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Food based dietary patterns and chronic disease prevention.
Matthias B Schulze, Miguel A Martínez-González, Teresa T Fung, Alice H Lichtenstein, Nita G Forouhi
Sep 20, 2018
Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research...
Digital Employee Training With Digital Adoption Platforms Boost Learning and Knowledge Management of Corporate IT Systems
Due to increasing digitalization, employees need to use an increasing number of corporate IT systems. Digital Adoption Platforms (DAPs) recently address the resulting need for increased learning and skills to master such...
Published by: IGI Global Scientific Publishing
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Oleg Pak, Susan Scheibe, Azadeh Esfandiary, Mareike Gierhardt, Akylbek Sydykov, Angela Logan, Athanasios Fysikopoulos, Florian Veit, Matthias Hecker, Florian Kroschel, Karin Quanz, Alexandra Erb, Katharina Schäfer, Mirja Fassbinder, Nasim Alebrahimdehkordi, Hossein A Ghofrani, Ralph T Schermuly, Ralf P Brandes, Werner Seeger, Michael P Murphy, Norbert Weissmann, Natascha Sommer
Jun 18, 2018
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular...
Affective and cognitive orientations in group perception
Three studies examined the role of Need for Affect (NFA) and Need for Cognition (NFC) in intergroup perception. We hypothesized that NFA predicts a preference for stereotypically warm groups over stereotypically cold groups...
Affective and cognitive orientations in group perception
Three studies examined the role of Need for Affect (NFA) and Need for Cognition (NFC) in intergroup perception. We hypothesized that NFA predicts a preference for stereotypically warm groups over stereotypically cold groups...
Spatial processes in linear ordering
Memory performance in linear order reasoning tasks (A > B, B > C, C > D, etc.) shows quicker, and more accurate responses to queries on wider (AD) than narrower (AB) pairs on a hypothetical linear mental model (A – B –...
Optical Voltage Sensing Using DNA Origami.
Elisa A Hemmig, Clare Fitzgerald, Christopher Maffeo, Lisa Hecker, Sarah E Ochmann, Aleksei Aksimentiev, Philip Tinnefeld, Ulrich F Keyser
May 01, 2018
We explore the potential of DNA nanotechnology for developing novel optical voltage sensing nanodevices that convert a local change of electric potential into optical signals. As a proof-of-concept of the sensing mechanism, we...
DNA nanotechnology coarse-grained simulations nanocapillary optical voltage measurements single-molecule FRET Biosensing Techniques DNA Electricity Electrodes Equipment Design Fluorescence Resonance Energy Transfer Fluorescent Dyes Ion Transport NANOSTRUCTURES Nanotechnology Nucleic Acid Conformation
The mammalian mitochondrial epitranscriptome.
Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been...
A functional genetic toolbox for human tissue-derived organoids
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins
Oct 28, 2021
“Under Pressure!”
Matthias Klumpp, Caroline Ruiner, Vera Hagemann, Jonathan Meinecke, Christina Debbing, Marc Hesenius
Jan 01, 2024
The use of digital technologies or applications can have positive and negative effects on workers: Digital technologies might support workers' decision-making by providing necessary information, but digital technologies might...
Published by: IGI Global Scientific Publishing
MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload.
Rogério Faustino Ribeiro Junior, Erinne Rose Dabkowski, Kadambari Chandra Shekar, Kelly A O Connell, Peter A Hecker, Michael P Murphy
Jun 18, 2018
Heart failure remains a major public-health problem with an increase in the number of patients worsening from this disease. Despite current medical therapy, the condition still has a poor prognosis. Heart failure is complex but...
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Jun 07, 2022
BACKGROUND: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates...
Programming Light-Harvesting Efficiency Using DNA Origami.
Elisa A Hemmig, Celestino Creatore, Bettina Wünsch, Lisa Hecker, Philip Mair, M Andy Parker, Stephen Emmott, Philip Tinnefeld, Ulrich F Keyser, Alex W Chin
Feb 26, 2016
Spatial processes in linear ordering
Memory performance in linear order reasoning tasks (A > B, B > C, C > D, etc.) shows quicker, and more accurate responses to queries on wider (AD) than narrower (AB) pairs on a hypothetical linear mental model (A – B –...
The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.
Matthias Zilbauer
Nov 05, 2019
DNA methylation is one of the main epigenetic mechanisms, known to be operative in mammals. Extensive evidence has highlighted its pivotal role in several fundamental biological processes including organogenesis, X-chromosome...
Entrance laws for annihilating Brownian motions and the continuous-space voter model
Consider a system of particles moving independently as Brownian motions until two of them meet, when the colliding pair annihilates instantly. The construction of such a system of annihilating Brownian motions (aBMs) is...
Annihilating Brownian motions Entrance laws Moment duality Stepping stone model Symbiotic branching voter model /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Analyzing inexact hypergradients for bilevel learning
Estimating hyperparameters has been a long-standing problem in machine learning. We consider the case where the task at hand is modeled as the solution to an optimization problem. Here the exact gradient with respect to the...
A new look at duality for the symbiotic branching model
The symbiotic branching model is a spatial population model describing the dynamics of two interacting types that can only branch if both types are present. A classical result for the underlying stochastic partial...
Annihilating Brownian motions Moment duality Mutually catalytic branching Rescaled interface Stepping stone model Symbiotic branching model /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty
Optimal Encoding in Stochastic Latent-Variable Models.
In this work we explore encoding strategies learned by statistical models of sensory coding in noisy spiking networks. Early stages of sensory communication in neural systems can be viewed as encoding channels in the...
Efficient Hyperparameter Tuning with Dynamic Accuracy Derivative-Free Optimization
Many machine learning solutions are framed as optimization problems which rely on good hyperparameters. Algorithms for tuning these hyperparameters usually assume access to exact solutions to the underlying learning problem...
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