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Results: 30
Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review.
Mariana Guimarães, Marina Statelova, René Holm, Christos Reppas, Moira Symilllides, Maria Vertzoni, Nikoletta Fotaki
Apr 30, 2019
Objectives: In this review, the current biopharmaceutical approaches for evaluation of oral formulation performance in paediatrics are discussed. Key findings: The paediatric gastrointestinal (GI) tract undergoes numerous...
Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review.
Mariana Guimarães, Marina Statelova, René Holm, Christos Reppas, Moira Symilllides, Maria Vertzoni, Nikoletta Fotaki
Apr 30, 2019
Objectives: In this review, the current biopharmaceutical approaches for evaluation of oral formulation performance in paediatrics are discussed. Key findings: The paediatric gastrointestinal (GI) tract undergoes numerous...
How Data Can Drive Initiatives to Improve Patient Safety and Reduce Risk
Medical errors and improper care of patients are estimated to contribute to as many as 250,000 deaths each year. Critical insight into how, why, and where these incidents occur can be gained from close examination of medical...
Published by: IGI Global Scientific Publishing
Support amongst UK pig farmers and agricultural stakeholders for the use of food losses in animal feed.
While food losses (foods which were intended for human consumption, but which ultimately are not directly eaten by people) have been included in animal feed for millennia, the practice is all but banned in the European Union....
Supporting and preparing patients for radiotherapy
Georgia K. B. Halkett, Susan Merchant, Sian K Smith, Moira O'Connor, Michael Jefford, Sanchia Aranda, Penelope Schofield
Nov 30, 2020
Objective: Patients are often anxious and lack knowledge of radiotherapy prior to
commencing treatment. Evidence-based interventions are required to reduce patient
anxiety and increase patient preparation before...
commencing treatment. Evidence-based interventions are required to reduce patient
anxiety and increase patient preparation before...
cancer communication communication skills training patient anxiety patient perspective patient preparation for radiotherapy radiation therapists radiotherapy education sustainability HEALTH /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Epidemiology and control of human schistosomiasis in Tanzania.
Humphrey D Mazigo, Fred Nuwaha, Safari M Kinung'hi, Domenica Morona, Angela Pinot de Moira, Shona Wilson, Jorg Heukelbach, David W Dunne
Jan 21, 2013
Telemedicine in rheumatology
Melanie Sloan, Elliott Lever, Rupert Harwood, Caroline Gordon, Chris Wincup, Moira Blane, James Brimicombe, Peter Lanyon, Paul Howard, Stephen Sutton, David D'Cruz, Felix Naughton
Nov 09, 2021
OBJECTIVES: The Covid-19 pandemic necessitated a rapid global transition towards telemedicine; yet much remains unknown about telemedicine's acceptability and safety in rheumatology. To help address this gap and inform practice...
Supporting and preparing patients for radiotherapy
Georgia K. B. Halkett, Susan Merchant, Sian K Smith, Moira O'Connor, Michael Jefford, Sanchia Aranda, Penelope Schofield
Nov 30, 2020
Objective: Patients are often anxious and lack knowledge of radiotherapy prior to
commencing treatment. Evidence-based interventions are required to reduce patient
anxiety and increase patient preparation before...
commencing treatment. Evidence-based interventions are required to reduce patient
anxiety and increase patient preparation before...
cancer communication communication skills training patient anxiety patient perspective patient preparation for radiotherapy radiation therapists radiotherapy education sustainability HEALTH /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
'But you don't look sick'
Melanie Sloan, Michael Bosley, Moira Blane, Lynn Holloway, Colette Barrere, David D'Cruz, Chanpreet Walia, Felix Naughton, Paul Howard, Stephen Sutton, Caroline Gordon
Dec 18, 2020
Lupus is a multi-system autoimmune rheumatic disease with increased morbidity and mortality. Some manifestations are life-threatening with many aspects of living with the disease, difficulties in diagnosis and accessing...
