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Results: 357
Neuroserpin Inclusion Bodies in a FENIB Yeast Model.
Valentina Vapore, Corrado Mazzaglia, Diego Sibilia, Mara Del Vecchio, Gernot Fruhmann, Marta Valenti, Elena Miranda, Teresa Rinaldi, Joris Winderickx, Cristina Mazzoni
Jul 28, 2021
FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized by the intracellular deposition of polymers of neuroserpin (NS), which...
In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells.
Laura Ostermann, Julia Ladewig, Franz-Josef Müller, Jaideep Kesavan, Jignesh Tailor, Austin Smith, Oliver Brüstle, Philipp Koch
Aug 21, 2019
During nervous system development, early neuroepithelial stem (NES) cells with a highly polarized morphology and responsiveness to regionalizing morphogens give rise to radial glia (RG) cells, which generate region-specific...
Regional disparities and seasonal differences in climate risk to rice labour.
The 880 million agricultural workers of the world are especially vulnerable to increasing heat stress due to climate change, affecting the health of individuals and reducing labour productivity. In this study, we focus on rice...
Outcomes of Patients with Nelson's Syndrome after Primary Treatment
Athanasios Fountas, Eugenie S Lim, William M Drake, Andrew S Powlson, Mark Gurnell, Niamh M Martin, Khyatisha Seejore, Robert D Murray, James MacFarlane, Rupa Ahluwalia, Francesca Swords, Muhammad Ashraf, Aparna Pal, Zhuomin Chong, Marie Freel, Tala Balafshan, Tejpal S Purewal, Rowena G Speak, John Newell-Price, Claire E Higham, Ziad Hussein, Stephanie E Baldeweg, Jolyon Dales, Narendra Reddy, Miles J Levy, Niki Karavitaki
Dec 16, 2019
CONTEXT: Long-term outcomes of patients with Nelson's syndrome (NS) have been poorly explored, especially in the modern era. OBJECTIVE: To elucidate tumor control rates, effectiveness of various treatments, and markers of...
Cushing’s Nelson’s syndrome bilateral adrenalectomy tumor progression ACTH-Secreting Pituitary Adenoma Adenoma Adolescent Adult Aged Biomarkers Tumor Child Cohort Studies Female Follow-Up Studies Humans Male Middle Aged Nelson Syndrome Neoadjuvant Therapy Prognosis Retrospective Studies Treatment Outcome United Kingdom Young Adult
Polycarboxylate / nanosilica modified quaternary cement formulations - enhancements and limitations
The effect of polycarboxylate/nanosilica (nS) particles in quaternary cement formulations comprising Portland cement (PC), limestone powder (LS) and fly ash (FA) was investigated for the first time. The reference formulation...
A long-lived neutron star merger remnant in GW170817
L. Piro, Bing Zhang, Eleanora Troja, Geoffrey Ryan, Hendrik Van Eerten, R Ricci, M. H. Wieringa, A. Tiengo, N Butler, S. B. Cenko, O. D. Fox, H. G. Khandrika, G. Novara, T. Sakamoto
Feb 01, 2019
Multimessenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field B ≈ 1012 G is fully...
Nested sampling for materials
Abstract: We review the materials science applications of the nested sampling (NS) method, which was originally conceived for calculating the evidence in Bayesian inference. We describe how NS can be adapted to sample the...
Five vortex equations
NS Manton
Apr 28, 2017
The Taubes equation for Abelian Higgs vortices is generalised to five distinct U(1) vortex equations. These include the Popov and Jackiw–Pi vortex equations, and two further equations. The Baptista metric, a conformal rescaling...
Polycarboxylate / nanosilica modified quaternary cement formulations - enhancements and limitations
The effect of polycarboxylate/nanosilica (nS) particles in quaternary cement formulations comprising Portland cement (PC), limestone powder (LS) and fly ash (FA) was investigated for the first time. The reference formulation...
Nested sampling for materials
Abstract
We review the materials science applications of the nested sampling (NS) method, which was originally conceived for calculating the evidence in...
