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Results: 78771
Acute kidney injury after thoracic surgery
Vinci Naruka, Mikel A Mckie, Rasoel Khushiwal, James Clayton, Giuseppe Aresu, Adam Peryt, Sofía S Villar, Jon MacKay, Aman S Coonar
Jul 17, 2019
OBJECTIVES: Because the mortality rate is very low in thoracic surgery, its use as a quality discriminator is limited. Acute kidney injury (AKI) is a candidate measure because it is associated with increased rates of morbidity...
Optimal Timing of External Ventricular Drainage after Severe Traumatic Brain Injury
Charlene Y. C. Chau, Saniya Mediratta, Mikel A. McKie, Barbara Gregson, Selma Tulu, Ari Ercole, Davi J. F. Solla, Wellingson S. Paiva, Peter J. Hutchinson, Angelos G. Kolias
Jun 27, 2020
External ventricular drainage (EVD) may be used for therapeutic cerebrospinal fluid (CSF) drainage to control intracranial pressure (ICP) after traumatic brain injury (TBI). However, there is currently uncertainty regarding the...
Multicentre evaluation of renal impairment in thoracic surgery (MERITS)
Vinci Naruka, Mikel Alexander McKie, Navid Ahmadi, EA Claudia Pama, Aman S Coonar, Merits Collaborators
Oct 29, 2022
OBJECTIVES: To measure the unit-level variation in Acute Kidney Injury (AKI) incidence post-thoracic surgery over a contemporary 1-year period. Secondary aims include examining the associations with sex, age group, operation...
Optimal Timing of External Ventricular Drainage after Severe Traumatic Brain Injury
Charlene YC Chau, Saniya Mediratta, Mikel A Mckie, Barbara Gregson, Selma Tulu, Ari Ercole, Davi JF Solla, Wellingson S Paiva, Peter J Hutchinson, Angelos G Kolias
Jun 25, 2020
External ventricular drainage (EVD) may be used for therapeutic cerebrospinal fluid (CSF) drainage to control intracranial pressure (ICP) after traumatic brain injury (TBI). However, there is currently uncertainty regarding the...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Optimal protamine dosing after cardiopulmonary bypass
Lachlan F Miles, Christiana Burt, Joseph Arrowsmith, Mikel A Mckie, Sofia S Villar, Pooveshnie Govender, Ruth Shaylor, Zihui Tan, Ravi de Silva, Florian Falter
Jun 17, 2021
BACKGROUND: The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the dose of heparin required pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models of heparin clearance...
Optimal protamine dosing after cardiopulmonary bypass
Lachlan F Miles, Christiana Burt, Joseph Arrowsmith, Mikel A Mckie, Sofia S Villar, Pooveshnie Govender, Ruth Shaylor, Zihui Tan, Ravi de Silva, Florian Falter
Jul 28, 2021
Background
The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the dose of heparin required pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models of heparin...
Published by: PLoS Medicine
Positioning imatinib for pulmonary arterial hypertension
Martin R Wilkins, Mikel A Mckie, Martin Law, Andreas A Roussakis, Lars Harbaum, Colin Church, J Gerry Coghlan, Robin Condliffe, Luke S Howard, David G Kiely, Jim Lordan, Alexander Rothman, Jay Suntharalingam, Mark Toshner, Stephen J Wort, Sofía S Villar
Oct 18, 2021
Pulmonary arterial hypertension is an unmet clinical need. Imatinib, a tyrosine kinase inhibitor, 200 to 400 mg daily reduces pulmonary artery pressure and increases functional capacity in this patient group, but is generally...
Optimal protamine dosing after cardiopulmonary bypass
Lachlan F. Miles, Christiana Burt, Joseph Arrowsmith, Mikel A. McKie, Sofia S. Villar, Pooveshnie Govender, Ruth Shaylor, Zihui Tan, Ravi de Silva, Florian Falter
Jun 21, 2021
Positioning imatinib for pulmonary arterial hypertension
Martin R Wilkins, Mikel A Mckie, Martin Law, Andreas A Roussakis, Lars Harbaum, Colin Church, J Gerry Coghlan, Robin Condliffe, Luke S Howard, David G Kiely, Jim Lordan, Alexander Rothman, Jay Suntharalingam, Mark Toshner, Stephen J Wort, Sofía S Villar
Jan 28, 2022
Pulmonary arterial hypertension is an unmet clinical need. Imatinib, a tyrosine kinase inhibitor, 200 to 400 mg daily reduces pulmonary artery pressure and increases functional capacity in this patient group, but is generally...
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
Luigi Aloia, Mikel Alexander McKie, Grégoire Vernaz, Lucía Cordero-Espinoza, Niya Aleksieva, Jelle van den Ameele, Francesco Antonica, Berta Font-Cunill, Alexander Raven, Riccardo Aiese Cigliano, German Belenguer, Richard L Mort, Andrea H Brand, Magdalena Zernicka-Goetz, Stuart J Forbes, Eric A Miska, Meritxell Huch
Oct 21, 2019
Adaptor Proteins Signal Transducing Animals Bile Ducts Cell Cycle Proteins DNA Methylation DNA-Binding Proteins Epigenesis Genetic epigenome Epithelial Cells Female Gene Expression Profiling Hippo Signaling Pathway Liver Liver Regeneration Male Mice Transgenic Organoids Primary Cell Culture Protein Serine-Threonine Kinases Proto-Oncogene Proteins Signal Transduction Transcriptome YAP-Signaling Proteins
A nebulised antitumour necrosis factor receptor-1 domain antibody in patients at risk of postoperative lung injury
James Ryan, Andrew I Bayliffe, Daniel F McAuley, Joyce Yeung, David R Thickett, Phillip A Howells, Ciara O'Donnell, Arlette M Vassallo, Tracey J Wright, Elizabeth McKie, Kelly Hardes, Charlotte Summers, Martin O Shields, William Powley, Robert Wilson, Aili L Lazaar, Andrew Fowler, Gavin D Perkins
Nov 20, 2020
BACKGROUND: Tumour necrosis factor receptor 1 (TNFR1) signalling mediates the cell death and inflammatory effects of TNF-α. OBJECTIVE: The current clinical trial investigated the effects of a nebulised TNFR1 antagonist...
A Recurrent Pathogenic Variant in TPM2 Reveals Further Phenotypic and Genetic Heterogeneity in Multiple Pterygium Syndrome-Related Disorders.
Julie Vogt, Atif Al-Saedi, Tracey Willis, Alison Male, Arthur McKie, Nigel Kiely, Eamonn R Maher
Mar 05, 2020
Multiple pterygium syndrome (MPS) disorders are a phenotypically and genetically heterogeneous group of conditions characterised by multiple joint contractures (arthrogryposis), pterygia (joint webbing) and other developmental...
TPM2 Arthrogryposis beta tropomyosin camptodactyly distal contractures multiple pterygium syndrome trismus Abnormalities Multiple Adolescent Arthrogryposis Child Child Preschool Databases Genetic Exome Female Genetic Heterogeneity Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Humans Infant Male Malignant Hyperthermia Mutation Phenotype Skin Abnormalities Tropomyosin
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Multivariate and repeated measures (MRM)
Martyn McFarquhar, Shane McKie, Richard Emsley, John Suckling, Rebecca Elliott, Stephen Williams
Mar 04, 2016
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
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