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Results: 32
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Oleg Pak, Susan Scheibe, Azadeh Esfandiary, Mareike Gierhardt, Akylbek Sydykov, Angela Logan, Athanasios Fysikopoulos, Florian Veit, Matthias Hecker, Florian Kroschel, Karin Quanz, Alexandra Erb, Katharina Schäfer, Mirja Fassbinder, Nasim Alebrahimdehkordi, Hossein A Ghofrani, Ralph T Schermuly, Ralf P Brandes, Werner Seeger, Michael P Murphy, Norbert Weissmann, Natascha Sommer
Jun 18, 2018
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular...
Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.
Lois G Kim, Michael J Sweeting, Morag Armer, Jo Jacomelli, Akhtar Nasim, Seamus C Harrison
Jul 01, 2021
BACKGROUND: The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large...
Age Factors Aged Aortic Aneurysm Abdominal Aortic Rupture covid-19 Communicable Disease Control Computer Simulation Cost of Illness Elective Surgical Procedures England Health Policy Humans Male Mass Screening Models Statistical Pandemics Patient Acceptance of Health Care Risk Assessment Risk Factors Severity of Illness Index State Medicine Time-to-Treatment Ultrasonography
Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic
Lois G. Kim, Michael J. Sweeting, Morag Armer, Jo Jacomelli, Akhtar Nasim, Seamus C. Harrison
Jun 17, 2021
Background: The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large...
Incorporating tumour pathology information into breast cancer risk prediction algorithms.
Nasim Mavaddat, Timothy R Rebbeck, Sunil R Lakhani, Douglas F Easton, Antonis C Antoniou
Jun 17, 2011
Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.
Lois G Kim, Michael J Sweeting, Morag Armer, Jo Jacomelli, Akhtar Nasim, Seamus C Harrison
Jul 28, 2021
Background
The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for...
Humans Aortic Rupture Aortic Aneurysm Abdominal Ultrasonography Mass Screening Severity of Illness Index Models Statistical Risk Assessment Risk Factors Age Factors Communicable Disease Control Cost of Illness Health Policy Computer Simulation Aged State Medicine Patient Acceptance of Health Care England Male Pandemics Time-to-Treatment Elective Surgical Procedures covid-19
Published by: PLOS ONE
Positron emission tomography-guided magnetic resonance spectroscopy in Alzheimer disease.
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
Mar 13, 2018
OBJECTIVE: To determine whether the level of metabolites in magnetic resonance spectroscopy (MRS) is a representative marker of underlying pathological changes identified in positron emission tomographic (PET) images in...
Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening.
Mikael Eriksson, Kamila Czene, Fredrik Strand, Sophia Zackrisson, Peter Lindholm, Kristina Lång, Daniel Förnvik, Hanna Sartor, Nasim Mavaddat, Doug Easton, Per Hall
Sep 23, 2020
Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease.
Nasim Sheikh-Bahaei, Roido Manavaki, S Ahmad Sajjadi, Andrew N Priest, John T O'Brien, Jonathan H Gillard
Apr 11, 2019
BACKGROUND: Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer's disease (AD), there is limited knowledge about the role of lCMB in AD pathology. OBJECTIVE: To understand the nature...
Alzheimer’s disease FDG-PET PiB-PET cerebral metabolism cerebral perfusion lobar cerebral microbleeds susceptibility weighted imaging Aged Aged 80 and over Alzheimer Disease Amyloid beta-Peptides Brain cerebral hemorrhage Cognitive Dysfunction Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Male Positron-Emission Tomography
Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease.
James D Stefaniak, Li Su, Elijah Mak, Nasim Sheikh-Bahaei, Katie Wells, Karen Ritchie, Adam Waldman, Craig W Ritchie, John T O'Brien
Jan 25, 2018
INTRODUCTION: Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is...
