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Results: 33
An entropic safety catch controls hepatitis C virus entry and antibody resistance.
Lenka Stejskal, Mphatso D Kalemera, Charlotte B Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D Lees, David S Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, christopher Illingworth, Adrian J Shepherd, Joe Grove
Jul 28, 2022
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2...
An entropic safety catch controls hepatitis C virus entry and antibody resistance.
Lenka Stejskal, Mphatso D Kalemera, Charlotte B Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D Lees, David S Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, Christopher JR Illingworth, Adrian J Shepherd, Joe Grove
Aug 07, 2022
E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2...
Within-host spatiotemporal dynamic of systemic salmonellosis
During the last two decades our understanding of the complex in vivo host-pathogen interactions has increased due to technical improvements and new research tools. The rapid advancement of molecular biology, flow cytometry and...
An experimental design tool to optimize inference precision in data-driven mathematical models of bacterial infections in vivo.
The management of bacterial diseases calls for a detailed knowledge about the dynamic changes in host-bacteria interactions. Biological insights are gained by integrating experimental data with mechanistic mathematical models to...
Is Digital Game-Based Learning Possible in Mathematics Classrooms?
The literature reports that while digital educational games are used in the elementary classroom, they are rarely, if ever, used in the upper secondary mathematics classroom. In order to investigate this situation, a survey was...
Published by: IGI Global Scientific Publishing
Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections.
Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections.
Bacterial infections still constitute a major cause of mortality and morbidity worldwide. The unavailability of therapeutics, antimicrobial resistance and the chronicity of infections due to incomplete clearance contribute to...
mechanistic model mathematical biology within-host dynamics host–pathogen interactions parameter inference
Published by: Pathogens and disease
PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector.
Chiamaka V Ukegbu, Maria Giorgalli, Sofia Tapanelli, Luisa DP Rona, Amie Jaye, Claudia Wyer, Fiona Angrisano, Andrew M Blagborough, George K Christophides, Dina Vlachou
Aug 12, 2020
After being ingested by a female Anopheles mosquito during a bloodmeal on an infected host, and before they can reach the mosquito salivary glands to be transmitted to a new host, Plasmodium parasites must establish an infection...
complement-like response malaria transmission mosquito innate immunity mosquito population replacement transmission blocking vaccines Animals Anopheles Female host-parasite interactions Humans Immune Evasion Malaria Falciparum Mosquito Vectors Oocysts Plasmodium falciparum Protozoan Proteins Sporozoites
Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and aid to differential diagnosis
Myrto Stylianou, Nicholas Murphy, Luis R Peraza, Sara Graziadio, Ruth Cromarty, Alison Killen, JT O'Brien, Alan J Thomas, Fiona EN LeBeau, John-Paul Taylor
Jul 05, 2018
Management of lupus nephritis
Myrto Kostopoulou, Antonis Fanouriakis, Kim Cheema, John Boletis, George Bertsias, David Jayne, Dimitrios T Boumpas
Nov 24, 2020
OBJECTIVES: To analyse the current evidence for the management of lupus nephritis (LN) informing the 2019 update of the EULAR/European Renal Association-European Dialysis and Transplant Association recommendations. METHODS...
Lupus Erythematosus Lupus Nephritis systemic therapeutics Biomarkers Biopsy Calcineurin Clinical Decision-Making Disease Management Disease Susceptibility Drug Resistance Humans Immunosuppressive Agents Kidney Kidney Failure Chronic Lupus Nephritis Molecular Targeted Therapy Practice Guidelines as Topic Severity of Illness Index Treatment Outcome
A data-based mathematical modelling study to quantify the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica during treatment and relapse.
Myrto Vlazaki, Omar Rossi, David J Price, Callum McLean, Andrew J Grant, Pietro Mastroeni, Olivier Restif
Jun 18, 2020
Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome.
Cornelis A Albers, Ana Cvejic, Rémi Favier, Evelien E Bouwmans, Marie-Christine Alessi, Paul Bertone, Gregory Jordan, Ross NW Kettleborough, Graham Kiddle, Myrto Kostadima, Randy J Read, Botond Sipos, Suthesh Sivapalaratnam, Peter A Smethurst, Jonathan Stephens, Katrin Voss, Alan Nurden, Augusto Rendon, Paquita Nurden, Willem H Ouwehand
Aug 20, 2020
Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these abnormalities cause mostly moderate but in rare...
