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Food based dietary patterns and chronic disease prevention.
Matthias B Schulze, Miguel A Martínez-González, Teresa T Fung, Alice H Lichtenstein, Nita G Forouhi
Sep 20, 2018
Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research...
ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
Anne K Braczynski, Stefan Vlaho, Klaus Müller, Ilka Wittig, Anna-Eva Blank, Dominique S Tews, Ulrich Drott, Stephanie Kleinle, Angela Abicht, Rita Horvath, Karl H Plate, Werner Stenzel, Hans H Goebel, Andreas Schulze, Patrick N Harter, Matthias Kieslich, Michel Mittelbronn
Mar 07, 2019
TMEM70 is involved in the biogenesis of mitochondrial ATP synthase and mutations in the TMEM70 gene impair oxidative phosphorylation. Herein, we report on pathology and treatment of ATP synthase deficiency in four siblings. A...
Digital Employee Training With Digital Adoption Platforms Boost Learning and Knowledge Management of Corporate IT Systems
Due to increasing digitalization, employees need to use an increasing number of corporate IT systems. Digital Adoption Platforms (DAPs) recently address the resulting need for increased learning and skills to master such...
Published by: IGI Global Scientific Publishing
Microscopic origin of entropy-driven polymorphism in hybrid organic-inorganic perovskite materials
Entropy is a critical, but often overlooked, factor in determining the relative stabilities of crystal phases. The importance of entropy is most pronounced in softer materials, where small changes in free energy can drive...
Microscopic origin of entropy-driven polymorphism in hybrid organic-inorganic perovskite materials
Entropy is a critical, but often overlooked, factor in determining the relative stabilities of crystal phases. The importance of entropy is most pronounced in softer materials, where small changes in free energy can drive...
Tuning the Mechanical Response of Metal−Organic Frameworks by Defect Engineering
Stefano Dissegna, Pia Vervoorts, Claire Hobday, Tina Duren, Dominik Daisenberger, Andrew Smith, Roland A Fischer, Gregor Kieslich
Sep 19, 2018
The incorporation of defects into crystalline materials provides an important tool to fine-tune properties throughout various fields of materials science. We performed high-pressure powder X-ray diffraction experiments...
Tuning the Mechanical Response of Metal−Organic Frameworks by Defect Engineering
Stefano Dissegna, Pia Vervoorts, Claire Hobday, Tina Duren, Dominik Daisenberger, Andrew Smith, Roland A Fischer, Gregor Kieslich
Sep 19, 2018
The incorporation of defects into crystalline materials provides an important tool to fine-tune properties throughout various fields of materials science. We performed high-pressure powder X-ray diffraction experiments...
Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension.
Franziska Diekmann, Philippe Chouvarine, Hannes Sallmon, Louisa Meyer-Kobbe, Moritz Kieslich, Brian D Plouffe, Shashi K Murthy, Ralf Lichtinghagen, Ekaterina Legchenko, Georg Hansmann
Oct 26, 2021
Pulmonary arterial hypertension (PAH) is a progressive condition with an unmet need for early diagnosis, better monitoring, and risk stratification. The receptor for advanced glycation end products (RAGE) is activated in...
RV hypertrophy biomarker Inflammation Proliferation pulmonary arterial hypertension soluble receptor for advanced glycation end products (sRAGE) vascular injury Adult Aged Aged 80 and over Biomarkers Case-Control Studies Female Germany Humans Male Middle Aged Prognosis pulmonary arterial hypertension Receptor for Advanced Glycation End Products Sensitivity and Specificity Solubility Young Adult
The mammalian mitochondrial epitranscriptome.
Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been...
Synthesis and Properties of a Lead-Free Hybrid Double Perov-skite
Fengxia Wei, Zeyu Deng, Shijing Sun, Fenghua Zhang, Donald Evans, Gregor Kieslich, Satoshi Tominaka, Michael Carpenter, Jie Zhang, PD Bristowe, Anthony Cheetham
Mar 02, 2018
The discovery of lead-free hybrid double perovskites provides a viable approach in the search for stable and environmentally benign photovoltaic materials as alternatives to the lead-containing systems such as MAPbX3 (X = Cl...
Public participation in decision-making on the coverage of new antivirals for hepatitis C.
Katharina Kieslich, Jeonghoon Ahn, Gabriele Badano, Kalipso Chalkidou, Leonardo Cubillos, Renata Curi Hauegen, Chris Henshall, Carleigh B Krubiner, Peter Littlejohns, Lanting Lu, Steven D Pearson, Annette Rid, Jennifer A Whitty, James Wilson
Jun 24, 2016
Agenda-setting DAAs Direct-acting antivirals Hepatitis C PPI Priority-setting Public and patient involvement Sofosbuvir Antiviral Agents Brazil Community Participation Decision Making England Health Care Rationing Hepatitis C Humans Insurance Coverage insurance health Republic of Korea Sofosbuvir United States
A functional genetic toolbox for human tissue-derived organoids
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins
Oct 28, 2021
“Under Pressure!”
Matthias Klumpp, Caroline Ruiner, Vera Hagemann, Jonathan Meinecke, Christina Debbing, Marc Hesenius
Jan 01, 2024
The use of digital technologies or applications can have positive and negative effects on workers: Digital technologies might support workers' decision-making by providing necessary information, but digital technologies might...
Published by: IGI Global Scientific Publishing
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Jun 07, 2022
BACKGROUND: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates...
The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.
Matthias Zilbauer
Nov 05, 2019
DNA methylation is one of the main epigenetic mechanisms, known to be operative in mammals. Extensive evidence has highlighted its pivotal role in several fundamental biological processes including organogenesis, X-chromosome...
Entrance laws for annihilating Brownian motions and the continuous-space voter model
Consider a system of particles moving independently as Brownian motions until two of them meet, when the colliding pair annihilates instantly. The construction of such a system of annihilating Brownian motions (aBMs) is...
Annihilating Brownian motions Entrance laws Moment duality Stepping stone model Symbiotic branching voter model /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Analyzing inexact hypergradients for bilevel learning
Estimating hyperparameters has been a long-standing problem in machine learning. We consider the case where the task at hand is modeled as the solution to an optimization problem. Here the exact gradient with respect to the...
A new look at duality for the symbiotic branching model
The symbiotic branching model is a spatial population model describing the dynamics of two interacting types that can only branch if both types are present. A classical result for the underlying stochastic partial...
Annihilating Brownian motions Moment duality Mutually catalytic branching Rescaled interface Stepping stone model Symbiotic branching model /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty
Optimal Encoding in Stochastic Latent-Variable Models.
In this work we explore encoding strategies learned by statistical models of sensory coding in noisy spiking networks. Early stages of sensory communication in neural systems can be viewed as encoding channels in the...
Efficient Hyperparameter Tuning with Dynamic Accuracy Derivative-Free Optimization
Many machine learning solutions are framed as optimization problems which rely on good hyperparameters. Algorithms for tuning these hyperparameters usually assume access to exact solutions to the underlying learning problem...
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