Cerebral microbleed cerebral small vessel disease Dementia MRI Middle age Risk Factors White matter hyperintensity Adult Alzheimer Disease Apolipoprotein E4 cerebral small vessel diseases Cross-Sectional Studies Family Health Female Genetic Predisposition to Disease Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged prevalence Regression Analysis statistics Nonparametric white matter
Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study.
Xin Yang, Mikael Eriksson, Kamila Czene, Andrew Lee, Goska Leslie, Michael Lush, Jean Wang, Joe Dennis, Leila Dorling, Sara Carvalho, Nasim Mavaddat, Jacques Simard, Marjanka K Schmidt, Douglas F Easton, Per Hall, Antonis C Antoniou
Nov 03, 2022
Familial relative risks for breast cancer by pathological subtype
Nasim Mavaddat, Paul D Pharoah, Fiona Blows, Kristy E Driver, Elena Provenzano, Deborah Thompson, Robert J Macinnis, Mitul Shah, SEARCH Team, Douglas F Easton, Antonis C Antoniou
Jun 17, 2011
BOADICEA
Andrew Lee, Nasim Mavaddat, Amber N Wilcox, Alex P Cunningham, Tim Carver, Simon Hartley, Chantal Babb de Villiers, Angel Izquierdo, Jacques Simard, Marjanka K Schmidt, Fiona M Walter, Nilanjan Chatterjee, Montserrat Garcia-Closas, Marc Tischkowitz, Paul Pharoah, Douglas F Easton, Antonis C Antoniou
Jan 28, 2019
PURPOSE: Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA)...
BOADICEA PRS Breast Cancer rare variants Risk prediction Ataxia Telangiectasia Mutated Proteins BRCA1 Protein BRCA2 Protein Breast Neoplasms Checkpoint Kinase 2 Fanconi Anemia Complementation Group N Protein Female Genetic Predisposition to Disease Genetic Testing Humans Multifactorial Inheritance Mutation Ovarian Neoplasms Polymorphism Single Nucleotide Risk Assessment Risk Factors
Comprehensive epithelial tubo-ovarian cancer risk prediction model incorporating genetic and epidemiological risk factors.
Andrew Lee, Xin Yang, Jonathan Tyrer, Aleksandra Gentry-Maharaj, Andy Ryan, Nasim Mavaddat, Alex P Cunningham, Tim Carver, Stephanie Archer, Goska Leslie, Jatinder Kalsi, Faiza Gaba, Ranjit Manchanda, Simon Gayther, Susan J Ramus, Fiona M Walter, Marc Tischkowitz, Ian Jacobs, Usha Menon, Douglas F Easton, Paul Pharoah, Antonis C Antoniou
Jan 10, 2022
Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.
Anja Rudolph, Minsun Song, Mark N Brook, Roger L Milne, Nasim Mavaddat, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Amber N Wilcox, John L Hopper, Melissa C Southey, Renske Keeman, Peter A Fasching, Matthias W Beckmann, Manuela Gago-Dominguez, Jose E Castelao, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Thomas Brüning, Arto Mannermaa, Veli-Matti Kosma, Diether Lambrechts, Machteld Keupers, Fergus J Couch, Celine Vachon, Graham G Giles, Robert J Macinnis, Jonine Figueroa, Louise Brinton, Kamila Czene, Judith S Brand, Marike Gabrielson, Keith Humphreys, Angela Cox, Simon S Cross, Alison M Dunning, Nick Orr, Anthony Swerdlow, Per Hall, Paul DP Pharoah, Marjanka K Schmidt, Douglas F Easton, Nilanjan Chatterjee, Jenny Chang-Claude, Montserrat García-Closas
Feb 01, 2018
BACKGROUND: Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and environmental risk factors will improve risk prediction;...
