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Presidential Candidate Sen. Bernie Sanders to Hold Rally at Winthrop
Winthrop University
Jan 01, 0001
HIGHLIGHTS Presidential Candidate Bernie Sanders will hold a rally on Sept. 20 at Winthrop's amphitheatre. Sanders is a Democratic Senator from Vermont.
Published by: Winthrop University
U.S. Sen. Bernie Sanders Makes Appearance at Winthrop for Rock Hill Rally
Winthrop University
Jan 01, 0001
Sanders is a Democratic candidate for president of the United States. Appearing with Sanders will be Cornel West, an activist, public intellectual and frequent commentator on political and social issues. West is a professor of...
Published by: Winthrop University
‘SANDERS OF THE RIVER, STILL THE BEST JOB FOR A BRITISH BOY’; RECRUITMENT TO THE COLONIAL ADMINISTRATIVE SERVICE AT THE END OF EMPIRE
ABSTRACT In February 1951, the Sunday Express printed a piece extolling the virtues of a Colonial Service career, under the headline: ‘Sanders of the River, Still the...
CHRIS JEPPESEN
Sep 29, 2018
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.
Somatic Evolution in Non-neoplastic IBD-Affected Colon.
Sigurgeir Olafsson, Rebecca E McIntyre, Tim Coorens, Timothy Butler, Hyunchul Jung, Philip S Robinson, Henry Lee-Six, Mathijs A Sanders, Kenneth Arestang, Claire Dawson, Monika Tripathi, Konstantina Strongili, Yvette Hooks, Michael R Stratton, Miles Parkes, Inigo Martincorena, Tim Raine, Peter J Campbell, Carl A Anderson
Jan 18, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts...
Crohn's Disease IL17 PIGR ZC3H12A inflammatory bowel disease intestinal epithelia Mutation Rate mutational signatures somatic mutations Ulcerative colitis Adult Aged Aged 80 and over aging Clonal Evolution Colitis Colitis Ulcerative Crohn Disease DNA-Binding Proteins Epithelial Cells F-Box-WD Repeat-Containing Protein 7 Female Humans INDEL Mutation Inflammatory Bowel Diseases Interleukin-17 Intestinal Mucosa Male Middle Aged Mutation Rate Phylogeny Point Mutation Receptors Cell Surface Ribonucleases Toll-Like Receptors Transcription Factors whole genome sequencing
APOBEC mutagenesis is a common process in normal human small intestine.
Yichen Wang, Philip S Robinson, Tim HH Coorens, Luiza Moore, Henry Lee-Six, Ayesha Noorani, Mathijs A Sanders, Hyunchul Jung, Riku Katainen, Robert Heuschkel, Roxanne Brunton-Sim, Robyn Weston, Debbie Read, Beverley Nobbs, Rebecca C Fitzgerald, Kourosh Saeb-Parsy, Iñigo Martincorena, Peter J Campbell, Simon Rushbrook, Matthias Zilbauer, Simon James Alexander Buczacki, Michael R Stratton
Feb 16, 2023
Diverse mutational landscapes in human lymphocytes.
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A Sanders, Alex TJ Cagan, Craig McDonald, Miriam Belmonte, Mairi S Shepherd, Felipe A Vieira Braga, Robert J Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David G Kent, Peter J Campbell
Sep 10, 2022
APOBEC mutagenesis is a common process in normal human small intestine.
Yichen Wang, Philip S Robinson, Tim HH Coorens, Luiza Moore, Henry Lee-Six, Ayesha Noorani, Mathijs A Sanders, Hyunchul Jung, Riku Katainen, Robert Heuschkel, Roxanne Brunton-Sim, Robyn Weston, Debbie Read, Beverley Nobbs, Rebecca C Fitzgerald, Kourosh Saeb-Parsy, Iñigo Martincorena, Peter J Campbell, Simon Rushbrook, Matthias Zilbauer, Simon James Alexander Buczacki, Michael R Stratton
Feb 26, 2023
APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer types. However, there is an incomplete understanding of its stimulus, when it occurs in the progression from normal to cancer cell and the APOBEC...
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Philip S. Robinson, Tim H. H. Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Olafsson, Bernard C. H. Lee, Andrew R. J. Lawson, Henry Lee-Six, Luiza Moore, Mathijs A. Sanders, James Hewinson, Lynn Martin, Claudia M. A. Pinna, Sara Galavotti, Raheleh Rahbari, Peter J. Campbell, Iñigo Martincorena, Ian Tomlinson, Michael R. Stratton
Oct 06, 2021
How Do We Construct a Child-Friendly Emergency Management Framework?
