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Plasticity of the Nuclear Pore Complex Revealed With Proteomics
Zhanna Hakhverdyan
Jan 01, 0001
Cellular functions are performed by the concerted action of macromolecular assemblies. These protein machines rarely have permanent, invariable structures. Instead, the subunits forming the macromolecular assemblies exchange...
Published by: Rockefeller University
Biophysical Characterization of Structure and Dynamics of Nuclear Pore Complex Components
Martin Kampmann
Jan 01, 0001
The Nuclear Pore Complex (NPC) mediates nucleo-cytoplasmic transport in all eukaryotes and is among the largest cellular assemblies of proteins, called nucleoporins (nups). The details of NPC architecture, dynamics, and...
nuclear pore complex Electron microscopy Nup84 complex structural biology fluorescence anisotropy polarized fluorescence microscopy Life Sciences
Published by: Rockefeller University
Channel nuclear pore complex subunits are required for transposon silencing in Drosophila.
Marzia Munafò, Victoria R Lawless, Alessandro Passera, Serena MacMillan, Susanne Bornelöv, Irmgard U Haussmann, Matthias Soller, Gregory J Hannon, Benjamin Czech
Jul 05, 2021
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective...
D. melanogaster Cell Biology Chromosomes Gene Expression nuclear pore complex nucleoporins piRNAs piwi-interacting RNAs RNA export transposon silencing Animals Animals Genetically Modified Cell Line DNA Transposable Elements Drosophila Proteins Drosophila melanogaster Female Gene Expression Regulation Nuclear Pore Nuclear Pore Complex Proteins Nucleocytoplasmic Transport Proteins Ovary RNA Interference RNA Long Noncoding RNA Small Interfering
Conformational Dynamics of the Nuclear Pore Complex Studied With Coarse-Grained Modelling and Polarized Light Microscopy
Joan Pulupa
Jan 01, 0001
In my thesis work, I explored the organization and dynamics of the nuclear pore complex (NPC) through coarse-grained modelling and polarized-total internal reflection fluorescence (pol-TIRF) microscopy. The NPC is a large (~120...
Published by: Rockefeller University
Engineering the Photoresponse of InAs Nanowires.
Jack A Alexander-Webber, Catherine K Groschner, Abhay A Sagade, Gregory Tainter, M Fernando Gonzalez-Zalba, Riccardo Di Pietro, Jennifer Wong-Leung, H Hoe Tan, Chennupati Jagadish, Stephan Hofmann, Hannah J Joyce
Feb 09, 2018
We report on individual-InAs nanowire optoelectronic devices which can be tailored to exhibit either negative or positive photoconductivity (NPC or PPC). The NPC photoresponse time and magnitude is found to be highly tunable by...
Structure and Organization of Nuclear Pore Proteins
Claire Atkinson
Jan 01, 0001
The nuclear pore complex (NPC) is a large macromolecular assembly that controls the flow of molecules between the nucleus and the cytoplasm. Elucidating the structure and organization of this complex will be crucial to...
Published by: Rockefeller University
Proteomic, Bioinformatic and Functional Characterization of the Nuclear Pore Complex of the African Trypanosome
Jeffrey Allen DeGrasse
Jan 01, 0001
The eukaryotic genome, and its associated proteins, is intricately packaged and sequestered within the boundary of a double membrane, known as the nuclear envelope (NE). Transport across the NE is mediated by large protein...
Published by: Rockefeller University
Ouk ´Ismen Oudén
Geoffrey Horrocks
Oct 05, 2013
In Ancient Greek a single set of indefinite enclitic pronouns was used indifferently in both negative/affective environments (i.e. like negative polarity items (NPI)) and in positive ones (i.e. like positive polarity items...
Biochemical Analysis of the Protein-Protein Interactions Involved in Karyopherin-Mediated Transport Across the Nuclear Pore Complex
Jaclyn Tetenbaum-Novatt
Jan 01, 0001
Nucleocytoplasmic transport occurs through the nuclear pore complex (NPC), which in yeast is a highly symmetric ~50 MDa complex consisting of approximately 30 different proteins. Small molecules can freely exchange through the...
Published by: Rockefeller University
Mechanism of Nuclear Protein Import and Export an In Vitro Approach
Monique Floer
Jan 01, 0001
Protein import and export into and out of the cell nucleus requires a signal in the protein to be transported. Furthermore, several factors are involved in recognition of the signal, delivery of the protein to the nuclear pore...
Published by: Rockefeller University
Why and how to apply Weber's Law to coevolution and mimicry
Abstract: In mimicry systems, receivers discriminate between the stimuli of models and mimics. Weber's Law of proportional processing states that receiver discrimination is based on proportional, not absolute, differences...
perspective avian brood parasitism coevolution mimicry proportional processing receiver perception stimulus magnitude
Published by: Evolution
Architecture of a Coat for the Nuclear Pore Membrane
Kuo-Chiang Hsia
Jan 01, 0001
Nuclear pore complexes (NPCs) reside in the nuclear membrane and mediate macromolecules exchange between the nucleus and cytoplasm. Although the protein components of NPCs, termed collectively nucleoporin, have been identified...
Published by: Rockefeller University
Conflict within species determines the value of a mutualism between species.
Mutually beneficial interactions between species play a key role in maintaining biodiversity and ecosystem function. Nevertheless, such mutualisms can erode into antagonistic interactions. One explanation is that the fitness...
Use of Semantic Technologies to Inform Progress Toward Zero-Carbon Economy
To investigate the effect of possible changes to decarbonise the economy, a detailed picture of the current production system is needed. Material/energy flow analysis (MEFA) allows for building such a model. There are, however...
Use of Semantic Technologies to Inform Progress Toward Zero-Carbon Economy
To investigate the effect of possible changes to decarbonise the economy, a detailed picture of the current production system is needed. Material/energy flow analysis (MEFA) allows for building such a model. There are, however...
Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.
Jennifer N Dulin, Andrew F Adler, Hiromi Kumamaru, Gunnar HD Poplawski, Corinne Lee-Kubli, Hans Strobl, Daniel Gibbs, Ken Kadoya, James W Fawcett, Paul Lu, Mark H Tuszynski
May 10, 2018
Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of reciprocal connections between host and graft. While it has been...
Identification and Characterization of Mlp1p and Mlp2p : Molecular Components of Filaments Localized at the Interface between the Nuclear Pore Complex and Nuclear Interior
Caterina Strambio-De-Castillia
Jan 01, 0001
In eukaryotic cells the segregation of the genome in a closed organelle requires an efficient mechanism to ensure the constant exchange of material between the nucleus and the cytoplasm. Nuclear pore complexes (NPCs) provide the...
Published by: Rockefeller University
Collaboration enhances career progression in academic science, especially for female researchers.
Collaboration and diversity are increasingly promoted in science. Yet how collaborations influence academic career progression, and whether this differs by gender, remains largely unknown. Here, we use co-authorship ego networks...
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