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Aug 02, 2021
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Jul 31, 2020
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk
Nasim Mavaddat, Antonis C Antoniou, Thea M Mooij, Maartje J Hooning, Bernadette A Heemskerk-Gerritsen, GENEPSO, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, EMBRACE, Daniel Barrowdale, Debra Frost, D Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, HEBON, Klaartje van Engelen, Marian JE Mourits, Margreet Gem Ausems, Linetta B Koppert, John L Hopper, Esther M John, Wendy K Chung, Irene L Andrulis, Mary B Daly, Saundra S Buys, kConFab Investigators, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E van Leeuwen, Brita Arver, Håkan Olsson, Rita K Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L Milne, David E Goldgar, Matti A Rookus, Nadine Andrieu, Douglas F Easton, IBCCS, kConFab, BCFR
Feb 03, 2020
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P Tyrer, Manjeet K Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H Wu, Daniel O Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L Chan, Su Ming Tan, Jaime Seah, Esther M John, Allison W Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J Spinelli, Kristan J Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul DP Pharoah, Wei Zheng, Alison M Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F Easton, Soo-Hwang Teo, Antonis C Antoniou
Sep 09, 2020
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from...
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk
Nasim Mavaddat, Antonis C Antoniou, Thea M Mooij, Maartje J Hooning, Bernadette A Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J E Mourits, Margreet G E M Ausems, Linetta B Koppert, John L Hopper, Esther M John, Wendy K Chung, Irene L Andrulis, Mary B Daly, Saundra S Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E van Leeuwen, Brita Arver, Håkan Olsson, Rita K Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L Milne, David E Goldgar, Matti A Rookus, Nadine Andrieu, Douglas F Easton
Feb 19, 2020
BACKGROUND:The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially...
Published by: Breast cancer research : BCR
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk
Nasim Mavaddat, Antonis C. Antoniou, Thea M. Mooij, Maartje J. Hooning, Bernadette A. Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D. Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J. E. Mourits, Margreet G. E. M. Ausems, Linetta B. Koppert, John L. Hopper, Esther M. John, Wendy K. Chung, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F. Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E. Van Leeuwen, Brita Arver, Håkan Olsson, Rita K. Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L. Milne, David E. Goldgar, Matti A. Rookus, Nadine Andrieu, Douglas F. Easton, Lilian Laborde, Emmanuel Breysse, Dominique Stoppa-Lyonnet, Bruno Buecher, Emmanuelle Fourme-Mouret, Jean-Pierre Fricker, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Laurence Faivre, Elisabeth Luporsi, Véronique Mari, Laurence Gladieff, Hagay Sobol, François Eisinger, Michel Longy, Catherine Dugast, Chrystelle Colas, Isabelle Coupier, Carole Corsini, Philippe Vennin, Claude Adenis, Tan Dat Nguyen, Capucine Delnatte, Julie Tinat, Isabelle Tennevet, Jean-Marc Limacher, Christine Maugard, Yves-Jean Bignon, Liliane Demange, Clotilde Penet, Hélène Dreyfus, Odile Cohen-Haguenauer, Laurence Venat-Bouvet, Dominique Leroux, Hélène Zattara-Cannoni, Sandra Fert-Ferrer, Odile Bera, Steve Ellis, F. B. L. Hogervorst, J. M. Collée, C. J. van Asperen, A. R. Mensenkamp, M. G. E. M. Ausems, H. E. J. Meijers-Heijboer, K. van Engelen, M. J. Blok, J. C. Oosterwijk, J. Verloop, E. van den Broek
Jan 15, 2021
Abstract: Background: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be...
The impact of coding germline variants on contralateral breast cancer risk and survival.
