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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
Food based dietary patterns and chronic disease prevention.
Matthias B Schulze, Miguel A Martínez-González, Teresa T Fung, Alice H Lichtenstein, Nita G Forouhi
Sep 20, 2018
Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research...
Hidden Specificities in Enzyme Catalysis
Matthias Häckh, Xavier Lucas, Marija Marolt, Peter F Leadlay, Michael Müller, Stefan Günther, Steffen Lüdeke
Feb 12, 2019
Enzymes often convert both physiological and non-physiological substrates with high stereoselectivity; yet, for some enzymes, opposite product chirality is observed. A possible explanation is the existence of hidden...
Digital Employee Training With Digital Adoption Platforms Boost Learning and Knowledge Management of Corporate IT Systems
Due to increasing digitalization, employees need to use an increasing number of corporate IT systems. Digital Adoption Platforms (DAPs) recently address the resulting need for increased learning and skills to master such...
Published by: IGI Global Scientific Publishing
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
Singlet exciton fission in a modified acene with improved stability and high photoluminescence yield.
Peter J Budden, Leah R Weiss, Matthias Müller, Naitik A Panjwani, Simon Dowland, Jesse R Allardice, Michael Ganschow, Jan Freudenberg, Jan Behrends, Uwe HF Bunz, Richard H Friend
Feb 09, 2021
We report a fully efficient singlet exciton fission material with high ambient chemical stability. 10,21-Bis(triisopropylsilylethynyl)tetrabenzo[a,c,l,n]pentacene (TTBP) combines an acene core with triphenylene wings that...
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
Anne K Braczynski, Stefan Vlaho, Klaus Müller, Ilka Wittig, Anna-Eva Blank, Dominique S Tews, Ulrich Drott, Stephanie Kleinle, Angela Abicht, Rita Horvath, Karl H Plate, Werner Stenzel, Hans H Goebel, Andreas Schulze, Patrick N Harter, Matthias Kieslich, Michel Mittelbronn
Mar 07, 2019
TMEM70 is involved in the biogenesis of mitochondrial ATP synthase and mutations in the TMEM70 gene impair oxidative phosphorylation. Herein, we report on pathology and treatment of ATP synthase deficiency in four siblings. A...
CT colonography
Christian Bräuer, Philippe Lefere, Stefaan Gryspeerdt, Helmut Ringl, Ali Al-Mukhtar, Paul Apfaltrer, Dominik Berzaczy, Barbara Füger, Julia Furtner, Christina Müller-Mang, Matthias Pones, Martina Scharitzer, Ramona Woitek, Anno Graser, Michael Weber, Thomas Mang
Dec 20, 2018
OBJECTIVES: To assess whether electronic cleansing (EC) of tagged residue and different computed tomography (CT) windows influence the size of colorectal polyps in CT colonography (CTC). METHODS: A database of 894...
CT colonography Cancer screening Colonic Polyps Neoplasms colorectal Virtual colonoscopy Aged Algorithms Analysis of Variance Colonic Polyps Colonography Computed Tomographic Female Humans Image Processing Computer-Assisted Male Middle Aged Reference Standards Retrospective Studies Sensitivity and Specificity
Singlet exciton fission in a modified acene with improved stability and high photoluminescence yield
Peter J. Budden, Leah R. Weiss, Matthias Müller, Naitik A. Panjwani, Simon Dowland, Jesse R. Allardice, Michael Ganschow, Jan Freudenberg, Jan Behrends, Uwe H. F. Bunz, Richard H. Friend
Mar 09, 2021
Abstract: We report a fully efficient singlet exciton fission material with high ambient chemical stability. 10,21-Bis(triisopropylsilylethynyl)tetrabenzo[a,c,l,n]pentacene (TTBP) combines an acene core with triphenylene wings...
Genetic control of cellular morphogenesis in Müller glia.
The mammalian mitochondrial epitranscriptome.
Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been...
Small-Molecule Activation of YAP for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Small Molecule Activation of Yap for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Modelling Charcot-Marie-Tooth disease in a dish reveals common cell type-specific alterations.
This scientific commentary refers to ‘Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction’, by Van Lent et al. (doi:10.1093/brain/awab226).
Gedanken über die Religion: Der “stille” Krieg zwischen Schelling und Schleiermacher (1799–1807), by Ryan Scheerlinck, Stuttgart-Bad Cannstatt
Vicki Müller-Lüneschloß
Apr 05, 2022
The title of Scheerlinck’s study on the relationship between two of the most important thinkers of Romanticism, the philosopher F.W.J. Schelling and the theologian F.D.E. Schleiermacher, undoubtedly alludes to the latter’s main...
Published by: Memorial University Libraries
A functional genetic toolbox for human tissue-derived organoids
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins
Oct 28, 2021
Comment on Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25.
Attention Deficit Hyperactivity Disorder Diagnosis And Classification EPIDEMIOLOGY Adolescent Adult Age Factors Attention Deficit Disorder with Hyperactivity Child Diagnostic and Statistical Manual of Mental Disorders Humans Young Adult
Published by: Am J Psychiatry
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