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Results: 38
Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England.
OBJECTIVES: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. DESIGN: We developed a Bayesian model to...
Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England
Objectives: To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. Design: We developed a Bayesian model to...
The antecedents and consequences of affordable value innovations for emerging markets
Emerging markets offer tremendous growth opportunities for firms. While established multinational firms typically focus on premium segments in emerging markets, they often fail to leverage additional growth opportunities in...
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development.
Melissa A Edeling, Subramaniam Sanker, Takaki Shima, PK Umasankar, Stefan Höning, Hye Y Kim, Lance A Davidson, Simon C Watkins, Michael Tsang, David J Owen, Linton M Traub
May 11, 2020
PACSIN/Syndapin proteins are membrane-active scaffolds that participate in endocytosis. The structure of the Drosophila Syndapin N-terminal EFC domain reveals a crescent shaped antiparallel dimer with a high affinity for...
Amino Acid Sequence Animals Carrier Proteins Cell Movement Embryo Nonmammalian Embryonic Development HeLa Cells Humans Liposomes Molecular Sequence Data Notochord Oligonucleotides Antisense Phenotype Protein Binding Protein Structure Tertiary Structure-Activity Relationship Zebrafish Zebrafish Proteins
ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis.
Jordan M Reese, Elizabeth S Bruinsma, Adam W Nelson, Igor Chernukhin, Jason S Carroll, Ying Li, Malayannan Subramaniam, Vera J Suman, Vivian Negron, David G Monroe, James N Ingle, Matthew P Goetz, John R Hawse
Jul 17, 2019
Triple-negative breast cancer (TNBC) accounts for a disproportionately high number of deaths due to a lack of targeted therapies and an increased likelihood of distant recurrence. Estrogen receptor beta (ERβ), a...
Needle(s) in the Haystack-Synchronous Multifocal Tumor-Induced Osteomalacia.
Anand K Annamalai, Krishnaswamy Sampathkumar, Shubhada Kane, Nitin S Shetty, Suyash Kulkarni, Venkatesh Rangarajan, Nilendu Purandare, Prathamesh S Pai, Ankit D Mahuvakar, Radhakrishnan Shanthi, Govindarajulu Suriyakumar, Vipla Puri, Subramaniam Aram, Chandrasekhar Gopalakrishnan, Mathirajan Chelian, KG Srinivasan, Anthony J Gill, Mark Gurnell, Roderick Clifton-Bligh
Jan 14, 2016
Research priorities for neuroimmunology
Georgina MacKenzie, Sumithra Subramaniam, Lindsey J Caldwell, Denise Fitzgerald, Neil A Harrison, Soyon Hong, Sarosh R Irani, Golam M Khandaker, Adrian Liston, Veronique E Miron, Valeria Mondelli, B Paul Morgan, Carmine Pariante, Divya K Shah, Leonie S Taams, Jessica L Teeling, Rachel Upthegrove
Jan 07, 2022
Neuroimmunology in the broadest sense is the study of interactions between the nervous and the immune systems. These interactions play important roles in health from supporting neural development, homeostasis and plasticity to...
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene
Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds, Pradeep J Nathan, Sam R Miller, Bhopinder K Sarai, Kay Maltby, Disala Fernando, Liling Warren, Louise K Hosking, Dawn Waterworth, Anna Korzeniowska, Beta Win, Duncan B Richards, Lakshmi Vasist Johnson, Paul C Fletcher, Edward T Bullmore
Apr 22, 2016
Needle(s) in the Haystack – Synchronous Multifocal Tumor Induced Osteomalacia
Anand K. Annamalai, Krishnaswamy Sampathkumar, Shubhada Kane, Nitin S. Shetty, Suyash Kulkarni, Venkatesh Rangarajan, Nilendu Purandare, Prathamesh S. Pai, Ankit D. Mahuvakar, Radhakrishnan Shanthi, Govindarajulu Suriyakumar, Vipla Puri, Aram Subramaniam, Chandrasekhar Gopalakrishnan, Mathirajan Chelian, K. G. Srinivasan, Anthony J. Gill, Mark Gurnell, Roderick Clifton-Bligh
Feb 23, 2016
CamBAfx
Cinly Ooi, Edward T Bullmore, Alle-Meije Wink, Levent Sendur, Anna Barnes, Sophie Achard, John Aspden, Sanja Abbott, Shigang Yue, Manfred Kitzbichler, David Meunier, Voichita Maxim, Raymond Salvador, Julian Henty, Roger Tait, Naresh Subramaniam, John Suckling
Jul 14, 2021
CamBAfx is a workflow application designed for both researchers who use workflows to process data (consumers) and those who design them (designers). It provides a front-end (user interface) optimized for data processing designed...
Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils
Ellen Hubin, Stéphanie Deroo, Gabriele Kaminksi Schierle, Clemens Kaminski, Louise Serpell, Vinod Subramaniam, Nico van Nuland, Kerensa Broersen, Vincent Raussens, Rabia Sarroukh
Feb 12, 2020
Most Alzheimer's disease (AD) cases are late-onset and characterized by the aggregation and deposition of the amyloid-beta (Aβ) peptide in extracellular plaques in the brain. However, a few rare and hereditary Aβ mutations, such...
In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques
Panicos Shangaris, Stavros P. Loukogeorgakis, Sindhu Subramaniam, Christina Flouri, Laurence H. Jackson, Wei Wang, Michael P. Blundell, Shanrun Liu, Simon Eaton, Nahla Bakhamis, Durrgah Latchumi Ramachandra, Panayiotis Maghsoudlou, Luca Urbani, Simon N. Waddington, Ayad Eddaoudi, Joy Archer, Michael N. Antoniou, Daniel J. Stuckey, Manfred Schmidt, Adrian J. Thrasher, Thomas M. Ryan, Paolo De Coppi, Anna L. David
Aug 11, 2020
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekaterina Petrovich-Kopitman, Tomasz Janus, Nathali Kaushansky, Tao Cheng, Irit Sagi, Mariusz Z Ratajczak, Simón Méndez-Ferrer, John E Dick, Regina P Markus, Tsvee Lapidot
Nov 20, 2018
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production...
TNF Bone Marrow differentiation and egress hematopoietic stem and progenitor cells light and darkness maintenance and retention melatonin Norepinephrine stem cell repopulation potential vascular permeability Animals Cell Differentiation Cells Cultured Darkness Epigenesis Genetic Hematopoietic Stem Cells LIGHT Mice Mice Inbred C57BL Transcription Factors
In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques.
Panicos Shangaris, Stavros P Loukogeorgakis, Sindhu Subramaniam, Christina Flouri, Laurence H Jackson, Wei Wang, Michael P Blundell, Shanrun Liu, Simon Eaton, Nahla Bakhamis, Durrgah Latchumi Ramachandra, Panayiotis Maghsoudlou, Luca Urbani, Simon N Waddington, Ayad Eddaoudi, Joy Archer, Michael N Antoniou, Daniel J Stuckey, Manfred Schmidt, Adrian J Thrasher, Thomas M Ryan, Paolo De Coppi, Anna L David
Oct 22, 2019
In utero gene therapy (IUGT) to the fetal hematopoietic compartment could be used to treat congenital blood disorders such as β-thalassemia. A humanised mouse model of β-thalassemia was used, in which heterozygous animals are...
Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer.
Kirsten GM Aspros, Jodi M Carter, Tanya L Hoskin, Vera J Suman, Malayannan Subramaniam, Michael J Emch, Zhenqing Ye, Zhifu Sun, Jason P Sinnwell, Kevin J Thompson, Xiaojia Tang, Esther PB Rodman, Xiyin Wang, Adam W Nelson, Igor Chernukhin, Feda H Hamdan, Elizabeth S Bruinsma, Jason S Carroll, Martin E Fernandez-Zapico, Steven A Johnsen, Krishna R Kalari, Haojie Huang, Roberto A Leon-Ferre, Fergus J Couch, James N Ingle, Matthew P Goetz, John R Hawse
Mar 21, 2022
Triple Negative Breast Cancer (TNBC) accounts for 15-20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities. Thus, there is an urgent need to identify novel...
Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer.
Kirsten GM Aspros, Jodi M Carter, Tanya L Hoskin, Vera J Suman, Malayannan Subramaniam, Michael J Emch, Zhenqing Ye, Zhifu Sun, Jason P Sinnwell, Kevin J Thompson, Xiaojia Tang, Esther PB Rodman, Xiyin Wang, Adam W Nelson, Igor Chernukhin, Feda H Hamdan, Elizabeth S Bruinsma, Jason Carroll, Martin E Fernandez-Zapico, Steven A Johnsen, Krishna R Kalari, Haojie Huang, Roberto A Leon-Ferre, Fergus J Couch, James N Ingle, Matthew P Goetz, John R Hawse
Feb 17, 2022
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease
Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, UK IBD BioResource Investigators, Tim Raine, Miles Parkes, UK IBD BioResource Investigators, Tariq Ahmad, Nick Kennedy, Peter Irving, Natalie Prescott, Charlie Lees, John Mansfield, Chris Lamb, Jack Satsangi, Alison Simmons, Alisa Hart, Sreedhar Subramanian, Chris Probert, Richard Shenderey, Anton Gunasekera, Klaartje Bel Kok, Babur Javaid, Leena Sinha, Salil Singh, Cathryn Preston, Mark Jarvis, Ruth Penn, Anjan Dhar, Achuth Shenoy, Kath Phillis, Arabis Oglesby, Jude Tilbury, Glyn Scott, Joseph Collum, Martyn Carter, Jamie Barbour, John Gordon, John Ramage, Ganesh Sivagi, Phil Roberts, Monica Bose, Shaji Sebastian, Joy Wilkins, Paul Banim, Alexana Kent, Ajay Verma, Dawn Warren, Alan Wiles, Matthew Johnson, Konrad Koss, Chirag Oza, Khalid Elamin, Annette Woods, Bijay Baburajan, Chris MacDonald, Byron Theron, Mark Tremelling, Udi Shmueli, Roisin Bevan, Jimmy Limdi, Prakash Nair, Deven Vani, Stephen Lewis, Michelle Baker-Moffat, Gordon Moran, Simon McLaughlin, Aminda de Silva, John Beckly, Anew Cole, Charles Murray, Alan Lobo, Melissa Smith, Sanju Mathew, John Saunders, Helen Steed, Matthew Brookes, Juliette Loehry, Monira Rahman, Jeff Butterworth, Ajay Muddu, Katie Clark, Christian Selinger, Arvind Ramadas, John McLaughlin, Richard Pollok, Colin Rees, Simon Panter, David Hobday, Stephen Foley, Vinod Patel, Emma Wesley, Daniel Gavin, Cathryn Edwards, Stuart Bloom, Chuka Nwokolo, John deCaestecker, Mina Hanna, Albert Davies, Laura Hancock, Fraser Cummings, Subramaniam Ramakrishnan, Theresa Tindall, Jonathan Landy, Richard Appleby, Dan Sharpstone, Andy Li, Richard Keld, Lin Mear, Anne Philips, Horace Willia, Laura Hancock Ben Warner, Dharmaraj Durai, Elaine Brinkworth, Zahid Mahmood, Rachel Cooney
Oct 06, 2020
Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date...
