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Neuroserpin Inclusion Bodies in a FENIB Yeast Model.
Valentina Vapore, Corrado Mazzaglia, Diego Sibilia, Mara Del Vecchio, Gernot Fruhmann, Marta Valenti, Elena Miranda, Teresa Rinaldi, Joris Winderickx, Cristina Mazzoni
Jul 28, 2021
FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized by the intracellular deposition of polymers of neuroserpin (NS), which...
In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells.
Laura Ostermann, Julia Ladewig, Franz-Josef Müller, Jaideep Kesavan, Jignesh Tailor, Austin Smith, Oliver Brüstle, Philipp Koch
Aug 21, 2019
During nervous system development, early neuroepithelial stem (NES) cells with a highly polarized morphology and responsiveness to regionalizing morphogens give rise to radial glia (RG) cells, which generate region-specific...
Outcomes of Patients with Nelson's Syndrome after Primary Treatment
Athanasios Fountas, Eugenie S Lim, William M Drake, Andrew S Powlson, Mark Gurnell, Niamh M Martin, Khyatisha Seejore, Robert D Murray, James MacFarlane, Rupa Ahluwalia, Francesca Swords, Muhammad Ashraf, Aparna Pal, Zhuomin Chong, Marie Freel, Tala Balafshan, Tejpal S Purewal, Rowena G Speak, John Newell-Price, Claire E Higham, Ziad Hussein, Stephanie E Baldeweg, Jolyon Dales, Narendra Reddy, Miles J Levy, Niki Karavitaki
Dec 16, 2019
CONTEXT: Long-term outcomes of patients with Nelson's syndrome (NS) have been poorly explored, especially in the modern era. OBJECTIVE: To elucidate tumor control rates, effectiveness of various treatments, and markers of...
Cushing’s Nelson’s syndrome bilateral adrenalectomy tumor progression ACTH-Secreting Pituitary Adenoma Adenoma Adolescent Adult Aged Biomarkers Tumor Child Cohort Studies Female Follow-Up Studies Humans Male Middle Aged Nelson Syndrome Neoadjuvant Therapy Prognosis Retrospective Studies Treatment Outcome United Kingdom Young Adult
Meeting the support needs of patients with complex regional pain syndrome through innovative use of wiki technology
Background: Using online discussion forums can have a positive impact on psychological well-being through development of shared group identity and validation of thoughts, feelings and experiences. This may be particularly...
Meeting the support needs of patients with complex regional pain syndrome through innovative use of wiki technology
Background: Using online discussion forums can have a positive impact on psychological well-being through development of shared group identity and validation of thoughts, feelings and experiences. This may be particularly...
Polycarboxylate / nanosilica modified quaternary cement formulations - enhancements and limitations
The effect of polycarboxylate/nanosilica (nS) particles in quaternary cement formulations comprising Portland cement (PC), limestone powder (LS) and fly ash (FA) was investigated for the first time. The reference formulation...
A long-lived neutron star merger remnant in GW170817
L. Piro, Bing Zhang, Eleanora Troja, Geoffrey Ryan, Hendrik Van Eerten, R Ricci, M. H. Wieringa, A. Tiengo, N Butler, S. B. Cenko, O. D. Fox, H. G. Khandrika, G. Novara, T. Sakamoto
Feb 01, 2019
Multimessenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field B ≈ 1012 G is fully...
Nested sampling for materials
Abstract: We review the materials science applications of the nested sampling (NS) method, which was originally conceived for calculating the evidence in Bayesian inference. We describe how NS can be adapted to sample the...
Getting out and about in older adults
Mark G Davis, Kenneth R Fox, Melvyn Hillsdon, Jo C Coulson, Debbie J Sharp, Afroditi Stathi, Janice L Thompson
Oct 21, 2011
Background: A key public health objective is increasing health-enhancing physical activity (PA) for older adults (OAs). Daily trip frequency is independently associated with objectively assessed PA volumes (OAs). Little is...
Five vortex equations
NS Manton
Apr 28, 2017
The Taubes equation for Abelian Higgs vortices is generalised to five distinct U(1) vortex equations. These include the Popov and Jackiw–Pi vortex equations, and two further equations. The Baptista metric, a conformal rescaling...
Polycarboxylate / nanosilica modified quaternary cement formulations - enhancements and limitations
The effect of polycarboxylate/nanosilica (nS) particles in quaternary cement formulations comprising Portland cement (PC), limestone powder (LS) and fly ash (FA) was investigated for the first time. The reference formulation...
Objective indicators of physical activity and sedentary time and associations with subjective well-being in adults aged 70 and over
Janet Withall, Afroditi Stathi, Mark Davis, Jo Coulson, Janice L Thompson, Kenneth R Fox
Jan 02, 2014
This study explored the associations of the volume and intensity of physical activity and the volume of sedentary time with subjective well-being in a diverse group of 228 older adults in the UK (111 female, mean age 78.2 years...
A systematic review on the efficacy of tranexamic acid in head and neck surgery
Warda Jamshaid, Maryam Jamshaid, Chris Coulson, Neil Sharma, Jameel Muzaffar, Hannah Nieto
Apr 12, 2023
Background: Intraoperative and postoperative blood loss is a major risk in head and neck (H&N) surgery. Recently the use of tranexamic acid (TXA) has been investigated by multiple studies for reducing intraoperative and...
Nested sampling for materials
Abstract
We review the materials science applications of the nested sampling (NS) method, which was originally conceived for calculating the evidence in...
Quantum statistical mechanics of vortices
Abstract
The asymptotic partition function for quantized abelian Higgs vortices at high temperature T is found to leading and subleading order, and from...
NS Manton
Jul 18, 2022
Tetrahedral intrinsic structure of Oxygen-16 revisited
Abstract
A model for vibrational and rotational excitations of an intrinsic tetrahedral structure of the Oxygen-16 nucleus has been investigated, building on classic work of...
A long-lived neutron star merger remnant in GW170817
L. Piro, Bing Zhang, Eleanora Troja, Geoffrey Ryan, Hendrik Van Eerten, R Ricci, M. H. Wieringa, A. Tiengo, N Butler, S. B. Cenko, O. D. Fox, H. G. Khandrika, G. Novara, T. Sakamoto
Feb 01, 2019
Multimessenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field B ≈ 1012 G is fully...
Resolving MISS conceptions and misconceptions
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