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Results: 63
Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale.
Martin Steger, Vadim Demichev, Mattias Backman, Uli Ohmayer, Phillip Ihmor, Stefan Müller, Markus Ralser, Henrik Daub
Oct 18, 2021
Mass spectrometry (MS)-based ubiquitinomics provides system-level understanding of ubiquitin signaling. Here we present a scalable workflow for deep and precise in vivo ubiquitinome profiling, coupling an improved sample...
Pre-operative oral nutritional supplementation with dietary advice versus dietary advice alone in weight-losing patients with colorectal cancer
Sorrel T Burden, Debra J Gibson, Simon Lal, James Hill, Mark Pilling, Mattias Soop, Aswatha Ramesh, Chris Todd
May 30, 2018
BACKGROUND: Pre-operative weight loss has been consistently associated with increased post-operative morbidity. The study aims to determine if pre-operative oral nutritional supplements (ONSs) with dietary advice reduce...
Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale
Martin Steger, Vadim Demichev, Mattias Backman, Uli Ohmayer, Phillip Ihmor, Stefan Müller, Markus Ralser, Henrik Daub
Sep 13, 2021
Abstract: Mass spectrometry (MS)-based ubiquitinomics provides system-level understanding of ubiquitin signaling. Here we present a scalable workflow for deep and precise in vivo ubiquitinome profiling, coupling an improved...
Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.
Martin Wahlestedt, Vasileios Ladopoulos, Isabel Hidalgo, Manuel Sanchez Castillo, Rebecca Hannah, Petter Säwén, Haixia Wan, Monika Dudenhöffer-Pfeifer, Mattias Magnusson, Gudmundur L Norddahl, Berthold Göttgens, David Bryder
Jun 27, 2018
Gene regulation Hematopoiesis Lineage commitment lymphopoiesis Myelopoiesis Transcription factor Animals Basic-Leucine Zipper Transcription Factors Cell Differentiation Cell Lineage Gene Expression Regulation Hematopoiesis Hematopoietic Stem Cells Leukemia Lymphopoiesis Mice Multipotent Stem Cells Myeloid Cells
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors.
Omid Fotouhi, Hanna Kjellin, C Christofer Juhlin, Yanbo Pan, Mattias Vesterlund, Mehran Ghaderi, Abdelhamid Yousef, Hillevi Andersson-Sand, Pedram Kharaziha, Stefano Caramuta, Magnus Kjellman, Jan Zedenius, Catharina Larsson, Lukas M Orre
Aug 11, 2020
Patients with small intestinal neuroendocrine tumors (SI-NETs) frequently develop spread disease; however, the underlying molecular mechanisms of disease progression are not known and effective preventive treatment strategies...
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Aug 02, 2021
Abstract: Background: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study...
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Jun 08, 2021
Abstract: Background: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study...
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.
Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T Odom, Linda Olsson, Naveen Ravi, Eleanor L Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Jun 20, 2019
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic...
Adolescent Aneuploidy CCCTC-Binding Factor Cell Cycle Proteins Child Child Preschool Chromatin Chromosomal Proteins Non-Histone Chromosome Aberrations Core Binding Factor Alpha 2 Subunit Female Gene Dosage Gene Expression Profiling Gene Expression Regulation Leukemic Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Precursor Cell Lymphoblastic Leukemia-Lymphoma Proteogenomics Proteome Proto-Oncogene Proteins c-ets Repressor Proteins Sequence Analysis RNA Transcription Genetic
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom.
Hilary A Robbins, Karine Alcala, Anthony J Swerdlow, Minouk J Schoemaker, Nick Wareham, Ruth C Travis, Philip AJ Crosbie, Matthew Callister, David R Baldwin, Rebecca Landy, Mattias Johansson
May 03, 2021
BACKGROUND: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study has compared...
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Jul 27, 2020
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Jul 28, 2021
Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates.
Xaquin Castro Dopico, Sandra Muschiol, Nastasiya F Grinberg, Soo Aleman, Daniel J Sheward, Leo Hanke, Marcus Ahl, Linnea Vikström, Mattias Forsell, Jonathan M Coquet, Gerald McInerney, Joakim Dillner, Gordana Bogdanovic, Ben Murrell, Jan Albert, Chris Wallace, Gunilla B Karlsson Hedestam
Mar 03, 2022
OBJECTIVES: Population-level measures of seropositivity are critical for understanding the epidemiology of an emerging pathogen, yet most antibody tests apply a strict cutoff for seropositivity that is not learnt in a...
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers.
