Search
Results: 115
The State of the Art of the DSM-5 "with Mixed Features" Specifier.
Norma Verdolini, Mark Agius, Laura Ferranti, Patrizia Moretti, Massimiliano Piselli, Roberto Quartesan
Oct 03, 2017
Determination of protein structural ensembles using cryo-electron microscopy.
Achieving a comprehensive understanding of the behaviour of proteins is greatly facilitated by the knowledge of their structures, thermodynamics and dynamics. All this information can be provided in an effective manner in terms...
Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.
Over the past decade, there has been a growing interest in investigating whether disordered proteins can be targeted for clinical purposes using small molecules [1-8]. While small-molecule binding to disordered proteins can be...
Revised British Society of Gastroenterology recommendation on the diagnosis and management of Barrett's oesophagus with low-grade dysplasia.
The most recent guidelines for the management of Barrett's oesophagus published in 2014 recommended endoscopic surveillance for patient with histological evidence of low-grade dysplasia (LGD) on random biopsies.1 In the last...
ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.
Marco Pieraccioli, Sara Nicolai, Consuelo Pitolli, Massimiliano Agostini, Alexey Antonov, Michal Malewicz, Richard A Knight, Giuseppe Raschellà, Gerry Melino
Oct 15, 2020
Derangement of cellular differentiation because of mutation or inappropriate expression of specific genes is a common feature in tumors. Here, we show that the expression of ZNF281, a zinc finger factor involved in several...
Barrett's esophagus and cancer risk
Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The...
Research advances in esophageal diseases
Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common...
Dale J Waterhouse, Wladyslaw Januszewicz, Sharib Ali, Rebecca C Fitzgerald, Massimiliano di Pietro, Sarah E Bohndiek
Apr 16, 2021
Early detection of esophageal neoplasia enables curative endoscopic therapy, but the current diagnostic standard of care has low sensitivity because early neoplasia is often inconspicuous with conventional white-light endoscopy....
Pilot randomized crossover study comparing the efficacy of transnasal disposable endosheath with standard endoscopy to detect Barrett's esophagus.
Mohammed K Shariff, Sibu Varghese, Maria O'Donovan, Zarah Abdullahi, Xinxue Liu, Rebecca C Fitzgerald, Massimiliano di Pietro
Feb 18, 2016
Autofluorescence-Directed Confocal Endomicroscopy in Combination With a Three-Biomarker Panel Can Inform Management Decisions in Barrett's Esophagus.
Massimiliano di Pietro, Elizabeth L Bird-Lieberman, Xinxue Liu, Tara Nuckcheddy-Grant, Helga Bertani, Maria O'Donovan, Rebecca C Fitzgerald
Nov 16, 2015
Aged Algorithms Aneuploidy Barrett Esophagus Biomarkers Biopsy Cyclin A Disease Progression Esophagoscopy esophagus False Positive Reactions Female Humans Male Microscopy Confocal Middle Aged Narrow Band Imaging Optical Imaging Precancerous Conditions Sensitivity and Specificity Tumor Suppressor Protein p53 Watchful Waiting
Endoscopic measurement of gastric pH associates with persistent acid reflux in patients treated with proton-pump inhibitors for gastroesophageal reflux disease.
Wladyslaw Januszewicz, James Hartley, William Waldock, Geoffrey Roberts, Bincy Alias, Anthony Hobson, Lorenz Wernisch, Massimiliano di Pietro
Aug 13, 2020
BACKGROUND: Proton-pump inhibitors (PPIs) are the mainstay of gastroesophageal reflux disease (GERD) treatment, however, up to 30% of patients have a poor symptomatic response. PH-impedance is the gold standard to assess whether...
Use of Cytosponge as a triaging tool to upper gastrointestinal endoscopy during the COVID-19 pandemic.
Massimiliano di Pietro, Ines Modolell, Maria O'Donovan, Catherine Price, Nastazja D Pilonis, Irene Debiram-Beecham, Rebecca C Fitzgerald
Sep 10, 2020
During the COVID-19 pandemic, endoscopy services have been severely curtailed—eg, in England, UK, a 30% reduction of diagnostic endoscopies has been reported for the period between January and April, 2020, compared with the same...
Barrett oesophagus.