Differential predictors for alcohol use in adolescents as a function of familial risk
Mira Tschorn, Robert C. Lorenz, Paul F. O’Reilly, Abraham Reichenberg, Erin B. Quinlan, Herta Flor, Antoine Grigis, Hugh Garavan, Bernd Ittermann, Dimitri Papadopoulos Orfanos, Luise Poustka, Sabina Millenet, Michael N. Smolka, Robert Whelan, Gunter Schumann, Michael A. Rapp, Trevor Robbins, Jeffrey Dalley, Naresh Subramaniam, David Theobald, Karl Mann, Christiane Bach, Maren Struve, Tobias Banaschewski, Marcella Rietschel, Rainer Spanagel, Frauke Nees, Mira Fauth-Bühler, Yvonne Grimmer, Mark Lathrop, Andreas Heinz, Lisa Albrecht, Nikolay Ivanov, Nicole Strache, Michael Rapp, Andreas Ströhle, Jan Reuter, Jürgen Gallinat, Henrik Walter, Isabel Gemmeke, Alexander Genauck, Caroline Parchetka, Katharina Weiß, Johann Kruschwitz, Bianca Raffaelli, Alev Isci, Laura Daedelow, Alexis Barbot, Benjamin Thyreau, Yannick Schwartz, Christophe Lalanne, Vincent Frouin, Dimitri Papadopoulos Orfanos, John Rogers, James Ireland, Dirk Lanzerath, Jianfeng Feng, Jean-Luc Martinot, Zuleima Bricaud, Fanny Gollier Briand, Hervé LemaÎtre, Ruben Miranda, Eric Artiges, Jessica Massicotte, Marie-Laure Paillère Martinot, Helene Vulser, Jani Pentillä, Irina Filippi, André Galinowski, Pauline Bezivin, Anna Cattrell, Tianye Jia, Sylvane Desrivières, Helen Werts, Lauren Topper, Laurence Reed, Chris Andrew, Catherine Mallik, Barbara Ruggeri, Charlotte Nymberg, Gareth Barker, Patricia J. Conrod, Lindsay Smith, Eva Loth, Stephanie Havatzias, Sheyda Shekarrizi, Emily Kitson, Alice Robinson, Deborah Hall, Chiara Rubino, Hannah Wright, Kerstin Stueber, Eanna Hanratty, Eleanor Kennedy, Fabiana Mesquita de Carvahlo, Argyris Stringaris, Gabriel Robert, Alex Ing, Christine Macare, Bing Xu, Tao Yu, Erin Burke Quinlan, Patrick Constant, Semiha Aydin, Ruediger Brühl, Albrecht Ihlenfeld, Bernadeta Walaszek, Michael Smolka, Thomas Hübner, Kathrin Müller, Stephan Ripke, Sarah Jurk, Eva Mennigen, Dirk Schmidt, Nora Vetter, Veronika Ziesch, Juliane H. Fröhner, Arun L. W. Bokde, Daniel Carter, Emily Walsh, Susanne O’Driscoll, Maria Leonora Fatimah Agan, Mairead McMorrow, Sinead Nugent, Colm Connolly, Eoin Dooley, Clodagh Cremen, Jennifer Jones, John O’Keefe, Martin O’Connor, Jean-Baptiste Poline, Christian Büchel, Uli Bromberg, Tahmine Fadai, Juliana Yacubian, Sophia Schneider, Maria Lobatchewa, Claire Lawrence, Craig Newman, Kay Head, Nadja Heym, Penny Gowland, Alicia Stedman, Mehri Kaviani, Susannah Taplin, Dai Stephens, Tomáš Paus, Zdenka Pausova, Amir Tahmasebi
Mar 04, 2021
Abstract: Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that...
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Maria Escala-Garcia, Jean Abraham, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L Auer, Päivi Auvinen, Matthias W Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J Chanock, Suet-Feung Chin, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Janet A Dunn, Alison M Dunning, Miriam Dwek, Helena M Earl, Diana M Eccles, A Heather Eliassen, Carolina Ellberg, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Angela George, Graham G Giles, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Patricia A Harrington, Louise Hiller, Maartje J Hooning, John L Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J Hunter, Anna Jakubowska, Esther M John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M Kitahara, Linetta B Koppert, Peter Kraft, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L Milne, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, William G Newman, Andrew F Olshan, Janet E Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C Southey, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Manuel R Teixeira, Mary Beth Terry, Heather Thorne, Rob AEM Tollenaar, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Clare Turnbull, Celine M Vachon, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Argyrios Ziogas, Paul DP Pharoah, Per Hall, Lodewyk FA Wessels, Georgia Chenevix-Trench, Gary D Bader, Thilo Dörk, Douglas F Easton, Sander Canisius, Marjanka K Schmidt
Jan 06, 2020
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential...