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Aug 26, 2020
Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter...
Liver Transplantation for Acute Intermittent Porphyria.
Mattias Lissing, Greg Nowak, René Adam, Vincent Karam, Alexander Boyd, Laurent Gouya, Wouter Meersseman, Espen Melum, Urszula Ołdakowska-Jedynak, Florian P Reiter, Jordi Colmenero, Rosario Sanchez, Uta Herden, Janneke Langendonk, Paolo Ventura, Helena Isoniemi, Olivier Boillot, Felix Braun, Stéphanie Perrodin, Elizabeth Mowlem, Staffan Wahlin, European Liver and Intestine Transplant Association
Apr 21, 2021
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
Sun-Gou Ji, Brian D Juran, Sören Mucha, Trine Folseraas, Luke Jostins, Espen Melum, Natsuhiko Kumasaka, Elizabeth J Atkinson, Erik M Schlicht, Jimmy Z Liu, Tejas Shah, Javier Gutierrez-Achury, Kirsten M Boberg, Annika Bergquist, Severine Vermeire, Bertus Eksteen, Peter R Durie, Martti Farkkila, Tobias Müller, Christoph Schramm, Martina Sterneck, Tobias J Weismüller, Daniel N Gotthardt, David Ellinghaus, Felix Braun, Andreas Teufel, Mattias Laudes, Wolfgang Lieb, Gunnar Jacobs, Ulrich Beuers, Rinse K Weersma, Cisca Wijmenga, Hanns-Ulrich Marschall, Piotr Milkiewicz, Albert Pares, Kimmo Kontula, Olivier Chazouillères, Pietro Invernizzi, Elizabeth Goode, Kelly Spiess, Carmel Moore, Jennifer Sambrook, Willem H Ouwehand, David J Roberts, John Danesh, Annarosa Floreani, Aliya F Gulamhusein, John E Eaton, Stefan Schreiber, Catalina Coltescu, Christopher L Bowlus, Velimir A Luketic, Joseph A Odin, Kapil B Chopra, Kris V Kowdley, Naga Chalasani, Michael P Manns, Brijesh Srivastava, George Mells, Richard N Sandford, Graeme Alexander, Daniel J Gaffney, Roger W Chapman, Gideon M Hirschfield, Mariza de Andrade, UK-PSC Consortium, International IBD Genetics Consortium, International PSC Study Group, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Carl A Anderson
Nov 21, 2017
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC...
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.
Tibor V Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian'an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A Scott, Nicholas J Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W Franks
Aug 15, 2017
BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes...
Prospective cohort study Genetic epidemiology longitudinal analysis Morbidity single nucleotide polymorphism Total cholesterol Triglycerides Adult Aged Coronary Artery Disease Cross-Sectional Studies Female Genetic Loci Genome-Wide Association Study Genotype Humans Lipids Male Meta-Analysis as Topic Middle Aged Polymorphism Single Nucleotide Prospective Studies Sweden White People
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren
Jan 18, 2018
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population....
Animals Blood Glucose Body Fat Distribution Body Mass Index Fasting Female Gene Expression Regulation genetic variation Genome-Wide Association Study Genotype High-Throughput Nucleotide Sequencing Humans Insulin MicroRNAs Middle Aged Polymorphism Single Nucleotide RNA Messenger RNA Small Nucleolar RNA Small Untranslated Subcutaneous Fat
The European NAFLD Registry
Timothy Hardy, Kristy Wonders, Ramy Younes, Guruprasad P Aithal, Rocio Aller, Michael Allison, Pierre Bedossa, Fay Betsou, Jerome Boursier, M Julia Brosnan, Alastair Burt, Jeremy Cobbold, Helena Cortez-Pinto, Chris P Day, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Stephen Harrison, Luca Miele, Patrik Nasr, George Papatheodoridis, Salvatore Petta, Dina Tiniakos, Richard Torstenson, Luca Valenti, Adriaan G Holleboom, Hannele Yki-Jarvinen, Andreas Geier, Manuel Romero-Gomez, Vlad Ratziu, Elisabetta Bugianesi, Jörn M Schattenberg, Quentin M Anstee, LITMUS Consortium
Dec 16, 2020
Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is closely associated with obesity, type 2 diabetes, hypertension and dyslipidaemia, represents an increasing global public health challenge. There is...
