Search
Results: 10
Evaluation of a fully automated bioinformatics tool to predict antibiotic resistance from MRSA genomes.
Narender Kumar, Kathy E Raven, Beth Blane, Danielle Leek, Nicholas M Brown, Eugene Bragin, Paul A Rhodes, Julian Parkhill, Sharon J Peacock
Jan 06, 2020
OBJECTIVES: The genetic prediction of phenotypic antibiotic resistance based on analysis of WGS data is becoming increasingly feasible, but a major barrier to its introduction into routine use is the lack of fully automated...
Pilot Evaluation of a Fully Automated Bioinformatics System for Analysis of Methicillin-Resistant Staphylococcus aureus Genomes and Detection of Outbreaks.
Nicholas M Brown, Beth Blane, Kathy E Raven, Narender Kumar, Danielle Leek, Eugene Bragin, Paul A Rhodes, David A Enoch, Rachel Thaxter, Julian Parkhill, Sharon J Peacock
Aug 30, 2019
Genomic surveillance that combines bacterial sequencing and epidemiological information will become the gold standard for outbreak detection, but its clinical translation is hampered by the lack of automated interpretation...
Staphylococcus aureus Bioinformatics microbiology whole-genome sequencing Anti-Bacterial Agents Automation Laboratory Bacterial Typing Techniques Computational Biology Disease Outbreaks England Genome Bacterial Humans Methicillin Methicillin-Resistant Staphylococcus aureus Multilocus Sequence Typing Pilot Projects Prospective Studies Sequence Analysis DNA Staphylococcal Infections whole genome sequencing
Thirty-year clinical outcomes after haematopoietic stem cell transplantation in neuronopathic Gaucher disease.
Aimee Donald, Cecilia Kämpe Björkvall, Ashok Vellodi, GAUCHERITE Consortium, Timothy M Cox, Derralyn Hughes, Simon A Jones, Robert Wynn, Maciej Machaczka
Jul 19, 2022
BACKGROUND: Neuronopathic Gaucher Disease (nGD) describes the condition of a subgroup of patients with the Lysosomal Storage Disorder (LSD), Gaucher disease with involvement of the central nervous system (CNS) which results from...
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
TR Webb, J Erdmann, KE Stirrups, NO Stitziel, NGD Masca, H Jansen, S Kanoni, CP Nelson, PG Ferrario, IR König, JD Eicher, AD Johnson, SE Hamby, C Betsholtz, A Ruusalepp, O Franzén, EE Schadt, JLM Björkegren, PE Weeke, PL Auer, UM Schick, Y Lu, H Zhang, M-P Dube, A Goel, M Farrall, GM Peloso, H-H Won, R Do, E van Iperen, J Kruppa, A Mahajan, RA Scott, C Willenborg, PS Braund, JC van Capelleveen, ASF Doney, LA Donnelly, R Asselta, PA Merlini, S Duga, N Marziliano, JC Denny, C Shaffer, NE El-Mokhtari, A Franke, S Heilmann, C Hengstenberg, P Hoffmann, OL Holmen, K Hveem, J-H Jansson, K-H Jöckel, T Kessler, J Kriebel, KL Laugwitz, E Marouli, N Martinelli, MI McCarthy, NR van Zuydam, C Meisinger, T Esko, E Mihailov, SA Escher, M Alver, S Moebus, AD Morris, J Virtamo, M Nikpay, O Olivieri, S Provost, A AlQarawi, NR Robertson, KO Akinsansya, DF Reilly, TF Vogt, W Yin, FW Asselbergs, C Kooperberg, RD Jackson, E Stahl, M Müller-Nurasyid, K Strauch, TV Varga, M