Adult Aged Animals Animals Genetically Modified Base Sequence Blood Platelets Cytoplasmic Granules Embryo Nonmammalian Female Gene Expression Regulation Developmental Gray Platelet Syndrome Humans Male Middle Aged Molecular Sequence Data Nerve Tissue Proteins Pedigree Secretory Vesicles Sequence Analysis DNA Sequence Homology Nucleic Acid Young Adult Zebrafish
Cell type-specific novel long non-coding RNA and circular RNA in the BLUEPRINT hematopoietic transcriptomes atlas.
Luigi Grassi, Osagie G Izuogu, Natasha AN Jorge, Denis Seyres, Mariona Bustamante, Frances Burden, Samantha Farrow, Neda Farahi, Fergal J Martin, Adam Frankish, Jonathan M Mudge, Myrto Kostadima, Romina Petersen, John J Lambourne, Sophia Rowlston, Enca Martin-Rendon, Laura Clarke, Kate Downes, Xavier Estivill, Paul Flicek, Joost HA Martens, Marie-Laure Yaspo, Hendrik G Stunnenberg, Willem H Ouwehand, Fabio Passetti, Ernest Turro, Mattia Frontini
Jul 14, 2020
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.
Biola M Javierre, Oliver S Burren, Steven P Wilder, Roman Kreuzhuber, Steven M Hill, Sven Sewitz, Jonathan Cairns, Steven W Wingett, Csilla Várnai, Michiel J Thiecke, Frances Burden, Samantha Farrow, Antony J Cutler, Karola Rehnström, Kate Downes, Luigi Grassi, Myrto Kostadima, Paula Freire-Pritchett, Fan Wang, BLUEPRINT Consortium, Hendrik G Stunnenberg, John A Todd, Daniel R Zerbino, Oliver Stegle, Willem H Ouwehand, Mattia Frontini, Chris Wallace, Mikhail Spivakov, Peter Fraser
Nov 18, 2016
chromosome conformation Disease gene prioritization Gene regulation non-coding genetic variation promoter capture Hi-C Blood Cells Cell Lineage Cell Separation Chromatin Disease Enhancer Elements Genetic Epigenomics Genetic Predisposition to Disease Genome-Wide Association Study Hematopoiesis Humans Polymorphism Single Nucleotide Promoter Regions Genetic Quantitative Trait Loci
Identifying and correcting epigenetics measurements for systematic sources of variation.
Flavie Perrier, Alexei Novoloaca, Srikant Ambatipudi, Laura Baglietto, Akram Ghantous, Vittorio Perduca, Myrto Barrdahl, Sophia Harlid, Ken K Ong, Alexia Cardona, Silvia Polidoro, Therese Haugdahl Nøst, Kim Overvad, Hanane Omichessan, Martijn Dollé, Christina Bamia, José Marìa Huerta, Paolo Vineis, Zdenko Herceg, Isabelle Romieu, Pietro Ferrari
Jul 23, 2018
BACKGROUND: Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and contribute...
2019 Update of the Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA–EDTA) recommendations for the management of lupus nephritis
Antonis Fanouriakis, Myrto Kostopoulou, Kim Cheema, Hans-Joachim Anders, Martin Aringer, Ingeborg Bajema, John Boletis, Eleni Frangou, Frederic A Houssiau, Jane Hollis, Adexandre Karras, Francesca Marchiori, Stephen D Marks, Gabriella Moroni, Marta Mosca, Ioannis Parodis, Manuel Praga, Matthias Schneider, Josef S Smolen, Vladimir Tesar, Maria Trachana, Ronald F van Vollenhoven, Alexandre E Voskuyl, Y K Onno Teng, Bernadette van Leew, George Bertsias, David Jayne, Dimitrios T Boumpas
Apr 24, 2020
2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis.