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Maria Escala-Garcia, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L. Auer, Päivi Auvinen, Matthias W. Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J. Chanock, Suet-Feung Chin, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Janet A. Dunn, Alison M. Dunning, Miriam Dwek, Helena M. Earl, Diana M. Eccles, A. Heather Eliassen, Carolina Ellberg, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M. Gapstur, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Angela George, Graham G. Giles, David E. Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A. Haiman, Niclas Håkansson, Ute Hamann, Patricia A. Harrington, Louise Hiller, Maartje J. Hooning, John L. Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J. Hunter, Anna Jakubowska, Esther M. John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M. Kitahara, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L. Milne, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, William G. Newman, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L. Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C. Southey, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Manuel R. Teixeira, Mary Beth Terry, Heather Thorne, Rob A. E. M. Tollenaar, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Clare Turnbull, Celine M. Vachon, Lizet E. van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Argyrios Ziogas, Paul D. P. Pharoah, Per Hall, Lodewyk F. A. Wessels, Georgia Chenevix-Trench, Gary D. Bader, Thilo Dörk, Douglas F. Easton, Sander Canisius, Marjanka K. Schmidt
Jan 15, 2021
Abstract: Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the...
Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Anna Morra, Maria Escala-Garcia, Jonathan Beesley, Renske Keeman, Sander Canisius, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L. Auer, Annelie Augustinsson, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Thomas Brüning, Saundra S. Buys, Bette Caan, Daniele Campa, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Ting-Yuan David Cheng, Christine L. Clarke, Sarah V. Colonna, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Thilo Dörk, Laure Dossus, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Lin Fritschi, Manuela Gago-Dominguez, José A. García-Sáenz, Graham G. Giles, Mervi Grip, Pascal Guénel, Melanie Gündert, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Steven N. Hart, Jaana M. Hartikainen, Arndt Hartmann, Wei He, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Anthony Howell, David J. Hunter, Agnes Jager, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Y. Jung, Rudolf Kaaks, Machteld Keupers, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Martha Linet, Robert N. Luben, Jan Lubiński, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, John W. M. Martens, Maria Elena Martinez, Dimitrios Mavroudis, Kyriaki Michailidou, Roger L. Milne, Anna Marie Mulligan, Taru A. Muranen, Heli Nevanlinna, William G. Newman, Sune F. Nielsen, Børge G. Nordestgaard, Andrew F. Olshan, Håkan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa V. Patel, Bernard Peissel, Paolo Peterlongo, Dijana Plaseska-Karanfilska, Karolina Prajzendanc, Ross Prentice, Nadege Presneau, Brigitte Rack, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Rebecca Roylance, Matthias Ruebner, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Andreas Schneeweiss, Christopher Scott, Mitul Shah, Snezhana Smichkoska, Melissa C. Southey, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Lauren R. Teras, Mary Beth Terry, Rob A. E. M. Tollenaar, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Qin Wang, Amber N. Hurson, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Hiltrud Brauch, Montserrat García-Closas, Paul D. P. Pharoah, Douglas F. Easton, Georgia Chenevix-Trench, Marjanka K. Schmidt, Anne-Lise Børresen-Dale, Kristine K. Sahlberg, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, Grethe I. Grenaker Alnæs, Christine Clarke, Deborah Marsh, Rodney Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter Simpson, J. Dinny Graham, Mythily Sachchithananthan
Aug 18, 2021
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
Abstract
Background
Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can...
