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The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease.
David C Schöndorf, Dina Ivanyuk, Pascale Baden, Alvaro Sanchez-Martinez, Silvia De Cicco, Cong Yu, Ivana Giunta, Lukas K Schwarz, Gabriele Di Napoli, Vasiliki Panagiotakopoulou, Sigrun Nestel, Marcus Keatinge, Jan Pruszak, Oliver Bandmann, Bernd Heimrich, Thomas Gasser, Alexander J Whitworth, Michela Deleidi
Sep 08, 2018
While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates...
GBA NAD+ Parkinson’s disease Induced Pluripotent Stem Cells Lysosomal Storage Diseases Mitochondria neurodegeneration Animals Autophagy Disease Models Animal Dopaminergic Neurons Drosophila melanogaster Endoplasmic reticulum stress Glucosylceramidase Humans Induced Pluripotent Stem Cells Mitochondria Mitochondrial Dynamics Motor Activity NAD Neurons Niacinamide Parkinson Disease Pyridinium Compounds Unfolded Protein Response
Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology.
This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary...
An adaptive guidance meta-heuristic for the vehicle routing problem with splits and clustered backhauls
This paper presents the case study of an Italian carrier, Grendi Trasporti Marittimi, which provides freight transportation services by trucks and containers. Its trucks deliver container loads from a port to import customers...
Author Correction: An earlier revolution
A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper.
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.
Active targeting by means of drug encapsulated nanoparticles decorated with targeting bioactive moieties represents the next frontier in drug delivery; it reduces drug side effects and increases the therapeutic index. Peptides...
Was Brexit triggered by the old and unhappy? Or by financial feelings?
On 23 June 2016, the United Kingdom voted in favour of ‘Brexit’. This paper is an attempt to understand why. It examines the micro-econometric predictors of anti-EU sentiment. The paper provides the first evidence for the idea...
An adaptive guidance meta-heuristic for the vehicle routing problem with splits and clustered backhauls
This paper presents the case study of an Italian carrier, Grendi Trasporti Marittimi, which provides freight transportation services by trucks and containers. Its trucks deliver container loads from a port to import customers...
Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids.
Was Brexit triggered by the old and unhappy? Or by financial feelings?
On 23 June 2016, the United Kingdom voted in favour of ‘Brexit’. This paper is an attempt to understand why. It examines the micro-econometric predictors of anti-EU sentiment. The paper provides the first evidence for the idea...
Neural Signal to Violations of Abstract Rules Using Speech-Like Stimuli.
As the evidence of predictive processes playing a role in a wide variety of cognitive domains increases, the brain as a predictive machine becomes a central idea in neuroscience. In auditory processing, a considerable amount of...
Single Cell Gene Expression to Understand the Dynamic Architecture of the Heart.
Andrea Massaia, Patricia Chaves, Sara Samari, Ricardo Júdice Miragaia, Kerstin Meyer, Sarah Amalia Teichmann, Michela Noseda
May 14, 2019
The recent development of single cell gene expression technologies, and especially single cell transcriptomics, have revolutionized the way biologists and clinicians investigate organs and organisms, allowing an unprecedented...
Laparoscopic vs. open feeding jejunostomy insertion in oesophagogastric cancer
Sotiris Mastoridis, Giada Bracalente, Christine-Bianca Hanganu, Michela Neccia, Antonio Giuliani, Richard Gillies, Robert Marshall, Nicholas Maynard, Bruno Sgromo
Oct 13, 2021
Abstract: Background: Jejunal feeding is an invaluable method by which to improve the nutritional status of patients undergoing neoadjuvant and surgical treatment of oesophageal malignancies. However, the insertion of a feeding...
Laparoscopic vs. open feeding jejunostomy insertion in oesophagogastric cancer.
Sotiris Mastoridis, Giada Bracalente, Christine-Bianca Hanganu, Michela Neccia, Antonio Giuliani, Richard Gillies, Robert Marshall, Nicholas Maynard, Bruno Sgromo
Nov 22, 2021
BACKGROUND: Jejunal feeding is an invaluable method by which to improve the nutritional status of patients undergoing neoadjuvant and surgical treatment of oesophageal malignancies. However, the insertion of a feeding...
Climate warming restructures an aquatic food web over 28 years.