Waldenberger, Wellcome Trust Case Control Consortium, L Zeng, R Chowdhury, V Salomaa, I Ford, JW Jukema, P Amouyel, J Kontto, MORGAM Investigators, BG Nordestgaard, J Ferrières, D Saleheen, N Sattar, P Surendran, A Wagner, R Young, JMM Howson, AS Butterworth, J Danesh, D Ardissino, EP Bottinger, R Erbel, PW Franks, D Girelli, AS Hall, GK Hovingh, A Kastrati, W Lieb, T Meitinger, WE Kraus, SH Shah, R McPherson, M Orho-Melander, O Melander, A Metspalu, CNA Palmer, A Peters, DJ Rader, MP Reilly, RJF Loos, AP Reiner, DM Roden, J-C Tardif, JR Thompson, NJ Wareham, H Watkins, CJ Willer, NJ Samani, H Schunkert, P Deloukas, S Kathiresan, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators
Apr 04, 2017
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Nathan O Stitziel, Kathleen E Stirrups, Nicholas GD Masca, Jeanette Erdmann, Paola G Ferrario, Inke R König, Peter E Weeke, Thomas R Webb, Paul L Auer, Ursula M Schick, Yingchang Lu, He Zhang, Marie-Pierre Dube, Anuj Goel, Martin Farrall, Gina M Peloso, Hong-Hee Won, Ron Do, Erik van Iperen, Stavroula Kanoni, Jochen Kruppa, Anubha Mahajan, Robert A Scott, Christina Willenberg, Peter S Braund, Julian C van Capelleveen, Alex SF Doney, Louise A Donnelly, Rosanna Asselta, Piera A Merlini, Stefano Duga, Nicola Marziliano, Josh C Denny, Christian M Shaffer, Nour Eddine El-Mokhtari, Andre Franke, Omri Gottesman, Stefanie Heilmann, Christian Hengstenberg, Per Hoffman, Oddgeir L Holmen, Kristian Hveem, Jan-Håkan Jansson, Karl-Heinz Jöckel, Thorsten Kessler, Jennifer Kriebel, Karl L Laugwitz, Eirini Marouli, Nicola Martinelli, Mark I McCarthy, Natalie R Van Zuydam, Christa Meisinger, Tõnu Esko, Evelin Mihailov, Stefan A Escher, Maris Alver, Susanne Moebus, Andrew D Morris, Martina Müller-Nurasyid, Majid Nikpay, Oliviero Olivieri, Louis-Philippe Lemieux Perreault, Alaa AlQarawi, Neil R Robertson, Karen O Akinsanya, Dermot F Reilly, Thomas F Vogt, Wu Yin, Folkert W Asselbergs, Charles Kooperberg, Rebecca D Jackson, Eli Stahl, Konstantin Strauch, Tibor V Varga, Melanie Waldenberger, Lingyao Zeng, Aldi T Kraja, Chunyu Liu, George B Ehret, Christopher Newton-Cheh, Daniel I Chasman, Rajiv Chowdhury, Marco Ferrario, Ian Ford, J Wouter Jukema, Frank Kee, Kari Kuulasmaa, Børge G Nordestgaard, Markus Perola, Danish Saleheen, Naveed Sattar, Praveen Surendran, David Tregouet, Robin Young, Joanna MM Howson, Adam S Butterworth, John Danesh, Diego Ardissino, Erwin P Bottinger, Raimund Erbel, Paul W Franks, Domenico Girelli, Alistair S Hall, G Kees Hovingh, Adnan Kastrati, Wolfgang Lieb, Thomas Meitinger, William E Kraus, Svati H Shah, Ruth McPherson, Marju Orho-Melander, Olle Melander, Andres Metspalu, Colin NA Palmer, Annette Peters, Daniel Rader, Muredach P Reilly, Ruth JF Loos, Alex P Reiner, Dan M Roden, Jean-Claude Tardif, John R Thompson, Nicholas J Wareham, Hugh Watkins, Cristen J Willer, Sekkar Kathiresan, Panos Deloukas, Nilesh J Samani, Heribert Schunkert
Apr 05, 2016
Exome-wide association study of plasma lipids in >300,000 individuals.
Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David Cm Liewald, Li An Lin, Allan Linneberg, Ruth JF Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas GD Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin NA Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R Van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter WF Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Charge Diabetes Working Group, EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, Joanna MM Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
May 21, 2018
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC)...
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Praveen Surendran, Elena V Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James Cook, Lingyan Chen, Borbala Mifsud, Chen Yao, Aldi T Kraja, James H Cartwright, Jacklyn N Hellwege, Ayush Giri, Vinicius Tragante, Gudmar Thorleifsson, Dajiang J Liu, Bram P Prins, Isobel D Stewart, Claudia P Cabrera, James M Eales, Artur Akbarov, Paul L Auer, Lawrence F Bielak, Joshua C Bis, Vickie S Braithwaite, Jennifer A Brody, E Warwick Daw, Helen R Warren, Fotios Drenos, Sune Fallgaard Nielsen, Jessica D Faul, Eric B Fauman, Cristiano Fava, Teresa Ferreira, Christopher N Foley, Nora Franceschini, He Gao, Olga Giannakopoulou, Franco Giulianini, Daniel F Gudbjartsson, Xiuqing Guo, Sarah E Harris, Aki S Havulinna, Anna Helgadottir, Jennifer E Huffman, Shih-Jen Hwang, Stavroula Kanoni, Jukka Kontto, Martin G Larson, Ruifang Li-Gao, Jaana Lindström, Luca A Lotta, Yingchang Lu, Jian'an Luan, Anubha Mahajan, Giovanni Malerba, Nicholas GD Masca, Hao Mei, Cristina Menni, Dennis O Mook-Kanamori, David Mosen-Ansorena, Martina Müller-Nurasyid, Guillaume Paré, Dirk S Paul, Markus Perola, Alaitz Poveda, Rainer Rauramaa, Melissa Richard, Tom G Richardson, Nuno Sepúlveda, Xueling Sim, Albert V Smith, Jennifer A Smith, James R Staley, Alena Stanáková, Patrick Sulem, Sébastien Thériault, Unnur Thorsteinsdottir, Stella Trompet, Tibor V Varga, Digna R Velez Edwards, Giovanni Veronesi, Stefan Weiss, Sara M Willems, Jie Yao, Robin Young, Bing Yu, Weihua Zhang, Jing-Hua Zhao, Wei Zhao, Wei Zhao, Evangelos Evangelou, Stefanie Aeschbacher, Eralda Asllanaj, Stefan Blankenberg, Lori L Bonnycastle, Jette Bork-Jensen, Ivan Brandslund, Peter S Braund, Stephen Burgess, Kelly Cho, Cramer Christensen, John Connell, Renée de Mutsert, Anna F Dominiczak, Marcus Dörr, Gudny Eiriksdottir, Aliki-Eleni Farmaki, J Michael Gaziano, Niels Grarup, Megan L Grove, Göran Hallmans, Torben Hansen, Christian T Have, Gerardo Heiss, Marit E Jørgensen, Pekka Jousilahti, Eero Kajantie, Mihir Kamat, AnneMari Käräjämäki, Fredrik Karpe, Heikki A Koistinen, Csaba P Kovesdy, Kari Kuulasmaa, Tiina Laatikainen, Lars Lannfelt, I-Te Lee, Wen-Jane Lee, Lifelines Cohort Study, Allan Linneberg, Lisa W Martin, Marie Moitry, Girish Nadkarni, Matt J Neville, Colin NA Palmer, George J Papanicolaou, Oluf Pedersen, James Peters, Neil Poulter, Asif Rasheed, Katrine L Rasmussen, N William Rayner, Reedik Mägi, Frida Renström, Rainer Rettig, Jacques Rossouw, Pamela J Schreiner, Peter S Sever, Emil L Sigurdsson, Tea Skaaby, Yan V Sun, Johan Sundstrom, Gudmundur Thorgeirsson, Tõnu Esko, Elisabetta Trabetti, Philip