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A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
Treatment outcomes among adults with HIV/non-communicable disease multimorbidity attending integrated care clubs in Cape Town, South Africa.
Diabetes mellitus Hypertension HIV/AIDS South Africa integrated care Non-communicable diseases multimorbidity Adherence clubs
Published by: AIDS research and therapy
Treatment outcomes among adults with HIV/non-communicable disease multimorbidity attending integrated care clubs in Cape Town, South Africa.
BACKGROUND: The growing burden of the HIV and non-communicable disease (NCD) syndemic in Sub- Saharan Africa has necessitated introduction of integrated models of care in order to leverage existing HIV care infrastructure for...
Treatment outcomes among adults with HIV/non-communicable disease multimorbidity attending integrated care clubs in Cape Town, South Africa
Tuberculosis, Human Immunodeficiency Virus, and the Association With Transient Hyperglycemia in Periurban South Africa.
Mmamapudi Kubjane, Natacha Berkowitz, Rene Goliath, Naomi S Levitt, Robert J Wilkinson, Tolu Oni
Sep 18, 2019
The Global Burden of Meningitis in Children
Claire Wright, Natacha Blake, Linda Glennie, Vinny Smith, Rose Bender, Hmwe Kyu, Han Yong Wunrow, Li Liu, Diana Yeung, Maria Deloria Knoll, Brian Wahl, James M Stuart, Caroline Trotter
Mar 15, 2021
The World Health Organization (WHO) has developed a global roadmap to defeat meningitis by 2030. To advocate for and track progress of the roadmap, the burden of meningitis as a syndrome and by pathogen must be accurately...
Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo.
Bieke Tack, Daniel Vita, José Nketo, Naomie Wasolua, Nathalie Ndengila, Natacha Herssens, Emmanuel Ntangu, Grace Kasidiko, Gaëlle Nkoji-Tunda, Marie-France Phoba, Justin Im, Hyon Jin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs
Mar 16, 2023
Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells.
Kilian Mazaleyrat, Cherif Badja, Natacha Broucqsault, Raphaël Chevalier, Camille Laberthonnière, Camille Dion, Lyla Baldasseroni, Claire El-Yazidi, Morgane Thomas, Richard Bachelier, Alexandre Altié, Karine Nguyen, Nicolas Lévy, Jérôme D Robin, Frédérique Magdinier
Sep 09, 2020
Induced pluripotent stem cells (iPSCs) obtained by reprogramming primary somatic cells have revolutionized the fields of cell biology and disease modeling. However, the number protocols for generating mature muscle fibers with...
Duchenne muscular dystrophy Facio-Scapulo-Humeral Dystrophy Limb girdle muscular dystrophy Myotonic Dystrophy Z-lines contraction DIFFERENTIATION human induced pluripotent cells Motor Neurons Muscular Dystrophy Myoblasts myotubes satellite cells Cell Differentiation Humans Muscle Fibers Skeletal Muscular Dystrophy Duchenne Pluripotent Stem Cells
Anthropogenic stressors impact fish sensory development and survival via thyroid disruption.
Marc Besson, William E Feeney, Isadora Moniz, Loïc François, Rohan M Brooker, Guillaume Holzer, Marc Metian, Natacha Roux, Vincent Laudet, David Lecchini
Jul 28, 2021
Switchmate! An Electrophysiological Attempt to Adjudicate Between Competing Accounts of Adjective-Noun Code-Switching.
Awel Vaughan-Evans, Maria Carmen Parafita Couto, Bastien Boutonnet, Noriko Hoshino, Peredur Webb-Davies, Margaret Deuchar, Guillaume Thierry
Dec 01, 2020
Here, we used event-related potentials to test the predictions of two prominent accounts of code-switching in bilinguals: The Matrix Language Framework (MLF; Myers-Scotton, 1993) and an application of the Minimalist Programme...
Cannabidiol for the treatment of cannabis use disorder
Tom Freeman, Chandni Hindocha, Gianluca Baio, Natacha Shaban, Emily Thomas, Danica Astbury, Abigail Freeman, Rachel Hannah Lees, Sam Craft, Paul Morrison, Michael Bloomfield, Dominic O'Ryan, Jane Kinghorn, Celia Morgan, Ali Mofeez, H Valerie Curran
Oct 01, 2020
Background A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe....
Osseointegration of porous apatite-wollastonite and poly(lactic acid) composite structures created using 3D printing techniques.
Ion Tcacencu, Natacha Rodrigues, Naif Alharbi, Matthew Benning, Sotiria Toumpaniari, Elena Mancuso, Martyn Marshall, Oana Bretcanu, Mark Birch, Andrew McCaskie, Kenneth Dalgarno
Sep 05, 2018
A novel apatite-wollastonite/poly(lactic acid) (AW/PLA) composite structure, which matches cortical and cancellous bone properties has been produced and evaluated in vitro and in vivo. The composites structure has been produced...