Quantum statistical mechanics of vortices
Abstract
The asymptotic partition function for quantized abelian Higgs vortices at high temperature T is found to leading and subleading order, and from...
NS Manton
Jul 18, 2022
Tetrahedral intrinsic structure of Oxygen-16 revisited
Abstract
A model for vibrational and rotational excitations of an intrinsic tetrahedral structure of the Oxygen-16 nucleus has been investigated, building on classic work of...
A long-lived neutron star merger remnant in GW170817
L. Piro, Bing Zhang, Eleanora Troja, Geoffrey Ryan, Hendrik Van Eerten, R Ricci, M. H. Wieringa, A. Tiengo, N Butler, S. B. Cenko, O. D. Fox, H. G. Khandrika, G. Novara, T. Sakamoto
Feb 01, 2019
Multimessenger observations of GW170817 have not conclusively established whether the merger remnant is a black hole (BH) or a neutron star (NS). We show that a long-lived magnetized NS with a poloidal field B ≈ 1012 G is fully...
Resolving MISS conceptions and misconceptions
Cuttlefish retrieve whether they smelt or saw a previously encountered item.
According to the Source Monitoring Framework, the origin of a memory is remembered through the retrieval of specific features (e.g. perceptive, sensitive, affective signals). In two source discrimination tasks, we studied the...
Iterated ϕ <sup>4</sup> kinks
A first order equation for a static ${\phi}^4$ kink in the presence of an
impurity is extended into an iterative scheme. At the first iteration, the
solution is the standard kink, but at the second iteration the kink...
Tetrahedral intrinsic structure of Oxygen-16 revisited
Abstract
A model for vibrational and rotational excitations of an intrinsic tetrahedral structure of the Oxygen-16 nucleus has been investigated, building on classic work of...
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.
Alejandro Sifrim, Marc-Phillip Hitz, Anna Wilsdon, Jeroen Breckpot, Saeed H Al Turki, Bernard Thienpont, Jeremy McRae, Tomas W Fitzgerald, Tarjinder Singh, Ganesh Jawahar Swaminathan, Elena Prigmore, Diana Rajan, Hashim Abdul-Khaliq, Siddharth Banka, Ulrike MM Bauer, Jamie Bentham, Felix Berger, Shoumo Bhattacharya, Frances Bu'Lock, Natalie Canham, Irina-Gabriela Colgiu, Catherine Cosgrove, Helen Cox, Ingo Daehnert, Allan Daly, John Danesh, Alan Fryer, Marc Gewillig, Emma Hobson, Kirstin Hoff, Tessa Homfray, INTERVAL Study, Anne-Karin Kahlert, Ami Ketley, Hans-Heiner Kramer, Katherine Lachlan, Anne Katrin Lampe, Jacoba J Louw, Ashok Kumar Manickara, Dorin Manase, Karen P McCarthy, Kay Metcalfe, Carmel Moore, Ruth Newbury-Ecob, Seham Osman Omer, Willem H Ouwehand, Soo-Mi Park, Michael J Parker, Thomas Pickardt, Martin O Pollard, Leema Robert, David J Roberts, Jennifer Sambrook, Kerry Setchfield, Brigitte Stiller, Chris Thornborough, Okan Toka, Hugh Watkins, Denise Williams, Michael Wright, Seema Mital, Piers EF Daubeney, Bernard Keavney, Judith Goodship, UK10K consortium, Riyadh Mahdi Abu-Sulaiman, Sabine Klaassen, Caroline F Wright, Helen V Firth, Jeffrey C Barrett, Koenraad Devriendt, David R FitzPatrick, J David Brook, Deciphering Developmental Disorders Study, Matthew E Hurles
Nov 20, 2017
Congenital heart defects (CHDs) have a neonatal incidence of 0.8-1% (refs. 1,2). Despite abundant examples of monogenic CHD in humans and mice, CHD has a low absolute sibling recurrence risk (∼2.7%), suggesting a considerable...
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