S Tsao, Tiinamaija Tuomi, Stephen T Turner, Ioanna Tzoulaki, Ilonca Vaartjes, Anne-Claire Vergnaud, Cristen J Willer, Peter WF Wilson, Daniel R Witte, Ekaterina Yonova-Doing, He Zhang, Naheed Aliya, Peter Almgren, Philippe Amouyel, Folkert W Asselbergs, Michael R Barnes, Alexandra I Blakemore, Michael Boehnke, Michiel L Bots, Erwin P Bottinger, Julie E Buring, John C Chambers, Yii-Der Ida Chen, Rajiv Chowdhury, David Conen, Adolfo Correa, George Davey Smith, Rudolf A de Boer, Ian J Deary, George Dedoussis, Panos Deloukas, Emanuele Di Angelantonio, Paul Elliott, EPIC-CVD, EPIC-InterAct, Stephan B Felix, Jean Ferrières, Ian Ford, Myriam Fornage, Paul W Franks, Stephen Franks, Philippe Frossard, Giovanni Gambaro, Tom R Gaunt, Leif Groop, Vilmundur Gudnason, Tamara B Harris, Caroline Hayward, Branwen J Hennig, Karl-Heinz Herzig, Erik Ingelsson, Jaakko Tuomilehto, Marjo-Riitta Järvelin, J Wouter Jukema, Sharon LR Kardia, Frank Kee, Jaspal S Kooner, Charles Kooperberg, Lenore J Launer, Lars Lind, Ruth JF Loos, Abdulla Al Shafi Majumder, Markku Laakso, Mark I McCarthy, Olle Melander, Karen L Mohlke, Alison D Murray, Børge Grønne Nordestgaard, Marju Orho-Melander, Chris J Packard, Sandosh Padmanabhan, Walter Palmas, Ozren Polasek, David J Porteous, Andrew M Prentice, Michael A Province, Caroline L Relton, Kenneth Rice, Paul M Ridker, Olov Rolandsson, Frits R Rosendaal, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Naveed Sattar, Wayne H-H Sheu, Blair H Smith, Nicole Soranzo, Timothy D Spector, John M Starr, Sylvain Sebert, Kent D Taylor, Timo A Lakka, Nicholas J Timpson, Martin D Tobin, Understanding Society Scientific Group, Pim van der Harst, Peter van der Meer, Vasan S Ramachandran, Niek Verweij, Jarmo Virtamo, Uwe Völker, David R Weir, Eleftheria Zeggini, Fadi J Charchar, Million Veteran Program, Nicholas J Wareham, Claudia Langenberg, Maciej Tomaszewski, Adam S Butterworth, Mark J Caulfield, John Danesh, Todd L Edwards, Hilma Holm, Adriana M Hung, Cecilia M Lindgren, Chunyu Liu, Alisa K Manning, Andrew P Morris, Alanna C Morrison, Christopher J O'Donnell, Bruce M Psaty, Danish Saleheen, Kari Stefansson, Eric Boerwinkle, Daniel I Chasman, Daniel Levy, Christopher Newton-Cheh, Patricia B Munroe, Joanna MM Howson
Nov 04, 2020
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P Cook, Alisa K Manning, Niels Grarup, Xueling Sim, Daniel R Barnes, Kate Witkowska, James R Staley, Vinicius Tragante, Taru Tukiainen, Hanieh Yaghootkar, Nicholas Masca, Daniel F Freitag, Teresa Ferreira, Olga Giannakopoulou, Andrew Tinker, Magdalena Harakalova, Evelin Mihailov, Chunyu Liu, Aldi T Kraja, Sune Fallgaard Nielsen, Asif Rasheed, Maria Samuel, Wei Zhao, Lori L Bonnycastle, Anne U Jackson, Narisu Narisu, Amy J Swift, Lorraine Southam, Jonathan Marten, Jeroen R Huyghe, Alena Stančáková, Cristiano Fava, Therese Ohlsson, Angela Matchan, Kathleen E Stirrups, Jette Bork-Jensen, Anette P Gjesing, Jukka Kontto, Markus Perola, Susan Shaw-Hawkins, Aki S Havulinna, He Zhang, Louise A Donnelly, Christopher J Groves, N William Rayner, Matt J Neville, Neil R Robertson, Andrianos M Yiorkas, Karl-Heinz Herzig, Eero Kajantie, Weihua Zhang, Sara M Willems, Lars Lannfelt, Giovanni Malerba, Nicole