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Results: 6
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Oleg Pak, Susan Scheibe, Azadeh Esfandiary, Mareike Gierhardt, Akylbek Sydykov, Angela Logan, Athanasios Fysikopoulos, Florian Veit, Matthias Hecker, Florian Kroschel, Karin Quanz, Alexandra Erb, Katharina Schäfer, Mirja Fassbinder, Nasim Alebrahimdehkordi, Hossein A Ghofrani, Ralph T Schermuly, Ralf P Brandes, Werner Seeger, Michael P Murphy, Norbert Weissmann, Natascha Sommer
Jun 18, 2018
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular...
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic
Charlotte Thibeault, Barbara Mühlemann, Elisa T Helbig, Mirja Mittermaier, Tilman Lingscheid, Pinkus Tober-Lau, Lil A Meyer-Arndt, Leonie Meiners, Paula Stubbemann, Sascha S Haenel, Laure Bosquillon de Jarcy, Lena Lippert, Moritz Pfeiffer, Miriam S Stegemann, Robert Roehle, Janine Wiebach, Stefan Hippenstiel, Thomas Zoller, Holger Müller-Redetzky, Alexander Uhrig, Felix Balzer, Christof von Kalle, Norbert Suttorp, Terry C Jones, Christian Drosten, Martin Witzenrath, Leif E Sander, Pa-COVID study Group, Victor M Corman, Florian Kurth
Jul 28, 2021
Artificial respiration COVID-19 Nucleic Acid Testing Coronavirus disease 2019 (COVID-19) Mechanical ventilation prospective study Respiratory Distress Syndrome Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Symptom Assessment Viral concentration covid-19 Cohort Studies Germany Hospitalization Humans Hypertension Kinetics Prospective Studies Respiration Artificial Risk Factors SARS-CoV-2 Tertiary Care Centers Time Factors Viral Load Virus Shedding
A time-resolved proteomic and prognostic map of COVID-19.
Vadim Demichev, Pinkus Tober-Lau, Oliver Lemke, Tatiana Nazarenko, Charlotte Thibeault, Harry Whitwell, Annika Röhl, Anja Freiwald, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Simran Kaur Aulakh, Elisa T Helbig, Paula Stubbemann, Lena J Lippert, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Mirja Mittermaier, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Philipp Enghard, Aleksej Zelezniak, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Holger Müller-Redetzky, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Markus Ralser, Florian Kurth
Jul 28, 2021
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by...
Proteomics Biomarkers physiological parameters Machine Learning disease prognosis clinical disease progression covid-19 patient trajectories longitudinal profiling
Published by: Cell systems
A proteomic survival predictor for COVID-19 patients in intensive care.
Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J Lippert, Elisa T Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Florian Kurth, Markus Ralser
Mar 24, 2023
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores...
Published by: PLOS digital health
A proteomic survival predictor for COVID-19 patients in intensive care.
Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J Lippert, Elisa T Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, PA-COVID-19 Study group, Florian Kurth, Markus Ralser
Jan 28, 2022
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores...
A time-resolved proteomic and prognostic map of COVID-19.
Vadim Demichev, Pinkus Tober-Lau, Oliver Lemke, Tatiana Nazarenko, Charlotte Thibeault, Harry Whitwell, Annika Röhl, Anja Freiwald, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Simran Kaur Aulakh, Elisa T Helbig, Paula Stubbemann, Lena J Lippert, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Mirja Mittermaier, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Philipp Enghard, Aleksej Zelezniak, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Holger Müller-Redetzky, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, PA-COVID-19 Study group, Markus Ralser, Florian Kurth
Jul 30, 2021
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by...
covid-19 Biomarkers clinical disease progression disease prognosis longitudinal profiling Machine Learning patient trajectories physiological parameters Proteomics Age Factors Biomarkers Blood Cell Count Blood Gas Analysis covid-19 Disease Progression Enzyme Activation Humans Inflammation Machine Learning Prognosis Proteome Proteomics SARS-CoV-2