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Food based dietary patterns and chronic disease prevention.
Matthias B Schulze, Miguel A Martínez-González, Teresa T Fung, Alice H Lichtenstein, Nita G Forouhi
Sep 20, 2018
Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research...
Digital Employee Training With Digital Adoption Platforms Boost Learning and Knowledge Management of Corporate IT Systems
Due to increasing digitalization, employees need to use an increasing number of corporate IT systems. Digital Adoption Platforms (DAPs) recently address the resulting need for increased learning and skills to master such...
Published by: IGI Global Scientific Publishing
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana SH Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
May 30, 2018
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to...
Ischemia–reperfusion injury Mitochondria Myocardial Ischemia myocardial metabolism Adult Aged Aged 80 and over Biomarkers Coronary Angiography Female Follow-Up Studies Humans Magnetic Resonance Imaging Cine Male Middle Aged Myocardial Reperfusion Injury Myocardium Percutaneous Coronary Intervention Prognosis Retrospective Studies ST Elevation Myocardial Infarction Succinic Acid Time Factors
The mammalian mitochondrial epitranscriptome.
Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been...
A functional genetic toolbox for human tissue-derived organoids
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins
Oct 28, 2021
“Under Pressure!”
Matthias Klumpp, Caroline Ruiner, Vera Hagemann, Jonathan Meinecke, Christina Debbing, Marc Hesenius
Jan 01, 2024
The use of digital technologies or applications can have positive and negative effects on workers: Digital technologies might support workers' decision-making by providing necessary information, but digital technologies might...
Published by: IGI Global Scientific Publishing
Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.
M Kohlhauer, VR Pell, N Burger, AM Spiroski, A Gruszczyk, JF Mulvey, Amin Mottahedin, ASH Costa, C Frezza, B Ghaleh, MP Murphy, R Tissier, T Krieg
Mar 26, 2019
Hypothermia induced at the onset of ischemia is a potent experimental cardioprotective strategy for myocardial infarction. The aim of our study was to determine whether the beneficial effects of hypothermia may be due to...
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Jun 07, 2022
BACKGROUND: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates...
The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.
Matthias Zilbauer
Nov 05, 2019
DNA methylation is one of the main epigenetic mechanisms, known to be operative in mammals. Extensive evidence has highlighted its pivotal role in several fundamental biological processes including organogenesis, X-chromosome...
Entrance laws for annihilating Brownian motions and the continuous-space voter model
Consider a system of particles moving independently as Brownian motions until two of them meet, when the colliding pair annihilates instantly. The construction of such a system of annihilating Brownian motions (aBMs) is...
Annihilating Brownian motions Entrance laws Moment duality Stepping stone model Symbiotic branching voter model /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Analyzing inexact hypergradients for bilevel learning
Estimating hyperparameters has been a long-standing problem in machine learning. We consider the case where the task at hand is modeled as the solution to an optimization problem. Here the exact gradient with respect to the...
A new look at duality for the symbiotic branching model
The symbiotic branching model is a spatial population model describing the dynamics of two interacting types that can only branch if both types are present. A classical result for the underlying stochastic partial...
Annihilating Brownian motions Moment duality Mutually catalytic branching Rescaled interface Stepping stone model Symbiotic branching model /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty
Optimal Encoding in Stochastic Latent-Variable Models.
In this work we explore encoding strategies learned by statistical models of sensory coding in noisy spiking networks. Early stages of sensory communication in neural systems can be viewed as encoding channels in the...
Efficient Hyperparameter Tuning with Dynamic Accuracy Derivative-Free Optimization
Many machine learning solutions are framed as optimization problems which rely on good hyperparameters. Algorithms for tuning these hyperparameters usually assume access to exact solutions to the underlying learning problem...
Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons.
Synergistic multi-spectral CT reconstruction with directional total variation
This work considers synergistic multi-spectral CT reconstruction where information from all available energy channels is combined to improve the reconstruction of each individual channel. We propose to fuse these available...
Improving prediction of disease outcome for inflammatory bowel disease
Introduction: Inflammatory bowel diseases (IBDs) are lifelong conditions causing relapsing inflammation of the intestine. In the absence of a cure, clinical management of IBDs is extremely challenging since they present with a...
Correlation-Adjusted Regression Survival Scores for High-Dimensional Variable Selection
biomarker discovery Breast Cancer multigene signature personalized medicine prostate cancer survival modeling Aged Aged 80 and over Biomarkers Tumor Breast Neoplasms Computer Simulation Female Genetic Markers Humans Male Middle Aged Proportional Hazards Models Prostatic Neoplasms Regression Analysis Survival Analysis Watchful Waiting
Vortex dynamics in the presence of excess energy for the Landau-Lifshitz-Gilbert equation
We study the Landau-Lifshitz-Gilbert equation for the dynamics of a magnetic vortex system. We present a PDE-based method for proving vortex dynamics that does not rely on strong well-preparedness of the initial data and allows...
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