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Results: 10549
Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures.
Yvonne HF Teng, Hong Sheng Quah, Lisda Suteja, João ML Dias, Annalisa Mupo, Rachael JM Bashford-Rogers, George S Vassiliou, Melvin LK Chua, Daniel SW Tan, Darren WT Lim, N Gopalakrishna Iyer
Oct 29, 2021
Despite the conventional view that a truly random V(D)J recombination process should generate a highly diverse immune repertoire, emerging reports suggest that there is a certain bias toward the generation of shared/public...
A Comparative Analysis of Deep Learning Approaches for Network Intrusion Detection Systems (N-IDSs)
Recently, due to the advance and impressive results of deep learning techniques in the fields of image recognition, natural language processing and speech recognition for various long-standing artificial intelligence (AI) tasks...
Published by: IGI Global Scientific Publishing
The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls
BACKGROUND: Modern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes...
Non-Lorentzian SU(1, n) Spacetime Symmetry In Various Dimensions
We discuss non-Lorentzian Lagrangian field theories in $2n-1$ dimensions that
admit an $SU(1,n)$ spacetime symmetry which includes a scaling transformation.
These can be obtained by a conformal compactification of a...
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.
Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel SW Tan, N Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline SJ Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Mar 25, 2021
c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here...
Animals Antineoplastic Agents Carcinoma Squamous Cell Cell Line Tumor Head and Neck Neoplasms Humans Lung Neoplasms Mice Mutation Phenotype Phosphorylation Polymorphism Genetic Prognosis Protein Binding Protein Interaction Domains and Motifs Protein Kinase Inhibitors Proto-Oncogene Proteins c-met Receptor ErbB-2 Signal Transduction Xenograft Model Antitumor Assays
Exact properties of an integrated correlator in N = 4 SU( N ) SYM
Abstract: We present a novel expression for an integrated correlation function of four superconformal primaries in SU(N) N = 4 supersymmetric Yang-Mills (N = 4 SYM) theory. This integrated correlator, which is based on...
Factorisation of 3d N = 4 twisted indices and the geometry of vortex moduli space
We study the twisted indices of $\mathcal{N}=4$ supersymmetric gauge theories
in three dimensions on spatial $S^{2}$ with an angular momentum refinement. We
demonstrate factorisation of the index into holomorphic blocks for...
Crystal structure of X-prolyl aminopeptidase from <i>Caenorhabditis elegans</i>
Shalini Iyer, Penelope J. La-Borde, Karl A P Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya
Jan 01, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X-prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N-terminus of peptides possessing a...
Crystal structure of X-prolyl aminopeptidase from <i>Caenorhabditis elegans</i>
Shalini Iyer, Penelope J. La-Borde, Karl A P Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya
Jan 01, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X-prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N-terminus of peptides possessing a...
HONORING TORSEN N. WIESEL
The Rockefeller University
Jan 01, 0001
A Celebration in Honor of Torsten N. Wiesel: Entering his Tenth Decade
Published by: The Rockefeller University
Voltammetric Monitoring of a Solid-Liquid Phase Transition in N,N,N’,N’-Tetraoctyl-2,6-diamino-9,10-anthraquinone (TODAQ)
Sun Yhik Ahn, Thomas Forder, Matthew Jones, Richard Blackburn, Paul Fordred, Steven Bull, Frank Marken
Jan 31, 2020
Exploratory experiments on effects from a phase transition are reported for a low-melting microcrystalline anthraquinone (N,N,N′,N′-tetraoctyl-2,6-diamino-9,10-anthraquinone or TODAQ). Data for the solid-liquid phase...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
k-Root-n
Blockchains such as the bitcoin blockchain depend on reaching a global consensus on the distributed ledger; therefore, they suffer from well-known scalability problems. This paper proposes an algorithm that avoids...
Zvi Schreiber
Feb 08, 2020
Exact properties of an integrated correlator in N = 4 SU(N) SYM
Abstract
We present a novel expression for an integrated correlation function of four superconformal primaries in SU(N )...
The N-terminal RASSF family
The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the...
Voltammetric Monitoring of a Solid-Liquid Phase Transition in N,N,N’,N’-Tetraoctyl-2,6-diamino-9,10-anthraquinone (TODAQ)
Sun Yhik Ahn, Thomas Forder, Matthew Jones, Richard Blackburn, Paul Fordred, Steven Bull, Frank Marken
Jan 31, 2020
Exploratory experiments on effects from a phase transition are reported for a low-melting microcrystalline anthraquinone (N,N,N′,N′-tetraoctyl-2,6-diamino-9,10-anthraquinone or TODAQ). Data for the solid-liquid phase...
On (n+1/2)-Engel groups
Let n be a positive integer. We say that a group G is an (n+1/2)-Engel group if it satisfies the law [ x, y n, x ] = 1. The variety of (n+1/2)-Engel groups lies between the varieties of n-Engel groups and (n+1) -Engel groups. In...
The N-terminal RASSF family
The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the...
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical investigation for the treatment of SCLC. As well as acting as a neuropeptide...
Acetylcysteine Animals Antineoplastic Agents Antineoplastic Agents Phytogenic Apoptosis CHO Cells Carcinoma Small Cell Cell Division Cricetinae Drug Synergism Etoposide Free Radical Scavengers Glutathione Growth Inhibitors JNK Mitogen-Activated Protein Kinases Lipid Peroxidation Lung Neoplasms MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases Oligopeptides Oxidation-Reduction Reactive Oxygen Species Stimulation Chemical Transcription Factor AP-1 Transcription Genetic Tumor Cells Cultured
On (n+1/2)-Engel groups
Let n be a positive integer. We say that a group G is an (n+1/2)-Engel group if it satisfies the law [ x, y n, x ] = 1. The variety of (n+1/2)-Engel groups lies between the varieties of n-Engel groups and (n+1) -Engel groups. In...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
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