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Results: 25
Treatment outcomes among adults with HIV/non-communicable disease multimorbidity attending integrated care clubs in Cape Town, South Africa.
BACKGROUND: The growing burden of the HIV and non-communicable disease (NCD) syndemic in Sub- Saharan Africa has necessitated introduction of integrated models of care in order to leverage existing HIV care infrastructure for...
The Global Burden of Meningitis in Children
Claire Wright, Natacha Blake, Linda Glennie, Vinny Smith, Rose Bender, Hmwe Kyu, Han Yong Wunrow, Li Liu, Diana Yeung, Maria Deloria Knoll, Brian Wahl, James M Stuart, Caroline Trotter
Mar 15, 2021
The World Health Organization (WHO) has developed a global roadmap to defeat meningitis by 2030. To advocate for and track progress of the roadmap, the burden of meningitis as a syndrome and by pathogen must be accurately...
Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo.
Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells.
Kilian Mazaleyrat, Cherif Badja, Natacha Broucqsault, Raphaël Chevalier, Camille Laberthonnière, Camille Dion, Lyla Baldasseroni, Claire El-Yazidi, Morgane Thomas, Richard Bachelier, Alexandre Altié, Karine Nguyen, Nicolas Lévy, Jérôme D Robin, Frédérique Magdinier
Sep 09, 2020
Induced pluripotent stem cells (iPSCs) obtained by reprogramming primary somatic cells have revolutionized the fields of cell biology and disease modeling. However, the number protocols for generating mature muscle fibers with...
Duchenne muscular dystrophy Facio-Scapulo-Humeral Dystrophy Limb girdle muscular dystrophy Myotonic Dystrophy Z-lines contraction DIFFERENTIATION human induced pluripotent cells Motor Neurons Muscular Dystrophy Myoblasts myotubes satellite cells Cell Differentiation Humans Muscle Fibers Skeletal Muscular Dystrophy Duchenne Pluripotent Stem Cells
Cannabidiol for the treatment of cannabis use disorder
Tom Freeman, Chandni Hindocha, Gianluca Baio, Natacha Shaban, Emily Thomas, Danica Astbury, Abigail Freeman, Rachel Hannah Lees, Sam Craft, Paul Morrison, Michael Bloomfield, Dominic O'Ryan, Jane Kinghorn, Celia Morgan, Ali Mofeez, H Valerie Curran
Oct 01, 2020
Background A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe....
Osseointegration of porous apatite-wollastonite and poly(lactic acid) composite structures created using 3D printing techniques.
Ion Tcacencu, Natacha Rodrigues, Naif Alharbi, Matthew Benning, Sotiria Toumpaniari, Elena Mancuso, Martyn Marshall, Oana Bretcanu, Mark Birch, Andrew McCaskie, Kenneth Dalgarno
Sep 05, 2018
A novel apatite-wollastonite/poly(lactic acid) (AW/PLA) composite structure, which matches cortical and cancellous bone properties has been produced and evaluated in vitro and in vivo. The composites structure has been produced...
Cannabidiol for the treatment of cannabis use disorder
Tom Freeman, Chandni Hindocha, Gianluca Baio, Natacha Shaban, Emily Thomas, Danica Astbury, Abigail Freeman, Rachel Hannah Lees, Sam Craft, Paul Morrison, Michael Bloomfield, Dominic O'Ryan, Jane Kinghorn, Celia Morgan, Ali Mofeez, H Valerie Curran
Oct 01, 2020
Background A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe....
The Global Burden of Meningitis in Children
Claire Wright, Natacha Blake, Linda Glennie, Vinny Smith, Rose Bender, Hmwe Kyu, Han Yong Wunrow, Li Liu, Diana Yeung, Maria Deloria Knoll, Brian Wahl, James M. Stuart, Caroline Trotter
Feb 14, 2021
The World Health Organization (WHO) has developed a global roadmap to defeat meningitis by 2030. To advocate for and track progress of the roadmap, the burden of meningitis as a syndrome and by pathogen must be accurately...
Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo.
Bieke Tack, Daniel Vita, José Nketo, Naomie Wasolua, Nathalie Ndengila, Natacha Herssens, Emmanuel Ntangu, Grace Kasidiko, Gaëlle Nkoji-Tunda, Marie-France Phoba, Justin Im, Hyon Jin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs
Apr 05, 2023
Humans salmonella Bacterial Infections Sepsis Malaria Malaria Falciparum Hospital Mortality Cohort Studies Child Infant Democratic Republic of the Congo
Published by: PLoS neglected tropical diseases
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research.
