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Michael Heidelberger, 1933
The Rockefeller University
Jan 01, 0001
Dr. Michael Heidelberger. Contributions of Chemistry of the Knowledge of Immune Processes
Lecture delivered March 17th, 1933
Posted with permission
Published by: The William & Wilkins Company
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
JEFFREY RAVETCH AND MICHAEL YOUNG
The Rockefeller University
Jan 01, 0001
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Published by: The Rockefeller University
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Quantitative Temporal Viromics.
The abundance, localization, modifications, and protein-protein interactions of many host cell and virus proteins can change dynamically throughout the course of any viral infection. Studying these changes is critical for a...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics.
Human cytomegalovirus (HCMV) is an important pathogen in immunocompromised individuals and neonates, and a paradigm for viral immune evasion. We previously developed a quantitative proteomic approach that identified 133 proteins...
Mass testing of university students for covid-19.
People can clearly incubate and transmit SARS-CoV-2 in the absence of symptoms. Nonetheless, the value of mass testing (large scale asymptomatic screening to identify cases) has been contested. In principle, isolation of people...
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum.
Elizabeth S Egan, Michael P Weekes, Usheer Kanjee, Jale Manzo, Ashwin Srinivasan, Christine Lomas-Francis, Connie Westhoff, Junko Takahashi, Mitsunobu Tanaka, Seishi Watanabe, Carlo Brugnara, Steven P Gygi, Yoshihiko Tani, Manoj T Duraisingh
Jun 25, 2018
The ATP-binding cassette transporter ABCB6 was recently discovered to encode the Langereis (Lan) blood group antigen. Lan null individuals are asymptomatic, and the function of ABCB6 in mature erythrocytes is not understood....
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes
Abstract: Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical...
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes.
Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical monocytes play the...
Published by: Scientific reports
Human Cytomegalovirus Long Non-coding RNA1.2 Suppresses Extracellular Release of the Pro-inflammatory Cytokine IL-6 by Blocking NF-κB Activation
Betty Lau, Karen Kerr, Quan Gu, Katie Nightingale, Robin Antrobus, Nicolás M. Suárez, Richard J. Stanton, Eddie C. Y. Wang, Michael P. Weekes, Andrew J. Davison
Aug 05, 2020
Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and...
Compositional Proteomics
Jonathon J O'Brien, Jeremy D O'Connell, Joao A Paulo, Sanjukta Thakurta, Christopher M Rose, Michael P Weekes, Edward L Huttlin, Steven P Gygi
Feb 16, 2018
Mass spectrometry (MS) has become an accessible tool for whole proteome quantitation with the ability to characterize protein expression across thousands of proteins within a single experiment. A subset of MS quantification...
Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products
Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.
Selasi Dankwa, Mudit Chaand, Usheer Kanjee, Rays HY Jiang, Luis V Nobre, Jonathan M Goldberg, Amy K Bei, Mischka A Moechtar, Christof Grüring, Ambroise D Ahouidi, Daouda Ndiaye, Tandakha N Dieye, Souleymane Mboup, Michael P Weekes, Manoj T Duraisingh
Nov 28, 2018
Plasmodium falciparum, the parasite that causes the deadliest form of malaria, has evolved multiple proteins known as invasion ligands that bind to specific erythrocyte receptors to facilitate invasion of human erythrocytes. The...
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.
Benjamin J Ravenhill, Usheer Kanjee, Ambroise Ahouidi, Luis Nobre, James Williamson, Jonathan M Goldberg, Robin Antrobus, Tandakha Dieye, Manoj T Duraisingh, Michael P Weekes
Aug 19, 2019
Red blood cells (RBCs) play a critical role in oxygen transport, and are the focus of important diseases including malaria and the haemoglobinopathies. Proteins at the RBC surface can determine susceptibility to disease, however...
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
covid-19 FFP3 PPE SARS-CoV-2 EPIDEMIOLOGY Global Health healthcare worker infectious disease mask microbiology viruses Adult Aerosols Aged covid-19 Health Personnel Humans Incidence infection control masks Middle Aged Models Theoretical Respiratory Protective Devices SARS-CoV-2 United Kingdom Young Adult
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