Search
Results: 155
Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers
Joo Ern Ang, Rupinder Pandher, Joo Chew Ang, Yasmin J Asad, Alan T Henley, Melanie Valenti, Gary Box, Alexis de Haven Brandon, Richard D Baird, Lori Friedman, Mika Derynck, Bart Vanhaesebroeck, Suzanne A Eccles, Stan B Kaye, Paul Workman, Johann S de Bono, Florence I Raynaud
May 27, 2016
Why invent the handle? Electromyography (EMG) and efficiency of use data investigating the prehistoric origin and selection of hafted stone knives
Abstract: For over 3 million years hominins held stone-cutting tools in the hand, gripping the portion of tool displaying a sharp cutting edge directly. During the late Middle Pleistocene human populations started to produce...
Why invent the handle? Electromyography (EMG) and efficiency of use data investigating the prehistoric origin and selection of hafted stone knives
Abstract: For over 3 million years hominins held stone-cutting tools in the hand, gripping the portion of tool displaying a sharp cutting edge directly. During the late Middle Pleistocene human populations started to produce...
First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors.
Debashis Sarker, Joo Ern Ang, Richard Baird, Rebecca Kristeleit, Krunal Shah, Victor Moreno, Paul A Clarke, Florence I Raynaud, Gallia Levy, Joseph A Ware, Kathryn Mazina, Ray Lin, Jenny Wu, Jill Fredrickson, Jill M Spoerke, Mark R Lackner, Yibing Yan, Lori S Friedman, Stan B Kaye, Mika K Derynck, Paul Workman, Johann S de Bono
Jan 26, 2015
Administration Oral Adult Aged Dose-Response Relationship Drug Drug-Related Side Effects and Adverse Reactions Female Humans Indazoles Male Maximum Tolerated Dose Middle Aged Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf Sulfonamides
Behavioral reconsolidation interference with episodic memory within-subjects is elusive.
In studies of behavioral reconsolidation interference, reactivation of a consolidated memory using some form of reminder is followed by the presentation of new information that can cause interference with that memory. Under...
Transforming China's electricity sector
The political failure of China's first independent regulator in a strategic industry - the State Electricity Regulatory Commission (SERC), 2002-2013 - provides a natural experiment to uncover fundamental challenges to a...
UNVEILING THE DIVERSITY OF SCHOLARLY DEBATE ON LIVING LABS
Living labs (LLs) are becoming an increasingly popular approach to engage in open innovation. Although applications and influence of LLs have grown rapidly over the last decade, the landscape of LL research remains...
Learn to Train Like You Fight
This qualitative study includes nine semi-structured interviews with cybersecurity experts from different security-related organizations who are familiar with cybersecurity exercises. Its contribution to cybersecurity workforce...
Published by: IGI Global Scientific Publishing
A computationally efficient Bayesian seemingly unrelated regressions model for high‐dimensional quantitative trait loci discovery
Leonardo Bottolo, Marco Banterle, Sylvia Richardson, Mika Ala‐Korpela, Marjo‐Riitta Järvelin, Alex Lewin
May 09, 2021
Comparison of risk factors for coronary heart disease morbidity versus mortality.
Despite declining rates, coronary heart disease remains a burdensome cause of death and disability worldwide. In on-going efforts to identify new environmental and genetic risk factors for the condition, events based on disease...
Living Labs
Living Labs have received increasing attention over the last decade. However, despite their growing popularity and ability to positively impact organisations’ innovation performance, mainstream innovation management...
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition
Qin Wang, Clare Oliver-Williams, Olli T Raitakari, Jorma Viikari, Terho Lehtimäki, Mika Kähönen, Marjo-Riitta Järvelin, Veikko Salomaa, Markus Perola, John Danesh, Johannes Kettunen, Adam S Butterworth, Michael V Holmes, Mika Ala-Korpela
Nov 05, 2020
ANGPTL3 ANGPTL4 Amino Acids Drug targets Glycoprotein acetyls LPL lipoprotein lipids Lipoprotein subclasses Mendelian randomization Angiopoietin-Like Protein 3 Angiopoietin-Like Protein 4 Angiopoietin-like Proteins Angiopoietins Diabetes mellitus Type 2 Humans Mendelian Randomization Analysis Pharmaceutical Preparations
Cyanogenesis in Arthropods
Chemical defences are key components in insect⁻plant interactions, as insects continuously learn to overcome plant defence systems by, e.g., detoxification, excretion or sequestration. Cyanogenic glucosides are natural products...
