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The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare...
AN ASSESSMENT OF FRANCOIS BERNIER’S TRAVEL ACCOUNT
Sakul Kundra
Dec 14, 2019
French commercial and, later, political expansion in South Asia from 1600 to 1800 has attracted the attention of many historians. French travellers played a significant part in exploring overseas markets and establishing...
Published by: Department of History, University of Karachi
The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare...
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.
Ivy Kim-Ni Chiang, Martin Fritzsche, Cathy Pichol-Thievend, Alice Neal, Kelly Holmes, Anne Lagendijk, Jeroen Overman, Donatella D'Angelo, Alice Omini, Dorien Hermkens, Emmanuelle Lesieur, Ke Liu, Indrika Ratnayaka, Monica Corada, George Bou-Gharios, Jason Carroll, Elisabetta Dejana, Stefan Schulte-Merker, Benjamin Hogan, Monica Beltrame, Sarah De Val, Mathias Francois
Apr 17, 2019
Arterial enhancer artery Endothelial Cell human MOUSE Notch1 SoxF Transcriptional regulation Zebrafish Amino Acid Sequence Animals Animals Genetically Modified arteries Arteriovenous Malformations Enhancer Elements Genetic Female Gene Expression Regulation Developmental Human Umbilical Vein Endothelial Cells Humans Male Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Pregnancy Receptor Notch1 SOXF Transcription Factors Sequence Homology Amino Acid Signal Transduction Zebrafish Zebrafish Proteins
Silicone vs. Polyurethane Stent
Ureteric stents are conventionally used in daily urological practice. There is ongoing debate on the superiority of different stent materials, particularly in terms of patient tolerance. We conducted a literature review to...
The convictions of a realist
Mathias Haeussler
Sep 20, 2018
This article reconstructs concepts of ‘European solidarity’ in Helmut Schmidt’s political thought. Tracing Schmidt’s beliefs from the late 1940s to the period of his chancellorship and beyond, it shows how his concepts of...
The relationship between usage and citations in an open access mega-journal
Abstract: How do the level of usage of an article, the timeframe of its usage and its subject area relate to the number of citations it accrues? This paper aims to answer this question through an observational study of usage and...
COVID 19
Purpose: The purpose of this essay is to enrich the discussion at the intersection of responsible management education (RME) and the pandemic with new views that explore together the inhibitors of and drivers for a strengthening...
Structural biology of DOCK-family guanine nucleotide exchange factors.
DOCK proteins are a family of multi-domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase-dependent cellular processes. DOCK proteins are...
Transforming Unjust Structures
The "capability approach" of development economist Amartya Sen, who received the Nobel Prize for Economics in 1998, poses a major challenge to the dominant paradigm of neo-classical economics. According to Sen, human well-being...
Published by: Springer
Risks of AI-Assisted Learning on Student Critical Thinking
Artificial Intelligence (AI) has increasingly become a transformative force in the education sector, offering unprecedented opportunities to enhance learning experiences and outcomes. This study examines the potential adverse...
Published by: IGI Global Scientific Publishing
Designing E-Government Legal Institutions
The aim of this article is to understand the way digital government laws are designed through the analysis and comparison of general objectives, governance mechanisms and roles assigned to stakeholders of six local state digital...
Published by: IGI Global Scientific Publishing
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.
Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril Ab Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, Jason S Carroll, Timothy L Bailey, Peter Koopman, Ralf Jauch, Mark J Smyth, Matthew A Cooper, Yann Gambin, Mathias Francois
May 02, 2019
Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have...
Biochemistry developmental biology Gene Expression MOUSE protein protein interactions small molecules Stem Cells Transcription Factors tumour angiogenesis Zebrafish Animals Antineoplastic Agents Biophysical Phenomena blood vessels Breast Neoplasms Disease Models Animal Genomics Mice Proteomics SOXF Transcription Factors Transcription Genetic Treatment Outcome Zebrafish Zebrafish Proteins
Transforming Unjust Structures
The "capability approach" of development economist Amartya Sen, who received the Nobel Prize for Economics in 1998, poses a major challenge to the dominant paradigm of neo-classical economics. According to Sen, human well-being...
Published by: Springer
Research information standards adoption
While Research Information continues to mature as an area of expertise, discussions regarding the implementation and adoption of standardisation initiatives, such as CASRAI and CERIF, have intensified. Possessing the capacity to...
The Lantern Vol. 27, No. 3, Fall 1960
Joel Roberts, Phil Rowe, Phyllis W. Furst, Steve Dearsley, Carol Flood, Jill Springer, Naomi Ruth Herre, Betty Heale, J. H. Ryan, Bea Hauer, Michael Boris, Pete Vennema, Anne Mendelson, Sandy L. Pfaffhausen, Timothy H. C. R. Combe
Jan 01, 0001
Thoughts in DaVinici's Coffeehouse Kinesiology Class No One is Named Alistair The Beat Generation The Super Highway Blues Panic and the Mountain Peak The Lake Later Ares The Light The Room Thoughts After...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction religion James L. Boswell Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
The Ursinus Weekly, March 4, 1929
Ursinus represented at luncheon given in honor of Mary E. Wooley Contracts awarded for 1930 Ruby work Week of prayer led by Mr. Phillips Elliott an inspiring event Co-eds basketball team bows to Cedar Crest college College...
Ursinus College Collegeville Pennsylvania newspaper Basketball Poems scarlet fever cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses
Steven Mathias Anderson
Jan 01, 0001
The transcription and translation products of two avian acute leukemia viruses, avian erythroblastosisvirus (AEV) and avian myeloblastosisvirus (AMV) , were examined. AEV is defective in virus replication and requires the...
Published by: Rockefeller University
The geometry of multi-marginal Skorokhod Embedding
The Skorokhod Embedding Problem is one of the classical problems in the theory of stochastic processes, with applications in many different fields [cf. the surveys (Hobson in: Paris-Princeton lectures on mathematical finance...
Health Determinants among North Americans Experiencing Homelessness and Traumatic Brain Injury
Traumatic brain injury (TBI) in those experiencing homelessness has been described in recent literature as a contributor to increased morbidity, decreased functional independence, and early mortality. In this systematically...
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