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Alumnus Matthew Neal Awarded Science Teaching Fellowship
Winthrop University
Jan 01, 0001
Matthew Neal '13, '14 is a recipient of a 2014 Knowles Science Teaching Foundation (KSTF) Teaching Fellowship. The Greenville, South Carolina, native will begin his first year of teaching this fall.
Published by: Winthrop University
Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma
Melissa E Petersen, Fan Zhang, Nicole Schupf, Sharon J Krinsky-McHale, James Hall, Mark Mapstone, Amrita Cheema, Wayne Silverman, Ira Lott, Michael S Rafii, Benjamin Handen, William Klunk, Elizabeth Head, Brad Christian, Tatiana Foroud, Florence Lai, H Diana Rosas, Shahid Zaman, Beau M Ances, Mei-Cheng Wang, Benjamin Tycko, Joseph H Lee, Sid O'Bryant, Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS)
May 26, 2021
INTRODUCTION: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and...
A modified Cued Recall Test for detecting prodromal AD in adults with Down syndrome.
Sharon J Krinsky-McHale, Sigan Hartley, Christy Hom, Margaret Pulsifer, Isabel CH Clare, Benjamin L Handen, Ira T Lott, Nicole Schupf, Wayne Silverman, Alzheimer's Biomarker Consortium—Down Syndrome (ABC‐DS) Investigators
Oct 03, 2022
INTRODUCTION: The development of valid methods to diagnose prodromal Alzheimer's disease (AD) in adults with Down syndrome (DS) is one of the many goals of the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS). METHODS...
Matthew Manwarren to Perform Free Piano Concert in Celebration of 50th Birthday
Winthrop University
Jan 01, 0001
Pianist Matthew Manwarren, a professor of music at Winthrop University, will present a free solo piano recital on Sunday, Nov. 18, at 4 p.m. This concert is being presented as a celebration of the artist's 50th birthday. The...
Published by: Winthrop University
Thalamus mediates neocortical Down state transition via GABAB-receptor-targeting interneurons.
Y Audrey Hay, Nicolas Deperrois, Tanja Fuchsberger, Thomas Matthew Quarrell, Anna-Lucia Koerling, Ole Paulsen
Jun 30, 2021
Slow-wave sleep is characterized by near-synchronous alternation of active Up states and quiescent Down states in the neocortex. Although the cortex itself can maintain these oscillations, the full expression of Up-Down states...
Department of Theatre and Dance's New Play Takes on Matthew Shepard Tragedy
Winthrop University
Jan 01, 0001
"The Laramie Project" tells the story of the after-effects of the Matthew Shepard tragedy through real-life interviews. Show times are Oct 24-27 at 8 p.m. with a 2 p.m. showing Oct. 28.
Published by: Winthrop University
The Alzheimer's Biomarker Consortium-Down Syndrome
Benjamin L Handen, Ira T Lott, Bradley T Christian, Nicole Schupf, Sid OBryant, Mark Mapstone, Anne M Fagan, Joseph H Lee, Dana Tudorascu, Mei-Cheng Wang, Elizabeth Head, William Klunk, Beau Ances, Florence Lai, Shahid Zaman, Sharon Krinsky-McHale, Adam M Brickman, H Diana Rosas, Annie Cohen, Howard Andrews, Sigan Hartley, Wayne Silverman, Alzheimer's Biomarker Consortium‐Down Syndrome (ABC‐DS)
Aug 28, 2020
INTRODUCTION: Adults with Down syndrome (DS) are at exceptionally high risk for Alzheimer's disease (AD), with virtually all individuals developing key neuropathological features by age 40. Identifying biomarkers of AD...
Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome.
Hana D'Souza, Luke Mason, Kin Y Mok, Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, R Asaad Baksh, John Hardy, Andre Strydom, Michael SC Thomas, London Down Syndrome (LonDownS) Consortium
Oct 05, 2020
IMPORTANCE: Risk of Alzheimer disease (AD) is particularly high for individuals with Down syndrome (DS). The ε4 allele of the apolipoprotein E gene (APOE ε4) is associated with an additional risk for AD. In typical development...
White matter microstructure associations with episodic memory in adults with Down syndrome
Austin Bazydlo, Matthew Zammit, Minjie Wu, Douglas Dean, Sterling Johnson, Dana Tudorascu, Ann Cohen, Karly Cody, Beau Ances, Charles Laymon, William Klunk, Shahid Zaman, Benjamin Handen, Andrew Alexander, Bradley Christian, Sigan Hartley
May 26, 2021
BACKGROUND: Nearly all persons with Down syndrome will show pathology of Alzheimer's disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheimer's...
White matter microstructure associations with episodic memory in adults with Down syndrome
Austin Bazydlo, Matthew Zammit, Minjie Wu, Douglas Dean, Sterling Johnson, Dana Tudorascu, Ann Cohen, Karly Cody, Beau Ances, Charles Laymon, William Klunk, Shahid Zaman, Benjamin Handen, Andrew Alexander, Bradley Christian, Sigan Hartley
Apr 21, 2021
Abstract: Background: Nearly all persons with Down syndrome will show pathology of Alzheimer’s disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of...
