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Results: 74
Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.
Ca2+ signalling Cyclic AMP Inositol trisphosphate receptor Parathyroid hormone Adenylyl Cyclases Calcium Calcium Signaling Carbachol Colforsin Cyclic AMP Cyclic AMP-Dependent Protein Kinases Cytosol HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors Parathyroid Hormone Receptor Parathyroid Hormone Type 1
Polyglycerol-based hydrogels and nanogels
Hydrogels and nanogels have emerged as promising materials for biomedical applications owing to their large surface area and tunable mechanical and chemical properties. Their large surface area is well suited for bioconjugation...
Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants
Wai H Lim, Brigitte Adams, Stephen Alexander, Antonia HM Bouts, Frans Claas, Michael Collins, Elisabeth Cornelissen, Heather Dunckley, Huib de Jong, Lloyd D'Orsogna, Anna Francis, Sebastiaan Heidt, Jean Herman, Rhonda Holdsworth, Joshua Kausman, Rabia Khalid, Jon Jin Kim, Siah Kim, Noël Knops, Vasilis Kosmoliaptsis, Cynthia Kramer, Dirk Kuypers, Nicholas Larkins, Suetonia C Palmer, Chanel Prestidge, Agnieszka Prytula, Ankit Sharma, Meena Shingde, Anne Taverniti, Armando Teixeira-Pinto, Peter Trnka, Francis Willis, Daniel Wong, Germaine Wong
Jan 05, 2022
BACKGROUND: Parental donor kidney transplantation is the most common treatment option for children and adolescents with kidney failure. Emerging data from observational studies have reported improved short- and medium-term...
Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants
Wai H Lim, Brigitte Adams, Stephen Alexander, Antonia HM Bouts, Frans Claas, Michael Collins, Elisabeth Cornelissen, Heather Dunckley, Huib de Jong, Lloyd D'Orsogna, Anna Francis, Sebastiaan Heidt, Jean Herman, Rhonda Holdsworth, Joshua Kausman, Rabia Khalid, Jon Jin Kim, Siah Kim, Noël Knops, Vasilis Kosmoliaptsis, Cynthia Kramer, Dirk Kuypers, Nicholas Larkins, Suetonia C Palmer, Chanel Prestidge, Agnieszka Prytula, Ankit Sharma, Meena Shingde, Anne Taverniti, Armando Teixeira-Pinto, Peter Trnka, Francis Willis, Daniel Wong, Germaine Wong
Jan 28, 2022
BACKGROUND: Parental donor kidney transplantation is the most common treatment option for children and adolescents with kidney failure. Emerging data from observational studies have reported improved short- and medium-term...
Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K.
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.
Cullin‐3 ROMK WNK kinases hyperkalemia Proteasome ubiquitin‐ligase complex Adaptor Proteins Signal Transducing Animals Biomarkers Cell Line Cullin Proteins Gene Knock-In Techniques Genetic Predisposition to Disease Kidney Membrane Potentials Mice Transgenic Microfilament Proteins Mutation Oocytes Phenotype Potassium Potassium Channels Inwardly Rectifying Protein Processing Post-Translational Protein Serine-Threonine Kinases Pseudohypoaldosteronism Transfection Xenopus laevis
WNK signalling pathways in blood pressure regulation.
hyperkalemia Hypertension NCC Proteasome SPAK/OSR1 phosphorylation Ubiquitin-E3 ligase complex WNK kinases Animals blood pressure Cullin Proteins Humans Hypertension Neovascularization Physiologic Protein Serine-Threonine Kinases Pseudohypoaldosteronism Receptors Drug Signal Transduction Sodium Chloride Symporters Sodium-Potassium-Chloride Symporters
Polyglycerol-based hydrogels and nanogels
Hydrogels and nanogels have emerged as promising materials for biomedical applications owing to their large surface area and tunable mechanical and chemical properties. Their large surface area is well suited for bioconjugation...
Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma
Meena Rafiq, Andrew Hayward, Charlotte Warren-Gash, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Georgios Lyratzopoulos, Sara Thomas
Feb 07, 2020
BACKGROUND: Immunodeficiency syndromes (acquired/congenital/iatrogenic) are known to increase Hodgkin lymphoma (HL) risk, but the effects of allergic immune dysregulation and corticosteroids are poorly understood. OBJECTIVE: We...
allergic disease Hodgkin lymphoma allergic rhinitis Asthma Atopic dermatitis corticosteroids eczema risk Adolescent Adrenal Cortex Hormones Adult Case-Control Studies Child Child Preschool Female Hodgkin Disease Humans Hypersensitivity Immediate Immunocompromised Host Immunosuppressive Agents Male United Kingdom Young Adult
Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K.
A potassium (K+ ) rich diet is known to have an antihypertensive effect that has been embodied by the NHLBI in the DASH diet. However, the molecular basis for this blood pressure-lowering effect has been unclear, until a recent...
Scope of professional roles for genetic counsellors and clinical geneticists in the United Kingdom
Anna Middleton, Nicola Taverner, Catherine Houghton, Sarah Smithson, Meena Balasubramanian, Frances Elmslie
Jan 07, 2023
This document is written on behalf of the two professional bodies in the United Kingdom that represent genetic counsellors (the Association of Genetic Nurses and Counsellors) and clinical geneticists (the Clinical Genetics...
Empirical Investigation of Participation on Crowdsourcing Platforms
Crowdsourcing platforms have gained importance in recent times, and their success is dependent mainly on the participation of the crowd. Participation is a function of both intrinsic and extrinsic motivation. Moreover, with the...
Published by: IGI Global Scientific Publishing
Current Dynamics and Future Growth of Online Travel Agencies
Although the literature on online travel agencies is growing, it is fragmented and incoherent. Hence, this review aims to synthesize the online travel agencies and suggest directions for future research on online travel...
Published by: IGI Global Scientific Publishing
Effect of Long Term Exposure to Petrol Fumes on Liver Function- A Study in Petrol Pump Attendants
Petrol is an integral part of modern world. Various studies suggest that ingredients of petrol have a toxic effect on various organs. Petrol pump attends are exposed to petrol fumes. This study was conducted in petrol pump...
Published by: IJHS Medical Association
Analytical validation of new ELISAs for the quantitation of polyclonal free light chains and comparison to existing assays for healthy and patient samples
Jennifer L J Heaney, John Campbell, Margaret Goodall, Tim Plant, Meena Shemar, Christopher Hand, Mark T. Drayson
Mar 31, 2020
Background: Polyclonal FLCs can be used as a biomarker of inflammation and immune activation in a range of diseases. This study evaluated the performance of new FLC ELISAs (Seralite FLC ELISA) for the quantitation of...
Analytical validation of new ELISAs for the quantitation of polyclonal free light chains and comparison to existing assays for healthy and patient samples
Jennifer L J Heaney, John Campbell, Margaret Goodall, Tim Plant, Meena Shemar, Christopher Hand, Mark T. Drayson
Mar 31, 2020
Background: Polyclonal FLCs can be used as a biomarker of inflammation and immune activation in a range of diseases. This study evaluated the performance of new FLC ELISAs (Seralite FLC ELISA) for the quantitation of...
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India
Jitendra PS Sawhney, Veerappa A Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S Pieper, A John Camm, Ajay K Kakkar, GARFIELD-AF Investigators
Mar 18, 2020
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics...
Effect of Long Term Exposure to Petrol Fumes on Liver Function- A Study in Petrol Pump Attendants
Petrol is an integral part of modern world. Various studies suggest that ingredients of petrol have a toxic effect on various organs. Petrol pump attends are exposed to petrol fumes. This study was conducted in petrol pump...
Published by: IJHS Medical Association
Global Development on LCA Research
G. Dangayach, Gaurav Gaurav, Alok Singh, Chandni Khandelwal, Sumit Gupta, Sundeep Kumar, M. Meena
Jan 01, 2023
Research on life cycle assessment (LCA) has been conducted over three decades. According to ISO 14040, LCA is an international standard that provides a methodology for assessing the environmental impact of products and...
Published by: IGI Global Scientific Publishing
Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers
Abstract Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have...
