Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model.
Kunitaka Yoshida,
Mitsuhiro Iyori,
Andrew M Blagborough,
Ahmed M Salman,
Pawan Dulal,
Katarzyna A Sala,
Daisuke S Yamamoto,
Shahid M Khan,
Chris J Janse,
Sumi Biswas,
Tatsuya Yoshii,
Yenni Yusuf,
Masaharu Tokoro,
Adrian VS Hill,
Shigeto Yoshida
Jan 31, 2020
With the increasing prevalence of artemisinin-resistant malaria parasites, a highly efficacious and durable vaccine for malaria is urgently required. We have developed an experimental virus-vectored vaccine platform based on an...