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Recombinant snakebite antivenoms
Snakebite envenoming is a major public health burden in tropical parts of the developing world. In sub-Saharan Africa, neglect has led to a scarcity of antivenoms threatening the lives and limbs of snakebite victims....
Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Andreas H Laustsen, José María Gutiérrez, Cecilie Knudsen, Kristoffer H Johansen, Erick Bermúdez-Méndez, Felipe A Cerni, Jonas A Jürgensen, Line Ledsgaard, Andrea Martos-Esteban, Mia Øhlenschlæger, Urska Pus, Mikael R Andersen, Bruno Lomonte, Mikael Engmark, Manuela B Pucca
Jun 19, 2018
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being...
Adverse reactions Animal envenoming Antibodies Antibody expression Antivenom Antivenom design Biotechnology Immunogenicity Neglected tropical diseases pharmacodynamics Pharmacokinetics Recombinant antivenom Scorpion sting Snakebite Spider bite Venom Venom neutralization Animals Antibodies Antivenins Camelus Humans Recombinant Proteins Venoms
Assessing Maturity in Data-Driven Culture
Research on assessing a group's maturity in data-driven culture is rare and fragmented. This article investigates how maturity in data-driven culture can be assessed from a historical perspective. A case study was done on how...
Published by: IGI Global Scientific Publishing
13 Organizations' Attempts to Become Data-Driven
Becoming a data-driven organization is a vision for several organizations. It has been frequently mentioned in the literature that data-driven organizations are likely to be more successful than organizations that mostly make...
Published by: IGI Global Scientific Publishing
Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line.
Inherited mutations in the mitochondrial (mt)DNA are a major cause of human disease, with approximately 1 in 5000 people affected by one of the hundreds of identified pathogenic mtDNA point mutations or deletions. Due to the...
Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone
The marginal zone of the spleen is a precisely ordered region that contains specialized subsets of B lymphocytes and macrophages. Disruption of the negative signaling inositol phosphatase, SH2-containing inositol-5-phosphatase 1...
Published by: Rockefeller University
In-air and in-water performance comparison of Passive Gamma Emission Tomography with activated Co-60 rods
Riina Virta, Tatiana Bubba, Mikael Moring, Samuli Siltanen, Tapani Honkamaa, Peter Dendooven
Dec 31, 2023
A first-of-a-kind geological repository for spent nuclear fuel is being built in Finland and will soon start operations. To make sure all nuclear material stays in peaceful use, the fuel is measured with two complementary...
A Review of the Segmental Diameter of the Healthy Human Spinal Cord.
Knowledge of the average size and variability of the human spinal cord can be of importance when treating pathological conditions in the spinal cord. Data on healthy human spinal cord morphometrics have been published for more...
In vivo measurement of the effective atomic number of breast skin using spectral mammography.
X-ray characteristics of body tissues are of crucial importance for developing and optimizing x-ray imaging techniques, in particular for dosimetry and spectral imaging applications. For breast imaging, the most important...
In-air and in-water performance comparison of Passive Gamma Emission Tomography with activated Co-60 rods
Riina Virta, Tatiana Bubba, Mikael Moring, Samuli Siltanen, Tapani Honkamaa, Peter Dendooven
Dec 31, 2023
A first-of-a-kind geological repository for spent nuclear fuel is being built in Finland and will soon start operations. To make sure all nuclear material stays in peaceful use, the fuel is measured with two complementary...
Accuracy in local staging of prostate cancer by adding a three-dimensional T2-weighted sequence with radial reconstructions in magnetic resonance imaging.
Fredrik Jäderling, Tommy Nyberg, Michael Öberg, Stefan Carlsson, Mikael Skorpil, Lennart Blomqvist
Jun 08, 2018
BACKGROUND: The evidence supporting the use of magnetic resonance imaging (MRI) in prostate cancer detection has been established, but its accuracy in local staging is questioned. PURPOSE: To investigate the additional value of...
Transcriptional networks controlling the cell cycle.
Martin Bonke, Mikko Turunen, Maria Sokolova, Anna Vähärautio, Teemu Kivioja, Minna Taipale, Mikael Björklund, Jussi Taipale
Nov 04, 2020
In this work, we map the transcriptional targets of 107 previously identified Drosophila genes whose loss caused the strongest cell-cycle phenotypes in a genome-wide RNA interference screen and mine the resulting data...
