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Cultural trauma, counter-narratives, and dialogical intellectuals
In this article, we offer a new conceptualization of intellectuals as carriers of cultural trauma through a case study of the Aum Affair, a series of crimes and terrorist attacks committed by the Japanese new religious movement...
Characterizing palliative care needs in people with or at risk of developing diabetic foot ulcers.
Liliane Mendonça, Bárbara Antunes, Joana Rigor, Daniela Martins-Mendes, Matilde Monteiro-Soares
Dec 22, 2022
AIMS: Diabetic foot ulcers (DFUs) have a significant impact on a patient's quality of life and life expectancy, with mortality rates comparable with malignant diseases. However, there is a lack of data regarding palliative care...
A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot-Marie-Tooth disease.
James R Edgar, Anita K Ho, Matilde Laurá, Rita Horvath, Mary M Reilly, J Paul Luzio, Rhys C Roberts
Sep 28, 2020
Autosomal dominant mutations in LITAF are responsible for the rare demyelinating peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). The LITAF protein is expressed in many human cell types and we have...
Charcot–Marie–Tooth endosome LITAF lysosome Peripheral neuropathy phosphoinositide Adult Charcot-Marie-Tooth disease Endosomes Female FIBROBLASTS Flavoproteins Gene Knockout Techniques Humans Loss of Function Mutation Lysosomes Male Microscopy Confocal Microscopy Electron Middle Aged Nuclear Proteins Phosphoric Monoester Hydrolases Transcription Factors Transient Receptor Potential Channels Vacuoles
Set-shifting-related basal ganglia deformation as a novel familial marker of obsessive-compulsive disorder.
Masanori Isobe, Matilde Vaghi, Naomi A Fineberg, Annemieke M Apergis-Schoute, Edward T Bullmore, Barbara J Sahakian, Trevor W Robbins, Samuel R Chamberlain
Mar 17, 2021
The symptoms of obsessive-compulsive disorder (OCD) are suggestive of cognitive rigidity, and previous work identified impaired flexible responding on set-shifting tasks in such patients. The basal ganglia are central to habit...
Atypical action updating in a dynamic environment associated with adolescent obsessive-compulsive disorder.
Aleya A Marzuki, Matilde M Vaghi, Anna Conway-Morris, Muzaffer Kaser, Akeem Sule, Annemieke Apergis-Schoute, Barbara J Sahakian, Trevor W Robbins
May 10, 2022
BACKGROUND: Computational research had determined that adults with obsessive-compulsive disorder (OCD) display heightened action updating in response to noise in the environment and neglect metacognitive information (such as...
A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer.
Iain R Macpherson, Pavlina Spiliopoulou, Saeed Rafii, Matilde Saggese, Richard D Baird, Javier Garcia-Corbacho, Antoine Italiano, Jacques Bonneterre, Mario Campone, Nicola Cresti, John Posner, Yousuke Takeda, Akinori Arimura, James Spicer
Jan 20, 2020
BACKGROUND: Epertinib (S-222611) is a potent reversible inhibitor of HER2, EGFR and HER4. This trial evaluated the safety, tolerability, pharmacokinetics and antitumour activity of daily oral epertinib combined with trastuzumab...
EGFR Epertinib HER2 HER2-positive breast cancer Trastuzumab Adult Aged Antineoplastic Combined Chemotherapy Protocols Brain Neoplasms Breast Neoplasms Capecitabine Dose-Response Relationship Drug Drug Administration Schedule Female Humans Male Middle Aged Quinazolines Receptor ErbB-2 Trastuzumab Treatment Outcome Vinorelbine
A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease
James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts
Oct 18, 2021
Abstract: Autosomal dominant mutations in LITAF are responsible for the rare demyelinating peripheral neuropathy, Charcot–Marie–Tooth disease type 1C (CMT1C). The LITAF protein is expressed in many human cell types and we have...
A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease
James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts
Oct 15, 2020
Abstract: Autosomal dominant mutations in LITAF are responsible for the rare demyelinating peripheral neuropathy, Charcot–Marie–Tooth disease type 1C (CMT1C). The LITAF protein is expressed in many human cell types and we have...
F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis.
