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The Source of the Current of Injury
Jacques Loeb and Reinhard Beutner. The source of the current of injury
Reprinted from Science, 1912, Jun 21, 35(912):970-971
Published by: Rockefeller University
Food based dietary patterns and chronic disease prevention.
Matthias B Schulze, Miguel A Martínez-González, Teresa T Fung, Alice H Lichtenstein, Nita G Forouhi
Sep 20, 2018
Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research...
Digital Employee Training With Digital Adoption Platforms Boost Learning and Knowledge Management of Corporate IT Systems
Due to increasing digitalization, employees need to use an increasing number of corporate IT systems. Digital Adoption Platforms (DAPs) recently address the resulting need for increased learning and skills to master such...
Published by: IGI Global Scientific Publishing
Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.
Mario Baumgart, Steffen Priebe, Marco Groth, Nils Hartmann, Uwe Menzel, Luca Pandolfini, Philipp Koch, Marius Felder, Michael Ristow, Christoph Englert, Reinhard Guthke, Matthias Platzer, Alessandro Cellerino
Mar 01, 2016
GAGE Nothobranchius furzeri RNA transport RNA-seq aging history trait hormesis hourglass life ribosome lifespan regulation longevity longitudinal study mitohormesis rejuvenation weighted gene coexpression network analysis (WGCNA) Zebrafish Animals Cyprinodontiformes Longitudinal Studies RNA Sequence Analysis RNA Vertebrates
Two-year outcomes of minimally invasive XEN Gel Stent implantation in primary open-angle and pseudoexfoliation glaucoma.
PURPOSE: The aim of this study was to evaluate the efficacy of XEN® Gel Stent implantation in the treatment of primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (XFG) regarding the reduction of intraocular...
Ab interno XEN Gel Stent Glaucoma minimally invasive glaucoma surgery Exfoliation syndrome Female Follow-Up Studies glaucoma drainage implants Glaucoma Open-Angle Humans Intraocular Pressure Male Minimally Invasive Surgical Procedures Prosthesis Design Retrospective Studies Stents Time Factors Tonometry Ocular Treatment Outcome
Shallow water equations with depth-dependent anisotropic porosity for subgrid-scale topography
This paper derives a novel formulation of the depth-averaged shallow water equations with anisotropic porosity for computational efficiency reasons. The aim is to run simulations on coarser grids while maintaining an acceptable...
Lane Detection Algorithm Based on Road Structure and Extended Kalman Filter
Lane detection still demonstrates low accuracy and missing robustness when recorded markings are interrupted by strong light or shadows or missing marking. This article proposes a new algorithm using a model of road structure...
Published by: IGI Global Scientific Publishing
"I am not delusional!" Sensory dysaesthesia secondary to degenerative cervical myelopathy.
Degenerative cervical myelopathy (DCM) is the most common cause of adult spinal cord dysfunction, most classically presenting with a broad-based gait and clumsy hands. Limb sensory loss and paraesthesia are considered common...
Recombination Rate Heterogeneity within Arabidopsis Disease Resistance Genes.
Molecular and atomic gas along and across the main sequence of star-forming galaxies
Amelie Saintonge, Barbara Catinella, Luca Cortese, Reinhard Genzel, Riccardo Giovanelli, Martha P. Haynes, Steven Janowiecki, Carsten Kramer, Katharina A. Lutz, David Schiminovich, Linda J. Tacconi, Stijn Wuyts, Gioacchino Accurso
Oct 21, 2016
We use spectra from the ALFALFA, GASS and COLD GASS surveys to quantify variations in the mean atomic and molecular gas mass fractions throughout the SFR-M* plane and along the main sequence (MS) of star-forming...
The mammalian mitochondrial epitranscriptome.
Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been...
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.
Lisa Hurler, Erik JM Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo JMGE Brandwijk, Wieke de Bruin, Paul A Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka
Dec 24, 2022
The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and...
C1-INH complexes assay development and validation classical pathway activation early complement activation lectin pathway activation Adult Humans Complement C1 Inhibitor Protein Complement System Proteins covid-19 Lectins Mannose-Binding Protein-Associated Serine Proteases Enzyme-Linked Immunosorbent Assay
Gene drives for schistosomiasis transmission control
Theresa Maier, Nicolas James Wheeler, Erica K. O. Namigai, Josh Tycko, Richard Ernest Grewelle, Yimtubezinash Woldeamanuel, Katharina Klohe, Javier Perez-Saez, Susanne H. Sokolow, Giulio A. De Leo, Timothy P. Yoshino, Mostafa Zamanian, Jutta Reinhard-Rupp
Dec 19, 2019
Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas....
“Under Pressure!”
Matthias Klumpp, Caroline Ruiner, Vera Hagemann, Jonathan Meinecke, Christina Debbing, Marc Hesenius
Jan 01, 2024
The use of digital technologies or applications can have positive and negative effects on workers: Digital technologies might support workers' decision-making by providing necessary information, but digital technologies might...
Published by: IGI Global Scientific Publishing
RNA-Seq Time Series of Vitis vinifera Bud Development Reveals Correlation of Expression Patterns with the Local Temperature Profile.
Boas Pucker, Anna Schwandner, Sarah Becker, Ludger Hausmann, Prisca Viehöver, Reinhard Töpfer, Bernd Weisshaar, Daniela Holtgräwe
Nov 13, 2020
Plants display sophisticated mechanisms to tolerate challenging environmental conditions and need to manage their ontogenesis in parallel. Here, we set out to generate an RNA-Seq time series dataset throughout grapevine (Vitis...
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Jun 07, 2022
BACKGROUND: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates...
NRASQ61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells.
Ishani Banik, Phil F Cheng, Christopher M Dooley, Jana Travnickova, Munise Merteroglu, Reinhard Dummer, Elizabeth E Patton, Elisabeth M Busch-Nentwich, Mitchell P Levesque
Sep 18, 2020
NRAS mutation Zebrafish Anisomycin Melanoma p38-MAPK14 pathway Animals Anisomycin Apoptosis Cell Proliferation GTP Phosphohydrolases Gene Expression Regulation Neoplastic Humans Melanoma Membrane Proteins Mitogen-Activated Protein Kinase 14 Mutation Protein Kinase Inhibitors Protein Synthesis Inhibitors Tumor Cells Cultured Zebrafish
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.
Lisa Hurler, Erik JM Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo JMGE Brandwijk, Wieke de Bruin, Paul A Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka
Nov 21, 2022
The value of blood derived DNA methylation signatures in advancing our understanding of Crohn's Disease pathogenesis.
Matthias Zilbauer
Nov 05, 2019
DNA methylation is one of the main epigenetic mechanisms, known to be operative in mammals. Extensive evidence has highlighted its pivotal role in several fundamental biological processes including organogenesis, X-chromosome...
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