degradable star polymers via a RAFT/ROCOP strategy
An epoxy derivative of a naturally occuring vinylphenolic compound, 4-vinylguaiacol (4VGEP), was used for the synthesis of a well-defined (Mw/Mn = 1.08–1.14), bio-based styrene-type polymer. Block copolymers of 4VGEP with...
Insights into gene expression profiles induced by Socs3 depletion in keratinocytes.
Archana Bajpai, Takashi Ishii, Kosuke Miyauchi, Vipul Gupta, Yuka Nishio-Masaike, Yuki Shimizu-Yoshida, Masato Kubo, Hiroaki Kitano
Jul 11, 2019
Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells. The molecular mechanisms and key regulatory pathways involved in these...
VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants
Takayuki Tamaki, Satoyo Oya, Makiko Naito, Yasuko Ozawa, Tomoyuki Furuya, Masato Saito, Mayuko Sato, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Ykä Helariutta, Yuki Kondo
Apr 22, 2021
Abstract: The phloem transports photosynthetic assimilates and signalling molecules. It mainly consists of sieve elements (SEs), which act as “highways” for transport, and companion cells (CCs), which serve as “gates” to...
Reassessment of the phylogenetic relationships of the late Miocene apes Hispanopithecus and Rudapithecus based on vestibular morphology.
Alessandro Urciuoli, Clément Zanolli, Sergio Almécija, Amélie Beaudet, Jean Dumoncel, Naoki Morimoto, Masato Nakatsukasa, Salvador Moyà-Solà, David R Begun, David M Alba
May 24, 2021
Late Miocene great apes are key to reconstructing the ancestral morphotype from which earliest hominins evolved. Despite consensus that the late Miocene dryopith great apes Hispanopithecus laietanus (Spain) and Rudapithecus...
VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants
Takayuki Tamaki, Satoyo Oya, Makiko Naito, Yasuko Ozawa, Tomoyuki Furuya, Masato Saito, Mayuko Sato, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Ykä Helariutta, Yuki Kondo
Feb 18, 2021
Abstract: The phloem transports photosynthetic assimilates and signalling molecules. It mainly consists of sieve elements (SEs), which act as “highways” for transport, and companion cells (CCs), which serve as “gates” to...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 16, 2020
Abstract: Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380...
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
Masato Miyake, Akitoshi Nomura, Atsushi Ogura, Kenji Takehana, Yoshihiro Kitahara, Kazuna Takahara, Kazue Tsugawa, Chinobu Miyamoto, Naoko Miura, Ryosuke Sato, Kiyoe Kurahashi, Heather P Harding, Miho Oyadomari, David Ron, Seiichi Oyadomari
Apr 28, 2016
CCDC88A mutations cause PEHO-like syndrome in humans and mouse.
Michael S Nahorski, Masato Asai, Emma Wakeling, Alasdair Parker, Naoya Asai, Natalie Canham, Susan E Holder, Ya-Chun Chen, Joshua Dyer, Angela F Brady, Masahide Takahashi, C Geoffrey Woods
Feb 10, 2016
VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants.
Takayuki Tamaki, Satoyo Oya, Makiko Naito, Yasuko Ozawa, Tomoyuki Furuya, Masato Saito, Mayuko Sato, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Ykä Helariutta, Yuki Kondo
Jun 05, 2020
The phloem transports photosynthetic assimilates and signalling molecules. It mainly consists of sieve elements (SEs), which act as "highways" for transport, and companion cells (CCs), which serve as "gates" to load/unload...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John RB Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 22, 2019
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Momoko Horikoshi, Felix R Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A Toro, Sergio R Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K Ong, John RB Perry
Aug 16, 2018
Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured...
Human artificial chromosome with a conditional centromere for gene delivery and gene expression.
Yuichi Iida, Jung-Hyun Kim, Yasuhiro Kazuki, Hidetoshi Hoshiya, Masato Takiguchi, Masahiro Hayashi, Indri Erliandri, Hee-Sheung Lee, Alex Samoshkin, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina, Vladimir Larionov, Mitsuo Oshimura
Dec 18, 2020
Human artificial chromosomes (HACs), which carry a fully functional centromere and are maintained as a single-copy episome, are not associated with random mutagenesis and offer greater control over expression of ectopic genes on...
Animals CHO Cells Cell Line Centromere Chickens Chromosomes Artificial Human Cricetinae Cricetulus Gene Expression Gene Targeting Gene Transfer Techniques Genetic Therapy Genetic Vectors Green Fluorescent Proteins Humans In Situ Hybridization Fluorescence Operator Regions Genetic Plasmids Polymerase Chain Reaction Recombination Genetic Tetracyclines Transgenes
Gene network inference and visualization tools for biologists
Daniel Hurley, Hiromitsu Araki, Yoshinori Tamada, Ben Dunmore, Deborah Sanders, Sally Humphreys, Muna Affara, Seiya Imoto, Kaori Yasuda, Yuki Tomiyasu, Kosuke Tashiro, Christopher Savoie, Vicky Cho, Stephen Smith, Satoru Kuhara, Satoru Miyano, D Stephen Charnock-Jones, Edmund J Crampin, Cristin G Print
Jan 23, 2018
Gene regulatory networks inferred from RNA abundance data have generated significant interest, but despite this, gene network approaches are used infrequently and often require input from bioinformaticians. We have assembled a...
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
May 12, 2022
Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and...
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