Holistic care lupus Misdiagnosis Patient views Patient–physician interaction Quality of life Adaptation Physiological Diagnostic Errors Female Health Knowledge Attitudes practice Health Services Accessibility Humans Lupus Erythematosus Systemic Physician-Patient Relations qualitative research Quality of life resilience Psychological social support United Kingdom
‘But you don’t look sick’
Melanie Sloan, Michael Bosley, Moira Blane, Lynn Holloway, Colette Barrere, David D’Cruz, Chanpreet Walia, Felix Naughton, Paul Howard, Stephen Sutton, Caroline Gordon
Mar 11, 2021
Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection.
Edward J Farnell, Nidhi Tyagi, Stephanie Ryan, Iain W Chalmers, Angela Pinot de Moira, Frances M Jones, Jakub Wawrzyniak, Colin M Fitzsimmons, Edridah M Tukahebwa, Nicholas Furnham, Rick M Maizels, David W Dunne
Mar 26, 2015
Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni/hookworm coinfection.
Angela Pinot de Moira, Colin M Fitzsimmons, Frances M Jones, Shona Wilson, Pierre Cahen, Edridah Tukahebwa, Harriet Mpairwe, Joseph K Mwatha, Jeffrey M Bethony, Per S Skov, Narcis B Kabatereine, David W Dunne
Mar 11, 2021
BACKGROUND: The poor correlation between allergen-specific immunoglobulin E (asIgE) and clinical signs of allergy in helminth infected populations suggests that helminth infections could protect against allergy by uncoupling...
The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC)
Matthew Hammond, Allan B Clark, Anthony P Cahn, Edwin Chilvers, William Duncan Fraser, David M Livermore, Toby M Maher, Helen Parfrey, Ann Marie Swart, Susan Stirling, David Thickett, Moira Whyte, Andrew Wilson
Jun 19, 2018
Lung Humans Disease Progression Anti-Bacterial Agents Vital Capacity Forced Expiratory Volume Treatment Outcome Patient Admission Lung Transplantation Double-Blind Method Time Factors Adult Female Male Multicenter Studies as Topic Randomized Controlled Trials as Topic Clinical Trials Phase III as Topic Idiopathic Pulmonary Fibrosis Trimethoprim Sulfamethoxazole Drug Combination United Kingdom
Published by: Trials
‘But you don’t look sick’
Melanie Sloan, Michael Bosley, Moira Blane, Lynn Holloway, Colette Barrere, David D’Cruz, Chanpreet Walia, Felix Naughton, Paul Howard, Stephen Sutton, Caroline Gordon
Oct 28, 2021
Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development.
Andrew J Woo, Chelsea-Ann A Patry, Alireza Ghamari, Gabriela Pregernig, Daniel Yuan, Kangni Zheng, Taylor Piers, Moira Hibbs, Ji Li, Miguel Fidalgo, Jenny Y Wang, Joo-Hyeon Lee, Peter J Leedman, Jianlong Wang, Ernest Fraenkel, Alan B Cantor
Sep 13, 2019
Erythroid maturation requires the concerted action of a core set of transcription factors. We previously identified the Krüppel-type zinc finger transcription factor Zfp148 (also called ZBP-89) as an interacting partner of the...