Stefanie H Mueller, Alvina G Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Thais Baert, Laura E Beane Freeman, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y Brucker, Saundra S Buys, Jose E Castelao, Tsun L Chan, Jenny Chang-Claude, Stephen J Chanock, Ji-Yeob Choi, Wendy K Chung, Kristine K Sahlberg, Anne-Lise Børresen-Dale, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E Kiserud, Kristin V Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, Grethe I Grenaker Alnæs, Sarah V Colonna, Sten Cornelissen, Fergus J Couch, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Laure Dossus, Miriam Dwek, Diana M Eccles, Arif B Ekici, A Heather Eliassen, Christoph Engel, D Gareth Evans, Peter A Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat García-Closas, José A García-Sáenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guénel, Melanie Gündert, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Elaine F Harkness, Patricia A Harrington, Jaana M Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J Hooning, Reiner Hoppe, John L Hopper, Richard S Houlston, Anthony Howell, David J Hunter, Dezheng Huo, Deborah Marsh, Rodney Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter Simpson, Dinny Graham, Mythily Sachchithananthan, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M John, Michael E Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K Khusnutdinova, Sung-Won Kim, Cari M Kitahara, Stella Koutros, Peter Kraft, Vessela N Kristensen, Katerina Kubelka-Sabit, Allison W Kurian, Ava Kwong, James V Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A Murphy, Heli Nevanlinna, William G Newman, Dieter Niederacher, Katie M O’Brien, Nadia Obi, Kenneth Offit, Olufunmilayo I Olopade, Andrew F Olshan, Håkan Olsson, Sue K Park, Alpa V Patel, Achal Patel, Charles M Perou, Julian Peto, Paul DP Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U Rashid, Gad Rennert, Atocha Romero, Kathryn J Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Michael O Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M Tamimi, William J Tapper, Jack A Taylor, Soo Hwang Teo, Lauren R Teras, Amanda E Toland, Rob AEM Tollenaar, Diana Torres, Gabriela Torres-Mejía, Melissa A Troester, Thérèse Truong, Celine M Vachon, Joseph Vijai, Clarice R Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H Wu, Taiki Yamaji, Xiaohong R Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M Dunning, Douglas F Easton, Harry Hemingway, Ute Hamann, Karoline B Kuchenbaecker
Jan 26, 2023
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Maria Escala-Garcia, Jean Abraham, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L Auer, Päivi Auvinen, Matthias W Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y Brucker, Barbara Burwinkel, Carlos Caldas, Federico Canzian, Jenny Chang-Claude, Stephen J Chanock, Suet-Feung Chin, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Janet A Dunn, Alison M Dunning, Miriam Dwek, Helena M Earl, Diana M Eccles, A Heather Eliassen, Carolina Ellberg, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Angela George, Graham G Giles, David E Goldgar, Anna González-Neira, Mervi Grip, Pascal Guénel, Qi Guo, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Patricia A Harrington, Louise Hiller, Maartje J Hooning, John L Hopper, Anthony Howell, Chiun-Sheng Huang, Guanmengqian Huang, David J Hunter, Anna Jakubowska, Esther M John, Rudolf Kaaks, Pooja Middha Kapoor, Renske Keeman, Cari M Kitahara, Linetta B Koppert, Peter Kraft, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Alfons Meindl, Roger L Milne, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, William G Newman, Andrew F Olshan, Janet E Olson, Håkan Olsson, Nick Orr, Paolo Peterlongo, Christos Petridis, Ross L Prentice, Nadege Presneau, Kevin Punie, Dhanya Ramachandran, Gad Rennert, Atocha Romero, Mythily Sachchithananthan, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Lukas Schwentner, Christopher Scott, Jacques Simard, Christof Sohn, Melissa C Southey, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Manuel R Teixeira, Mary Beth Terry, Heather Thorne, Rob A E M Tollenaar, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Clare Turnbull, Celine M Vachon, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Argyrios Ziogas, Paul D P Pharoah, Per Hall, Lodewyk F A Wessels, Georgia Chenevix-Trench, Gary D Bader, Thilo Dörk, Douglas F Easton, Sander Canisius, Marjanka K Schmidt
Feb 19, 2020
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential...
Published by: Nature Communications
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