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Results: 52
Multivariate spatio-temporal modelling for assessing Antarctica's present-day contribution to sea-level rise
Antarctica is the world's largest fresh-water reservoir, with the potential to raise sea levels by about 60m. An ice sheet contributes to sea-level rise (SLR) when its rate of ice discharge and/or surface melting exceeds...
Multivariate spatio-temporal modelling for assessing Antarctica's present-day contribution to sea-level rise
Antarctica is the world's largest fresh-water reservoir, with the potential to raise sea levels by about 60m. An ice sheet contributes to sea-level rise (SLR) when its rate of ice discharge and/or surface melting exceeds...
Toxification of polycyclic aromatic hydrocarbons by commensal bacteria from human skin.
Juliane Sowada, Lisa Lemoine, Karsten Schön, Christoph Hutzler, Andreas Luch, Tewes Tralau
Feb 03, 2020
The ubiquitous occurrence of polycyclic aromatic hydrocarbons (PAHs) leads to constant human exposure at low levels. Toxicologically relevant are especially the high-molecular weight substances due to their (pro-)carcinogenic...
Benzo[a]pyrene Cytotoxicity Genotoxicity Microbiome PAHs Polycyclic Aromatic Hydrocarbons Toxification Bacillus licheniformis Cell Line Cell Survival Comet Assay DNA Damage Gas Chromatography-Mass Spectrometry Humans Keratinocytes Metabolic Detoxication Phase I Microbiota Micrococcus luteus Polycyclic Aromatic Hydrocarbons Skin
La Maladie féminine: Genre, hérédité et milieu dans trois romans d'Émile Zola
Emily Shiplett
Jan 01, 0001
After analyzing the effects that heredity and society have on Zola's characters, we will focus more specifically on gender, and the illnesses women develop in the Rougon-Macquart series. Indeed, illnesses are presented very...
Emile Zola Gender women Disease illness Arts and Humanities French and Francophone Language and Literature
Published by: Ursinus College
Mitochondrial and nuclear disease panel (Mito-aND-Panel)
Angela Abicht, Florentine Scharf, Stephanie Kleinle, Ulrike Schön, Elke Holinski-Feder, Rita Horvath, Anna Benet-Pagès, Isabel Diebold
Mar 07, 2019
BACKGROUND: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a robust high-throughput...
NUMTs heteroplasmy detection high-throughput sequencing mitochondrial and nuclear disease panel mitochondrial disorders mtDNA-server Costs and Cost Analysis DNA Mitochondrial Genetic Testing High-Throughput Nucleotide Sequencing Humans Mitochondrial Diseases Sensitivity and Specificity Sequence Analysis DNA
A Systematic Review of the Validity and Reliability of Assessment Tools for Executive Function and Adaptive Function Following Brain Pathology among Children and Adolescents in Low- and Middle-Income Countries.
Kwabena Kusi-Mensah, Nana Dansoah Nuamah, Stephen Wemakor, Joel Agorinya, Ramata Seidu, Charles Martyn-Dickens, Andrew Bateman
Nov 02, 2022
Minimal but increasing number of assessment instruments for Executive functions (EFs) and adaptive functioning (AF) have either been developed for or adapted and validated for use among children in low and middle income...
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing
Nana Mensah, Yue Tang, Shaun Cawthraw, Manal AbuOun, Jackie Fenner, Nicholas R Thomson, Alison E Mather, Liljana Petrovska-Holmes
Jul 01, 2020
BACKGROUND: UK public health organisations perform routine antimicrobial susceptibility tests (ASTs) to characterise the potential for antimicrobial resistance in Salmonella enterica serovars. Genetic determinants of these...
Agar dilution Antimicrobial susceptibility tests Broth microdilution Disk diffusion Salmonella enterica serovar typhimurium whole genome sequencing Anti-Bacterial Agents Drug Resistance Multiple Bacterial Genome Bacterial Genotype Humans Microbial Sensitivity Tests Phenotype Salmonella enterica Salmonella typhimurium Sensitivity and Specificity Serogroup whole genome sequencing
SARCP
In the domain of cyber security, the defence mechanisms of networks have traditionally been placed in a reactionary role. Cyber security professionals are therefore disadvantaged in a cyber-attack situation due to the fact that...
