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Results: 74
Chromosomal copy number heterogeneity predicts survival rates across cancers.
Erik van Dijk, Tom van den Bosch, Kristiaan J Lenos, Khalid El Makrini, Lisanne E Nijman, Hendrik FB van Essen, Nico Lansu, Michiel Boekhout, Joris H Hageman, Rebecca C Fitzgerald, Cornelis JA Punt, Jurriaan B Tuynman, Hugo JG Snippert, Geert JPL Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M Miedema
Jul 09, 2021
Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast...
Adolescent Adult Aged Aged 80 and over Child Computer Simulation DNA Copy Number Variations Datasets as Topic Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genetic Heterogeneity Genomics Humans Male Middle Aged Models Genetic Mutation Neoplasms Prognosis Progression-Free Survival Risk Assessment Survival Rate Tumor Microenvironment Young Adult
Chromosomal copy number heterogeneity predicts survival rates across cancers.
Erik van Dijk, Tom van den Bosch, Kristiaan J Lenos, Khalid El Makrini, Lisanne E Nijman, Hendrik F B van Essen, Nico Lansu, Michiel Boekhout, Joris H Hageman, Rebecca C Fitzgerald, Cornelis J A Punt, Jurriaan B Tuynman, Hugo J G Snippert, Geert J P L Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M Miedema
Jun 28, 2021
Humans Neoplasms Prognosis Survival Rate Risk Assessment Gene Expression Profiling Genomics Gene Expression Regulation Neoplastic Genetic Heterogeneity Mutation Models Genetic Computer Simulation Adolescent Adult Aged Aged 80 and over Middle Aged Child Female Male Young Adult DNA Copy Number Variations Tumor Microenvironment Datasets as Topic Progression-Free Survival
Published by: Nature Communications
Chromosomal copy number heterogeneity predicts survival rates across cancers
Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
May 27, 2021
Orthogonality of fluxes in general nonlinear reaction networks
We consider the chemical reaction networks and study currents in these systems. Reviewing recent decomposition of rate functionals from large deviation theory for Markov processes, we adapt these results for reaction networks....
Finite electric displacement simulations of polar ionic solid-electrolyte interfaces
Tasker type III polar terminations of ionic crystals carry a net surface charge as well as a dipole moment and are fundamentally unstable. In contact with electrolytes, such polar surfaces can be stabilized by adsorption of...
Science by, with and for citizens
Abstract: This study illustrates how citizen-driven radiation monitoring has emerged in post-Fukushima Japan, where citizens generate their own radiation data and measurement devices to provide public with actionable data about...
Electromechanics of the liquid water vapour interface.
Two collective properties distinguishing the thin liquid water vapour interface from the bulk liquid are the anisotropy of the pressure tensor giving rise to surface tension and the orientational alignment of the molecules...
Orthogonality of fluxes in general nonlinear reaction networks
We consider the chemical reaction networks and study currents in these systems. Reviewing recent decomposition of rate functionals from large deviation theory for Markov processes, we adapt these results for reaction networks....
A novel flexible capacitive load sensor for use in a mobile unicompartmental knee replacement bearing
Instrumented knee replacements can provide in vivo data quantifying physiological loads acting on the knee. To date instrumented mobile unicompartmental knee replacements (UKR) have not been realised. Ideally instrumentation...
A novel flexible capacitive load sensor for use in a mobile unicompartmental knee replacement bearing
Instrumented knee replacements can provide in vivo data quantifying physiological loads acting on the knee. To date instrumented mobile unicompartmental knee replacements (UKR) have not been realised. Ideally instrumentation...
Wicked Solution for Wicked Problems
At the crossroads of interacting biological, socioeconomic, behavioral, and institutional factors, vector-borne diseases are complex 'wicked problems'. In this article, we argue that citizen science can help in vector control by...
Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by the nucleosome remodelling and deacetylation complex.
Ramy Ragheb, Sarah Gharbi, Julie Cramard, Oluwaseun Ogundele, Susan L Kloet, Thomas Burgold, Michiel Vermeulen, Nicola Reynolds, Brian Hendrich
Jun 05, 2020
Differentiation of mammalian pluripotent cells involves large-scale changes in transcription and, among the molecules that orchestrate these changes, chromatin remodellers are essential to initiate, establish and maintain a new...
Hydrodynamic and Contact Contributions to Continuous Shear Thickening in Colloidal Suspensions.
Neil YC Lin, Ben M Guy, Michiel Hermes, Chris Ness, Jin Sun, Wilson CK Poon, Itai Cohen
Sep 09, 2019
Shear thickening is a widespread phenomenon in suspension flow that, despite sustained study, is still the subject of much debate. The longstanding view that shear thickening is due to hydrodynamic clusters has been challenged...
Joint modelling of serological and hospitalization data reveals that high levels of pre-existing immunity and school holidays shaped the influenza A pandemic of 2009 in the Netherlands.
Dennis E Te Beest, Paul J Birrell, Jacco Wallinga, Daniela De Angelis, Michiel van Boven
Jul 17, 2018
Obtaining a quantitative understanding of the transmission dynamics of influenza A is important for predicting healthcare demand and assessing the likely impact of intervention measures. The pandemic of 2009 provides an ideal...
Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex.
Anzy Miller, Meryem Ralser, Susan L Kloet, Remco Loos, Ryuichi Nishinakamura, Paul Bertone, Michiel Vermeulen, Brian Hendrich
Sep 08, 2016
Co-repressor ES CELLS ENHANCER NuRD Sall4 Transcription factor Animals Cell Differentiation Cell Line Chromatin Immunoprecipitation Computational Biology DNA-Binding Proteins Gene Expression Regulation Developmental Mass Spectrometry Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Nucleosomes Pluripotent Stem Cells Reverse Transcriptase Polymerase Chain Reaction Transcription Factors
Sensor Fusion of Odometer, Compass and Beacon Distance for Mobile Robots
Rufus Fraanje, René Beltman, Fidelis Theinert, Michiel van Osch, Teade Punter, John Bolte
Jan 01, 2020
The estimation of the pose of a differential drive mobile robot from noisy odometer, compass, and beacon distance measurements is studied. The estimation problem, which is a state estimation problem with unknown input, is...
Published by: IGI Global Scientific Publishing
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