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Metal-Bound Methisazone; Novel Drugs Targeting Prophylaxis and Treatment of SARS-CoV-2, a Molecular Docking Study.
Ahmed Abdelaal Ahmed Mahmoud M Alkhatip, Michail Georgakis, Lucio R Montero Valenzuela, Mohamed Hamza, Ehab Farag, Jaqui Hodgkinson, Hisham Hosny, Ahmed M Kamal, Mohamed Wagih, Amr Naguib, Hany Yassin, Haytham Algameel, Mohamed Elayashy, Mohamed Abdelhaq, Mohamed I Younis, Hassan Mohamed, Mohammed Abdulshafi, Mohamed A Elramely
Mar 16, 2021
SARS-CoV-2 currently lacks effective first-line drug treatment. We present promising data from in silico docking studies of new Methisazone compounds (modified with calcium, Ca; iron, Fe; magnesium, Mg; manganese, Mn; or zinc...
covid-19 SARS-CoV-2 Molecular docking prophylaxis Treatment Antiviral Agents Calcium Coronavirus 3C Proteases Coronavirus Papain-Like Proteases Coronavirus RNA-Dependent RNA Polymerase Drug Design Humans Iron Magnesium manganese Metals Methisazone Models Molecular Molecular Docking Simulation Molecular Dynamics Simulation Protein Binding SARS-CoV-2 Spike Glycoprotein Coronavirus Zinc COVID-19 Drug Treatment
Enhanced pre-operative axillary staging using intradermal microbubbles and contrast-enhanced ultrasound to detect and biopsy sentinel lymph nodes in breast cancer
Karina Cox, Sian Taylor-Phillips, Nisha Sharma, Jennifer Weeks, Philippa Mills, Ali Sever, Adrian Lim, Isobel Haigh, Mohamed Hashem, Tania de Silva, Keshthra Satchithananda, Mengxing Tang, Matthew Wallis
Feb 12, 2018
OBJECTIVE: To compare the experience of four UK Centres in the use of intradermal microbubbles and contrast enhanced ultrasound (CEUS) to pre-operatively identify and biopsy sentinel lymph nodes (SLN) in patients with breast...
Bio-Inspired Robots Imitating Human Organs with Embodied Intelligence Behaviour
Abstract
Soft robotics is an emerging field that introduces promising engineering methods that replicate biological behaviours. Soft robotics aims to obtain a delicate interaction...
Embodied Artificial Intelligence
Abstract
There has been a long-standing debate about the extent to which the human mind controls the human body and vice-versa. Today this debate still powers a profound scientific...
A Multidomain Relational Framework to Guide Institutional AI Research and Adoption
Vincent J. Straub, Deborah Morgan, Youmna Hashem, John Francis, Saba Esnaashari, Jonathan Bright
Jun 09, 2023
Calls for new metrics, technical standards, and governance mechanisms to guide and evaluate the adoption of ethical Artificial Intelligence (AI) in institutions are now commonplace. Yet, most research and policy efforts do...
Comparative Analysis of Model-Based Predictive Shared Control for Delayed Operation in Object Reaching and Recognition Tasks With Tactile Sensing
Leone Costi, Luca Scimeca, Perla Maiolino, Thilina Dulantha Lalitharatne, Thrishantha Nanayakkara, Ryman Hashem, Fumiya Iida
Nov 02, 2021
Communication delay represents a fundamental challenge in telerobotics: on one hand, it compromises the stability of teleoperated robots, on the other hand, it decreases the user’s awareness of the designated task. In scientific...
Evaluation of Laparoscopy Virtual Reality Training on the Improvement of Trainees' Surgical Skills.
Mohamed Elessawy, Mohamed Mabrouk, Thorsten Heilmann, Marion Weigel, Mohamed Zidan, Ghada Abu-Sheasha, Andre Farrokh, Dirk Bauerschlag, Nicolai Maass, Mohamed Ibrahim, Dina Kamel
Feb 03, 2021
Background and objectives: The primary objective was to evaluate the benefit of training with virtual reality simulation. The secondary objective was to describe the short-term skill acquisition obtained by simulation training...
Face mediated human–robot interaction for remote medical examination
Abstract Realtime visual feedback from consequences of actions is useful for future safety-critical human–robot interaction applications such as remote physical examination of patients. Given...
