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Studies on the formation of DNA-cationic lipid composite films and DNA hybridization in the composites
The formation of composite films of double-stranded DNA and cationic lipid molecules (octadecylamine, ODA) and the hybridization of complementary single-stranded DNA molecules in such composite films are demonstrated. The...
Coating materials Lipids Genetics molecules hybridization Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
Hybridization of DNA by sequential immobilization of oligonucleotides at the air-water interface
The hybridization of DNA by sequential electrostatic and hydrogen-bonding immobilization of single-stranded complementary oligonucleotides at the air-water interface with cationic Langmuir monolayers is demonstrated. The...
Monolayers Interfaces Genetics molecules hybridization Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
Cationic surfactant mediated hybridization and hydrophobization of DNA molecules at the liquid/liquid interface and their phase transfer
Murali Sastry, Ashavani Kumar, Mrunalini Pattarkine, Vidya Ramakrishnan, Krishna N. Ganesh
Jan 01, 0001
Hybridization of complementary oligonucleotides mediated by a cationic surfactant at the water/hexane interface leads to hydrophobic, double-helical DNA which may be readily phase transferred to the organic phase and cast into...
Cationic surfactant hybridization DNA water/hexane interface Substrate Hydrophobic Oligonucleotides Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
Total AC loss study of 2G HTS coils for fully HTS machine applications
The application of HTS coils for fully HTS machines has become a new research focus. In the stator of an electrical machine, HTS coils are subjected to a combination of an AC applied current and AC external magnetic field....
Total AC loss study of 2G HTS coils for fully HTS machine applications
The application of HTS coils for fully HTS machines has become a new research focus. In the stator of an electrical machine, HTS coils are subjected to a combination of an AC applied current and AC external magnetic field....
Enhanced Magnetic Field Sensing Using Planar High-Temperature Superconductor Shields
Jozef Kvitkovic, Sagarkumar Patel, Min Zhang, Zhenyu Zhang, Joseph Peetz, Adam Marney, Sastry Pamidi
Jun 01, 2018
Experimental and finite element model studies of magnetic shielding characteristics of one-side planar sheet structures of the second generation high-temperature superconducting (2GHTS) coated conductor tapes show that...
Hall probe magnetic field magnetic shield shielding factor YBCO tape /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Temperature protocols to guide selective self-assembly of competing structures.
Multicomponent self-assembly mixtures offer the possibility of encoding multiple target structures with the same set of interacting components. Selective retrieval of one of the stored structures has been attempted by preparing...
Enhanced Magnetic Field Sensing Using Planar High-Temperature Superconductor Shields
Jozef Kvitkovic, Sagarkumar Patel, Min Zhang, Zhenyu Zhang, Joseph Peetz, Adam Marney, Sastry Pamidi
Jun 01, 2018
Experimental and finite element model studies of magnetic shielding characteristics of one-side planar sheet structures of the second generation high-temperature superconducting (2GHTS) coated conductor tapes show that...
Hall probe magnetic field magnetic shield shielding factor YBCO tape /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death.
Alessandra Granata, Felipe Serrano, William George Bernard, Madeline McNamara, Lucinda Low, Priya Sastry, Sanjay Sinha
Oct 31, 2016
Aortic Aneurysm Apoptosis Fibrillin-1 Gene Expression Regulation Humans Induced Pluripotent Stem Cells Kruppel-Like Factor 4 Kruppel-Like Transcription Factors Marfan Syndrome Models Biological Muscle Smooth Vascular Signal Transduction Transforming Growth Factor beta p38 Mitogen-Activated Protein Kinases
A high-resolution structure of the EF-hand domain of human polycystin-2.
Autosomal dominant polycystic kidney disease (ADPKD) affects over 1:1000 of the worldwide population and is caused by mutations in two genes, PKD1 and PKD2. PKD2 encodes a 968-amino acid membrane spanning protein, Polycystin-2...
Genetic dissection of the phosphoinositide cycle in Drosophila photoreceptors.
Che-Hsiung Liu, Murali K Bollepalli, Samuel V Long, Sabrina Asteriti, Julie Tan, Julie A Brill, Roger C Hardie
Apr 26, 2018
Phototransduction in Drosophila is mediated by phospholipase C-dependent hydrolysis of PIP2-, and is an important model for phosphoinositide signalling. Although generally assumed to operate by generic machinery conserved from...
