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Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys
Shawn M. Flynn, Phillip M. Epperly, April T. Davenport, Gerta Cami-Kobeci, Stephen M. Husbands, Mei Chuan Ko, Paul W. Czoty
Apr 10, 2019
Alcohol use disorder (AUD) persists as a devastating public health problem; widely effective pharmacological treatments are needed. Evidence from rodent models suggests that stimulating brain receptors for the neuropeptide...
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates
Huiping Ding, Paul W Czoty, Norikazu Kiguchi, Gerta Cami-Kobeci, Devki D Sukhtankar, Michael A Nader, Stephen M Husbands, Mei-Chuan Ko
Sep 13, 2016
Despite the critical need, no previous research has substantiated safe opioid analgesics without abuse liability in primates. Recent advances in medicinal chemistry have led to the development of ligands with mixed mu opioid...
Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys
Shawn M. Flynn, Phillip M. Epperly, April T. Davenport, Gerta Cami-Kobeci, Stephen M. Husbands, Mei Chuan Ko, Paul W. Czoty
Apr 10, 2019
Alcohol use disorder (AUD) persists as a devastating public health problem; widely effective pharmacological treatments are needed. Evidence from rodent models suggests that stimulating brain receptors for the neuropeptide...
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates
Huiping Ding, Paul W Czoty, Norikazu Kiguchi, Gerta Cami-Kobeci, Devki D Sukhtankar, Michael A Nader, Stephen M Husbands, Mei-Chuan Ko
Sep 13, 2016
Despite the critical need, no previous research has substantiated safe opioid analgesics without abuse liability in primates. Recent advances in medicinal chemistry have led to the development of ligands with mixed mu opioid...
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Sukru Anil Dogan, Raffaele Cerutti, Cristiane Benincá, Gloria Brea-Calvo, Howard Trevor Jacobs, Massimo Zeviani, Marten Szibor, Carlo Viscomi
Sep 08, 2018
Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We...
ROS alternative oxidase antioxidant Autophagy mitochondrial biogenesis mitochondrial disease redox signaling satellite cells stress responses Animals Autophagy Female Male Mice Mice Inbred C57BL Mice Knockout Mitochondrial Myopathies Mitochondrial Proteins Muscle Skeletal Organelle Biogenesis Oxidation-Reduction Oxidoreductases Plant Proteins Reactive Oxygen Species Signal Transduction
Imprinted <i>Grb10,</i> encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (<i>Igf1r</i>) and insulin receptor (<i>Insr</i>) genes
Background
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Imprinted <i>Grb10,</i> encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (<i>Igf1r</i>) and insulin receptor (<i>Insr</i>) genes
Background
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Mitigating the Torque Ripple in Electric Traction using Proportional Integral Resonant Controller
Permanent magnet (PM) machines offer high efficiencies which are attractive to be used in vehicle propulsion systems, however, their design creates an inherent torque ripple. This is particularly problematic for electric...
High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy
Colin A Goebel, Emma Brown, Fabian B Fahlbusch, Alexandra L Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Späth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P Regensburger, Ferdinand Knieling
Aug 06, 2022
BACKGROUND: Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The aim of...
Some Reflections on Joseph Needham's Intellectual Heritage.
Jianjun Mei
Apr 03, 2020
In this essay, I reflect on Joseph Needham's intellectual heritage, its impact on understanding the world history of knowledge circulation, and its broad influence on generations of scholars. I present two case studies of...
Mitigating the Torque Ripple in Electric Traction using Proportional Integral Resonant Controller
Permanent magnet (PM) machines offer high efficiencies which are attractive to be used in vehicle propulsion systems, however, their design creates an inherent torque ripple. This is particularly problematic for electric...
Diagnosing the
<scp>UK</scp>
productivity slowdown
This paper explores the slowdown in labour productivity growth in the UK and other advanced economies by decomposing its growth into contributions from different sectors of the economy, looking at both within‐industry...
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids
Amelia Lane, Katarina Jovanovic, Ciara Shortall, Daniele Ottaviani, Anna Brugulat-Panes, Nele Schwarz, Rosellina Guarascio, Matthew J Hayes, Arpad Palfi, Naomi Chadderton, G Jane Farrar, Alison J Hardcastle, Michael E Cheetham
Jul 07, 2020
RP2 mutations cause a severe form of X-linked retinitis pigmentosa (XLRP). The mechanism of RP2-associated retinal degeneration in humans is unclear, and animal models of RP2 XLRP do not recapitulate this severe phenotype. Here...
AAV CRISPR gene editing Cell Death Disease Modeling gene therapy Genetic inherited disease Retinal Degeneration retinal organoid stem cell Cell Death Cell Survival Dependovirus GTP-Binding Proteins Gene Expression Regulation Gene Knockdown Techniques Humans Induced Pluripotent Stem Cells Membrane Proteins Models Biological Organoids Retina Retinal Rod Photoreceptor Cells Retinitis Pigmentosa
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
Denise van Uden, Thomas Koudstaal, Jennifer AC van Hulst, Ingrid M Bergen, Chelsea Gootjes, Nicholas W Morrell, Geert van Loo, Jan H von der Thüsen, Thierry PP van den Bosch, Maria-Rosa Ghigna, Frédéric Perros, David Montani, Mirjam Kool, Karin A Boomars, Rudi W Hendriks
Apr 26, 2021
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old...
BMPR2 Tnfaip3 Toll-like receptor Dendritic Cells Inflammation pulmonary arterial hypertension Animals Bone Morphogenetic Protein Receptors Type II Dendritic Cells Familial Primary Pulmonary Hypertension Gene Deletion Heart Ventricles Humans Immunity Innate Mice Mutation Toll-Like Receptor 4 Tumor Necrosis Factor alpha-Induced Protein 3
An Effective Emotional Analysis Method of Consumer Comment Text Based on ALBERT-ATBiFRU-CNN
Mei Yang
Dec 21, 2022
To address the challenges of insufficient feature extraction for text sentiment analysis in the e-commerce big data environment, the author proposes a deep learning-based emotion analysis method of consumer comment text....
Published by: IGI Global Scientific Publishing
Stable<i> trans</i> isomer as the kinetic and theromodynamic product for the oxidative addition of MeI to cycloplatinated(II) complexes comprising isocyanide ligands
Hamid R. Shahsavari, Reza Babadi Aghakhanpour, Mojdeh Hossein-Abadi, Reza Kia, Paul R. Raithby
Apr 01, 2018
The present investigation introduces a new series of cycloplatinated(II) complexes, with the general formula Pt(O-bpy)(Me)(CN-R)] (R = benzyl, 2-naphtyl and tert-butyl), which are able to generate the stable trans-Pt(IV)...
Stable<i> trans</i> isomer as the kinetic and theromodynamic product for the oxidative addition of MeI to cycloplatinated(II) complexes comprising isocyanide ligands
Hamid R. Shahsavari, Reza Babadi Aghakhanpour, Mojdeh Hossein-Abadi, Reza Kia, Paul R. Raithby
Apr 01, 2018
The present investigation introduces a new series of cycloplatinated(II) complexes, with the general formula Pt(O-bpy)(Me)(CN-R)] (R = benzyl, 2-naphtyl and tert-butyl), which are able to generate the stable trans-Pt(IV)...
Multi-Modal Regualtion of Actin Networks
Lin Mei
Jan 01, 0001
Eukaryotic cells employ the actin cytoskeleton to maintain cell shape, support motility, and sense and respond to external mechanical stimuli. An intricate network of actin filaments constitutes the foundation of tissue...
Published by: Rockefeller University
p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons.
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R Merlo
Feb 28, 2022
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. p140Cap knock-out (KO)...
Finite element modeling of thermo-active diaphragm walls
Abstract There are two major challenges faced by modern society: energy security, and lowering carbon dioxide gas emissions. Thermo-active diaphragm walls have a large potential to remedy one of...
Charity retailing in the United Kingdom
Nonprofit organizations are venturing into commercial activities due to the intense competition for the limited government funds and declining availability of donor funds for third-sector organizations that address social...
An integrated model of cause-related marketing strategy development
Researchers in the fields of marketing and corporate social responsibility have suggested that cause-related marketing (CRM) can provide firms with opportunities for managing their community relationships and for enhancing their...
Exploring the Influential Factors of Continuous Online Shopping Intention
Cheng-Mei Tung
Jan 01, 2022
This study explores consumers' continuous intention regarding online shopping in Taiwan. The technology acceptance model and expectation confirmation model are integrated to explore the influential factors in the continuous...
Published by: IGI Global Scientific Publishing
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