Published by: IGI Global Scientific Publishing
Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis.
The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively...
feedback loop Glycolysis Phosphoenolpyruvate Pyruvate Kinase triosephosphate isomerase Amino Acid Substitution Animals Binding Sites Biocatalysis Crystallography X-Ray Glyceraldehyde 3-Phosphate Glycolysis Humans Kinetics Molecular Dynamics Simulation Phosphoenolpyruvate Protein Binding Protein Structure Tertiary Rabbits Recombinant Proteins Substrate Specificity Triose-Phosphate Isomerase
Identification of visual cortex cell types and species differences using single-cell RNA sequencing.
Jia-Ru Wei, Zhao-Zhe Hao, Chuan Xu, Mengyao Huang, Lei Tang, Nana Xu, Ruifeng Liu, Yuhui Shen, Sarah A Teichmann, Zhichao Miao, Sheng Liu
Jan 05, 2023
Global analysis of cytosine and adenine DNA modifications across the tree of life.
Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, Christoph B Messner, Nicholas Grayson, Floriana Capuano, Michael Mülleder, Markus Ralser
Jul 28, 2022
Interpreting the function and metabolism of enzymatic DNA modifications requires both position-specific and global quantities. Sequencing-based techniques that deliver the former have become broadly accessible, but analytical...
What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.
Jan Heyckendorf, Sönke Andres, Claudio U Köser, Ioana D Olaru, Thomas Schön, Erik Sturegård, Patrick Beckert, Viola Schleusener, Thomas A Kohl, Doris Hillemann, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Stefan Niemann, Christoph Lange, Matthias Merker
Feb 02, 2018
Rapid and accurate drug susceptibility testing (DST) is essential for the treatment of multi- and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of genotypic DST assays with phenotypic DST (pDST)...
Mycobacterium tuberculosis antibiotic resistance Molecular genetics Antitubercular Agents Bacterial Typing Techniques Cohort Studies Drug Resistance Multiple Bacterial Extensively Drug-Resistant Tuberculosis Genome Bacterial Genotype Humans Kanamycin Levofloxacin Microbial Sensitivity Tests Moxifloxacin Mycobacterium tuberculosis Phenotype Rifampin Tuberculosis Multidrug-Resistant whole genome sequencing
Reply to Dookie et al., "Whole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis".
Claudio U Köser, Jan Heyckendorf, Sönke Andres, Ioana D Olaru, Thomas Schön, Erik Sturegård, Patrick Beckert, Viola Schleusener, Thomas A Kohl, Doris Hillemann, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Stefan Niemann, Christoph Lange, Matthias Merker
Sep 17, 2018
We would like to thank Dr. Navisha Dookie and colleagues for their comment and for sharing their view on genotypic drug-susceptibility testing (DST) to predict phenotypic drug-susceptibility for the management of patients with...
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.
Matthias Merker, Thomas A Kohl, Ivan Barilar, Sönke Andres, Philip W Fowler, Erja Chryssanthou, Kristian Ängeby, Pontus Jureen, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Thomas Schön, Florian P Maurer, Timothy Walker, Claudio Köser, Stefan Niemann
Mar 10, 2020
BACKGROUND: A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome...
The return of metabolism
Anna Stincone, Alessandro Prigione, Thorsten Cramer, Mirjam MC Wamelink, Kate Campbell, Eric Cheung, Viridiana Olin-Sandoval, Nana-Maria Grüning, Antje Krüger, Mohammad Tauqeer Alam, Markus A Keller, Michael Breitenbach, Kevin M Brindle, Joshua D Rabinowitz, Markus Ralser
Sep 08, 2014
NADPH Cancer glucose 6‐phosphate dehydrogenase Glycolysis host–pathogen interactions inherited metabolic disease Metabolic Engineering metabolism of infection Metabolomics Oxidative Stress parasitic protozoa pentose phosphate pathway Stem Cells Humans Metabolic Diseases metabolism Pentose Phosphate Pathway
Global analysis of cytosine and adenine DNA modifications across the tree of life.
Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, Christoph B Messner, Nicholas Grayson, Floriana Capuano, Michael Mülleder, Markus Ralser
Sep 02, 2022
Complete pan-plastome sequences enable high resolution phylogenetic classification of sugar beet and closely related crop wild relatives.
Katharina Sielemann, Boas Pucker, Nicola Schmidt, Prisca Viehöver, Bernd Weisshaar, Tony Heitkam, Daniela Holtgräwe
Mar 13, 2022
BACKGROUND: As the major source of sugar in moderate climates, sugar-producing beets (Beta vulgaris subsp. vulgaris) have a high economic value. However, the low genetic diversity within cultivated beets requires introduction of...
The epidemiology of dengue outbreaks in 2016 and 2017 in Ouagadougou, Burkina Faso.
Justin Im, Ruchita Balasubramanian, Moussa Ouedraogo, Lady Rosny Wandji Nana, Ondari D Mogeni, Hyon Jin Jeon, Tayma van Pomeren, Andrea Haselbeck, Jacqueline Kyungah Lim, Kristi Prifti, Stephen Baker, Christian G Meyer, Jerome H Kim, John D Clemens, Florian Marks, Abdramane Bassiahi Soura
Sep 21, 2020
BACKGROUND: Dengue is prevalent in as many as 128 countries with more than 100 million clinical episodes reported annually and four billion people estimated to be at risk. While dengue fever is systematically diagnosed in large...
Unveiling the additive-assisted oriented growth of perovskite crystallite for high performance light-emitting diodes.
Lin Zhu, Hui Cao, Chen Xue, Hao Zhang, Minchao Qin, Jie Wang, Kaichuan Wen, Zewu Fu, Tao Jiang, Lei Xu, Ya Zhang, Yu Cao, Cailing Tu, Ju Zhang, Dawei Liu, Guangbin Zhang, Decheng Kong, Ning Fan, Gongqiang Li, Chang Yi, Qiming Peng, Jin Chang, Xinhui Lu, Nana Wang, Wei Huang, Jianpu Wang
Oct 26, 2021
Solution-processed metal halide perovskites have been recognized as one of the most promising semiconductors, with applications in light-emitting diodes (LEDs), solar cells and lasers. Various additives have been widely used in...
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.
Matthias Merker, Thomas A Kohl, Ivan Barilar, Sönke Andres, Philip W Fowler, Erja Chryssanthou, Kristian Ängeby, Pontus Jureen, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Thomas Schön, Florian P Maurer, Timothy Walker, Claudio Köser, Stefan Niemann
Apr 07, 2020
BACKGROUND:A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome...
Published by: Genome medicine
Wild-Type and Non-Wild-Type Mycobacterium tuberculosis MIC Distributions for the Novel Fluoroquinolone Antofloxacin Compared with Those for Ofloxacin, Levofloxacin, and Moxifloxacin.
Xia Yu, Guirong Wang, Suting Chen, Guomei Wei, Yuanyuan Shang, Lingling Dong, Thomas Schön, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Claudio U Köser, Hairong Huang
Jul 08, 2016
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex
An Exploratory Mixed Method Study on H5P Videos and Video-Related Activities in a MOOC Environment
Martin Ebner, Stefan Thurner, Sandra Schön, Lisa Schirmbrand, Marco Tatschl, Theresa Teschl, Philipp Leitner
Jan 01, 2022
In this paper, an exploratory mixed-method study is presented examining the video-related behavior of participants of a massive open online course (MOOC; N=1.238). Firstly, detailed log-file analysis of six videos has been...
Published by: IGI Global Scientific Publishing
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