Bayesian Inference-Based Estimation of Normal Aortic, Aneurysmal and Atherosclerotic Tissue Mechanical Properties
Shuo Wang, Aziz Tokgoz, Yuan Huang, Yongxue Zhang, Jiaxuan Feng, Priya Sastry, Chang Sun, Nichola Figg, Qingsheng Lu, Michael PF Sutcliffe, Zhongzhao Teng, Jonathan H Gillard
Jan 24, 2019
A Single Residue Mutation in the Gαq Subunit of the G Protein Complex Causes Blindness in Drosophila.
Jinguo Cao, Murali K Bollepalli, Yuhui Hu, Jin Zhang, Qiang Li, Hongmei Li, Hua Chang, Feng Xiao, Roger C Hardie, Yikang S Rong, Wen Hu
May 25, 2018
Heterotrimeric G proteins play central roles in many signaling pathways, including the phototransduction cascade in animals. However, the degree of involvement of the G protein subunit Gαq is not clear since animals with...
ERG G protein Gα PLC interaction Gαq light-induced retinal degeneration photoreceptor Phototransduction Alleles Animals Drosophila Proteins Drosophila melanogaster Electroretinography GTP-Binding Protein alpha Subunits Gq-G11 Gene Expression Regulation LIGHT Point Mutation Protein Binding Retina Retinal Degeneration Type C Phospholipases Vision Ocular
How Online Communities of People With Long-Term Conditions Function and Evolve
Sagar Joglekar, Nishanth Sastry, Neil S Coulson, Stephanie Jc Taylor, Anita Patel, Robbie Duschinsky, Amrutha Anand, Matt Jameson Evans, Chris J Griffiths, Aziz Sheikh, Pietro Panzarasa, Anna De Simoni
Nov 05, 2018
BACKGROUND: Self-management support can improve health and reduce health care utilization by people with long-term conditions. Online communities for people with long-term conditions have the potential to influence health, usage...
Not all SCN1A epileptic encephalopathies are Dravet syndrome
Lynette G Sadleir, Emily I Mountier, Deepak Gill, Suzanne Davis, Charuta Joshi, Catherine DeVile, Manju A Kurian, DDD Study, Simone Mandelstam, Elaine Wirrell, Katherine C Nickels, Hema R Murali, Gemma Carvill, Candace T Myers, Heather C Mefford, Ingrid E Scheffer
Feb 07, 2020
OBJECTIVE: To define a distinct SCN1A developmental and epileptic encephalopathy with early onset, profound impairment, and movement disorder. METHODS: A case series of 9 children were identified with a profound developmental...
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma
Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R. Middleton, Graham P. Collins
Jul 28, 2021
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma.
Stephen W Booth, Toby A Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R Middleton, Graham P Collins
Sep 24, 2021
BACKGROUND: This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients with...
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma.
Stephen W Booth, Toby A Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R Middleton, Graham P Collins
Aug 26, 2021
Background
This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients...
Published by: BMC cancer
Artificial Intelligence-Based Breast Cancer Detection Using WPSO
R. Thakur, Kayal Padmanandam, Murali Doma, Sunil Tambvekar, Keshav K., Bilal Abdualgalil
Aug 14, 2022
To detect breast cancer in the early stages, microcalcifications are considered a key symptom. Several scientific investigations were performed to fight against this disease for which machine learning techniques can be...
Published by: IGI Global Scientific Publishing
The ProtecT trial
Richard J Bryant, Jon Oxley, Grace J Young, Janet A Lane, Chris Metcalfe, Michael Davis, Emma L Turner, Richard M Martin, John R Goepel, Murali Varma, David F Griffiths, Ken Grigor, Nick Mayer, Anne Y Warren, Selina Bhattarai, John Dormer, Malcolm Mason, John Staffurth, Eleanor Walsh, Derek J Rosario, James WF Catto, David E Neal, Jenny L Donovan, Freddie C Hamdy, ProtecT study group
May 19, 2020
OBJECTIVE: To test the hypothesis that the baseline clinico-pathological features of the men with localized prostate cancer (PCa) included in the ProtecT (Prostate Testing for Cancer and Treatment) trial who progressed (n = 198)...
Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers
Abstract Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have...