Presymptomatic, asymptomatic and post-symptomatic transmission of SARS-CoV-2
Moira A Mugglestone, Natasha V Ratnaraja, Aggie Bak, Jasmin Islam, Jennie A Wilson, Jennifer Bostock, Samuel E Moses, James R Price, Michael Weinbren, Heather P Loveday, Lucy Rivett, Simon M Stoneham, A Peter R Wilson
May 12, 2022
Suitability and Allocation of Protein-Containing Foods According to Protein Tolerance in PKU
Maria Inês Gama, Sarah Adam, Sandra Adams, Heather Allen, Catherine Ashmore, Sarah Bailey, Barbara Cochrane, Clare Dale, Anne Daly, Giana De Sousa, Sarah Donald, Carolyn Dunlop, Charlotte Ellerton, Sharon Evans, Sarah Firman, Suzanne Ford, Francine Freedman, Moira French, Lisa Gaff, Joanna Gribben, Anne Grimsley, Ide Herlihy, Melanie Hill, Farzana Khan, Nicola McStravick, Chloe Millington, Nicola Moran, Camille Newby, Patty Nguyen, Janet Purves, Alex Pinto, Júlio César Rocha, Rachel Skeath, Amy Skelton, Simon Tapley, Alison Woodall, Carla Young, Anita MacDonald
Jan 10, 2023
Introduction: There is little practical guidance about suitable food choices for higher natural protein tolerances in patients with phenylketonuria (PKU). This is particularly important to consider with the introduction of...
Special Low Protein Foods Prescribed in England for PKU Patients
Georgina Wood, Alex Pinto, Sharon Evans, Anne Daly, Sandra Adams, Susie Costelloe, Joanna Gribben, Charlotte Ellerton, Anita Emm, Sarah Firman, Suzanne Ford, Moira French, Lisa Gaff, Emily Giuliano, Melanie Hill, Inderdip Hunjan, Camille Newby, Allison Mackenzie, Rachel Pereira, Celine Prescott, Louise Robertson, Heidi Seabert, Rachel Skeath, Simon Tapley, Allyson Terry, Alison Tooke, Karen van Wyk, Fiona J White, Lucy White, Alison Woodall, Júlio César Rocha, Anita MacDonald
Nov 12, 2021
Patients with phenylketonuria (PKU) are reliant on special low protein foods (SLPFs) as part of their dietary treatment. In England, several issues regarding the accessibility of SLPFs through the national prescribing system...
Post COVID‐19
Silviu O. Petrovan, David C. Aldridge, Harriet Bartlett, Andrew J. Bladon, Hollie Booth, Steven Broad, Donald M. Broom, Neil D. Burgess, Sarah Cleaveland, Andrew A. Cunningham, Maurizio Ferri, Amy Hinsley, Fangyuan Hua, Alice C. Hughes, Kate Jones, Moira Kelly, George Mayes, Milorad Radakovic, Chinedu A. Ugwu, Nasir Uddin, Diogo Veríssimo, Christian Walzer, Thomas B. White, James L. Wood, William J. Sutherland
Jul 07, 2021
Post COVID-19
Silviu O Petrovan, David C Aldridge, Harriet Bartlett, Andrew J Bladon, Hollie Booth, Steven Broad, Donald M Broom, Neil D Burgess, Sarah Cleaveland, Andrew A Cunningham, Maurizio Ferri, Amy Hinsley, Fangyuan Hua, Alice C Hughes, Kate Jones, Moira Kelly, George Mayes, Milorad Radakovic, Chinedu A Ugwu, Nasir Uddin, Diogo Veríssimo, Christian Walzer, Thomas B White, James L Wood, William J Sutherland
Jun 24, 2021
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Nadine D Arnold, Josephine A Pickworth, Laura E West, Sarah Dawson, Joana A Carvalho, Helen Casbolt, Adam T Braithwaite, James Iremonger, Lewis Renshall, Volker Germaschewski, Matthew McCourt, Philip Bland-Ward, Hager Kowash, Abdul G Hameed, Alexander MK Rothman, Maria G Frid, AA Roger Thompson, Holly R Evans, Mark Southwood, Nicholas W Morrell, David C Crossman, Moira Kb Whyte, Kurt R Stenmark, Christopher M Newman, David G Kiely, Sheila E Francis, Allan Lawrie
Jan 20, 2020
Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive pulmonary vascular remodelling that drives PAH. Osteoprotegerin (OPG) is...
Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.