Christopher C Conway, Miriam K Forbes, Kelsie T Forbush, Eiko I Fried, Michael N Hallquist, Roman Kotov, Stephanie N Mullins-Sweatt, Alexander J Shackman, Andrew E Skodol, Susan C South, Matthew Sunderland, Monika A Waszczuk, David H Zald, Mohammad H Afzali, Marina A Bornovalova, Natacha Carragher, Anna R Docherty, Katherine G Jonas, Robert F Krueger, Praveetha Patalay, Aaron L Pincus, Jennifer L Tackett, Ulrich Reininghaus, Irwin D Waldman, Aidan GC Wright, Johannes Zimmermann, Bo Bach, R Michael Bagby, Michael Chmielewski, David C Cicero, Lee Anna Clark, Tim Dalgleish, Colin G DeYoung, Christopher J Hopwood, Masha Y Ivanova, Robert D Latzman, Christopher J Patrick, Camilo J Ruggero, Douglas B Samuel, David Watson, Nicholas R Eaton
Mar 25, 2019
For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of...
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
Acute effects of cannabis on speech illusions and psychotic-like symptoms
Claire Mokrysz, Natacha D C Shaban, Tom P Freeman, Will Lawn, Rebecca A Pope, Chandni Hindocha, Abigail Freeman, Matthew B Wall, Michael A P Bloomfield, Celia J A Morgan, David J Nutt, H Valerie Curran
Sep 30, 2021
BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We...
Acute effects of cannabis on speech illusions and psychotic-like symptoms
Claire Mokrysz, Natacha D C Shaban, Tom P Freeman, Will Lawn, Rebecca A Pope, Chandni Hindocha, Abigail Freeman, Matthew B Wall, Michael A P Bloomfield, Celia J A Morgan, David J Nutt, H Valerie Curran
Sep 30, 2021
BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We...
Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.
Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin
Feb 18, 2021
Homozygosity for Slc25a21(tm1a(KOMP)Wtsi) results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment and inflammation in the middle ear. In humans it has been hypothesised...
Alleles Animals Dicarboxylic Acid Transporters Exons Female Gene Expression Regulation Genetic Engineering Homozygote Humans Male Membrane Transport Proteins Mice Mice Knockout Mitochondrial Membrane Transport Proteins Mouth Abnormalities Mutation Otitis Media PAX9 Transcription Factor Paired Box Transcription Factors Signal Transduction
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.
P Ramachandran, R Dobie, JR Wilson-Kanamori, EF Dora, BEP Henderson, NT Luu, JR Portman, KP Matchett, M Brice, JA Marwick, RS Taylor, M Efremova, R Vento-Tormo, NO Carragher, TJ Kendall, JA Fallowfield, EM Harrison, DJ Mole, SJ Wigmore, PN Newsome, CJ Weston, JP Iredale, F Tacke, JW Pollard, CP Ponting, JC Marioni, SA Teichmann, NC Henderson
Dec 19, 2019
Animals Case-Control Studies Cell Lineage Duffy Blood-Group System Endothelial Cells Female Hepatic Stellate Cells Hepatocytes Humans Liver Liver Cirrhosis MACROPHAGES Male Membrane Glycoproteins Membrane Proteins Mice Phenotype Receptor Platelet-Derived Growth Factor alpha Receptors Cell Surface Receptors Immunologic Single-Cell Analysis Tetraspanin 29 Transcriptome Transendothelial and Transepithelial Migration
Linked electronic health records for research on a nationwide cohort of more than 54 million people in England
Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Ashley Akbari, Amitava Banerjee, William Whiteley, Alvina Lai, Jonathan Sterne, Cathie Sudlow, CVD-COVID-UK Consortium, Abdel Douiri, Abdul Qadr Akinoso-Imran, Adrian Jonas, Ajay Shah, Alex Handy, Alun Davies, Amanj Kurdi, Anna Hansell, Annemarie Docherty, Arun Pherwani, Ashkan Dashtban, Ben Bray, Ben Cairns, Ben Goldacre, Ben Humberstone, Bilal Mateen, Brett Doble, Brian Roberts, Carole Morris, Caroline Dale, Caroline Rogers, Charles Wolfe, Christopher Tomlinson, Claire Lawson, Clea du Toit, Colin Berry, Craig Smith, Dan O’Connell, Daniel Harris, David Brind, David Cromwell, David