Steven A Kemp, Mark TK Cheng, William L Hamilton, Kimia Kamelian, Himanshu Chauhan, Tanzin Dikid, Hema Gogia, Hemlata Lall, Kalaiarasan Ponnusamy, Kaptan Verma, Mahesh Shanker Dhar, Manoj K Singh, Meena Datta, Namita Soni, Namonarayan Meena, Preeti Madan, Priyanka Singh, Ramesh Sharma, Rajeev Sharma, Sandhya Kabra, Sattender Kumar, Swati Kumari, Uma Sharma, Urmila Chaudhary, Sridhar Sivasubbu, Vinod Scaria, Chand Wattal, JK Oberoi, Reena Raveendran, S Datta, Saumitra Das, Arindam Maitra, Sreedhar Chinnaswamy, Nidhan Kumar Biswas, Ajay Parida, Sunil K Raghav, Punit Prasad, Apurva Sarin, Satyajit Mayor, Uma Ramakrishnan, Dasaradhi Palakodeti, Aswin Sai Narain Seshasayee, K Thangaraj, Murali Dharan Bashyam, Ashwin Dalal, Manoj Bhat, Yogesh Shouche, Ajay Pillai, Priya Abraham, Varsha Atul Potdar, Sarah S Cherian, Anita Sudhir Desai, Chitra Pattabiraman, MV Manjunatha, Reeta S Mani, Gautam Arunachal Udupi, Vinay Nandicoori, Karthik Bharadwaj Tallapaka, Divya Tej Sowpati, Sujit Singh, Partha Rakshit, Anurag Agrawal, Christopher JR Illingworth, Ravindra K Gupta
Jul 22, 2022
Machine Learning-Based Automatic Litter Detection and Classification Using Neural Networks in Smart Cities
Meena Malik, Chander Prabha, Punit Soni, Varsha Arya, Wadee Alhalabi, Brij Gupta, Aiiad Albeshri, Ammar Almomani
Jan 01, 2023
Machine learning and deep learning are one of the most sought-after areas in computer science which are finding tremendous applications ranging from elementary education to genetic and space engineering. The applications of...
Published by: IGI Global Scientific Publishing
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
Eric J. Brunner, Koutatsu Maruyama, Martin Shipley, Noriko Cable, Hiroyasu Iso, Ayako Hiyoshi, Daryth Stallone, Meena Kumari, Adam Tabak, Archana Singh-Manoux, John Wilson, Claudia Langenberg, Nick Wareham, David Boniface, Aroon Hingorani, Mika Kivimäki, Clare Llewellyn
Mar 29, 2021
Abstract: Background/objectives: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of...
A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.
Fang Fang, Benjamin Angulo, Ninuo Xia, Meena Sukhwani, Zhengyuan Wang, Charles C Carey, Aurélien Mazurie, Jun Cui, Royce Wilkinson, Blake Wiedenheft, Naoko Irie, M Azim Surani, Kyle E Orwig, Renee A Reijo Pera
Sep 11, 2018
Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and...
Animals Cell Differentiation Cell Line Gene Editing Gene Expression Regulation Developmental Human Embryonic Stem Cells Humans Male Mice Nude Octamer Transcription Factor-3 PAX5 Transcription Factor Positive Regulatory Domain I-Binding Factor 1 Protein Binding SOXB1 Transcription Factors Signal Transduction Spermatozoa Testis Time Factors Transcription Genetic
Pan-cancer analysis of transcripts encoding novel open-reading frames (nORFs) and their potential biological functions.
Chaitanya Erady, Adam Boxall, Shraddha Puntambekar, N Suhas Jagannathan, Ruchi Chauhan, David Chong, Narendra Meena, Apurv Kulkarni, Bhagyashri Kasabe, Kethaki Prathivadi Bhayankaram, Yagnesh Umrania, Adam Andreani, Jean Nel, Matthew T Wayland, Cristina Pina, Kathryn S Lilley, Sudhakaran Prabakaran
Jan 25, 2021
Uncharacterized and unannotated open-reading frames, which we refer to as novel open reading frames (nORFs), may sometimes encode peptides that remain unexplored for novel therapeutic opportunities. To our knowledge, no...
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