Monica Sanders
Jan 01, 2022
When considering vulnerable populations, or those with the most cascading obstacles that cause them to be susceptible to certain hazards and events, children are among the most vulnerable. Those living in poverty or in...
Published by: IGI Global Scientific Publishing
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Bernard CH Lee, Philip S Robinson, Tim HH Coorens, Helen HN Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A Sanders, Hoi Cheong Siu, James Hewinson, Sarah SK Yue, Wai Yin Tsui, Annie SY Chan, Anthony KW Chan, Siu Lun Ho, Peter J Campbell, Inigo Martincorena, Simon JA Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R Stratton
Jun 29, 2022
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic...
The landscape of somatic mutation in normal colorectal epithelial cells.
Henry Lee-Six, Sigurgeir Olafsson, Peter Ellis, Robert J Osborne, Mathijs A Sanders, Luiza Moore, Nikitas Georgakopoulos, Franco Torrente, Ayesha Noorani, Martin Goddard, Philip Robinson, Tim HH Coorens, Laura O'Neill, Christopher Alder, Jingwei Wang, Rebecca C Fitzgerald, Matthias Zilbauer, Nicholas Coleman, Kourosh Saeb-Parsy, Inigo Martincorena, Peter J Campbell, Michael R Stratton
Jan 02, 2020
The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. However, our understanding of the...
Clonal diversification and histogenesis of malignant germ cell tumours
Thomas RW Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C Dentro, Matthew D Young, Tim HH Coorens, Hyunchul Jung, Tim Butler, Matthew DC Neville, Daniel Leongamornlert, Mathijs A Sanders, Yvette Hooks, Alex Cagan, Thomas J Mitchell, Isidro Cortes-Ciriano, Anne Y Warren, David C Wedge, Rakesh Heer, Nicholas Coleman, Matthew J Murray, Peter J Campbell, Raheleh Rahbari, Sam Behjati
Aug 11, 2022
Published by: Nature Publishing Group UK
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Philip S Robinson, Laura E Thomas, Federico Abascal, Hyunchul Jung, Luke MR Harvey, Hannah D West, Sigurgeir Olafsson, Bernard CH Lee, Tim HH Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A Sanders, Stefanie V Lensing, Simon JA Buczacki, Rogier Ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J Campbell, Iñigo Martincorena, Julian R Sampson, Michael R Stratton
Aug 08, 2022
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal...
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.
Philip S Robinson, Tim HH Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Olafsson, Bernard CH Lee, Andrew RJ Lawson, Henry Lee-Six, Luiza Moore, Mathijs A Sanders, James Hewinson, Lynn Martin, Claudia MA Pinna, Sara Galavotti, Raheleh Rahbari, Peter J Campbell, Iñigo Martincorena, Ian Tomlinson, Michael R Stratton
Nov 01, 2021
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikołaj Słabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter JM Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell
Sep 01, 2021
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants...
Clonal diversification and histogenesis of malignant germ cell tumours.
Thomas RW Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C Dentro, Matthew D Young, Tim HH Coorens, Hyunchul Jung, Tim Butler, Matthew DC Neville, Daniel Leongamornlert, Mathijs A Sanders, Yvette Hooks, Alex Cagan, Thomas J Mitchell, Isidro Cortes-Ciriano, Anne Y Warren, David C Wedge, Rakesh Heer, Nicholas Coleman, Matthew J Murray, Peter J Campbell, Raheleh Rahbari, Sam Behjati
Sep 11, 2022
Diverse mutational landscapes in human lymphocytes.
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A Sanders, Alex TJ Cagan, Craig McDonald, Miriam Belmonte, Mairi S Shepherd, Felipe A Vieira Braga, Robert J Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David G Kent, Peter J Campbell
Aug 24, 2022
The lymphocyte genome is prone to many threats, including programmed mutation during differentiation1, antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of...
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Philip S Robinson, Laura E Thomas, Federico Abascal, Hyunchul Jung, Luke MR Harvey, Hannah D West, Sigurgeir Olafsson, Bernard CH Lee, Tim HH Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A Sanders, Stefanie V Lensing, Simon JA Buczacki, Rogier Ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J Campbell, Iñigo Martincorena, Julian R Sampson, Michael R Stratton
Jul 08, 2022
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal...
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Bernard CH Lee, Philip S Robinson, Tim HH Coorens, Helen HN Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A Sanders, Hoi Cheong Siu, James Hewinson, Sarah SK Yue, Wai Yin Tsui, Annie SY Chan, Anthony KW Chan, Siu Lun Ho, Peter J Campbell, Inigo Martincorena, Simon JA Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R Stratton
May 17, 2022
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic...
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