Hughes, David Moreno Martos, Debbie Ringham, Deborah Lawler, Deborah Lowe, Elena Nikiphorou, Eloise Withnell, Emanuele Di Angelantonio, Eva Morris, Ewan Birney, Fabian Falck, Fatemeh Torabi, Felix Greaves, Florian Falter, Francesco Zaccardi, Frank Kee, Gareth Davies, George Nicholson, Gwenetta Curry, Haoting Zhang, Harry Hemingway, Harry Wilde, Hoda Abbasizanjani, Honghan Wu, Howard Tang, Huan Wang, Ify Mordi, Jackie MacArthur, Jane Lyons, Jennifer Beveridge, Jessica Barrett, Jianhua Wu, Johan Thygesen, John Danesh, John Dennis, Jon Boyle, Julian Halcox, Kamlesh Khunti, Kate Cheema, Katherine Brown, Ken Li, Kim Kavanagh, Laura North, Laura Pasea, Libby Ellins, Livia Pierotti, Lucy Wright, Lydia Martin, Lynn Morrice, Mamas Mamas, Marion Bennie, Mark Barber, Mary Joan Macleod, Massimo Caputo, Maya Buch, Mehrdad Mizani, Michalis Katsoulis, Mike Gravenor, Mike Inouye, Mirek Skrypak, Moritz Gerstung, Munir Pirmohamed, Myer Glickman, Naomi Herz, Neil Davies, Nick Hall, Nilesh Samani, Olena Seminog, Paula Lorgelly, Pedro Machado, Qiuju Li, Raph Goldacre, Raymond Carragher, Reecha Sofat, Rohan Takhar, Ronan Lyons, Rouven Priedon, Rowena Griffiths, Rupert Payne, Ruwanthi Kolamunnage-Dona, Safa Salim, Sandosh Padmanabhan, Sarah Onida, Seamus Kent, Seb Bacon, Sinduja Manohar, Sonya Babu-Narayan, Spencer Keene, Susheel Varma, Thomas Lawrence, Tianxiao Wang, Tim Wilkinson, Tom Norris, Tom Palmer, Vahé Nafilyan
Apr 08, 2021
Abstract: Objective: To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining...
Linked electronic health records for research on a nationwide cohort of more than 54 million people in England
Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Ashley Akbari, Amitava Banerjee, William Whiteley, Alvina Lai, Jonathan Sterne, Cathie Sudlow, CVD-COVID-UK Consortium, Abdel Douiri, Abdul Qadr Akinoso-Imran, Adrian Jonas, Ajay Shah, Alex Handy, Alun Davies, Amanj Kurdi, Anna Hansell, Annemarie Docherty, Arun Pherwani, Ashkan Dashtban, Ben Bray, Ben Cairns, Ben Goldacre, Ben Humberstone, Bilal Mateen, Brett Doble, Brian Roberts, Carole Morris, Caroline Dale, Caroline Rogers, Charles Wolfe, Christopher Tomlinson, Claire Lawson, Clea du Toit, Colin Berry, Craig Smith, Dan O’Connell, Daniel Harris, David Brind, David Cromwell, David Hughes, David Moreno Martos, Debbie Ringham, Deborah Lawler, Deborah Lowe, Elena Nikiphorou, Eloise Withnell, Emanuele Di Angelantonio, Eva Morris, Ewan Birney, Fabian Falck, Fatemeh Torabi, Felix Greaves, Florian Falter, Francesco Zaccardi, Frank Kee, Gareth Davies, George Nicholson, Gwenetta Curry, Haoting Zhang, Harry Hemingway, Harry Wilde, Hoda Abbasizanjani, Honghan Wu, Howard Tang, Huan Wang, Ify Mordi, Jackie MacArthur, Jane Lyons, Jennifer Beveridge, Jessica Barrett, Jianhua Wu, Johan Thygesen, John Danesh, John Dennis, Jon Boyle, Julian Halcox, Kamlesh Khunti, Kate Cheema, Katherine Brown, Ken Li, Kim Kavanagh, Laura North, Laura Pasea, Libby Ellins, Livia Pierotti, Lucy Wright, Lydia Martin, Lynn Morrice, Mamas Mamas, Marion Bennie, Mark Barber, Mary Joan Macleod, Massimo Caputo, Maya Buch, Mehrdad Mizani, Michalis Katsoulis, Mike Gravenor, Mike Inouye, Mirek Skrypak, Moritz Gerstung, Munir Pirmohamed, Myer Glickman, Naomi Herz, Neil Davies, Nick Hall, Nilesh Samani, Olena Seminog, Paula Lorgelly, Pedro Machado, Qiuju Li, Raph Goldacre, Raymond Carragher, Reecha Sofat, Rohan Takhar, Ronan Lyons, Rouven Priedon, Rowena Griffiths, Rupert Payne, Ruwanthi Kolamunnage-Dona, Safa Salim, Sandosh Padmanabhan, Sarah Onida, Seamus Kent, Seb Bacon, Sinduja Manohar, Sonya Babu-Narayan, Spencer Keene, Susheel Varma, Thomas Lawrence, Tianxiao Wang, Tim Wilkinson, Tom Norris, Tom Palmer, Vahé Nafilyan
Apr 09, 2021
Abstract: Objective: To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining...