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The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.
Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini
Jul 21, 2022
Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different...
The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.
Michael E Baumgartner, Alex Mastrogiannopoulos, Iwo Kucinski, Paul F Langton, Eugenia Piddini
Aug 20, 2022
Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different...
Proteotoxic stress is a driver of the loser status and cell competition.
Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell competition, cells with a heterozygous mutation in ribosome genes, such as RpS3+/- cells, are eliminated by wild-type cells. How...
Dementia Research
Alzheimer's disease (AD) is a clinicopathologically defined syndrome leading to cognitive impairment. Following the recent failures of amyloid-based randomized controlled trials to change the course of AD, there are growing...
18F-FDG PET for Prediction of Conversion to Alzheimer's Disease Dementia in People with Mild Cognitive Impairment
The Grizzly, February 27, 2001
Lauren Cyrsky, Dan Reimold, Quinn Dinsmore, Patricia Quinn, Cara Nageli, Sarah Napolitan, Jenn Prendiville, Daniel Uszaki, NiPun Suri
Jan 01, 0001
Autopsy Reveals Student's Death Possibly due to Rare Heart Defect Ursinus Community Shocked, Saddened by Student's Passing Ursinus Senior wins Baumgartner Scholarship S&M on MTV a Reality in Near Future ESS Club Presents at...
Ursinus College Collegeville Pennsylvania newspaper Joseph DeLaurentis Roxanne Moore Shawn Witt Mike Keeper Exercise and Sports Science drunk driving pledging cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Synonymous mutation in adenosine triphosphatase copper-transporting beta causes enhanced exon skipping in Wilson disease.
Marlene Panzer, André Viveiros, Benedikt Schaefer, Nadja Baumgartner, Klaus Seppi, Atbin Djamshidian, Theodor Todorov, William JH Griffiths, Eckart Schott, Markus Schuelke, Dennis Eurich, Albert Friedrich Stättermayer, Adrian Bomford, Pierre Foskett, Julia Vodopiutz, Rudolf Stauber, Elke Pertler, Bernhard Morell, Herbert Tilg, Thomas Müller, Stefan Kiechl, Raul Jimenez-Heredia, Karl Heinz Weiss, Si Houn Hahn, Andreas Janecke, Peter Ferenci, Heinz Zoller
Mar 10, 2022
Fluid Intelligence Predicts Novel Rule Implementation in a Distributed Frontoparietal Control Network
Group-based parent training programmes for improving parental psychosocial health.
BACKGROUND: Parental psychosocial health can have a significant effect on the parent-child relationship, with consequences for the later psychological health of the child. Parenting programmes have been shown to have an impact...
¹⁸F-FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
Nadja Smailagic, Marco Vacante, Chris Hyde, Steven Martin, Obioha Ukoumunne, Christos Sachpekidis
Sep 08, 2018
BACKGROUND: ¹⁸F-FDFG uptake by brain tissue as measured by positron emission tomography (PET) is a well-established method for assessment of brain function in people with dementia. Certain findings on brain PET scans can...
Individual and group based parenting programmes for improving psychosocial outcomes for teenage parents and their children.
BACKGROUND: Parenting programmes are a potentially important means of supporting teenage parents and improving outcomes for their children, and parenting support is a priority across most Western countries. This review updates...
Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, Christine Baumgartner, Nicolas Rodondi, William H Smithson, Patricia M Kearney
Mar 02, 2020
Background: While there is an increasing consensus that clinical trial results should be shared with trial participants, there is a lack of evidence on the most appropriate methods. The aim of this study is to use a patient and...
patient and public involvement Research Dissemination SWAT Study Results Study within a trial Clinical trial result dissemination Patient Involvement In Clinical Trials Trial Results.
Published by: HRB Open Research
Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
Craig Ritchie, Nadja Smailagic, Anna H Noel-Storr, Yemisi Takwoingi, Leon Flicker, Sam E Mason, Rupert McShane
Sep 26, 2018
BACKGROUND: According to the latest revised National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (now known as the Alzheimer's Association)...
(11)C-PIB-PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
Shuo Zhang, Nadja Smailagic, Chris Hyde, Anna H Noel-Storr, Yemisi Takwoingi, Rupert McShane, Juan Feng
Oct 10, 2018
BACKGROUND: According to the latest revised National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (now known as the Alzheimer's Association)...
Evaluating Hospital-Based Surveillance for Outbreak Detection in Bangladesh
Birgit Nikolay, Henrik Salje, Katharine Sturm-Ramirez, Eduardo Azziz-Baumgartner, Nusrat Homaira, Makhdum Ahmed, A Danielle Iuliano, Repon C Paul, Mahmudur Rahman, M Jahangir Hossain, Stephen P Luby, Simon Cauchemez, Emily S Gurley
Feb 15, 2021
BACKGROUND: The International Health Regulations outline core requirements to ensure the detection of public health threats of international concern. Assessing the capacity of surveillance systems to detect these threats is...
BN-Substitution in Dithienylpyrenes Prevents Excimer Formation in Solution and in the Solid State.
Yannik Appiarius, Philipp J Gliese, Stephan AW Segler, Pascal Rusch, Jiangbin Zhang, Paul J Gates, Rumpa Pal, Lorraine A Malaspina, Kunihisa Sugimoto, Tim Neudecker, Nadja C Bigall, Simon Grabowsky, Artem A Bakulin, Anne Staubitz
Apr 19, 2022
Boron-nitrogen substitutions in polycyclic aromatic hydrocarbons (PAHs) have a strong impact on the optical properties of the molecules due to a significantly more heterogeneous electron distribution. However, besides these...
Regional cerebral blood flow single photon emission computed tomography for detection of Frontotemporal dementia in people with suspected dementia.
Hilary A Archer, Nadja Smailagic, Christeena John, Robin B Holmes, Yemisi Takwoingi, Elizabeth J Coulthard, Sarah Cullum
Oct 10, 2018
BACKGROUND: In the UK, dementia affects 5% of the population aged over 65 years and 25% of those over 85 years. Frontotemporal dementia (FTD) represents one subtype and is thought to account for up to 16% of all degenerative...
CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
Craig Ritchie, Nadja Smailagic, Anna H Noel-Storr, Obioha Ukoumunne, Emma C Ladds, Steven Martin
Sep 08, 2018
BACKGROUND: Research suggests that measurable change in cerebrospinal fluid (CSF) biomarkers occurs years in advance of the onset of clinical symptoms (Beckett 2010). In this review, we aimed to assess the ability of CSF tau...
Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI).
Ingrid Arevalo-Rodriguez, Nadja Smailagic, Marta Roqué I Figuls, Agustín Ciapponi, Erick Sanchez-Perez, Antri Giannakou, Olga L Pedraza, Xavier Bonfill Cosp, Sarah Cullum
Oct 10, 2018
BACKGROUND: Dementia is a progressive global cognitive impairment syndrome. In 2010, more than 35 million people worldwide were estimated to be living with dementia. Some people with mild cognitive impairment (MCI) will progress...
Blue-Green Color Tunable Solution Processable Organolead Chloride-Bromide Mixed Halide Perovskites for Optoelectronic Applications.
Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a primary care setting.
Dallas P Seitz, Calvin Ch Chan, Hailey T Newton, Sudeep S Gill, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Bruce A Fage
Oct 03, 2018
BACKGROUND: Alzheimer's disease and other forms of dementia are becoming increasingly common with the aging of most populations. The majority of individuals with dementia will first present for care and assessment in primary...
Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a community setting.
Bruce A Fage, Calvin Ch Chan, Sudeep S Gill, Anna H Noel-Storr, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Dallas P Seitz
Oct 03, 2018
BACKGROUND: Alzheimer's disease and related forms of dementia are becoming increasingly prevalent with the aging of many populations. The diagnosis of Alzheimer's disease relies on tests to evaluate cognition and discriminate...
Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia.
Natascha Schaefer, Christoph J Kluck, Kerry L Price, Heike Meiselbach, Nadine Vornberger, Stephan Schwarzinger, Stephanie Hartmann, Georg Langlhofer, Solveig Schulz, Nadja Schlegel, Knut Brockmann, Bryan Lynch, Cord-Michael Becker, Sarah CR Lummis, Carmen Villmann
Sep 02, 2015
assembly biogenesis glycine receptor human hyperekplexia rescue of function subcompartimentalization Amino Acid Sequence Animals COS Cells Child Chlorocebus aethiops Endoplasmic Reticulum Female Golgi Apparatus HEK293 Cells Humans Infant Intracellular Space Male Mice Molecular Sequence Data Neurons Pedigree Protein Structure Secondary Protein Structure Tertiary Receptors Glycine Stiff-Person Syndrome
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