Analysis of simultaneous multielectrode recordings with 4,096 channels
Matthias H Hennig, Alessandro Maccione, Mauro Gandolfo, Matthew Down, Stephen J Eglen, Luca Berdondini, Evelyne Sernagor
Jul 22, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
Assessment and Diagnosis of Down Syndrome Regression Disorder
Jonathan D Santoro, Lina Patel, Ryan Kammeyer, Robyn A Filipink, Grace Y Gombolay, Kathleen M Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L Santoro, Sammer M Marzouk, Mellad Khoshnood, Benjamin N Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A Stanley, Jessica S Sanders, Alison Christy, Elise M Sannar, Ruth Brown, Andrew A McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A Quinn, George T Capone, Brian Chicoine, Brian G Skotko, Michael S Rafii
Sep 02, 2022
OBJECTIVE: To develop standardization for nomenclature, diagnostic work up and diagnostic criteria for cases of neurocognitive regression in Down syndrome. BACKGROUND: There are no consensus criteria for the evaluation or...
Implementing Social Media
Social media is an important avenue for information dissemination and public communication in emergency management. Through social media content analysis and in-depth interviews, this study explores how county level emergency...
Published by: IGI Global Scientific Publishing
Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome
Elijah Mak, Monika Grigorova, Jessica Beresford-Webb, Maura Malpetti, Madeline Walpert, Stephanie Brown, Elizabeth Jones, Isabel Clare, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Oct 26, 2020
Positron emission tomography imaging of glucose hypometabolism and amyloid deposition are two well-established methods to evaluate preclinical changes in Alzheimer's disease and people with Down syndrome. However, the use of...
Understanding contemporary challenges to INGO legitimacy
In recent years, INGO legitimacy has been subject to growing scrutiny from analysts and practitioners alike. Critics have highlighted a backlash against INGOs in the Global South, a growing mismatch between INGO capacities and...
Reasonable Disagreement and the Neutralist Dilemma
Clare Chambers
Jul 10, 2018
This paper starts by investigating the idea of reasonable disagreement. It then considers Matthew Kramer’s argument that there is no neutral solution available to the disagreement over abortion. The paper argues that Kramer’s...
Assessment and Diagnosis of Down Syndrome Regression Disorder
Jonathan D Santoro, Lina Patel, Ryan Kammeyer, Robyn A Filipink, Grace Y Gombolay, Kathleen M Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L Santoro, Sammer M Marzouk, Mellad Khoshnood, Benjamin N Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A Stanley, Jessica S Sanders, Alison Christy, Elise M Sannar, Ruth Brown, Andrew A McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A Quinn, George T Capone, Brian Chicoine, Brian G Skotko, Michael S Rafii
Jul 29, 2022
Objective: To develop standardization for nomenclature, diagnostic work up and diagnostic criteria for cases of neurocognitive regression in Down syndrome. Background: There are no consensus criteria for the evaluation or...
Systematic bias in high-throughput sequencing data and its correction by BEADS.
Genomic sequences obtained through high-throughput sequencing are not uniformly distributed across the genome. For example, sequencing data of total genomic DNA show significant, yet unexpected enrichments on promoters and...
Understanding contemporary challenges to INGO legitimacy
In recent years, INGO legitimacy has been subject to growing scrutiny from analysts and practitioners alike. Critics have highlighted a backlash against INGOs in the Global South, a growing mismatch between INGO capacities and...
Spin-up and spin-down in a half cone
The spin-up and spin-down of a fluid in a rapidly-rotating, fluid-filled, closed half cone is studied both numerically and experimentally. This unusual set up is of interest because it represents a pathological case for the...
Role of tau deposition in early cognitive decline in Down syndrome.
Sigan L Hartley, Benjamin L Handen, Dana Tudorascu, Laise Lee, Annie Cohen, Brianna Piro-Gambetti, Matthew Zammit, William Klunk, Charles Laymon, Shahid Zaman, Beau M Ances, Marwan Sabbagh, Bradley T Christian
Apr 02, 2022
INTRODUCTION: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [18F]AV-1451 was associated with episodic memory problems beyond what was...
Reducing the Negative Effects of Psychological Contract Breach during Management-Imposed Change
Employees' experiences of psychological contract breach (PCB) contribute substantially to the failure of change initiatives. Consequently, if organizational leaders want to successfully implement change efforts, it is imperative...
Published by: IGI Global Scientific Publishing
Spin-up and spin-down in a half cone
The spin-up and spin-down of a fluid in a rapidly-rotating, fluid-filled, closed half cone is studied both numerically and experimentally. This unusual set up is of interest because it represents a pathological case for the...
Serving followers and family? A trickle-down model of how servant leadership shapes employee work performance
Previous studies have identified servant leadership as an important driver of organizational effectiveness. However, so far little research attention has been given to whether servant leadership displayed by leaders across an...
Serving followers and family? A trickle-down model of how servant leadership shapes employee work performance
Previous studies have identified servant leadership as an important driver of organizational effectiveness. However, so far little research attention has been given to whether servant leadership displayed by leaders across an...
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