Antonis Fanouriakis, Myrto Kostopoulou, Kim Cheema, Hans-Joachim Anders, Martin Aringer, Ingeborg Bajema, John Boletis, Eleni Frangou, Frederic A Houssiau, Jane Hollis, Adexandre Karras, Francesca Marchiori, Stephen D Marks, Gabriella Moroni, Marta Mosca, Ioannis Parodis, Manuel Praga, Matthias Schneider, Josef S Smolen, Vladimir Tesar, Maria Trachana, Ronald F van Vollenhoven, Alexandre E Voskuyl, YK Onno Teng, Bernadette van Leew, George Bertsias, David Jayne, Dimitrios T Boumpas
Nov 03, 2021
OBJECTIVE: To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN). METHODS: Following the EULAR standardised operating procedures, a systematic literature review was performed. Members of a...
Lupus Nephritis Systemic Lupus Erythematosus Treatment Antirheumatic Agents Azathioprine Calcineurin Inhibitors Drug Therapy Combination Europe Glomerular Filtration Rate Glucocorticoids Humans Hydroxychloroquine Immunosuppressive Agents Kidney Failure Chronic Lupus Nephritis Mycophenolic Acid Proteinuria Societies Medical
A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.
Constance CFMJ Baaten, Stuart Meacham, Susanne M de Witt, Marion AH Feijge, David J Adams, Jan-Willem N Akkerman, Judith MEM Cosemans, Luigi Grassi, Steve Jupe, Myrto Kostadima, Nadine JA Mattheij, Martin H Prins, Ramiro Ramirez-Solis, Oliver Soehnlein, Frauke Swieringa, Christian Weber, Jacqueline K White, Willem H Ouwehand, Johan WM Heemskerk
Nov 22, 2018
Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been...
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
Biola M Javierre, Oliver S Burren, Steven P Wilder, Roman Kreuzhuber, Steven M Hill, Sven Sewitz, Jonathan Cairns, Steven W Wingett, Csilla Várnai, Michiel J Thiecke, Frances Burden, Samantha Farrow, Antony J Cutler, Karola Rehnstrom, Kate Downes, Luigi Grassi, Myrto Kostadima, Paula Freire-Pritchett, Fan Wang, BLUEPRINT Consortium The, Hendrik G Stunnenberg, John A Todd, Daniel R Zerbino, Oliver Stegle, Willem Hendrik Ouwehand, Mattia Frontini, Chris Wallace, Mikhail Spivakov, Peter Fraser
Aug 16, 2017
This is the final version of the article. It first appeared from Elsevier (Cell Press) via https://doi.org/10.1016/j.cell.2016.09.037
Gene regulation chromosome conformation promoter capture Hi-C non-coding genetic variation Disease gene prioritization
Published by: Cell
Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.
Luigi Grassi, Farzin Pourfarzad, Sebastian Ullrich, Angelika Merkel, Felipe Were, Enrique Carrillo-de-Santa-Pau, Guoqiang Yi, Ida H Hiemstra, Anton TJ Tool, Erik Mul, Juliane Perner, Eva Janssen-Megens, Kim Berentsen, Hinri Kerstens, Ehsan Habibi, Marta Gut, Marie Laure Yaspo, Matthias Linser, Ernesto Lowy, Avik Datta, Laura Clarke, Paul Flicek, Martin Vingron, Dirk Roos, Timo K van den Berg, Simon Heath, Daniel Rico, Mattia Frontini, Myrto Kostadima, Ivo Gut, Alfonso Valencia, Willem H Ouwehand, Hendrik G Stunnenberg, Joost HA Martens, Taco W Kuijpers
Nov 22, 2018
Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important...
Transcriptional diversity during lineage commitment of human blood progenitors.
Lu Chen, Myrto Kostadima, Joost HA Martens, Giovanni Canu, Sara P Garcia, Ernest Turro, Kate Downes, Iain C Macaulay, Ewa Bielczyk-Maczynska, Sophia Coe, Samantha Farrow, Pawan Poudel, Frances Burden, Sjoert BG Jansen, William J Astle, Antony Attwood, Tadbir Bariana, Bernard de Bono, Alessandra Breschi, John C Chambers, Bridge Consortium, Fizzah A Choudry, Laura Clarke, Paul Coupland, Martijn van der Ent, Wendy N Erber, Joop H Jansen, Rémi Favier, Matthew E Fenech, Nicola Foad, Kathleen Freson, Chris van Geet, Keith Gomez, Roderic Guigo, Daniel Hampshire, Anne M Kelly, Hindrik HD Kerstens, Jaspal S Kooner, Michael Laffan, Claire Lentaigne, Charlotte Labalette, Tiphaine Martin, Stuart Meacham, Andrew Mumford, Sylvia Nürnberg, Emilio Palumbo, Bert A van der Reijden, David Richardson, Stephen J Sammut, Greg Slodkowicz, Asif U Tamuri, Louella Vasquez, Katrin Voss, Stephen Watt, Sarah Westbury, Paul Flicek, Remco Loos, Nick Goldman, Paul Bertone, Randy J Read, Sylvia Richardson, Ana Cvejic, Nicole Soranzo, Willem H Ouwehand, Hendrik G Stunnenberg, Mattia Frontini, Augusto Rendon
Nov 12, 2014
A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.