Anna Morra, Nasim Mavaddat, Taru A Muranen, Thomas U Ahearn, Jamie Allen, Irene L Andrulis, Päivi Auvinen, Heiko Becher, Sabine Behrens, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Hiltrud Brauch, Nicola J Camp, Sara Carvalho, Jose E Castelao, Melissa H Cessna, Jenny Chang-Claude, Georgia Chenevix-Trench, Kamila Czene, Brennan Decker, Joe Dennis, Thilo Dörk, Leila Dorling, Alison M Dunning, Arif B Ekici, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Manuela Gago-Dominguez, Montserrat García-Closas, Willemina R R Geurts-Giele, Graham G Giles, Pascal Guénel, Melanie Gündert, Eric Hahnen, Per Hall, Ute Hamann, Patricia A Harrington, Wei He, Päivi Heikkilä, Maartje J Hooning, Reiner Hoppe, Anthony Howell, Keith Humphreys, Anna Jakubowska, Audrey Y Jung, Renske Keeman, Vessela N Kristensen, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, Roger L Milne, Anna Marie Mulligan, William G Newman, Tjoung-Won Park-Simon, Paolo Peterlongo, Paul D P Pharoah, Valerie Rhenius, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Mitul Shah, Amanda B Spurdle, Ian Tomlinson, Thérèse Truong, Elke M van Veen, Maaike P G Vreeswijk, Qin Wang, Camilla Wendt, Xiaohong R Yang, Heli Nevanlinna, Peter Devilee, Douglas F Easton, Marjanka K Schmidt
Mar 28, 2023
Evidence linking coding germline variants in breast cancer (BC)-susceptibility genes other than BRCA1, BRCA2, and CHEK2 with contralateral breast cancer (CBC) risk and breast cancer-specific survival (BCSS) is scarce. The aim of...
survival Breast Cancer Susceptibility Genes Contralateral Breast Cancer Risk Coding Germline Variants Germ Cells Humans Breast Neoplasms Genetic Predisposition to Disease Germ-Line Mutation Genes BRCA2 Female
Published by: American journal of human genetics
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk
Nasim Mavaddat, Antonis C. Antoniou, Thea M. Mooij, Maartje J. Hooning, Bernadette A. Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D. Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J. E. Mourits, Margreet G. E. M. Ausems, Linetta B. Koppert, John L. Hopper, Esther M. John, Wendy K. Chung, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F. Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E. Van Leeuwen, Brita Arver, Håkan Olsson, Rita K. Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L. Milne, David E. Goldgar, Matti A. Rookus, Nadine Andrieu, Douglas F. Easton, Lilian Laborde, Emmanuel Breysse, Dominique Stoppa-Lyonnet, Bruno Buecher, Emmanuelle Fourme-Mouret, Jean-Pierre Fricker, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Laurence Faivre, Elisabeth Luporsi, Véronique Mari, Laurence Gladieff, Hagay Sobol, François Eisinger, Michel Longy, Catherine Dugast, Chrystelle Colas, Isabelle Coupier, Carole Corsini, Philippe Vennin, Claude Adenis, Tan Dat Nguyen, Capucine Delnatte, Julie Tinat, Isabelle Tennevet, Jean-Marc Limacher, Christine Maugard, Yves-Jean Bignon, Liliane Demange, Clotilde Penet, Hélène Dreyfus, Odile Cohen-Haguenauer, Laurence Venat-Bouvet, Dominique Leroux, Hélène Zattara-Cannoni, Sandra Fert-Ferrer, Odile Bera, Steve Ellis, F. B. L. Hogervorst, J. M. Collée, C. J. van Asperen, A. R. Mensenkamp, M. G. E. M. Ausems, H. E. J. Meijers-Heijboer, K. van Engelen, M. J. Blok, J. C. Oosterwijk, J. Verloop, E. van den Broek
Jun 06, 2020
Abstract: Background: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be...
Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.
Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N Wilcox, Sara Lindström, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Leslie Bernstein, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Qiuyin Cai, Daniele Campa, Federico Canzian, Angel Carracedo, Brian D Carter, Jose E Castelao, Stephen J Chanock, Nilanjan Chatterjee, Georgia Chenevix-Trench, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, James Y Dai, H Shelton Earp, Arif B Ekici, A Heather Eliassen, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Chi Gao, Susan M Gapstur, Mia M Gaudet, Graham G Giles, Anna González-Neira, Pascal Guénel, Lothar Haeberle, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sigrid Hatse, Jane Heyworth, Bernd Holleczek, Robert N Hoover, John L Hopper, Anthony Howell, David J Hunter, ABCTB Investigators, kConFab/AOCS Investigators, Esther M John, Michael E Jones, Rudolf Kaaks, Renske Keeman, Cari M Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Martha Linet, Jolanta Lissowska, Ana Llaneza, Robert J Macinnis, Maria Elena Martinez, Tabea Maurer, Catriona Mclean, Susan L Neuhausen, William G Newman, Aaron Norman, Katie M O'Brien, Andrew F Olshan, Janet E Olson, Håkan Olsson, Nick Orr, Charles M Perou, Guillermo Pita, Eric C Polley, Ross L Prentice, Gad Rennert, Hedy S Rennert, Kathryn J Ruddy, Dale P Sandler, Christobel Saunders, Minouk J Schoemaker, Ben Schöttker, Fredrick Schumacher, Christopher Scott, Rodney J Scott, Xiao-Ou Shu, Ann Smeets, Melissa C Southey, John J Spinelli, Jennifer Stone, Anthony J Swerdlow, Rulla M Tamimi, Jack A Taylor, Melissa A Troester, Celine M Vachon, Elke M van Veen, Xiaoliang Wang, Clarice R Weinberg, Caroline Weltens, Walter Willett, Stacey J Winham, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Argyrios Ziogas, Alison M Dunning, Paul DP Pharoah, Marjanka K Schmidt, Peter Kraft, Douglas F Easton, Roger L Milne, Montserrat García-Closas, Jenny Chang-Claude
Apr 14, 2020
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer...
Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.
Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Hiltrud Brauch, Michael Bremer, Sara Y Brucker, Barbara Burwinkel, Jose E Castelao, Tsun L Chan, Jenny Chang-Claude, Stephen J Chanock, Georgia Chenevix-Trench, Ji-Yeob Choi, Christine L Clarke, NBCS Collaborators, J Margriet Collée, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Isabel dos-Santos-Silva, Alison M Dunning, Miriam Dwek, Diana M Eccles, D Gareth Evans, Peter A Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Graham G Giles, David E Goldgar, Anna González-Neira, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Mikael Hartman, Bernadette AM Heemskerk-Gerritsen, Antoinette Hollestelle, John L Hopper, Ming-Feng Hou, Anthony Howell, ABCTB Investigators, kConFab Investigators, Hidemi Ito, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Esther M John, Audrey Jung, Daehee Kang, C Marleen Kets, Elza Khusnutdinova, Yon-Dschun Ko, Vessela N Kristensen, Allison W Kurian, Ava Kwong, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Alfons Meindl, Roger L Milne, Anna Marie Mulligan, Taru A Muranen, Susan L Neuhausen, Heli Nevanlinna, William G Newman, Andrew F Olshan, Janet E Olson, Håkan Olsson, Tjoung-Won Park-Simon, Julian Peto, Christos Petridis, Dijana Plaseska-Karanfilska, Nadege Presneau, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Rebecca Roylance, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Lukas Schwentner, Christopher Scott, Mee-Hoong See, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Sabine Siesling, Susan Slager, Christof Sohn, Melissa C Southey, John J Spinelli, Jennifer Stone, William J Tapper, Maria Tengström, Soo Hwang Teo, Mary Beth Terry, Rob AEM Tollenaar, Ian Tomlinson, Melissa A Troester, Celine M Vachon, Chantal Van Ongeval, Elke M van Veen, Robert Winqvist, Alicja Wolk, Wei Zheng, Argyrios Ziogas, Douglas F Easton, Per Hall, Marjanka K Schmidt
Oct 19, 2020
Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently...
Contralateral breast cancer EPIDEMIOLOGY Genetic polygenic risk score Adult Aged Asian People Breast Neoplasms Cohort Studies Estrogen Receptor alpha Female Gene Expression Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Middle Aged Multifactorial Inheritance Neoadjuvant Therapy Neoplasms Second Primary Prognosis Proportional Hazards Models Receptor ErbB-2 Receptors Progesterone Risk Assessment White People
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