Andrew J Tanentzap, Giuseppe Morabito, Pietro Volta, Michela Rogora, Norman D Yan, Marina Manca
Sep 04, 2020
Pavla Strnadova, Hongwei Ren, Robert Valentine, Michela Mazzon, Trevor R Sweeney, Ian Brierley, Geoffrey L Smith
Sep 04, 2015
Adaptive Immunity Animals CD8-Positive T-Lymphocytes Cell Line Female Gene Deletion Gene Expression Regulation Host-Pathogen Interactions Humans Immunity Innate Immunologic Memory Mice Inbred BALB C Mice Inbred C57BL Peptide Chain Initiation Translational Recombinant Fusion Proteins Recombinant Proteins Ribosome Subunits Large Eukaryotic Ribosome Subunits Small Eukaryotic Vaccinia vaccinia virus Viral Proteins Virulence
Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors.
Antonella Accardo, Filippo Galli, Rosalba Mansi, Luigi Del Pozzo, Michela Aurilio, Anna Morisco, Paola Ringhieri, Alberto Signore, Giancarlo Morelli, Luigi Aloj
Dec 18, 2018
BACKGROUND: Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabeled...
Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells.
Michael Claxton, Michela Pulix, Michelle KY Seah, Ralph Bernardo, Peng Zhou, Sultan Aljuraysi, Triantafillos Liloglou, Philippe Arnaud, Gavin Kelsey, Daniel M Messerschmidt, Antonius Plagge
Nov 30, 2022
Genomic imprinting is an epigenetic process through which genes are expressed in a parent-of-origin specific manner resulting in mono-allelic or strongly biased expression of one allele. For some genes, imprinted expression may...
Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.
Michela Mazzon, Cecilia Castro, Bastian Thaa, Lifeng Liu, Margit Mutso, Xiang Liu, Suresh Mahalingam, Julian L Griffin, Mark Marsh, Gerald M McInerney
May 23, 2018
Virus reprogramming of cellular metabolism is recognised as a critical determinant for viral growth. While most viruses appear to activate central energy metabolism, different viruses have been shown to rely on alternative...
Giant barocaloric effects over a wide temperature range in superionic conductor AgI.
Araceli Aznar, Pol Lloveras, Michela Romanini, María Barrio, Josep-Lluís Tamarit, Claudio Cazorla, Daniel Errandonea, Neil D Mathur, Antoni Planes, Xavier Moya, Lluís Mañosa
Jan 25, 2018
Current interest in barocaloric effects has been stimulated by the discovery that these pressure-driven thermal changes can be giant near ferroic phase transitions in materials that display magnetic or electrical order. Here we...
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells
Antonella Accardo, Giuseppina Salsano, Anna Morisco, Michela Aurilio, Antonio Parisi, Francesco Maione, Carla Cicala, Diego Tesauro, Luigi Aloj, Giuseppe De Rosa, Giancarlo Morelli
Dec 21, 2018
OBJECTIVES: Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This...
PC-3 Cells bombesin peptide doxorubicin delivery gastrin-releasing peptide receptors theranostic applications Animals Antineoplastic Agents Bombesin Cell Line Tumor Doxorubicin Drug Carriers Drug Delivery Systems Female Humans Liposomes Male Mice Mice Inbred BALB C Mice Nude nanomedicine Pentetic Acid Peptide Fragments Phosphatidylcholines Prostatic Neoplasms Receptors Bombesin Surface-Active Agents Xenograft Model Antitumor Assays
Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells.
Michael Claxton, Michela Pulix, Michelle KY Seah, Ralph Bernardo, Peng Zhou, Sultan Aljuraysi, Triantafillos Liloglou, Philippe Arnaud, Gavin Kelsey, Daniel M Messerschmidt, Antonius Plagge
Oct 26, 2022
Bayesian Skyline Plots disagree with range size changes based on Species Distribution Models for Holarctic birds
Eleanor F. Miller, Rhys E. Green, Andrew Balmford, Pierpaolo Maisano Delser, Robert Beyer, Marius Somveille, Michela Leonardi, William Amos, Andrea Manica
Jul 05, 2021
Abstract: During the Quaternary, large climate oscillations impacted the distribution and demography of species globally. Two approaches have played a major role in reconstructing changes through time: Bayesian Skyline Plots...
Original Article Original Articles Bayesian Skyline Plot demographic history species distribution models
Published by: Molecular Ecology
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