Modifiable causes of premature death in middle-age in Western Europe
David C Muller, Neil Murphy, Mattias Johansson, Pietro Ferrari, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Francoise Clavel, Laureen Dartois, Kuanrong Li, Rudolf Kaaks, Cornelia Weikert, Manuela Bergmann, Heiner Boeing, Anne Tjønneland, Kim Overvad, M Luisa Redondo, Antonio Agudo, Elena Molina-Portillo, Jone M Altzibar, Lluís Cirera, Eva Ardanaz, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Ruth C Travis, Christina Bamia, Philippos Orfanos, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, H Bas Bueno-De-Mesquita, WM Monique Verschuren, Ellen A Struijk, Petra H Peeters, Gunnar Engström, Olle Melander, Malin Sund, Elisabete Weiderpass, Guri Skeie, Eiliv Lund, Teresa Norat, Marc Gunter, Elio Riboli, Paul Brennan
Dec 04, 2017
Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition.
Julie A Schmidt, Georgina K Fensom, Sabina Rinaldi, Augustin Scalbert, Paul N Appleby, David Achaintre, Audrey Gicquiau, Marc J Gunter, Pietro Ferrari, Rudolf Kaaks, Tilman Kühn, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleutherios Anifantis, Claudia Agnoli, Domenico Palli, Morena Trevisan, Rosario Tumino, H Bas Bueno-De-Mesquita, Antonio Agudo, Nerea Larrañaga, Daniel Redondo-Sánchez, Aurelio Barricarte, José Maria Huerta, J Ramón Quirós, Nick Wareham, Kay-Tee Khaw, Aurora Perez-Cornago, Mattias Johansson, Amanda J Cross, Konstantinos K Tsilidis, Elio Riboli, Timothy J Key, Ruth C Travis
Jul 05, 2017
BACKGROUND: Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostate...
Acylcarnitines Amino Acids Biogenic amines European Prospective Investigation into Cancer and Nutrition (EPIC) Glycerophospholipids Hexose Mass Spectrometry Metabolomics prospective study prostate cancer risk sphingolipids Aged Biomarkers Case-Control Studies Cohort Studies Follow-Up Studies Humans Logistic Models Male Mass Spectrometry Middle Aged Nutritional Status Odds Ratio Prospective Studies Prostatic Neoplasms
One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.
Alina Vrieling, H Bas Bueno-De-Mesquita, Martine M Ros, Ellen Kampman, Katja K Aben, Frederike L Büchner, Eugène H Jansen, Nina Roswall, Anne Tjønneland, Marie-Christine Boutron-Ruault, Claire Cadeau, Jenny Chang-Claude, Rudolf Kaaks, Steffen Weikert, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Sabina Sieri, Domenico Palli, Salvatore Panico, Petra H Peeters, Elisabete Weiderpass, Guri Skeie, Paula Jakszyn, María-Dolores Chirlaque, Eva Ardanaz, María-José Sánchez, Roy Ehrnström, Johan Malm, Börje Ljungberg, Kay-Tee Khaw, Nick J Wareham, Paul Brennan, Mattias Johansson, Elio Riboli, Lambertus A Kiemeney
Feb 11, 2019
B-vitamins biomarker folate nested case-control urothelial cell carcinomas Aged Biomarkers Tumor Carcinoma Transitional Cell Case-Control Studies Female Folic Acid homocysteine Humans Male Middle Aged Odds Ratio Prospective Studies Risk Assessment Smoking Urinary Bladder Neoplasms Vitamin B 12 Vitamin B 6
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano Exezarreta, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Oct 18, 2021
BACKGROUND: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we...
Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.
Sofia Christakoudi, Artemisia Kakourou, Georgios Markozannes, Ioanna Tzoulaki, Elisabete Weiderpass, Paul Brennan, Marc Gunter, Christina C Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Marie-Christine Boutron-Ruault, Anne-Laure Madika, Gianluca Severi, Verena Katzke, Tilman Kühn, Manuela M Bergmann, Heiner Boeing, Anna Karakatsani, Georgia Martimianaki, Paschalis Thriskos, Giovanna Masala, Sabina Sieri, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Antonio Agudo, Daniel Redondo-Sánchez, Sandra M Colorado-Yohar, Olatz Mokoroa, Olle Melander, Tanja Stocks, Christel Häggström, Sophia Harlid, Bas Bueno-de-Mesquita, Carla H van Gils, Roel CH Vermeulen, Kay-Tee Khaw, Nicholas J Wareham, Tammy YN Tong, Heinz Freisling, Mattias Johansson, Hannah Lennon, Dagfinn Aune, Elio Riboli, Dimitrios Trichopoulos, Antonia Trichopoulou, Konstantinos K Tsilidis
Jul 22, 2019
Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident...
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