Nadia Akawi, Jeremy McRae, Morad Ansari, Meena Balasubramanian, Moira Blyth, Angela F Brady, Stephen Clayton, Trevor Cole, Charu Deshpande, Tomas W Fitzgerald, Nicola Foulds, Richard Francis, George Gabriel, Sebastian S Gerety, Judith Goodship, Emma Hobson, Wendy D Jones, Shelagh Joss, Daniel King, Nikolai Klena, Ajith Kumar, Melissa Lees, Chris Lelliott, Jenny Lord, Dominic McMullan, Mary O'Regan, Deborah Osio, Virginia Piombo, Elena Prigmore, Diana Rajan, Elisabeth Rosser, Alejandro Sifrim, Audrey Smith, Ganesh J Swaminathan, Peter Turnpenny, James Whitworth, Caroline F Wright, Helen V Firth, Jeffrey C Barrett, Cecilia W Lo, David R FitzPatrick, Matthew E Hurles, DDD Study
Feb 18, 2021
Discovery of most autosomal recessive disease-associated genes has involved analysis of large, often consanguineous multiplex families or small cohorts of unrelated individuals with a well-defined clinical condition. Discovery...
Cell Cycle Proteins Developmental Disabilities Exome Family Health Female Genes Recessive Genetic Association Studies Genetic Predisposition to Disease genetic variation Genotype Humans Male Matrix Metalloproteinases Secreted Pedigree Phenotype Protein-Arginine N-Methyltransferases Sequence Analysis DNA Ubiquitin-Protein Ligases United Kingdom
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Pranvera Sadiku, Joseph A Willson, Rebecca S Dickinson, Fiona Murphy, Alison J Harris, Amy Lewis, David Sammut, Ananda S Mirchandani, Eilise Ryan, Emily R Watts, AA Roger Thompson, Helen M Marriott, David H Dockrell, Cormac T Taylor, Martin Schneider, Patrick H Maxwell, Edwin R Chilvers, Massimilliano Mazzone, Veronica Moral, Chris W Pugh, Peter J Ratcliffe, Christopher J Schofield, Bart Ghesquiere, Peter Carmeliet, Moira Kb Whyte, Sarah R Walmsley
Apr 05, 2018
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Nadine D Arnold, Josephine A Pickworth, Laura E West, Sarah Dawson, Joana A Carvalho, Helen Casbolt, Adam T Braithwaite, James Iremonger, Lewis Renshall, Volker Germaschewski, Matthew McCourt, Philip Bland-Ward, Hager Kowash, Abdul G Hameed, Alexander M K Rothman, Maria G Frid, A A Roger Thompson, Holly R Evans, Mark Southwood, Nicholas W Morrell, David C Crossman, Moira K B Whyte, Kurt R Stenmark, Christopher M Newman, David G Kiely, Sheila E Francis, Allan Lawrie
Dec 16, 2019
Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive pulmonary vascular remodelling that drives PAH. Osteoprotegerin (OPG) is...
Loss of function NFKB1 variants are the most common monogenic cause of CVID in Europeans.
Paul Tuijnenburg, Hana Lango Allen, Siobhan O Burns, Daniel Greene, Machiel H Jansen, Emily Staples, Jonathan Stephens, Keren J Carss, Daniele Biasci, Helen Baxendale, Moira Thomas, Anita Chandra, Sorena Kiani-Alikhan, Hilary J Longhurst, Suranjith L Seneviratne, Eric Oksenhendler, Ilenia Simeoni, Godelieve J de Bree, Anton TJ Tool, Ester MM van Leeuwen, Eduard HTM Ebberink, Alexander B Meijer, Salih Tuna, Deborah Whitehorn, Matthew Brown, Ernest Turro, Adrian J Thrasher, Kenneth GC Smith, James E Thaventhiran, Taco W Kuijpers, NIHR-BioResource – Rare Diseases Consortium
Jun 12, 2018
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