Yonne Peters, Ali Al-Kaabi, Nicholas J Shaheen, Amitabh Chak, Andrew Blum, Rhonda F Souza, Massimiliano di Pietro, Prasad G Iyer, Oliver Pech, Rebecca C Fitzgerald, Peter D Siersema
Nov 01, 2019
Barrett oesophagus (BE), the only known histological precursor of oesophageal adenocarcinoma (EAC), is a condition in which the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive response to...
A sinister black finding in the stomach.
Wladyslaw Januszewicz, Pippa Corrie, Hongxiang Liu, James Chan, Rebecca C Fitzgerald, Massimiliano di Pietro
Oct 08, 2019
A 68-year-old woman undergoing a routine surveillance endoscopy—part of her follow-up for a Barrett's oesophagus—was found to have a solitary, black lesion, approximately 4 mm in diameter, in the gastric body (figure).
Acrylonitrile Aged Aniline Compounds Barrett Esophagus Benzimidazoles Drug Therapy Combination endoscopy Digestive System Female Humans Liver Liver Neoplasms Magnetic Resonance Imaging Melanoma Mutation Neoplasm Metastasis Paclitaxel Prognosis Stomach Tomography X-Ray Computed Tubulin Modulators Uveal Neoplasms
Dyslexia treatment studies
Enrico Toffalini, David Giofrè, Massimiliano Pastore, Barbara Carretti, Federica Fraccadori, Denes Szűcs
Mar 17, 2021
Poor response to treatment is a defining characteristic of reading disorder. In the present systematic review and meta-analysis, we found that the overall average effect size for treatment efficacy was modest, with a mean...
Differential processing of binocular and monocular gloss cues in human visual cortex.
Hua-Chun Sun, Massimiliano Di Luca, Hiroshi Ban, Alexander Muryy, Roland W Fleming, Andrew E Welchman
Mar 07, 2016
First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett's-related neoplasia.
Dale J Waterhouse, Sophia Bano, Wladyslaw Januszewicz, Dan Stoyanov, Rebecca C Fitzgerald, Massimiliano di Pietro, Sarah E Bohndiek
Sep 08, 2021
SIGNIFICANCE: The early detection of dysplasia in patients with Barrett's esophagus could improve outcomes by enabling curative intervention; however, dysplasia is often inconspicuous using conventional white-light endoscopy....
The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.
Mariagnese Barbera, Massimiliano di Pietro, Elaine Walker, Charlotte Brierley, Shona MacRae, Benjamin D Simons, Phil H Jones, John Stingl, Rebecca C Fitzgerald
Feb 13, 2020
OBJECTIVE: Knowledge of the cellular mechanisms involved in homeostasis of human squamous oesophagus in the steady state and following chronic injury is limited. We aimed to better understand these mechanisms by using a...
The effects of autistic traits and academic degree on visuospatial abilities.
Massimiliano Conson, Vincenzo Paolo Senese, Chiara Baiano, Isa Zappullo, Varun Warrier, UNICAMPSY17 group, Sara Salzano, Monica Positano, Simon Baron-Cohen
Dec 13, 2019
In the present study, we were interested to investigate how autistic traits (including systemizing and empathy) and academic degree influence individuals' visuospatial abilities. To this end, 352 university students completed...
Disembedding figures Empathy Quotient mental rotation SCIENCE Technology engineering and mathematics (STEM) Systemizing Quotient Autistic Disorder Educational Status Empathy Engineering Female Humans Imagination Male mathematics Natural Science Disciplines Psychiatric Status Rating Scales Psychomotor Performance Rotation SCIENCE Sex Characteristics Spatial Navigation Students Visual Perception Young Adult
Portal inflammation is independently associated with fibrosis and metabolic syndrome in pediatric nonalcoholic fatty liver disease.
Jake P Mann, Rita De Vito, Antonella Mosca, Anna Alisi, Matthew J Armstrong, Massimiliano Raponi, Ulrich Baumann, Valerio Nobili
Dec 20, 2018
UNLABELLED: Pediatric nonalcoholic fatty liver disease (NAFLD) histology demonstrates variable amounts of portal inflammation, which may be associated with more severe liver disease and fibrosis. We assessed the relationship...
|
|< |
< |
1 |