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Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).
Natalie Burrows, Gaelle Cane, Mathew Robson, Edoardo Gaude, William J Howat, Peter W Szlosarek, R Barbara Pedley, Christian Frezza, Margaret Ashcroft, Patrick H Maxwell
Mar 01, 2016
Animals Arginine Argininosuccinate Synthase Basic Helix-Loop-Helix Transcription Factors Blotting Western Cell Hypoxia Cell Line Tumor HCT116 Cells Humans Hydrolases Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Mechanistic Target of Rapamycin Complex 1 Mice SCID Multiprotein Complexes Neoplasms Nitric oxide Nitric Oxide Synthase Type II Perfusion Polyethylene Glycols TOR Serine-Threonine Kinases Tumor Burden Unfolded Protein Response Vascular Endothelial Growth Factor A Xenograft Model Antitumor Assays
Improving Organizational Sustainable Performance of Organizations Through Green Training
It is necessary to equip employees with green abilities as well as to develop their dedication towards green behaviour, in order to improve an organization's environmental performance. The purpose of this research is to evaluate...
Published by: IGI Global Scientific Publishing
Does Islamic Marketing Mix Affect Consumer Satisfaction?
Viju Mathew
Jan 01, 2022
Customer and customer satisfaction is considered to be the core for success. Targeting the growing Islamic customer population has given the opportunity to tap demand based on Islamic values. Apart from the standard marketing...
Published by: IGI Global Scientific Publishing
Connectivity of soft random geometric graphs
Mathew Penrose
Apr 01, 2016
Consider a graph on $n$ uniform random points in the unit square, each pair being connected by an edge with probability $p$ if the inter-point distance is at most $r$. We show that as $n \to \infty$ the probability of full...
Leaves on the line and in the plane
Mathew Penrose
May 05, 2020
The dead leaves model (DLM) provides a random tessellation of $d$-space, representing the visible portions of fallen leaves on the ground when $d=2$. For $d=1$, we establish formulae for the intensity, two-point correlations...
Evaluating Onsite and Online Internship Mode Using Consumptive Metrics
The paper aims to assess the effectiveness between onsite and online internship mode by measuring the critical components of learning through the Kirkpatrick's ‘consumptive metrics' model. The primary goal of internship is to...
Published by: IGI Global Scientific Publishing
Connectivity of soft random geometric graphs
Mathew Penrose
Apr 01, 2016
Consider a graph on $n$ uniform random points in the unit square, each pair being connected by an edge with probability $p$ if the inter-point distance is at most $r$. We show that as $n \to \infty$ the probability of full...
Leaves on the line and in the plane
Mathew Penrose
May 05, 2020
The dead leaves model (DLM) provides a random tessellation of $d$-space, representing the visible portions of fallen leaves on the ground when $d=2$. For $d=1$, we establish formulae for the intensity, two-point correlations...
Rank deficiency in sparse random GF[2] matrices
Mathew Penrose
Sep 14, 2014
Let M be a random m×n matrix with binary entries and i.i.d. rows. The weight (i.e., number of ones) of a row has a specified probability distribution, with the row chosen uniformly at random given its weight. Let N(n,m) denote...
Rank deficiency in sparse random GF[2] matrices
Mathew Penrose
Sep 14, 2014
Let M be a random m×n matrix with binary entries and i.i.d. rows. The weight (i.e., number of ones) of a row has a specified probability distribution, with the row chosen uniformly at random given its weight. Let N(n,m) denote...
The Grizzly, September 11, 1987
Jean M. Kiss, Lora L. Hart, Karen Singhofen, Andrea Power, Greg Stocke, Richard P. Richter, Matt Weintraub, Jill Theurer, Vince Leskusky, Michelle Grande, Craig DiLouie, Steve Gall, Ed Wentzel, Carla Rinde
Jan 01, 0001
The Stage is Set: Final Act to Complete Village Center to Broaden Ursinus Horizons We Are Seniors Student Orientation Series Addresses Alcohol Crackdown on Fake I.D. Users Letter: Maintenance Poo Poo's Paisley Two Bennett...
Ursinus College Collegeville Pennsylvania newspaper career planning comic books Neil Young Volleyball Heisman trophy Football Chuck Odgers field hockey cross country Jane Bennett Jamie Robson Janeen Flamer Steven Hood Student Alumni Relations Committee false identification Alcohol Berman art center Residential Village cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Role of CDKs and CDKIs in Murine Development.
Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic...
The Role of CDKs and CDKIs in Murine Development
Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic...
Local central limit theorems in stochastic geometry
We give a general local central limit theorem for the sum of two independent random variables, one of which satisfies a central limit theorem while the other satisfies a local central limit theorem with the same order variance....
Optimal Cheeger cuts and bisections of random geometric graphs
Let d ≥ 2. The Cheeger constant of a graph is the minimum surfaceto- volume ratio of all subsets of the vertex set with relative volume at most 1/2. There are several ways to define surface and volume here: The simplest...
Local central limit theorems in stochastic geometry
We give a general local central limit theorem for the sum of two independent random variables, one of which satisfies a central limit theorem while the other satisfies a local central limit theorem with the same order variance....
Boundaries, Vermas and factorisation
Abstract: We revisit the factorisation of supersymmetric partition functions of 3d N = 4 gauge theories. The building blocks are hemisphere partition functions of a class of UV N = (2, 2) boundary conditions that mimic the...
Optimal Cheeger cuts and bisections of random geometric graphs
Let d ≥ 2. The Cheeger constant of a graph is the minimum surfaceto- volume ratio of all subsets of the vertex set with relative volume at most 1/2. There are several ways to define surface and volume here: The simplest...
A Framework for Relationships in eCommerce Websites
Consumers are increasingly shifting their purchase patterns from in-store to online. Consequently, retailers have had to go online to remain competitive. Research pundits argued the success of going online lies in the website's...
Published by: IGI Global Scientific Publishing
Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.
Chiara Marchetti, Katherine G Zyner, Stephan A Ohnmacht, Mathew Robson, Shozeb M Haider, Jennifer P Morton, Giovanni Marsico, Tam Vo, Sarah Laughlin-Toth, Ahmed A Ahmed, Gloria Di Vita, Ingrida Pazitna, Mekala Gunaratnam, Rachael J Besser, Ana CG Andrade, Seckou Diocou, Jeremy A Pike, David Tannahill, R Barbara Pedley, TR Jeffry Evans, W David Wilson, Shankar Balasubramanian, Stephen Neidle
Mar 26, 2018
Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signaling pathways. A novel approach to the treatment of PDAC is described, involving the targeting of cancer genes in PDAC pathways having...
Animals Antimetabolites Antineoplastic Antineoplastic Agents Carcinoma Pancreatic Ductal Cell Line Tumor Computational Biology Computer Simulation DNA Damage Deoxycytidine Down-Regulation Drug Design Drug Resistance Neoplasm G-Quadruplexes Gene Expression Regulation Neoplastic Humans Mice Mice Nude Pancreatic Neoplasms Xenograft Model Antitumor Assays Gemcitabine
Inhomogeneous random graphs, isolated vertices, and Poisson approximation
Mathew D. Penrose
Mar 01, 2018
Consider a graph on randomly scattered points in an arbitrary space, with any two points x, y connected with probability φ(x, y). Suppose the number of points is large but the mean number of isolated points is O(1). We give...
Boundaries, Vermas and factorisation
Abstract: We revisit the factorisation of supersymmetric partition functions of 3d N = 4 gauge theories. The building blocks are hemisphere partition functions of a class of UV N = (2, 2) boundary conditions that mimic the...
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