Animals CDC2 Protein Kinase Cell Cycle Cell Line Cell Size Chromatin Immunoprecipitation Cluster Analysis Drosophila Feedback Physiological Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Microarray Analysis Mitosis Oligonucleotides Phosphorylation RNA Interference Sequence Analysis RNA
Volumetric mammographic density
Judith S Brand, Keith Humphreys, Deborah J Thompson, Jingmei Li, Mikael Eriksson, Per Hall, Kamila Czene, , Per Hall
Feb 12, 2015
Assessment of Platelet Function in Traumatic Brain Injury-A Retrospective Observational Study in the Neuro-Critical Care Setting.
Caroline Lindblad, Eric Peter Thelin, Michael Nekludov, Arvid Frostell, David W Nelson, Mikael Svensson, Bo-Michael Bellander
Jun 28, 2018
BACKGROUND: Despite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques. Multiple...
Predictors of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation
Alexander Fletcher-Sandersjöö, Jiri Bartek, Eric Peter Thelin, Anders Eriksson, Adrian Elmi-Terander, Mikael Broman, Bo-Michael Bellander
Dec 04, 2017
BACKGROUND: Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of ICH in...
Protein Profiling in Presymptomatic Individuals Separates Myeloperoxidase-Antineutrophil Cytoplasmic Antibody and Proteinase 3-Antineutrophil Cytoplasmic Antibody Vasculitides.
Biomineralization plasticity and environmental heterogeneity predict geographical resilience patterns of foundation species to future change.
Luca Telesca, Lloyd S Peck, Trystan Sanders, Jakob Thyrring, Mikael K Sejr, Elizabeth M Harper
Oct 16, 2019
Although geographical patterns of species' sensitivity to environmental changes are defined by interacting multiple stressors, little is known about compensatory processes shaping regional differences in organismal...
Human Bone Marrow Mesenchymal Stromal Cell-Derived CXCL12, IL-6 and GDF-15 and Their Capacity to Support IgG-Secreting Cells in Culture Are Divergently Affected by Doxorubicin
Various subsets of bone marrow mesenchymal stromal cells (BM MSCs), including fibroblasts, endothelial, fat and reticular cells, are implicated in the regulation of the hematopoietic microenvironment and the survival of...
Gintare Lasaviciute, Anna Höbinger, Dorina Ujvari, Daniel Salamon, Aisha Yusuf, Mikael Sundin, Eva Sverremark-Ekström, Rayan Chikhi, Anna Nilsson, Shanie Saghafian-Hedengren
Mar 15, 2021
Hematology Cancer Stem Cell Research - Nonembryonic - Non-Human Stem Cell Research - Nonembryonic - Human Stem Cell Research Pediatric Regenerative Medicine Transplantation 2 Aetiology 5.2 Cellular and gene therapies 5 Development of treatments and therapeutic interventions 2.1 Biological and endogenous factors Cancer Inflammatory and immune system
Prehospital Intubation and Outcome in Traumatic Brain Injury-Assessing Intervention Efficacy in a Modern Trauma Cohort.
Rebecka Rubenson Wahlin, David W Nelson, Bo-Michael Bellander, Mikael Svensson, Adel Helmy, Eric Peter Thelin
Aug 06, 2018
BACKGROUND: Prehospital intubation in traumatic brain injury (TBI) focuses on limiting the effects of secondary insults such as hypoxia, but no indisputable evidence has been presented that it is beneficial for outcome. The aim...
Emotional Eating, Health Behaviours, and Obesity in Children
Elli Jalo, Hanna Konttinen, Henna Vepsäläinen, Jean-Philippe Chaput, Gang Hu, Carol Maher, José Maia, Olga L. Sarmiento, Martyn Standage, Catrine Tudor-Locke, Peter T. Katzmarzyk, Mikael Fogelholm
Feb 07, 2019
Eating in response to negative emotions (emotional eating, EE) may predispose an individual to obesity. Yet, it is not well known how EE in children is associated with body mass index (BMI) and health behaviours (i.e., diet...
Eating behaviour psychological eating style negative emotions Emotion-Induced Eating Scale health behaviour BMI Psychological eating style Eating behaviour Emotion-induced eating scale Negative emotions health behaviour BMI Body Mass Index Feeding Behavior/psychology Child Behavior/psychology Cross-Sectional Studies Pediatric Obesity/etiology Humans Male Health Behavior Diet/psychology Emotions Exercise Female Surveys and Questionnaires Eating/psychology Child Sedentary Behavior /dk/atira/pure/subjectarea/asjc/1100/1106 name=Food Science /dk/atira/pure/subjectarea/asjc/2900/2916 name=Nutrition and Dietetics /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
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