Steven A Kemp, Mark TK Cheng, William L Hamilton, Kimia Kamelian, Himanshu Chauhan, Tanzin Dikid, Hema Gogia, Hemlata Lall, Kalaiarasan Ponnusamy, Kaptan Verma, Mahesh Shanker Dhar, Manoj K Singh, Meena Datta, Namita Soni, Namonarayan Meena, Preeti Madan, Priyanka Singh, Ramesh Sharma, Rajeev Sharma, Sandhya Kabra, Sattender Kumar, Swati Kumari, Uma Sharma, Urmila Chaudhary, Sridhar Sivasubbu, Vinod Scaria, Chand Wattal, JK Oberoi, Reena Raveendran, S Datta, Saumitra Das, Arindam Maitra, Sreedhar Chinnaswamy, Nidhan Kumar Biswas, Ajay Parida, Sunil K Raghav, Punit Prasad, Apurva Sarin, Satyajit Mayor, Uma Ramakrishnan, Dasaradhi Palakodeti, Aswin Sai Narain Seshasayee, K Thangaraj, Murali Dharan Bashyam, Ashwin Dalal, Manoj Bhat, Yogesh Shouche, Ajay Pillai, Priya Abraham, Varsha Atul Potdar, Sarah S Cherian, Anita Sudhir Desai, Chitra Pattabiraman, MV Manjunatha, Reeta S Mani, Gautam Arunachal Udupi, Vinay Nandicoori, Karthik Bharadwaj Tallapaka, Divya Tej Sowpati, Sujit Singh, Partha Rakshit, Anurag Agrawal, Christopher JR Illingworth, Ravindra K Gupta
Jul 22, 2022
The 2022 Europe report of the Lancet Countdown on health and climate change
Kim R van Daalen, Marina Romanello, Joacim Rocklöv, Jan C Semenza, Cathryn Tonne, Anil Markandya, Niheer Dasandi, Slava Jankin, Hicham Achebak, Joan Ballester, Hannah Bechara, Max W Callaghan, Jonathan Chambers, Shouro Dasgupta, Paul Drummond, Zia Farooq, Olga Gasparyan, Nube Gonzalez-Reviriego, Ian Hamilton, Risto Hänninen, Aleksandra Kazmierczak, Vladimir Kendrovski, Harry Kennard, Gregor Kiesewetter, Simon J Lloyd, Martin Lotto Batista, Jaime Martinez-Urtaza, Carles Milà, Jan C Minx, Mark Nieuwenhuijsen, Julia Palamarchuk, Marcos Quijal-Zamorano, Elizabeth JZ Robinson, Daniel Scamman, Oliver Schmoll, Maquins Odhiambo Sewe, Henrik Sjödin, Mikhail Sofiev, Balakrishnan Solaraju-Murali, Marco Springmann, Joaquin Triñanes, Josep M Anto, Maria Nilsson, Rachel Lowe
Nov 28, 2022
Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome.
Kristen A Panfilio, Iris M Vargas Jentzsch, Joshua B Benoit, Deniz Erezyilmaz, Yuichiro Suzuki, Stefano Colella, Hugh M Robertson, Monica F Poelchau, Robert M Waterhouse, Panagiotis Ioannidis, Matthew T Weirauch, Daniel ST Hughes, Shwetha C Murali, John H Werren, Chris GC Jacobs, Elizabeth J Duncan, David Armisén, Barbara MI Vreede, Patrice Baa-Puyoulet, Chloé S Berger, Chun-Che Chang, Hsu Chao, Mei-Ju M Chen, Yen-Ta Chen, Christopher P Childers, Ariel D Chipman, Andrew G Cridge, Antonin JJ Crumière, Peter K Dearden, Elise M Didion, Huyen Dinh, Harsha Vardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Cassandra G Extavour, Gérard Febvay, Markus Friedrich, Neta Ginzburg, Yi Han, Peter Heger, Christopher J Holmes, Thorsten Horn, Yi-Min Hsiao, Emily C Jennings, J Spencer Johnston, Tamsin E Jones, Jeffery W Jones, Abderrahman Khila, Stefan Koelzer, Viera Kovacova, Megan Leask, Sandra L Lee, Chien-Yueh Lee, Mackenzie R Lovegrove, Hsiao-Ling Lu, Yong Lu, Patricia J Moore, Monica C Munoz-Torres, Donna M Muzny, Subba R Palli, Nicolas Parisot, Leslie Pick, Megan L Porter, Jiaxin Qu, Peter N Refki, Rose Richter, Rolando Rivera-Pomar, Andrew J Rosendale, Siegfried Roth, Lena Sachs, M Emília Santos, Jan Seibert, Essia Sghaier, Jayendra N Shukla, Richard J Stancliffe, Olivia Tidswell, Lucila Traverso, Maurijn van der Zee, Séverine Viala, Kim C Worley, Evgeny M Zdobnov, Richard A Gibbs, Stephen Richards
Apr 18, 2019
BACKGROUND: The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology and excellent experimental tractability for molecular genetics. Building upon recent sequencing of...
