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Grey Matter Etymology and the neuron(e).
Arpan R Mehta, Puja R Mehta, Stephen P Anderson, Barbara LH MacKinnon, Alastair Compston
Jan 27, 2020
‘Neuron’ or ‘neurone’? While it is often assumed that these different spellings reflect usage of American versus British English, there are also inconsistencies within these cultural boundaries. Mehta et al. review historical...
The impact of childhood deprivation on adult neuropsychological functioning is associated with ADHD symptom persistence
Dennis Golm, Sagari Sarkar, Nuria Mackes, Graeme Fairchild, Mitul Mehta, Michael Rutter, Edmund Sonuga-Barke
Nov 01, 2021
Background: Institutional deprivation in early childhood is associated with neuropsychological deficits in adolescence. Using 20-year follow-up data from a unique natural experiment – the large scale adoption of children exposed...
Prevalence of Latent Tuberculosis Infection among Hospital Workers in a Tertiary Care Referral Centre
According to the World Health Organization, more than 2 billion people in the world are latently infected with Mycobacterium tuberculosis.The goal of testing for latent Mycobacterium tuberculosis infection is to identify persons...
Published by: IJHS Medical Association
Cooperative Behavior in the Ultimatum Game and Prisoner's Dilemma Depends on Players' Contributions.
Amy R Bland, Jonathan P Roiser, Mitul A Mehta, Thea Schei, Barbara J Sahakian, Trevor W Robbins, Rebecca Elliott
Mar 26, 2018
Economic games such as the Ultimatum Game (UG) and Prisoner's Dilemma (PD) are widely used paradigms for studying fairness and cooperation. Monetary versions of these games involve two players splitting an arbitrary sum of...
Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia.
Nicholas R Livingston, Peter Ct Hawkins, James Gilleen, Rong Ye, Lorena Valdearenas, Sukhi S Shergill, Mitul A Mehta
Sep 11, 2021
BACKGROUND: Cognitive flexibility deficits are present in patients with schizophrenia and are strong predictors of functional outcome but, as yet, have no pharmacological treatments. AIMS: The purpose of this study was to...
Schizophrenia Attentional set-shifting cognitive deficit functional magnetic resonance imaging phosphodiesterase inhibitor Adult Aged Aminopyridines Benzamides Cognitive Dysfunction Cross-Over Studies Cyclopropanes dorsolateral prefrontal cortex Dose-Response Relationship Drug Double-Blind Method Female Humans Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Phosphodiesterase 4 Inhibitors Prefrontal Cortex Schizophrenia
The impact of childhood deprivation on adult neuropsychological functioning is associated with ADHD symptom persistence
Dennis Golm, Sagari Sarkar, Nuria Mackes, Graeme Fairchild, Mitul Mehta, Michael Rutter, Edmund Sonuga-Barke
Nov 01, 2021
Background: Institutional deprivation in early childhood is associated with neuropsychological deficits in adolescence. Using 20-year follow-up data from a unique natural experiment – the large scale adoption of children exposed...
Prevalence of Latent Tuberculosis Infection among Hospital Workers in a Tertiary Care Referral Centre
According to the World Health Organization, more than 2 billion people in the world are latently infected with Mycobacterium tuberculosis.The goal of testing for latent Mycobacterium tuberculosis infection is to identify persons...
Published by: IJHS Medical Association
Associations between dimensions of behaviour, personality traits, and mental-health during the COVID-19 pandemic in the United Kingdom.
Adam Hampshire, Peter J Hellyer, Eyal Soreq, Mitul A Mehta, Konstantinos Ioannidis, William Trender, Jon E Grant, Samuel R Chamberlain
Aug 17, 2021
The COVID-19 pandemic (including lockdown) is likely to have had profound but diverse implications for mental health and well-being, yet little is known about individual experiences of the pandemic (positive and negative) and...
Cognitive deficits in people who have recovered from COVID-19.
Adam Hampshire, William Trender, Samuel R Chamberlain, Amy E Jolly, Jon E Grant, Fiona Patrick, Ndaba Mazibuko, Steve CR Williams, Joseph M Barnby, Peter Hellyer, Mitul A Mehta
Aug 28, 2021
BACKGROUND: There is growing concern about possible cognitive consequences of COVID-19, with reports of 'Long COVID' symptoms persisting into the chronic phase and case studies revealing neurological problems in severely...
Adaptive sample size modification in clinical trials
We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...
Adaptive sample size modification in clinical trials
We consider sample size re-estimation in a clinical trial, in particular when there is a significant delay before the measurement of patient response. Mehta and Pocock have proposed methods in which sample size is increased when...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks
Glimm et al. (2010) and Tamhane et al. (2010) studied the problem of testing a primary and a secondary endpoint, subject to a gatekeeping constraint, using a group sequential design (GSD) with K=2 looks. In this article, we...
A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks
Glimm et al. (2010) and Tamhane et al. (2010) studied the problem of testing a primary and a secondary endpoint, subject to a gatekeeping constraint, using a group sequential design (GSD) with K=2 looks. In this article, we...
Genomic risk prediction of coronary artery disease in women with breast cancer
Lathan Liou, Stephen Kaptoge, Joe Dennis, Mitul Shah, Jonathan Tyrer, Michael Inouye, Douglas F Easton, Paul DP Pharoah
Sep 05, 2021
BACKGROUND: Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of...
Breast Cancer cardiovascular disease Coronary Artery Disease coronary heart disease polygenic risk score SEARCH Breast Neoplasms Cancer Survivors Coronary Artery Disease Female Genome-Wide Association Study Genomics Genotype Humans Incidence Middle Aged Multifactorial Inheritance Proportional Hazards Models Prospective Studies Risk Factors United Kingdom
Loss surface of XOR artificial neural networks.
Training an artificial neural network involves an optimization process over the landscape defined by the cost (loss) as a function of the network parameters. We explore these landscapes using optimization tools developed for...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
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