Thilina D Lalitharatne, Leone Costi, Ryman Hashem, Ilana Nisky, Rachael E Jack, Thrishantha Nanayakkara, Fumiya Iida
Jul 23, 2022
Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.
Louise S Matheson, Daniel J Bolland, Peter Chovanec, Felix Krueger, Simon Andrews, Hashem Koohy, Anne E Corcoran
Jun 24, 2019
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We...
A Multidomain Relational Framework to Guide Institutional AI Research and Adoption
Vincent J. Straub, Deborah Morgan, Youmna Hashem, John Francis, Saba Esnaashari, Jonathan Bright
Jun 09, 2023
Calls for new metrics, technical standards, and governance mechanisms to guide and evaluate the adoption of ethical Artificial Intelligence (AI) in institutions are now commonplace. Yet, most research and policy efforts do...
Performance Evaluation of Different Machine Learning Classification Algorithms for Disease Diagnosis
Knowledge extraction within a healthcare field is a very challenging task since we are having many problems such as noise and imbalanced datasets. They are obtained from clinical studies where uncertainty and variability are...
Published by: IGI Global Scientific Publishing
Genotoxic and Anatomical Deteriorations Associated with Potentially Toxic Elements Accumulation in Water Hyacinth Grown in Drainage Water Resources
Potentially toxic elements (PTEs)-induced genotoxicity on aquatic plants is still an open question. Herein, a single clone from a population of water hyacinth covering a large distribution area of Nile River (freshwater)...
Farahat S Moghanm, Antar El-Banna, Mohamed A El-Esawi, Mohamed M Abdel-Daim, Ahmed Mosa, Khaled AA Abdelaal
Mar 11, 2020
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela F Brady, Anaïs Begemann, Tsunehiro Mizushima, Francisco J Guzmán-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier, Katharina Steindl, Anita Rauch, Stefan T Arold, C Geoffrey Woods, Masaaki Komatsu, Fowzan S Alkuraya
Apr 30, 2018
The post-translational modification of proteins through the addition of UFM1, also known as ufmylation, plays a critical developmental role as revealed by studies in animal models. The recent finding that biallelic mutations in...
To Debt or Not to Debt
We empirically analyze the market risk profiles of Islamic banks with two sets of conventional banks taken from the same geographical locations as Islamic banks and from a random global sample respectively for the period...
A hybrid profit and loss sharing model using interest free-debt and equity financing
In this paper two models are contrasted whereby a corporation is seeking to finance the purchase of a merchandise from a supplier through a profit and loss sharing contract. The first mode consist of financing the purchase...
Interoperability as a Key Enabler for Manufacturing in the Cloud
The emerging cloud paradigm has a prominent effect on manufacturing. The move from hardware bound systems to requirements based service
provision is enabling the transition to cloud manufacturing. A networked manufacturing...
provision is enabling the transition to cloud manufacturing. A networked manufacturing...
Cracking the Code
With the expanding reach of the Internet of Things, information security threats are increasing, including from the very professionals tasked with defending against these threats. This study identified factors impacting...
Published by: IGI Global Scientific Publishing
Nitrogen availability prevents oxidative effects of salinity on wheat growth and photosynthesis by up-regulating the antioxidants and osmolytes metabolism, and secondary metabolite accumulation.
The Death of Postcolonialism
Mohamed Salah Eddine Madiou
Nov 11, 2021
Postcolonialism stands today in flagrant contradiction with its mission. This assertion should scarcely come as a surprise. Come to think of it: what has postcolonialism done to colonization in the past few decades, save...
postcolonialism decolonial studies Gayatri Spivak Edward Said Edward Said postcolonial studies postcolonialism decolonial studies Gayatri Spivak Edward Said Edward Said postcolonial studies postcolonialism decolonial studies Gayatri Spivak Edward Said Edward Said postcolonial studies
Published by: Memorial University of Newfoundland
Metaheuristic-Based Control for Three-Phase Grid-Connected Solar Photovoltaic Systems
In this paper, a novel cascade control technique is proposed in order to identify the parameters of cascade controllers in a grid-connected photovoltaic (PV) system. Here, tuning of the inner and outer loop controllers is done...
Published by: IGI Global Scientific Publishing
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