Evolution of development Gene family evolution Gene structure Lateral gene transfer Phytophagy RNAi Transcription Factors Amino Acid Sequence Animals CYS2-HIS2 Zinc Fingers evolution Molecular Feeding Behavior Gene Dosage Gene Expression Profiling Gene Transfer Horizontal Genes Homeobox Genome Insect hemiptera Pigmentation Smell Transcription Factors
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Jauregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung, Russel Hirsch, R. James White, Marc Simon, David Badesch, Erika Rosenzweig, Charles Burger, Murali Chakinala, Thenappan Thenappan, Greg Elliott, Robert Simms, Harrison Farber, Robert Frantz, Jean Elwing, Nicholas Hill, Dunbar Ivy, James Klinger, Steven Nathan, Ronald Oudiz, Ivan Robbins, Robert Schilz, Terry Fortin, Jeffrey Wilt, Delphine Yung, Eric Austin, Ferhaan Ahmad, Nitin Bhatt, Tim Lahm, Adaani Frost, Zeenat Safdar, Zia Rehman, Robert Walter, Fernando Torres, Sahil Bakshi, Stephen Archer, Rahul Argula, Christopher Barnett, Raymond Benza, Ankit Desai, Veeranna Maddipati, Harm J. Bogaard, Colin Church, Gerry Coghlin, Robin Condliffe, Mélanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Simon Holden, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Jim Lordan, Rajiv D. Machado, Robert V. MacKenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Christopher J. Penkett, Joanna Pepke-Zaba, Laura Price, Christopher J. Rhodes, Werner Seeger, Florent Soubrier, Laura Southgate, Jay Suntharalingam, Andrew J. Swift, Mark R. Toshner, Anton Vonk Noordegraaf, John Wharton, Jim Wild, Stephen John Wort
Jun 04, 2021
Abstract: Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and...
Chronic neuropsychiatric sequelae of SARS‐CoV‐2
Gabriel A de Erausquin, Heather Snyder, Traolach S Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriela Gonzalez‐Aleman, Akram Hosseini, George D Vavougios, Perminder Sachdev, John Bankart, Niels Peter Ole Mors, Richard Lipton, Mindy Katz, Peter T Fox, Mohammad Zia Katshu, M Sriram Iyengar, Galit Weinstein, Hamid R Sohrabi, Rachel Jenkins, Dan J Stein, Jacques Hugon, Venetsanos Mavreas, John Blangero, Carlos Cruchaga, Murali Krishna, Ovais Wadoo, Rodrigo Becerra, Igor Zwir, William T Longstreth, Golo Kroenenberg, Paul Edison, Elizabeta Mukaetova‐Ladinska, Ekkehart Staufenberg, Mariana Figueredo‐Aguiar, Agustín Yécora, Fabiana Vaca, Hernan P Zamponi, Vincenzina Lo Re, Abdul Majid, Jonas Sundarakumar, Hector M Gonzalez, Mirjam I Geerlings, Ingmar Skoog, Alberto Salmoiraghi, Filippo Martinelli Boneschi, Vibuthi N Patel, Juan M Santos, Guillermo Rivera Arroyo, Antonio Caballero Moreno, Pascal Felix, Carla Gallo, Hidenori Arai, Masahito Yamada, Takeshi Iwatsubo, Malveeka Sharma, Nandini Chakraborty, Catterina Ferreccio, Dickens Akena, Carol Brayne, Gladys Maestre, Sarah Williams Blangero, Luis I Brusco, Prabha Siddarth, Timothy M Hughes, Alfredo Ramírez Zuñiga, Joseph Kambeitz, Agustin Ruiz Laza, Norrina Allen, Stella Panos, David Merrill, Agustín Ibáñez, Debby Tsuang, Nino Valishvili, Srishti Shrestha, Sophia Wang, Vasantha Padma, Kaarin J Anstey, Vijayalakshmi Ravindrdanath, Kaj Blennow, Paul Mullins, Emilia Łojek, Anand Pria, Thomas H Mosley, Penny Gowland, Timothy D Girard, Richard Bowtell, Farhaan S Vahidy
Sep 22, 2022
Abstract: Introduction: Coronavirus disease 2019 (COVID‐19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic....
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