Ilenia Simeoni, Jonathan C Stephens, Fengyuan Hu, Sri VV Deevi, Karyn Megy, Tadbir K Bariana, Claire Lentaigne, Sol Schulman, Suthesh Sivapalaratnam, Minka JA Vries, Sarah K Westbury, Daniel Greene, Sofia Papadia, Marie-Christine Alessi, Antony P Attwood, Matthias Ballmaier, Gareth Baynam, Emilse Bermejo, Marta Bertoli, Paul F Bray, Loredana Bury, Marco Cattaneo, Peter Collins, Louise C Daugherty, Rémi Favier, Deborah L French, Bruce Furie, Michael Gattens, Manuela Germeshausen, Cedric Ghevaert, Anne C Goodeve, Jose A Guerrero, Daniel J Hampshire, Daniel P Hart, Johan WM Heemskerk, Yvonne MC Henskens, Marian Hill, Nancy Hogg, Jennifer D Jolley, Walter H Kahr, Anne M Kelly, Ron Kerr, Myrto Kostadima, Shinji Kunishima, Michele P Lambert, Ri Liesner, José A López, Rutendo P Mapeta, Mary Mathias, Carolyn M Millar, Amit Nathwani, Marguerite Neerman-Arbez, Alan T Nurden, Paquita Nurden, Maha Othman, Kathelijne Peerlinck, David J Perry, Pawan Poudel, Pieter Reitsma, Matthew T Rondina, Peter A Smethurst, William Stevenson, Artur Szkotak, Salih Tuna, Christel van Geet, Deborah Whitehorn, David A Wilcox, Bin Zhang, Shoshana Revel-Vilk, Paolo Gresele, Daniel B Bellissimo, Christopher J Penkett, Michael A Laffan, Andrew D Mumford, Augusto Rendon, Keith Gomez, Kathleen Freson, Willem H Ouwehand, Ernest Turro
Sep 20, 2016
Identification of novel genetic markers of breast cancer survival.
Qi Guo, Marjanka K Schmidt, Peter Kraft, Sander Canisius, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Siddhartha Kar, Jonathan Beesley, Alison M Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Diether Lambrechts, Caroline Weltens, Karin Leunen, Stig E Bojesen, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru A Muranen, Fergus J Couch, Janet E Olson, Celine Vachon, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Frans B Hogervorst, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, John L Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C Southey, Angela Cox, Simon S Cross, Malcolm Wr Reed, Graham G Giles, Roger L Milne, Catriona Mclean, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, Ans Mw van den Ouweland, Federik Marme, Andreas Schneeweiss, Rongxi Yang, Barbara Burwinkel, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Bernd Holleczek, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Jingmei Li, Judith S Brand, Keith Humphreys, Peter Devilee, Rob AEM Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, Paolo Mariani, Peter A Fasching, Matthias W Beckmann, Alexander Hein, Arif B Ekici, Georgia Chenevix-Trench, Rosemary Balleine, kConFab Investigators, Kelly-Anne Phillips, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela Kristensen, Silje Nord, D Gareth Evans, Jean E Abraham, Helena M Earl, Louise Hiller, Janet A Dunn, Sarah Bowden, Christine Berg, Daniele Campa, W Ryan Diver, Susan M Gapstur, Mia M Gaudet, Susan E Hankinson, Robert N Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J Machiela, Walter Willett, Myrto Barrdahl, Federico Canzian, Suet-Feung Chin, Carlos Caldas, David J Hunter, Sara Lindstrom, Montserrat García-Closas, Per Hall, Douglas F Easton, Diana M Eccles, Nazneen Rahman, Heli Nevanlinna, Paul DP Pharoah
May 26, 2015
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