Capture of each and every chromosome by spindle microtubules is essential to prevent chromosome loss and aneuploidy. In somatic cells, astral microtubules search and capture chromosomes forming lateral attachments to...
NATIONWIDE POST EVENT SURVEY AND ANALYSIS OF THE 2011 TOHOKU EARTHQUAKE TSUNAMI
At 14:46 local time on March 11, 2011, a magnitude 9.0 earthquake occurred off the coast of northeast Japan. This earthquake generated a tsunami that struck Japan as well as various locations around the Pacific Ocean. With the...
Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E.
Cailin E Joyce, Adrienne G Yanez, Akihiro Mori, Akinori Yoda, Johanna S Carroll, Carl D Novina
Aug 20, 2019
Small molecules and antisense oligonucleotides that inhibit the translation initiation factors eIF4A1 and eIF4E have been explored as broad-based therapeutic agents for cancer treatment, based on the frequent upregulation of...
NATIONWIDE POST EVENT SURVEY AND ANALYSIS OF THE 2011 TOHOKU EARTHQUAKE TSUNAMI
At 14:46 local time on March 11, 2011, a magnitude 9.0 earthquake occurred off the coast of northeast Japan. This earthquake generated a tsunami that struck Japan as well as various locations around the Pacific Ocean. With the...
Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder
Matilde M Vaghi, Petra E Vértes, Manfred G Kitzbichler, Annemieke M Apergis-Schoute, Febe E van der Flier, Naomi A Fineberg, Akeem Sule, Rashid Zaman, Valerie Voon, Prantik Kundu, Edward T Bullmore, Trevor W Robbins
Sep 30, 2016
Cognitive flexibility Frontostriatal circuits functional connectivity Goal-directed planning Obsessive-Compulsive Disorder resting state Adult Attention Brain Mapping Cognition Corpus Striatum Executive Function Female Goals Humans Magnetic Resonance Imaging Male Neural Pathways Obsessive-Compulsive Disorder Prefrontal Cortex Severity of Illness Index
Cross-sectional analysis of a large cohort with X-linked Charcot-Marie-Tooth disease (CMTX1).
Francis B Panosyan, Matilde Laura, Alexander M Rossor, Chiara Pisciotta, Giuseppe Piscosquito, Joshua Burns, Jun Li, Sabrina W Yum, Richard A Lewis, John Day, Rita Horvath, David N Herrmann, Michael E Shy, Davide Pareyson, Mary M Reilly, Steven S Scherer, Inherited Neuropathies Consortium—Rare Diseases Clinical Research Network (INC-RDCRN)
Mar 07, 2019
OBJECTIVE: To extend the phenotypic description of Charcot-Marie-Tooth disease (CMTX1) and to draw new genotype-phenotype relationships. METHODS: Mutations in GJB1 cause the main X-linked form of CMTX (CMTX1). We report...
Conservative and disruptive modes of adolescent change in human brain functional connectivity.
František Váša, Rafael Romero-Garcia, Manfred G Kitzbichler, Jakob Seidlitz, Kirstie J Whitaker, Matilde M Vaghi, Prantik Kundu, Ameera X Patel, Peter Fonagy, Raymond J Dolan, Peter B Jones, Ian M Goodyer, Petra E Vértes, Edward T Bullmore
Feb 29, 2020
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of...
Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages.
Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayumi Akiyoshi, Morten E Allentoft, Ayako Kohno, Fuyuki Tokanai, Eske Willerslev, Naoki Kohno, Hidenori Nishihara
Sep 13, 2021
Little is known about how mammalian biogeography on islands was affected by sea-level fluctuations. In the Japanese Archipelago, brown bears (Ursus arctos) currently inhabit only Hokkaido, the northern island, but...
Published by: Royal Society open science
Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages.
Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayumi Akiyoshi, Morten E Allentoft, Ayako Kohno, Fuyuki Tokanai, Eske Willerslev, Naoki Kohno, Hidenori Nishihara
Sep 02, 2021
Little is known about how mammalian biogeography on islands was affected by sea-level fluctuations. In the Japanese Archipelago, brown bears (Ursus arctos) currently inhabit only Hokkaido, the northern island, but Pleistocene...
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