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Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids.
Thomas M Rawlings, Komal Makwana, Deborah M Taylor, Matteo A Molè, Katherine J Fishwick, Maria Tryfonos, Joshua Odendaal, Amelia Hawkes, Magdalena Zernicka-Goetz, Geraldine M Hartshorne, Jan J Brosens, Emma S Lucas
Nov 25, 2021
Decidual remodelling of midluteal endometrium leads to a short implantation window after which the uterine mucosa either breaks down or is transformed into a robust matrix that accommodates the placenta throughout pregnancy. To...
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim H H Coorens, Marta N Shahbazi, Antonia Weberling, Bailey A T Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jul 28, 2021
Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in...
Cells Cultured Germ Layers Humans Fibroblast Growth Factors Gene Expression Regulation Developmental Cell Lineage Embryonic Development Embryo Implantation Multigene Family Image Processing Computer-Assisted Embryo Mammalian Gastrulation Bone Morphogenetic Protein 1 Nodal Protein Single-Cell Analysis Wnt Signaling Pathway Spatio-Temporal Analysis RNA-seq
Published by: Nature Communications
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jun 17, 2021
Abstract: Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain...
Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure.
Matteo A Molè, Gabriel L Galea, Ana Rolo, Antonia Weberling, Oleksandr Nychyk, Sandra C De Castro, Dawn Savery, Reinhard Fässler, Patricia Ybot-González, Nicholas DE Greene, Andrew J Copp
Feb 28, 2020
Epithelial fusion is a key process of morphogenesis by which tissue connectivity is established between adjacent epithelial sheets. A striking and poorly understood feature of this process is "zippering," whereby a fusion point...
Cell Adhesion epithelial zippering Extracellular Matrix Fibronectin Fusion gap closure Integrins Morphogenesis Neurulation spina bifida Actomyosin Animals Cell Fusion Embryo Mammalian Epithelial Cells Female focal adhesions Integrin beta1 Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Morphogenesis Neural Crest Neural Tube Neurulation
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim HH Coorens, Marta N Shahbazi, Antonia Weberling, Bailey AT Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
May 13, 2021
Bone Morphogenetic Protein 1 Cell Lineage Cells Cultured Embryo Implantation Embryo Mammalian Embryonic Development Fibroblast Growth Factors Gastrulation Gene Expression Regulation Developmental Germ Layers Humans Image Processing Computer-Assisted Multigene Family Nodal Protein RNA-seq Single-Cell Analysis Spatio-Temporal Analysis Wnt Signaling Pathway
Digital Twin for Amyotrophic Lateral Sclerosis
This chapter focuses on the context in which patients such as those with Amyotrophic Lateral Sclerosis (ALS) are placed and what possibilities information and communication technologies (ICTs) offer to keep them in touch with...
Virtual Communities & Virtual Reality Social Sciences and Humanities Human Aspects of Technology Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
Bridging the Gap Between Strategic Environmental Assessment and Planning
Current planning practices in Europe are affected by regulations aiming at environmental protection and risk reduction; however, planners face difficulties in implementing the norms. This chapter discusses the influence of the...
Government and Law Public and Sector Management E-Planning Physical Sciences and Engineering Life Sciences
Published by: IGI Global Scientific Publishing
Using discrete element method (DEM) to create a cone penetration test (CPT)-based method to estimate the installation requirements of rotary-installed piles in sand
Yaseen Sharif, Michael Brown, Matteo Ciantia, Benjamin Cerfontaine, Craig Davidson, Jonathan A. Knappett, Gerrit Meijer, Jonathan Ball
Jul 31, 2021
Deep foundations may be used in a range of soil types where significant foundation resistance is required, but their installation is often associated with disturbance due to noise and vibration. Greater restrictions on use in...
Using discrete element method (DEM) to create a cone penetration test (CPT)-based method to estimate the installation requirements of rotary-installed piles in sand
Yaseen Sharif, Michael Brown, Matteo Ciantia, Benjamin Cerfontaine, Craig Davidson, Jonathan A. Knappett, Gerrit Meijer, Jonathan Ball
Jul 31, 2021
Deep foundations may be used in a range of soil types where significant foundation resistance is required, but their installation is often associated with disturbance due to noise and vibration. Greater restrictions on use in...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Ion Conduction Mechanism as a Fingerprint of Potassium Channels
K+-channels are membrane proteins that regulate the selective conduction of potassium ions across cell membranes. Although the atomic mechanisms of K+ permeation have been extensively investigated, previous work focused on...
Matter-Wave Diffraction from a Quasicrystalline Optical Lattice.
Quasicrystals are long-range ordered and yet nonperiodic. This interplay results in a wealth of intriguing physical phenomena, such as the inheritance of topological properties from higher dimensions, and the presence of...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
White-Matter Hyperintensity Load and Differences in Resting-State Network Connectivity Based on Mild Cognitive Impairment Subtype.
Martina Vettore, Matteo De Marco, Claudia Pallucca, Matteo Bendini, Maurizio Gallucci, Annalena Venneri
Oct 21, 2021
"Mild cognitive impairment" (MCI) is a diagnosis characterised by deficits in episodic memory (aMCI) or in other non-memory domains (naMCI). Although the definition of subtypes is helpful in clinical classification, it provides...
Ion Conduction Mechanism as a Fingerprint of Potassium Channels
K+-channels are membrane proteins that regulate the selective conduction of potassium ions across cell membranes. Although the atomic mechanisms of K+ permeation have been extensively investigated, previous work focused on...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
A Storable Mediatorless Electrochemical Biosensor for Herbicide Detection.
Matteo Tucci, Paolo Bombelli, Christopher J Howe, Silvia Vignolini, Stefano Bocchi, Andrea Schievano
Jan 13, 2020
A novel mediatorless photo-bioelectrochemical sensor operated with a biofilm of the cyanobacterium Synechocystis PCC6803 wt. for herbicide detection with long term stability (>20 days) was successfully developed and tested....
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
The opportunity cost of time window violations
This paper studies a variant of the vehicle routing problem with soft time windows (VRPSTW), inspired by real-world distribution problems. In applications, violations of the prescribed delivery time are commonly accepted....
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
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