Cannabidiol for the treatment of cannabis use disorder
Tom Freeman, Chandni Hindocha, Gianluca Baio, Natacha Shaban, Emily Thomas, Danica Astbury, Abigail Freeman, Rachel Hannah Lees, Sam Craft, Paul Morrison, Michael Bloomfield, Dominic O'Ryan, Jane Kinghorn, Celia Morgan, Ali Mofeez, H Valerie Curran
Oct 01, 2020
Background A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe....
The Global Burden of Meningitis in Children
Claire Wright, Natacha Blake, Linda Glennie, Vinny Smith, Rose Bender, Hmwe Kyu, Han Yong Wunrow, Li Liu, Diana Yeung, Maria Deloria Knoll, Brian Wahl, James M. Stuart, Caroline Trotter
Feb 14, 2021
The World Health Organization (WHO) has developed a global roadmap to defeat meningitis by 2030. To advocate for and track progress of the roadmap, the burden of meningitis as a syndrome and by pathogen must be accurately...
Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo.
Bieke Tack, Daniel Vita, José Nketo, Naomie Wasolua, Nathalie Ndengila, Natacha Herssens, Emmanuel Ntangu, Grace Kasidiko, Gaëlle Nkoji-Tunda, Marie-France Phoba, Justin Im, Hyon Jin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs
Apr 05, 2023
Humans salmonella Bacterial Infections Sepsis Malaria Malaria Falciparum Hospital Mortality Cohort Studies Child Infant Democratic Republic of the Congo
Published by: PLoS neglected tropical diseases
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity
Tom A Bond, Rebecca C Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C Yang, Marc J Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M Evans, Alex M Lewin, Paul F O'Reilly, Deborah A Lawlor, Marjo-Riitta Järvelin
Feb 01, 2022
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms...
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity
Tom A Bond, Rebecca C Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C Yang, Marc J Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M Evans, Alex M Lewin, Paul F O'Reilly, Deborah A Lawlor, Marjo-Riitta Järvelin
Mar 05, 2022
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms...
Acute effects of cannabis on speech illusions and psychotic-like symptoms
Claire Mokrysz, Natacha D C Shaban, Tom P Freeman, Will Lawn, Rebecca A Pope, Chandni Hindocha, Abigail Freeman, Matthew B Wall, Michael A P Bloomfield, Celia J A Morgan, David J Nutt, H Valerie Curran
Sep 30, 2021
BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We...
Acute effects of cannabis on speech illusions and psychotic-like symptoms
Claire Mokrysz, Natacha D C Shaban, Tom P Freeman, Will Lawn, Rebecca A Pope, Chandni Hindocha, Abigail Freeman, Matthew B Wall, Michael A P Bloomfield, Celia J A Morgan, David J Nutt, H Valerie Curran
Sep 30, 2021
BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We...
siRNA screen identifies QPCT as a druggable target for Huntington’s disease
Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Angeleen Fleming, Alessia Tarditi, Fiona Menzies, Teresa Ed Dami, Catherine Xu, Eduardo Gonzalez-Couto, Giulia Lazzeroni, Freddy Heitz, Daniela Diamanti, Luisa Massai, Venkata P Satagopam, Guido Marconi, Chiara Caramelli, Arianna Nencini, Matteo Andreini, Gian Luca Sardone, Nicola P Caradonna, Valentina Porcari, Carla Scali, Reinhard Schneider, Giuseppe Pollio, Cahir J O’Kane, Andrea Caricasole, David C Rubinsztein
May 19, 2015
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Angeleen Fleming, Alessia Tarditi, Fiona Menzies, Teresa Ed Dami, Catherine Xu, Eduardo Gonzalez-Couto, Giulia Lazzeroni, Freddy Heitz, Daniela Diamanti, Luisa Massai, Venkata P Satagopam, Guido Marconi, Chiara Caramelli, Arianna Nencini, Matteo Andreini, Gian Luca Sardone, Nicola P Caradonna, Valentina Porcari, Carla Scali, Reinhard Schneider, Giuseppe Pollio, Cahir J O'Kane, Andrea Caricasole, David C Rubinsztein
Jan 10, 2018
Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity by performing a...
Aminoacyltransferases Animals Cells Cultured Computational Biology Drosophila Drug Evaluation Preclinical Enzyme Inhibitors Green Fluorescent Proteins Humans Huntingtin Protein Huntington Disease Mice Mice Inbred C57BL Mutation Nerve Tissue Proteins Neurons RNA Small Interfering Zebrafish alpha-Crystallin B Chain
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