Soranzo, Elisabetta Trabetti, Niek Verweij, Evangelos Evangelou, Alireza Moayyeri, Anne-Claire Vergnaud, Christopher P Nelson, Alaitz Poveda, Tibor V Varga, Muriel Caslake, Anton Jm de Craen, Stella Trompet, Jian'an Luan, Robert A Scott, Sarah E Harris, David Cm Liewald, Riccardo Marioni, Cristina Menni, Aliki-Eleni Farmaki, Göran Hallmans, Frida Renström, Jennifer E Huffman, Maija Hassinen, Stephen Burgess, Ramachandran S Vasan, Janine F Felix, CHARGE-Heart Failure Consortium, Maria Uria-Nickelsen, Anders Malarstig, Dermot F Reily, Maarten Hoek, Thomas Vogt, Honghuang Lin, Wolfgang Lieb, EchoGen Consortium, Matthew Traylor, Hugh F Markus, METASTROKE Consortium, Heather M Highland, Anne E Justice, Eirini Marouli, GIANT Consortium, Jaana Lindström, Matti Uusitupa, Pirjo Komulainen, Timo A Lakka, Rainer Rauramaa, Ozren Polasek, Igor Rudan, Olov Rolandsson, Paul W Franks, George Dedoussis, Timothy D Spector, EPIC-InterAct Consortium, Pekka Jousilahti, Satu Männistö, Ian J Deary, John M Starr, Claudia Langenberg, Nick J Wareham, Morris J Brown, Anna F Dominiczak, John M Connell, J Wouter Jukema, Naveed Sattar, Ian Ford, Chris J Packard, Tõnu Esko, Reedik Mägi, Andres Metspalu, Rudolf A de Boer, Peter van der Meer, Pim van der Harst, Lifelines Cohort Study, Giovanni Gambaro, Erik Ingelsson, Lars Lind, Paul IW de Bakker, Mattijs E Numans, Ivan Brandslund, Cramer Christensen, Eva Rb Petersen, Eeva Korpi-Hyövälti, Heikki Oksa, John C Chambers, Jaspal S Kooner, Alexandra If Blakemore, Steve Franks, Marjo-Riitta Jarvelin, Lise L Husemoen, Allan Linneberg, Tea Skaaby, Betina Thuesen, Fredrik Karpe, Jaakko Tuomilehto, Alex SF Doney, Andrew D Morris, Colin NA Palmer, Oddgeir Lingaas Holmen, Kristian Hveem, Cristen J Willer, Tiinamaija Tuomi, Leif Groop, AnneMari Käräjämäki, Aarno Palotie, Samuli Ripatti, Veikko Salomaa, Dewan S Alam, Abdulla Al Shafi Majumder, Emanuele Di Angelantonio, Rajiv Chowdhury, Mark I McCarthy, Neil Poulter, Alice V Stanton, Peter Sever, Philippe Amouyel, Dominique Arveiler, Stefan Blankenberg, Jean Ferrières, Frank Kee, Kari Kuulasmaa, Martina Müller-Nurasyid, Giovanni Veronesi, Jarmo Virtamo, Panos Deloukas, Wellcome Trust Case Control Consortium, Paul Elliott, Understanding Society Scientific Group, Eleftheria Zeggini, Sekar Kathiresan, Olle Melander, Johanna Kuusisto, Markku Laakso, Sandosh Padmanabhan, David Porteous, Caroline Hayward, Generation Scotland, Francis S Collins, Karen L Mohlke, Torben Hansen, Oluf Pedersen, Michael Boehnke, Heather M Stringham, EPIC-CVD Consortium, Philippe Frossard, Christopher Newton-Cheh, CHARGE+ Exome Chip Blood Pressure Consortium, Martin D Tobin, Børge Grønne Nordestgaard, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium, CHD Exome+ Consortium, Mark J Caulfield, Anubha Mahajan, Andrew P Morris, Maciej Tomaszewski, Nilesh J Samani, Danish Saleheen, Folkert W Asselbergs, Cecilia M Lindgren, John Danesh, Louise V Wain, Adam S Butterworth, Joanna MM Howson, Patricia B Munroe
Jun 15, 2016
