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Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.
Attila Sveiczer, Andrew JP North, Natalia Mateu, Sarah L Kidd, Hannah F Sore, David R Spring
Jun 20, 2019
Novel divergent methodology to access sp3-rich spirocyclic fragments is reported. First, a robust modular synthesis of bis-alkene amino ester building blocks was developed. Three different carbocycles and six heterocycles were...
The Chinese Experience of Developing Cross-Border E-Commerce Under the “Belt and Road” Framework
Cross-border e-commerce is becoming the driver of digital globalization and is of strategic importance in the growth of world trade. Under the framework of the Belt and Road Initiative, China has released a number of guidelines...
Published by: IGI Global Scientific Publishing
The Learning Value of Personalization in Children's Reading Recommendation Systems
Natalia Kucirkova
Oct 01, 2019
This article critically reviews the personalization logic embedded in reading recommendation systems developed for 2- to 11-year-old children and its (dis)alignment with Papert's constructionist and socio-constructionist...
Published by: IGI Global Scientific Publishing
Audio vs. Video Conferencing for Language Learning
Natalia Barley
May 14, 2021
This chapter will trace recent trends in research on audio and video conferencing for language learning and teaching and outline the affordances and mediating effects of each platform that have communicative, socio-affective...
Published by: IGI Global Scientific Publishing
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Feb 19, 2020
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Published by: ACS omega
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O'Donovan, Kilian VM Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
May 26, 2020
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable...
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O'Donovan, Kilian V M Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
Jul 28, 2021
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable...
Published by: Chemical science
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Dec 16, 2019
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Advancing English Language Learners' Speaking Skills Using VoiceThread in Mobile Learning for Russian Tertiary Context
Maria Zemlyanova, Natalia Muravyeva, Svetlana Masterskikh, Lyudmila Shilova, Anna Shevtsova
Nov 01, 2021
This research examines the effectiveness of using the VoiceThread (VT) application (both web and mobile-based) for the development of oral English skills of Russian university students. The study involved 44 full-time bachelor...
Published by: IGI Global Scientific Publishing
The Antecedents of Satisfaction and Revisit Intention for Full-Service Restaurants
The purpose of this research is to identify the factors influencing customers' satisfaction and revisit intentions for full-service restaurants in Jakarta. The recent economic crisis is known to have had a great impact on...
Published by: IGI Global Scientific Publishing
Mobile Applications in Education
The purpose of the study is to consider the features of the use of mobile applications for the development of professional competencies, in particular cognitive skills, and their general impact on the effectiveness of learning....
Published by: IGI Global Scientific Publishing
In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix.
Rawlings Datir, Steven Kemp, Kate El Bouzidi, Petra Mlchocova, Richard Goldstein, Judy Breuer, Greg J Towers, Clare Jolly, Miguel E Quiñones-Mateu, Patrick S Dakum, Nicaise Ndembi, Ravindra K Gupta
Nov 18, 2020
Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought...
Africa Gag HIV antiretroviral antiretroviral resistance drug human immunodeficiency virus Protease Protease Inhibitors proteases resistance Amino Acid Substitution Dose-Response Relationship Drug Drug Resistance Viral Genome Viral Genotype HIV Antigens HIV Infections HIV-1 Humans Microbial Sensitivity Tests Mutation Phenotype Phylogeny Protease Inhibitors Sequence Deletion Viral Load gag Gene Products Human Immunodeficiency Virus
Defective ? interferon production in leprosy reversal with antigen and interleukin 2
[No abstract available]
Published by: Rockefeller University
Indirect effects of bullying on school mathematics achievement in Chile
Students who experience bullying at school present different negative outcomes, including lower academic achievement. However, the process by which bullying is connected to academic achievement is not clear. Using the Trends in...
Defects in the NC2 repressor affect both canonical and non-coding RNA polymerase II transcription initiation in yeast.
BACKGROUND: The formation of the pre-initiation complex in eukaryotic genes is a key step in transcription initiation. The TATA-binding protein (TBP) is a universal component of all pre-initiation complexes for all kinds of RNA...
Global optimization of spin Hamiltonians with gain-dissipative systems.
Recently, several platforms were proposed and demonstrated a proof-of-principle for finding the global minimum of the spin Hamiltonians such as the Ising and XY models using gain-dissipative quantum and classical systems. The...
Parental attachment security and problematic internet use in children
Problematic Internet Use (PIU) is a growing problem among children. Insecure attachment has been associated with PIU and emotion dysregulation. Furthermore, there is evidence suggesting that maladaptive Cognitive Emotion...
Indirect effects of bullying on school mathematics achievement in Chile
Students who experience bullying at school present different negative outcomes, including lower academic achievement. However, the process by which bullying is connected to academic achievement is not clear. Using the Trends in...
Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease.
Demyelinating diseases, such as multiple sclerosis (MS), are responsible for a significant portion of the neurological disability burden worldwide, especially in young adults. Demyelination can be followed by a spontaneous...
End user engagement in refugee shelter design
Debate about participatory design (PD) has focussed considerably upon process. Factors such as facilitation skills and commitment to a participatory ethos have been highlighted as factors mediating stakeholder engagement....
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