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Parasitic Protozoa
Guanine-quadruplex (G4) motifs, at both the DNA and RNA levels, have assumed an important place in our understanding of the biology of eukaryotes, bacteria and viruses. However, it is generally little known that their very first...
Conserved associations between G-quadruplex-forming DNA motifs and virulence gene families in malaria parasites
Abstract: Background: The Plasmodium genus of malaria parasites encodes several families of antigen-encoding genes. These genes tend to be hyper-variable, highly recombinogenic and variantly expressed. The best-characterized...
Aducanumab for Alzheimer's disease?
Patients and families need hope, not false hope
Conserved associations between G-quadruplex-forming DNA motifs and virulence gene families in malaria parasites.
BACKGROUND:The Plasmodium genus of malaria parasites encodes several families of antigen-encoding genes. These genes tend to be hyper-variable, highly recombinogenic and variantly expressed. The best-characterized family is the...
Published by: BMC genomics
DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi.
Malaria parasites are unusual, early-diverging protozoans with non-canonical cell cycles. They do not undergo binary fission, but divide primarily by schizogony. This involves the asynchronous production of multiple nuclei...
G-quadruplexes in pathogens
DNA can form several secondary structures besides the classic double helix: one that has received much attention in recent years is the G-quadruplex (G4). This is a stable four-stranded structure formed by the stacking of...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi.
Malaria parasites are unusual, early-diverging protozoans with non-canonical cell cycles. They do not undergo binary fission, but divide primarily by schizogony. This involves the asynchronous production of multiple nuclei...
Challenges, solutions and future directions in the evaluation of service innovations in health care and public health
Rosalind Raine, Ray Fitzpatrick, Helen Barratt, Gywn Bevan, Nick Black, Ruth Boaden, Peter Bower, Marion Campbell, Jean-Louis Denis, Kelly Devers, Mary Dixon-Woods, Lesley Fallowfield, Julien Forder, Robbie Foy, Nick Freemantle, Naomi J Fulop, Elizabeth Gibbons, Clare Gillies, Lucy Goulding, Richard Grieve, Jeremy Grimshaw, Emma Howarth, Richard J Lilford, Ruth McDonald, Graham Moore, Laurence Moore, Robin Newhouse, Alicia O’Cathain, Zeynep Or, Chrysanthi Papoutsi, Stephanie Prady, Jo Rycroft-Malone, Jasjeet Sekhon, Simon Turner, Samuel I Watson, Merrick Zwarenstein
May 25, 2016
Behavioral and Social Science Health Services Clinical Research 8.4 Research design and methodologies (health services) 8 Health and social care services research 8.1 Organisation and delivery of services 8.3 Policy Ethics and research governance Generic Health Relevance 3 Good Health and Well Being
Conserved associations between G-quadruplex-forming DNA motifs and virulence gene families in malaria parasites.
BACKGROUND: The Plasmodium genus of malaria parasites encodes several families of antigen-encoding genes. These genes tend to be hyper-variable, highly recombinogenic and variantly expressed. The best-characterized family is the...
The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome.
Plasmodium falciparum, a protozoan parasite and causative agent of human malaria, has one of the most A/T-biased genomes sequenced to date. This may give the genome and the transcriptome unusual structural features. Recent...
The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome.
Plasmodium falciparum, a protozoan parasite and causative agent of human malaria, has one of the most A/T-biased genomes sequenced to date. This may give the genome and the transcriptome unusual structural features. Recent...
Testing the role of SOX15 in human primordial germ cell fate.
Background: Potentially novel regulators of early human germline development have been identified recently, including SOX15 and SOX17, both of which show specific expression in human primordial germ cells. SOX17 is now known to...
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
In the early-diverging protozoan parasite Plasmodium , few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of...
James Edwards-Smallbone, Anders L Jensen, Lydia E Roberts, Francis Isidore G Totañes, Sarah R Hart, Catherine J Merrick
Mar 08, 2022
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
Anastasiya Sybirna, Walfred WC Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H Gruhn, Ran Brosh, M Azim Surani
Jan 15, 2020
G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum.
Franck Dumetz, Eugene Yui-Ching Chow, Lynne M Harris, Shiau Wei Liew, Anders Jensen, Mubarak I Umar, Betty Chung, Ting Fung Chan, Catherine J Merrick, Chun Kit Kwok
Jan 07, 2022
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
Anastasiya Sybirna, Walfred W C Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H Gruhn, Ran Brosh, M Azim Surani
Apr 11, 2020
PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remains unclear. Besides, a...
Published by: Nature Communications
Applying support-vector machine learning algorithms toward predicting host-guest interactions with cucurbit[7]uril.
Anthony Tabet, Thomas Gebhart, Guanglu Wu, Charlie Readman, Merrick Pierson Smela, Vijay K Rana, Cole Baker, Harry Bulstrode, Polina Anikeeva, David H Rowitch, Oren A Scherman
Jun 22, 2020
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