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renée de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dörr, Fotios Drenos, Marie-Pierre Dubé, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Krämer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian'an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O'Connell, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Ewing, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Vuckovic, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, Fernando Rivadeneira, Ingrid B Borecki, J Andrew Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltán Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-GENES Consortium, MAGIC Investigators
Mar 06, 2019
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted...
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Valérie Turcot, Yingchang Lu, Heather M Highland, Claudia Schurmann, Anne E Justice, Rebecca S Fine, Jonathan P Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L Young, Tamuno Alfred, Mary F Feitosa, Nicholas GD Masca, Alisa K Manning, Carolina Medina-Gomez, Poorva Mudgal, Maggie CY Ng, Alex P Reiner, Sailaja Vedantam, Sara M Willems, Thomas W Winkler, Gonçalo Abecasis, Katja K Aben, Dewan S Alam, Sameer E Alharthi, Matthew Allison, Philippe Amouyel, Folkert W Asselbergs, Paul L Auer, Beverley Balkau, Lia E Bang, Inês Barroso, Lisa Bastarache, Marianne Benn, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Jette Bork-Jensen, Michiel L Bots, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Gerome Breen, Murray H Brilliant, Linda Broer, Marco Brumat, Amber A Burt, Adam S Butterworth, Peter T Campbell, Stefania Cappellani, David J Carey, Eulalia Catamo, Mark J Caulfield, John C Chambers, Daniel I Chasman, Yii-Der I Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Massimiliano Cocca, Francis S Collins, James P Cook, Janie Corley, Jordi Corominas Galbany, Amanda J Cox, David S Crosslin, Gabriel Cuellar-Partida, Angela D'Eustacchio, John Danesh, Gail Davies, Paul IW Bakker, Mark CH Groot, Renée Mutsert, Ian J Deary, George Dedoussis, Ellen W Demerath, Martin Heijer, Anneke I Hollander, Hester M Ruijter, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Fotios Drenos, Mengmeng Du, Marie-Pierre Dubé, Alison M Dunning, Douglas F Easton, Todd L Edwards, David Ellinghaus, Patrick T Ellinor, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, I Sadaf Farooqi, Jessica D Faul, Sascha Fauser, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Ian Ford, Myriam Fornage, Oscar H Franco, Andre Franke, Paul W Franks, Nele Friedrich, Ruth Frikke-Schmidt, Tessel E Galesloot, Wei Gan, Ilaria Gandin, Paolo Gasparini, Jane Gibson, Vilmantas Giedraitis, Anette P Gjesing, Penny Gordon-Larsen, Mathias Gorski, Hans-Jörgen Grabe, Struan FA Grant, Niels Grarup, Helen L Griffiths, Megan L Grove, Vilmundur Gudnason, Stefan Gustafsson, Jeff Haessler, Hakon Hakonarson, Anke R Hammerschlag, Torben Hansen, Kathleen Mullan Harris, Tamara B Harris, Andrew T Hattersley, Christian T Have, Caroline Hayward, Liang He, Nancy L Heard-Costa, Andrew C Heath, Iris M Heid, Øyvind Helgeland, Jussi Hernesniemi, Alex W Hewitt, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Paul L Huang, Jennifer E Huffman, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Jan-Håkan Jansson, Gail P Jarvik, Gorm B Jensen, Yucheng Jia, Stefan Johansson, Marit E Jørgensen, Torben Jørgensen, J Wouter Jukema, Bratati Kahali, René S Kahn, Mika Kähönen, Pia R Kamstrup, Stavroula Kanoni, Jaakko Kaprio, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Sekar Kathiresan, Frank Kee, Lambertus A Kiemeney, Eric Kim, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Charles Kooperberg, Tellervo Korhonen, Peter Kovacs, Helena Kuivaniemi, Zoltán Kutalik, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Ethan M Lange, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Yongmei Liu, Ken S Lo, Artitaya Lophatananon, Andrew J Lotery, Anu Loukola, Jian'an Luan, Steven A Lubitz, Leo-Pekka Lyytikäinen, Satu Männistö, Gaëlle Marenne, Angela L Mazul, Mark I McCarthy, Roberta McKean-Cowdin, Sarah E Medland, Karina Meidtner, Lili Milani, Vanisha Mistry, Paul Mitchell, Karen L Mohlke, Leena Moilanen, Marie Moitry, Grant W Montgomery, Dennis O Mook-Kanamori, Carmel Moore, Trevor A Mori, Andrew D Morris, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Mike A Nalls, Narisu Narisu, Christopher P Nelson, Matt Neville, Sune F Nielsen, Kjell Nikus, Pål R Njølstad, Børge G Nordestgaard, Dale R Nyholt, Jeffrey R O'Connel, Michelle L O'Donoghue, Loes M Olde Loohuis, Roel A Ophoff, Katharine R Owen, Chris J Packard, Sandosh Padmanabhan, Colin NA Palmer, Nicholette D Palmer, Gerard Pasterkamp, Aniruddh P Patel, Alison Pattie, Oluf Pedersen, Peggy L Peissig, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Thomas N Person, Annette Peters, Eva Rb Petersen, Patricia A Peyser, Ailith Pirie, Ozren Polasek, Tinca J Polderman, Hannu Puolijoki, Olli T Raitakari, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Frida Renström, Myriam Rheinberger, Paul M Ridker, John D Rioux, Manuel A Rivas, David J Roberts, Neil R Robertson, Antonietta Robino, Olov Rolandsson, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Yadav Sapkota, Naveed Sattar, Robert E Schoen, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Svati H Shah, Wayne H-H Sheu, Xueling Sim, Andrew J Slater, Kerrin S Small, Albert V Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Amy J Swift, Hayato Tada, Katherine E Tansey, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Gerard Tromp, Stella Trompet, Emmanouil Tsafantakis, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Jonathan P Tyrer, Rudolf Uher, André G Uitterlinden, Matti Uusitupa, Sander W Laan, Cornelia M Duijn, Nienke Leeuwen, Jessica van Setten, Mauno Vanhala, Anette Varbo, Tibor V Varga, Rohit Varma, Digna R Velez Edwards, Sita H Vermeulen, Giovanni Veronesi, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Uwe Völker, Dragana Vuckovic, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Wang, Erin B Ware, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Daniel R Witte, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Pang Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, Wei Zhao, Wei Zhou, Krina T Zondervan, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-GENES Consortium, MAGIC Investigators, Understanding Society Scientific Group, Jerome I Rotter, John A Pospisilik, Fernando Rivadeneira, Ingrid B Borecki, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Kari E North, Cecilia M Lindgren, Joel N Hirschhorn, Ruth JF Loos
Feb 05, 2018
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing...