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IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing.
HIV-1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of delivering its genome into the host nucleus. Here, we show that viruses that are unable to package IP6 lack capsid protection and are detected by...
A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly.
Nadine Renner, Donna L Mallery, KM Rifat Faysal, Wang Peng, David A Jacques, Till Böcking, Leo C James
Feb 01, 2021
The HIV capsid self-assembles a protective conical shell that simultaneously prevents host sensing whilst permitting the import of nucleotides to drive DNA synthesis. This is accomplished through the construction of dynamic...
Psychophysiological reactivity, coping behaviour and intrusive memories upon multisensory Virtual Reality and Script-Driven Imagery analogue trauma
Tina Schweizer, Fritz Renner, Dali Sun, Birgit Kleim, Emily A Holmes, Brunna Tuschen-Caffier
Jan 11, 2019
BACKGROUND: Peri- and post-traumatic factors predict the differential development of stress-associated mental disorders. Prospective designs assessing these risk factors in real-time under controlled experimental conditions can...
Guided mental imagery Post-traumatic stress Psychopathology Risk Factors Stress and coping measures virtual reality Adaptation Psychological Arousal Cross-Over Studies Female Humans Imagery Psychotherapy Male Memory Prospective Studies Psychological Trauma Psychophysiology virtual reality Young Adult
The Ursinus Weekly, October 28, 1963
Sharon E. Robbins, John Bradley, Susan Bell, Carl F. Peek, Otto W. Renner, Craig Garner, Robert Livingston
Jan 01, 0001
69 women pledge sororities at bid signing Saturday Class of 1966 to sell slaves at Bazaar Annual Founders Day November 3; Five honorary degrees to be awarded Navy debate team bows UC 31-29 Young Democrats begin activities ...
Ursinus College Collegeville Pennsylvania newspaper sororities pledging Debating team Young Democrats Bazaar Halloween reading night Ruby Founders Day John M. Cummings Richard S. Schweiker Paul Crawford Scheirer Alfred L. Taxis Nobushige Ukai Brownback-Anders pre-medical society University of Hawaii Barry Goldwater YMCA YWCA Alan Paton Human Relations Commission librarianship career conference fraternities Football Anthony Sermarini Frank Videon Soccer field hockey cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
An attention-based view of family firm adaptation to discontinuous technologies
Recent studies show that managerial attention is a particularly important precursor of established firms’ responses to discontinuous technological change. However, little is known about the factors that shape managerial...
An attention-based view of family firm adaptation to discontinuous technologies
Recent studies show that managerial attention is a particularly important precursor of established firms’ responses to discontinuous technological change. However, little is known about the factors that shape managerial...
Mental imagery as a "motivational amplifier" to promote activities.
Facilitating engagement in rewarding activities is a key treatment target in depression. Mental imagery can increase engagement in planned behaviours, potentially due to its special role in representing emotionally salient...
Canadian Wraparound
For youth in the care of child welfare, the need for a greater emphasis on service integration and youth-centered approaches is widely agreed. This case study examined an implementation of the Wraparound approach, which focuses...
Published by: Memorial University of Newfoundland
Canadian Wraparound
For youth in the care of child welfare, the need for a greater emphasis on service integration and youth-centered approaches is widely agreed. This case study examined an implementation of the Wraparound approach, which focuses...
Published by: Memorial University of Newfoundland
Addressing concerns about smoking cessation and mental health
Smoking rates in people with depression and anxiety are twice as high as in the general population, even though people with depression and anxiety are motivated to stop smoking. Most healthcare professionals are aware that...
Current and emerging therapeutic approaches for T-cell acute lymphoblastic leukaemia.
leukaemia novel treatments Antineoplastic Agents Antineoplastic Agents Immunological Apoptosis Arabinonucleosides Bridged Bicyclo Compounds Heterocyclic Cyclin-Dependent Kinases Genetic Heterogeneity Humans Immunotherapy Immunotherapy Adoptive Janus Kinase Inhibitors Molecular Targeted Therapy Neoplasm Proteins Phosphoinositide-3 Kinase Inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Protein Kinase Inhibitors Protein-Tyrosine Kinases Receptor Notch1 Receptors Interleukin-7 Salvage therapy Signal Transduction Sulfonamides therapies Investigational Treatment Outcome
Why do incumbents respond heterogeneously to disruptive innovations? The interplay of domain identity and role identity.
We adopt a multifaceted view of organizational identity to contribute to research on organizational identity and incumbent adaptations to disruptive innovations. Based on a qualitative, multi-case study on the responses of...
Why do incumbents respond heterogeneously to disruptive innovations? The interplay of domain identity and role identity.
We adopt a multifaceted view of organizational identity to contribute to research on organizational identity and incumbent adaptations to disruptive innovations. Based on a qualitative, multi-case study on the responses of...
Addressing concerns about smoking cessation and mental health
Smoking rates in people with depression and anxiety are twice as high as in the general population, even though people with depression and anxiety are motivated to stop smoking. Most healthcare professionals are aware that...
High-pressure synthesis and storage of solid organic compounds in active subduction zones.
Baptiste Debret, Bénédicte Ménez, Bastien Walter, Hélène Bouquerel, Pierre Bouilhol, Nadine Mattielli, Céline Pisapia, Thomas Rigaudier, Helen Myfanwy Williams
Oct 18, 2022
Recent thermodynamic and experimental studies have suggested that volatile organic compounds (e.g., methane, formate, and acetate) can be produced and stabilized in subduction zones, potentially playing an important role in the...
Labour Law, Capitalism and the Juridical Form
Abstract
This article seeks to demonstrate the potential contribution that a closer attention to structural factors can make to our understanding of some of the practical problems...
Zoe Adams
Nov 03, 2020
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