High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease.
Verena Zuber, Dipender Gill, Mika Ala-Korpela, Claudia Langenberg, Adam Butterworth, Leonardo Bottolo, Stephen Burgess
Sep 21, 2020
BACKGROUND: Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the...
Living Labs
Living Labs have received increasing attention over the last decade. However, despite their growing popularity and ability to positively impact organisations’ innovation performance, mainstream innovation management literature...
Assessment of Relative Utility of Underlying vs Contributory Causes of Death.
Importance: In etiological research, investigators using death certificate data have traditionally extracted underlying cause of mortality alone. With multimorbidity being increasingly common, more than one condition is often...
Sequestration and biosynthesis of cyanogenic glucosides in passion vine butterflies and consequences for the diversification of their host plants.
Érika C Pinheiro de Castro, Mika Zagrobelny, Juan Pablo Zurano, Márcio Zikan Cardoso, René Feyereisen, Søren Bak
Jan 20, 2020
The colorful heliconiine butterflies are distasteful to predators due to their content of defense compounds called cyanogenic glucosides (CNglcs), which they biosynthesize from aliphatic amino acids. Heliconiine larvae feed...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 27, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Honeybees Tolerate Cyanogenic Glucosides from Clover Nectar and Flowers.
Antoine Lecocq, Amelia A Green, Érika Cristina Pinheiro De Castro, Carl Erik Olsen, Annette B Jensen, Mika Zagrobelny
Jun 12, 2018
Honeybees (Apis mellifera) pollinate flowers and collect nectar from many important crops. White clover (Trifolium repens) is widely grown as a temperate forage crop, and requires honeybee pollination for seed set. In this...
Hemophagocytic lymphohistiocytosis in 2 patients with multiple sclerosis treated with alemtuzumab.
Mika Saarela, Keerthi Senthil, Joanne Jones, Pentti J Tienari, Merja Soilu-Hänninen, Laura Airas, Alasdair Coles, Jukka T Saarinen
Nov 19, 2018
Nanotechnology-based electrochemical biosensors for monitoring breast cancer biomarkers
Hassan Nasrollahpour, Balal Khalilzadeh, Mohammad Hasanzadeh, Reza Rahbarghazi, Pedro Estrela, Abdolhossein Naseri, Savas Tasoglu, Mika Sillanpää
May 01, 2023
Breast cancer is categorized as the most widespread cancer type among women globally. On-time diagnosis can decrease the mortality rate by making the right decision in the therapy procedure. These features lead to a reduction in...
advanced nanomaterials Breast Cancer Diagnosis Electrochemistry Nanotechnology /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Johannes Kettunen, Michael V. Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D. Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T. Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Mika Ala-Korpela
Jan 06, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 10, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Adolescent Adult Alleles Apolipoproteins B Cholesterol Ester Transfer Proteins Cholesterol LDL Cohort Studies Coronary Disease Female Follow-Up Studies genetic variation Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipoproteins Male Middle Aged Triglycerides Young Adult
Nanotechnology-based electrochemical biosensors for monitoring breast cancer biomarkers
Hassan Nasrollahpour, Balal Khalilzadeh, Mohammad Hasanzadeh, Reza Rahbarghazi, Pedro Estrela, Abdolhossein Naseri, Savas Tasoglu, Mika Sillanpää
May 01, 2023
Breast cancer is categorized as the most widespread cancer type among women globally. On-time diagnosis can decrease the mortality rate by making the right decision in the therapy procedure. These features lead to a reduction in...
advanced nanomaterials Breast Cancer Diagnosis Electrochemistry Nanotechnology /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
|
|< |
< |
1 |